The document provides a review of key concepts and events from around 1500 CE. It covers topics like the Renaissance beginning in Italian city-states and spreading to Northern Europe, famous Renaissance artists like Michelangelo and Leonardo da Vinci, the development of humanism as an intellectual movement, the major religions and their geographic concentrations in Europe, Asia, Africa, and the Middle East, as well as overland and maritime trade routes that connected these various regions and facilitated the exchange of goods, ideas, and knowledge.