Improving Laboratory Performance Through Quality Control - The role of EQA in...Randox
Randox Quality Control's five simple steps to QC success. The second education guide from Randox QC for clinical laboratory staff. The guide will examine how EQA works, benefits of EQA and what a laboratory should look for when choosing an EQA scheme.
Troubleshooting QC Problems: Your QC has failed, what do you do next?Randox
Randox Quality Control's next 'Improving Laboratory Performance Through Quality Control' educational guide has been published with helpful tips that your laboratory can use in order to ensure it has effective troubleshooting procedures in place.
So you ran QC this morning and realised that one of your analytes has been flagged as 'out-of-control', what do you do next? Do you ignore the warning and continue patient testing, repeat the control until it's within range or do you halt patient testing and investigate the source of the error?
When it comes to troubleshooting QC errors, unfortunately there is no easy path to take. However, it's important that you have standard operating procedures in place, outlining what to do in the event of an out-of control error. Errors occur in laboratories all over the world. A lab with effective troubleshooting procedures in place will still have errors but will be able to detect them, quickly reducing their impact and reducing the risk of wasting both time and money.
How to write Standard Operating Procedures (SOPs) for clinical laboratories -...Tamer Soliman
How to write Standard Operating Procedures (SOPs) for Clinical Laboratories
Based on WHO Laboratory Quality Stepwise Implementation Tool
By Dr. Tamer Soliman
1. SOPs Introduction
1.1 Overview
1.2 Purpose
1.3 Benefits
1.4 Writing Styles
Recently ISO 15189:2022 have become available. This would help laboratories set up processes which would yield reproducible results and improve the quality of work.
Improving Laboratory Performance Through Quality Control - The role of EQA in...Randox
Randox Quality Control's five simple steps to QC success. The second education guide from Randox QC for clinical laboratory staff. The guide will examine how EQA works, benefits of EQA and what a laboratory should look for when choosing an EQA scheme.
Troubleshooting QC Problems: Your QC has failed, what do you do next?Randox
Randox Quality Control's next 'Improving Laboratory Performance Through Quality Control' educational guide has been published with helpful tips that your laboratory can use in order to ensure it has effective troubleshooting procedures in place.
So you ran QC this morning and realised that one of your analytes has been flagged as 'out-of-control', what do you do next? Do you ignore the warning and continue patient testing, repeat the control until it's within range or do you halt patient testing and investigate the source of the error?
When it comes to troubleshooting QC errors, unfortunately there is no easy path to take. However, it's important that you have standard operating procedures in place, outlining what to do in the event of an out-of control error. Errors occur in laboratories all over the world. A lab with effective troubleshooting procedures in place will still have errors but will be able to detect them, quickly reducing their impact and reducing the risk of wasting both time and money.
How to write Standard Operating Procedures (SOPs) for clinical laboratories -...Tamer Soliman
How to write Standard Operating Procedures (SOPs) for Clinical Laboratories
Based on WHO Laboratory Quality Stepwise Implementation Tool
By Dr. Tamer Soliman
1. SOPs Introduction
1.1 Overview
1.2 Purpose
1.3 Benefits
1.4 Writing Styles
Recently ISO 15189:2022 have become available. This would help laboratories set up processes which would yield reproducible results and improve the quality of work.
A routine session on quality assurance practice in a medical laboratory to sensitize and provide basics to those interested in working in a medical testing laboratory.
Designing an appropriate QC procedure for your laboratoryRandox
Improving Laboratory Performance Through Quality Control - Five Simple Steps for QC Success.
It is easy to get caught up in an abundance of QC statistics and forget the fundamental reason why
QC exists in the first instance. QC is about detecting errors and ensuring that the results you
produce are accurate and reliable. All QC procedures should focus on reducing the risk of harm
to the patient. We are not examining statistics; we are examining real patients, real results and real
lives. Around 70% of all medical decisions are based on laboratory results, which is why it is of
utmost importance that each and every laboratory, has a well-designed QC procedure in place.
Quality in clinical laboratory is a continuous journey of improving processes through team work, innovative solutions, regulatory compliance with final objective to meet the evolving needs of clinicians & patients.
Data Analytics For Beginners | Introduction To Data Analytics | Data Analytic...Edureka!
Data Analytics for R Course: https://www.edureka.co/r-for-analytics
This Edureka Tutorial on Data Analytics for Beginners will help you learn the various parameters you need to consider while performing data analysis.
The following are the topics covered in this session:
Introduction To Data Analytics
Statistics
Data Cleaning and Manipulation
Data Visualization
Machine Learning
Roles, Responsibilities and Salary of Data Analyst
Need of R
Hands-On
Statistics for Data Science: https://youtu.be/oT87O0VQRi8
Follow us to never miss an update in the future.
Instagram: https://www.instagram.com/edureka_learning/
Facebook: https://www.facebook.com/edurekaIN/
Twitter: https://twitter.com/edurekain
LinkedIn: https://www.linkedin.com/company/edureka
A routine session on quality assurance practice in a medical laboratory to sensitize and provide basics to those interested in working in a medical testing laboratory.
Designing an appropriate QC procedure for your laboratoryRandox
Improving Laboratory Performance Through Quality Control - Five Simple Steps for QC Success.
It is easy to get caught up in an abundance of QC statistics and forget the fundamental reason why
QC exists in the first instance. QC is about detecting errors and ensuring that the results you
produce are accurate and reliable. All QC procedures should focus on reducing the risk of harm
to the patient. We are not examining statistics; we are examining real patients, real results and real
lives. Around 70% of all medical decisions are based on laboratory results, which is why it is of
utmost importance that each and every laboratory, has a well-designed QC procedure in place.
Quality in clinical laboratory is a continuous journey of improving processes through team work, innovative solutions, regulatory compliance with final objective to meet the evolving needs of clinicians & patients.
Data Analytics For Beginners | Introduction To Data Analytics | Data Analytic...Edureka!
Data Analytics for R Course: https://www.edureka.co/r-for-analytics
This Edureka Tutorial on Data Analytics for Beginners will help you learn the various parameters you need to consider while performing data analysis.
The following are the topics covered in this session:
Introduction To Data Analytics
Statistics
Data Cleaning and Manipulation
Data Visualization
Machine Learning
Roles, Responsibilities and Salary of Data Analyst
Need of R
Hands-On
Statistics for Data Science: https://youtu.be/oT87O0VQRi8
Follow us to never miss an update in the future.
Instagram: https://www.instagram.com/edureka_learning/
Facebook: https://www.facebook.com/edurekaIN/
Twitter: https://twitter.com/edurekain
LinkedIn: https://www.linkedin.com/company/edureka
tIt appears that you've provided a set of instructions or input format for a machine learning task, particularly clustering using K-Means. Let's break down what each component means:
(number of clusters):
This is a placeholder for an actual numerical value that represents the desired number of clusters into which you want to divide your training data. In K-Means clustering, you need to specify in advance how many clusters (K) you want the algorithm to find in your data.
Training set:
The "training set" is your dataset, which contains the data points that you want to cluster. Each data point represents an observation or sample in your dataset.
(drop convention):
It's not clear from this input what "(drop convention)" refers to. It could be related to a specific data preprocessing or handling instruction, but without additional context or information, it's challenging to provide a precise explanation for this part.
In summary, you are expected to provide the number of clusters (K) that you want to discover in your training data, and the training data itself contains the observations or samples that will be used for clustering. The "(drop convention)" part may require further clarification or context to provide a meaningful explanation.Clustering is a fundamental concept in the field of machine learning and data analysis that involves grouping similar data points together based on certain criteria or patterns. It is a technique used to discover inherent structures, relationships, or similarities within a dataset when there are no predefined labels or categories. Clustering is widely employed in various domains, including marketing, biology, image analysis, recommendation systems, and more. In this comprehensive explanation of clustering, we will explore its principles, methods, applications, and key considerations.
Table of Contents
Introduction to Clustering
Key Concepts and Terminology
Types of Clustering
3.1. Partitioning Clustering
3.2. Hierarchical Clustering
3.3. Density-Based Clustering
3.4. Model-Based Clustering
Distance Metrics and Similarity Measures
Common Clustering Algorithms
5.1. K-Means Clustering
5.2. Hierarchical Agglomerative Clustering
5.3. DBSCAN (Density-Based Spatial Clustering of Applications with Noise)
5.4. Gaussian Mixture Models (GMM)
Evaluation of Clusters
Applications of Clustering
7.1. Customer Segmentation
7.2. Image Segmentation
7.3. Anomaly Detection
7.4. Document Clustering
7.5. Recommender Systems
7.6. Genomic Clustering
Challenges and Considerations
8.1. Determining the Number of Clusters (K)
8.2. Handling High-Dimensional Data
8.3. Initial Centroid Selection
8.4. Scaling and Normalization
8.5. Interpretation of Results
Best Practices in Clustering
Future Trends and Advances
Conclusion
1. Introduction to Clustering
Clustering, in the context of data analysis and machine learning, refers to the process of grouping a set of data points into subsets,
At the end of learning at an educational level, leaders often perceive difficulties in
determining the best students at a certain level of education. Cumulative Achievement Index may
not be used for decision makers in determining the best students. There are criteria other criteria that
influence them are actively organize, have never done a repair value, never follow short semester,
never leave. Using these criteria and using Multi-Criteria Decision Making (MCDM) based methods
applied to decision support systems can deliver the expected outcomes of higher education leaders.
Many methods can be used on decision support systems such as Promethee, Promethee II, Electre,
AHP, SAW, or TOPSIS. In this discussion, the author uses Extended Promethee II method in
determining the best student at a college.
The decision taken in the selection of scholarship recipients for students is one of the responsibilities held by the stakeholders at the high school leadership level. The decision-making stage consists of compliance with the terms or criteria set by the government as the scholarship provider. Implementation of decision support methods for selection of scholarship recipients is required. This can help the leadership to make the selection better. Many methods in decision support systems can solve and make decisions better, including preference selection index. The use of preference selection index applied in the decision support system will result in a more effective decision.
Course Outcome and Program Outcome Calculation(new method)Ravikumar Tiwari
This presentation explains the new method (based on attainment level) of Course Outcome and Program Outcome Calculation. (with reference to National Board of Accreditation new SAR)
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
1. How To Evaluate Ungraded Results?(CAP Surveys)Prepared By: BILAl Al-kadriJuNE, 2010
2. Proficiency Testing: A form of External Quality Control Good Laboratory practices Develops confidence in the accuracy & reliability of your results CAP Surveys three times/year (some two/year) Evaluate each analyte and specimen for negative/positive bias, trends or shifts
3. Documentation: Always maintain documentation of CAP surveys for minimum 2 YEARS. This includes Participant Summary, investigations. Reporting forms, evaluation reports, etc…
4. Documentation: You can download Participant Summary for each surveys as necessary. www.cap.org Refer to following slides for downloading
16. Calculate the Mean of the Means:52.9+51.6+49.2+…………..+53.7+46.7+46.9 = 55.8 23 Mean -15% is: 55.8 – (55.8 x 15/100)= 47.4 Mean +15% is: 55.8 – (55.8 x 15/100)= 47.4
17.
18. Calculate the Mean of the Means:4797.6 + 2309.27 + 1591.01 + 2019.5+ 2028.86 5 Mean -3SD is: 2549.25 + (3x268.37) = 1744.14 Mean +3SD is: 2549.25 + (3x268.37)= 3354.35
19.
20. Calculate the Mean of the Means:269.605+261.488+…………..+271.382+267.904 = 296.177 23 Mean - 20% is: 296.177– (296.177 x 20/100)= 236.942 Mean + 20% is: 296.177+ (296.177 x 20/100)= 355.412
21.
22. Calculate the Mean of the Means:2.49+3.37+3.17+…………..+2.64+2.71+2.86= 2.77 23 Mean - 20% is: 2.77– (2.77 x 20/100)= 2.22 Mean + 20% is: 2.77+ (2.77 x 20/100)= 3.32
23.
24. Calculate the Mean of the Means:18.82+34.73+33.41+…………..+29.4+28.27+29.58=28.46 26 Mean -15% is: 28.46– (28.46 x 15/100)= 24.19 Mean +15% is: 28.46 – (28.46 x 15/100)= 32.73
25. Conclusion: Code 27 – Lack of participant or referee consensus; Document a self-evaluation following instructions as per the Participant Summary. Every effort should be made to find the cause(s) of an unacceptable pt result.
