This document discusses various topics in forensic toxicology including:
1) Toxicology deals with the harmful effects of chemicals on the human body, including properties, toxicity, and treatment of poisons. Forensic toxicology examines the legal aspects.
2) Several factors influence the action of poisons such as dose, route of administration, health of the individual. Poisons can act locally, remotely, or both.
3) Conditions that should arouse suspicion of poisoning include sudden symptoms in healthy individuals, worsening of symptoms against medical treatment, and detection of poison in vomitus or food remains. Advanced analysis is needed to detect poisons in tissues.
Viscera is an important evidence in forensic toxicology to find out the poison used to kill a person. But how to preserve this viscera?
Read in this ppt!
Examination of chemicals like Phenolphthalein in Trap / Bribe Cases. It is very important to know for police and the general public how to use phenolphthalein in bribe case.
Viscera is an important evidence in forensic toxicology to find out the poison used to kill a person. But how to preserve this viscera?
Read in this ppt!
Examination of chemicals like Phenolphthalein in Trap / Bribe Cases. It is very important to know for police and the general public how to use phenolphthalein in bribe case.
Forensic semen analysis plays a vital role in identification of suspected person in rape cases. this slide consist of all the recquiried info. about semen and its analysis in forensic laboratories.
VSC VIDEO SPECTRAL COMPARATAOR FORENSIC APPLICATIONS BY SHAILESH CHAUBEY STUDENT OF FORENSIC SCIENCE & CRIMINOLOGY FROM BUNDELKHAND UNIVERSITY JHANSI UTTAR PRADESH INDIA . THIS PPT SHOWS ABOUT THE FEATURES, APPLICATIONS , CASE LAWS & NEED OF VSC IN FORENSIC ASPECTS FOR DOCUMENT EXAMINATION & HANDWRITING . THIS PRESENTATION WILL HELP TO GET MORE INFORMATION ABOUT VSC BY VARIOUS SLIDES.
whenever and wherever a Disaster takes place in the form of Tsunami, Earthquake, Terrorist attack or Bomb blast the bodies which we get at the crime scene are either damaged or sometimes face cannot be identified.
A digital imaging instrument manufactured by Foster + Freeman that employs combinations of light sources and filters to examine document evidence under various wavelengths of radiation ranging from ultraviolet to the infrared regions of the electromagnetic spectrum.
VSC is a preferred tool as it supports non destructive examination of documents. VSC uses multiple parameters like IR, UV, and White light providing accurate results.
this is used in crime investigators for finding the evidences where there is lack of availability of evidence. some cells that was peeled off from our any parts of body will be seen in the crime scene and it is possible to find these kind of evidence form the crime scene.
This presentation provides a knowledge about Toxicology, its types , definition, regulatory guidelines for conducting toxicological studies, OECD guidelines for GLP. This is an assignment in the subject, Pharmacological & Toxicological Screening Methods - II, 2nd Semester, M.Pharm (Pharmacology)
Forensic semen analysis plays a vital role in identification of suspected person in rape cases. this slide consist of all the recquiried info. about semen and its analysis in forensic laboratories.
VSC VIDEO SPECTRAL COMPARATAOR FORENSIC APPLICATIONS BY SHAILESH CHAUBEY STUDENT OF FORENSIC SCIENCE & CRIMINOLOGY FROM BUNDELKHAND UNIVERSITY JHANSI UTTAR PRADESH INDIA . THIS PPT SHOWS ABOUT THE FEATURES, APPLICATIONS , CASE LAWS & NEED OF VSC IN FORENSIC ASPECTS FOR DOCUMENT EXAMINATION & HANDWRITING . THIS PRESENTATION WILL HELP TO GET MORE INFORMATION ABOUT VSC BY VARIOUS SLIDES.
whenever and wherever a Disaster takes place in the form of Tsunami, Earthquake, Terrorist attack or Bomb blast the bodies which we get at the crime scene are either damaged or sometimes face cannot be identified.
A digital imaging instrument manufactured by Foster + Freeman that employs combinations of light sources and filters to examine document evidence under various wavelengths of radiation ranging from ultraviolet to the infrared regions of the electromagnetic spectrum.
VSC is a preferred tool as it supports non destructive examination of documents. VSC uses multiple parameters like IR, UV, and White light providing accurate results.
this is used in crime investigators for finding the evidences where there is lack of availability of evidence. some cells that was peeled off from our any parts of body will be seen in the crime scene and it is possible to find these kind of evidence form the crime scene.
This presentation provides a knowledge about Toxicology, its types , definition, regulatory guidelines for conducting toxicological studies, OECD guidelines for GLP. This is an assignment in the subject, Pharmacological & Toxicological Screening Methods - II, 2nd Semester, M.Pharm (Pharmacology)
poisoning, its types and emergent management.bhartisharma175
it explain about definition, causes, types of poison, severity , diagnostic evaluation, complication of poisoning, emergent management, supportive management and nursing management.
Poisoning in Children by Dr Shamavu Gabriel .pptxGabriel Shamavu
PAEDIATRICS EMERGENCY, BASIC AND ADVANCED LIFE SUPPORT
Approach and management of Poisoning in Children
Prepared by Dr GABRIEL KAKURU SHAMAVU, Resident (Medical Senior House Officer) in Paediatric Department / Kampala International University Teaching Hospital.
Mentorship: Professor Yamile Arias Ortiz
Anyone who is seeking information about Clinical toxicity, poisoning, poisoning treatment, comparison between snake venom and poison, food poisoning and treatment, source of poison exposure, poisonous incidence, rules of poison center; then this document will be helpful for you.
1. Toxicology, Scope of Pharmacology in Cosmetic Tech .pptxJagruti Marathe
Cosmetology is the study and application of beauty treatment. Branches of specialty include hairstyling, skin care, cosmetics, manicures/pedicures, non-permanent hair removal such as waxing and sugaring, and permanent hair removal processes such as electrology and intense pulsed light.
Chap 1 General principles involved in the management of poisoningChanukya Vanam . Dr
1. General principles involved in the management of poisoning
2. Antidotes and the clinical applications.
3. Supportive care in clinical Toxicology.
4. Gut Decontamination.
5. Elimination Enhancement.
6. Toxicokinetics.
introduction toxicology, general information on some basic toxins used in day to day life and also unknown toxins we are always in contact with but little do we know about them
Unit Lesson This unit covers the management of acute poisoni.docxdickonsondorris
Unit Lesson
This unit covers the management of acute poisonings. The effects and treatments of drugs, both prescription and illegal, will be discussed. The potential side effects of prescription drugs will also be discussed. You will be able to identify how the route of exposure affects the level of drugs in the body and how the absorption of drugs can be limited.
Chapter 23: Toxicology Principles in the Management of Acute Poisonings
Poisonings, both acute and chronic, are common. Both intentional and unintentional poisonings occur from prescription and illegal drugs. When studying poisonings, you should be familiar with the dose-response, target response with side effects, and the method used to limit absorption for both prescription and illegal drugs.
Acute poisonings are common and a medical team must be able to respond to the patient quickly. An assessment of the patient is needed, including tests to determine the blood levels of the drug. The medical team must then decide if they need to limit further absorption and consider if an antidote is available.
Prescription drugs are meant to induce a response in the body. But, a drug can also induce other responses, known as side effects. An example of a side effect is if you are taking antihistamines to reduce your allergy symptoms and the side effect is feeling drowsy/sleepy. Many drugs have serious side effects, for example, liver damage, kidney damage, decreased bone marrow function, and paralysis. These side effects have to be considered before taking a drug, and the benefits of taking the drug should outweigh the risk of the side effects. It should also be noted that that not everyone will experience the side effects listed for a drug. Drug interactions can also occur, for example, alcohol and painkillers can lead to an overdose. One can also be allergic to a drug; the reaction can be anything from a rash to an anaphylactic reaction.
The absorption of a drug is required for systemic toxicity to occur. If the exposure is through inhalation, then the individual must be removed from the exposure. If it is dermal exposure, then the drug must be removed from the skin by washing. If an individual has ingested too much of a drug, there are some options. If a life-threatening amount of drug has been ingested then a gastric lavage or stomach pump can be initiated. The patient can also be treated with activated charcoal; it can absorb a variety of drugs and toxic agents, limiting the further absorption (Richards & Bourgeois, 2014, p. 417). Activated charcoal is effective for aspirin, digoxin, and phenobarbitone. The routes of exposure affect the level of a drug into the body. When a drug is injected intravenously, the entire dose is delivered into the blood stream, resulting in the highest levels for the routes of exposure. Inhalation of a drug delivers it through the pulmonary system, but not all the drug is available for absorption. Absorption through the skin is dependent on the time, con ...
toxin
medicine
antidotes
medicolegal duties of a RMP
duties of a doctor
management of a case of poisoing
sources of poisons
gastric lavage
ideal homicidal poison
This presentation covers the nature and features of drug dependence. It also gives coverage to different psychological or biological models of drug addiction.
Enzymes are biological molecules (proteins) that act as catalysts and help complex reactions occur everywhere in life. Let's say you ate a piece of meat. Proteases would go to work and help break down the peptide bonds between the amino acids.
A chemical substance produced in the body that controls and regulates the activity of certain cells or organs. Many hormones are secreted by special glands, such as thyroid hormone produced by the thyroid gland.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
Honest Reviews of Tim Han LMA Course Program.pptxtimhan337
Personal development courses are widely available today, with each one promising life-changing outcomes. Tim Han’s Life Mastery Achievers (LMA) Course has drawn a lot of interest. In addition to offering my frank assessment of Success Insider’s LMA Course, this piece examines the course’s effects via a variety of Tim Han LMA course reviews and Success Insider comments.
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Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
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2. Toxicology is the branch of medicine that deals with
properties, action, toxicity and lethal dose, estimation of,
treatment and autopsy findings of poisons.
Forensic toxicology deals with medical and legal aspects of
the harmful effects of the chemicals on the human body.
Clinical toxicology refers to human diseases caused by or
associated with abnormal exposure to chemical substances.
Toxinology, refers to toxins produced by living organisms,
which are dangerous to man, e.g. venom of snakes, spiders
and bees, bacterial and fungal toxins, poisonous plants, etc
3. Drugs are natural or synthetic substances, which are used to
exert physiological or psychological effect on the consumer.
Poison :According to Webster’s Dictionary, ‘poison’ means a
substance, which through its chemical action usually kills,
injures or impairs an organism. Poison is defined as any
substance which when administered by any route can cause
disease, deformity or death.
Overdose: The terminology overdose in general implies an
intentional toxic exposure
4. According to the main symptoms produced, poisons are basically classified
into four groups, namely: corrosives, irritants, systemic poisons and other
poisons.
ACTION OF POISONS
Poisons act usually by three ways: locally, remotely and both
locally and remotely.
Locally acting: These act only at the site of application such
as skin/mucosa, e.g. corrosive poisons.
Remotely acting: These act only after being absorbed into the
circulatory system, e.g. narcotic poisons, cardiac poisons, etc.
Both locally and remotely acting: These act by local and
remote actions, synergistically, e.g. carbolic acid, etc.
5.
6.
7. Several factors influence the action of poison and they are:
Route of Administration
Addiction
Age
Dose
Health of Individual
Concentration of Poison
Idiosyncrasy: Idiosyncrasy means unexpected allergy or
intolerance. It brings about untoward effects or ill health or
death, e.g. allergy to certain drugs like penicillin, certain
foodstuffs like eggs, shellfish, etc.
8. Enumerated below are certain conditions observed in living persons, which should arouse
suspicion of poisoning to a physician:
• Appearance of symptoms suddenly in a healthy person or several people at a time.
• Sudden worsening of symptoms in a sick person, who was receiving correct treatment and
showing significant improvements or progress.
• Appearance of symptoms soon after ingestion of food or medicine.
• Manner and course of symptoms, e.g. symptoms that run steadily, a downhill course to death or
an uphill course to total recovery.
• Detection of poison in remnants of food or vomitus.
• Even on reporting of “no poison” on analysis of the suspected materials, the suspicion of
poisoning cannot be ruled out for the reasons such as:
– Poison may already be eliminated from the body by vomiting or metabolized and excreted
through natural
channels, leaving no evidence.
– The analysis technique might be faulty.
– The case may be a real case of disease and not a poisoning case at all.
9. • Advances of Synthetic Chemistry Diversify the
Poison in modern era:
– People take medication & chemical then ever before
– Combination of drugs and its side effect complicate
poisoning detection
– Poison detection need collaborative approach among
practitioner, pathologist,,forensic scientist
10. Toxicological evidence forensic aspect:
Medicine in toxic dose; Poison & Poison in small dose;
medicine
For Example ; Chloral Hydrate 300 mg is hypnotic &
3gm act knock out drop (poison) use for robbery, rape
cases
Barbiturates small dose treat insomnia, but coma &
death in normal person
11. • Proof of poisoning can be assist by following factors
– Sign & Symptoms ,suggesting toxic exposure
– Autopsy findings
– Evidence of pathological lesions
– Conclusive evidence;absorption of toxic substance in tissue
12. • Detection of poisons in biological/non biological
material in low concentration
• The proof to find, absorbed toxic substance in tissue
of visceral organ/blood/urine
• If specific substance suspected, direct analysis
can be made
• As rule general systematic toxicological
examination preferred even if particular poison
suspected
13. • Poisoning as a possible cause of death,facilitated by
– Scene Investigation ( Prescription,medications etc)
– History of case
– Autopsy findings
– Gross/Microscopic findings
• Addition histopathological,biochemical & serological
forensic examination helpful
14. • Putrefaction &ToxicologicalAnalysis: it
complicates toxicological analysis, problem in
interpretation of results
– Chemical changes in tissue , toxic substance hard to identify
e.g parathion, aconite
– Putrefaction produce toxic substance from normal tissue,
interfere in result
– Volatile substance lost due to putrefaction
– Ethy alcohal may produced from normal tissue in
advance putrefaction
15. • Apart from detection , concentration of poison
required in some cases
• Interpretation of quantitative data, i.e. fatal dose of
poison
• Record of poison & knowledge of toxicokinetics is
important
• During reporting extreme care should be taken
16. 1) No History/ No Clue of Poison:general scheme of study give negative result.
2) History Of Poisoning,No positive findings:it could happened if
a) The poison vomited out,detoxified or small quantity
e.g. succinyl choline injected as homicide, metabolized in body to succinate &
choline;which are normal constituent of body tissue
b) Less poison directly associated with higher time gap b/w ingestion & death
c) The absorbed poison not evenly distributed; organ/tissues
d) Rout of administration varies concentration e.g orally vs IV varies conc in blood &
liver
e) Toolittle specimen;hard to detect
f) Highly potent toxic substance
g) Victim treated may alter poison nature
Note:don’tinterpret report as“No Poison detected”
17. 3) Alteration by Biochemical Process: isolated material may not identical due to
alteration by biochemical process such as
– Finding phenobarbitone when primidone has been taken
– Finding oxazepam when diazepam has been taken
– Finding Morphine if heroin is involved
4) Lethal/therapeutic Dose varies: a substance may varies from slight effect to over
dosage,lethal dose cant be fixed
– Happened due to personal variation e.g age,sex,weight
5) Degree of Uncertainty: in quantitative measurement the reasonable range of
probable error would be around 2 +SD.
6) Normal vs Observed Concentration of Poison: toxic substance may or may not
present normally in body
-If present such as insecticides due to environmental pollution its magnitude may
be determined
-E.g average arsenic content of 1/2ppm but up to 4ppm may be considered
normal, chronic long term arsenic poisoning may result in 70 ppm of arsenic in
hairs & nails
18. • Text book of Medical Jurisprudence,Forensic medicine andToxicology, BV Subrahmanym
Seventh edition