This document discusses toxic minerals including lead, arsenic, mercury, and cadmium. It describes the sources of exposure, absorption, distribution, toxicity effects, and treatment options for poisoning from each of these heavy metals. Lead is discussed in most depth, outlining its various non-occupational exposure sources and noting the EPA limits for levels in drinking water, soil, and air. Symptoms of lead toxicity and chelation therapy using dimercaprol are also summarized.
mass spectrometry for pesticides residue analysis- L4sherif Taha
This is the fourth and the last lecture in series of lectures on mass spectrometry for pesticides residue analysis. this lecture present the commonly used mass to charge analyzer for pesticides residue analysis.
Opium is the air-dried milky exudate, or latex, obtained by incising the unripe capsules of the opium poppy Papaver somniferum (Papaveraceae).
the ripe capsule can contain up to 0.5% total alkaloids
Opium represents a much concentrated form and up to 25% of its mass is composed of alkaloids ( more than 40 alkaloids).
It's about how toxins affect our body and how our body build as defense mechanism to fight it. Biotransformation is a process when these toxins are converted into useful metabolites.
Heavy metals and its effects on plants and environmentHaider Ali Malik
Heavy metals are natural constituents of the earth’s crust , but indiscriminate human activities have drastically altered their geochemical cycles and biochemicals balance.
Any toxic metals may be called heavy metals.
Since heavy metals have a propensity to accumulate in selective body organs.
The average safety levels in food or water are often misleading high.
Heavy is any metal or metalloid of environmental concern.
Heavy metals are metallic element that have relatively high density usually greater than 5 g/cm3, or their density is greater than the density of water.
mass spectrometry for pesticides residue analysis- L4sherif Taha
This is the fourth and the last lecture in series of lectures on mass spectrometry for pesticides residue analysis. this lecture present the commonly used mass to charge analyzer for pesticides residue analysis.
Opium is the air-dried milky exudate, or latex, obtained by incising the unripe capsules of the opium poppy Papaver somniferum (Papaveraceae).
the ripe capsule can contain up to 0.5% total alkaloids
Opium represents a much concentrated form and up to 25% of its mass is composed of alkaloids ( more than 40 alkaloids).
It's about how toxins affect our body and how our body build as defense mechanism to fight it. Biotransformation is a process when these toxins are converted into useful metabolites.
Heavy metals and its effects on plants and environmentHaider Ali Malik
Heavy metals are natural constituents of the earth’s crust , but indiscriminate human activities have drastically altered their geochemical cycles and biochemicals balance.
Any toxic metals may be called heavy metals.
Since heavy metals have a propensity to accumulate in selective body organs.
The average safety levels in food or water are often misleading high.
Heavy is any metal or metalloid of environmental concern.
Heavy metals are metallic element that have relatively high density usually greater than 5 g/cm3, or their density is greater than the density of water.
For More Medicine Free PPT - http://playnever.blogspot.com/
For Health benefits and medicine videos Subscribe youtube channel - https://www.youtube.com/playlist?list=PLKg-H-sMh9G01zEg4YpndngXODW2bq92w
This presentation gives the description that which heavy metals are toxic for human health and how they interact with the metabolic processes and cause different diseases in human beings. There are also the threshold values given to help prevent the toxicity....
I mentioned the most common toxic material in this lecture"lead, iron, mercury, Arsenic" and I put CO in it.
so i hope it will be helpful for any one want to use it :D
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
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Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
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Francesca Gottschalk from the OECD’s Centre for Educational Research and Innovation presents at the Ask an Expert Webinar: How can education support child empowerment?
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Personal development courses are widely available today, with each one promising life-changing outcomes. Tim Han’s Life Mastery Achievers (LMA) Course has drawn a lot of interest. In addition to offering my frank assessment of Success Insider’s LMA Course, this piece examines the course’s effects via a variety of Tim Han LMA course reviews and Success Insider comments.
4. Toxic Minerals or “heavy metals”
• Found naturally in the earth crust
• Toxic and poisons in nature even at low concentration
• Exposed in ecosystem due high industrial uses, extensive mining,
smelting of ores, burning of coal, gas and oil, incineration of waste
materials around the world
• Environment, Plants, Animals and Humans are exposed to highest
levels
5. • Toxic metals are now everywhere and affect everyone on planet
earth. They have become a major cause of illness, aging and even
genetic defects
• Most common toxic minerals are Arsenic (As), lead (Pb), Mercury (Hg)
and Cadmium (Cd)
6. Lead (Pb)
• Soft gray metal, Naturally occur
in earth
• Occurs in organic and inorganic
form
• Insignificant environmentally
until about 1800
• Human activities mobilized lead
in the Environment
7. • Maximum concertation of lead allowed according to United State
Environmental Protection Agency (USEPA, 1987)
In Sludge (Soil) 85 mg/kg
In drinking water 0.01 mg/l
In aquatic H20 supporting marine life 0.0058 mg/l
Air 50 µg/m3
8. Sources of exposure
Occupational exposure
• Battery makers
• Cable makers
• Glass makers/polishers
• Gunshot/gun barrel makers
• Jewelers
• Lead burners
• Painters
• Pigment makers
• Pipe cutters
• Printers
Non-occupational exposure
• Battery burning
• Bullet retention
• Cooking in leaden pots
• Target shooting
• lead containing herbal medicines
• Ingestion of paints
• still used as additives in gasoline in
several countries
• Exists in cigarette smoke
• surface paints on the toys
• stagnant water in pipes
• Cosmetics
9.
10. Absorption
1. Gastro intestinal tract (GIT)
• Higher absorption in children than adults
• Lead absorption is dependent on several factors, including the
physical form of lead, the particle size ingested, the GI transit time,
and the nutritional status of the person ingesting.
• Increased with Fe, Ca, Zn deficiency
• Decreased if phosphorus, riboflavin, vitamin C, and vitamin E are in
the diet
• Adults: 11% - 16%
• Children : 40% - 50%
11. 2. Lungs
• 50-70 % of lead inhaled can be absorbed through lungs
3. Skin
Inorganic lead is unabsorbed
Organic form readily absorbed
12. Distribution in the body
• Absorbed lead is exchanged primarily among the following 3
compartments:
Blood (Max. limit: children < 5 µg/dl, Adults 10 µg/dl)
(ATSDR, 2012)
Soft tissue (liver, kidneys, lungs, brain, spleen, muscles, and heart)
Mineralizing tissues (bones and teeth)
• Lead readily crosses the placenta and exists in breast milk, with the fetus
retaining lead cumulatively throughout gestation.
• Specific health problems, such as malnutrition and iron deficiency, may
result in higher lead absorption in the mother. Elevated maternal lead
levels subsequently result in higher lead distribution to the fetus
13. Elimination from body
1. Kidney is responsible for 65% of lead’s elimination
• Process is dependent on glomerular filtration rate and renal plasma
flow
2. Biliary excretion is responsible for 35% of lead’s elimination
14. Toxicity
• Classified as carcinogenic by Agency for research on cancer
• Lead interferes with a variety of body processes and is toxic to many organs
and tissues. The heart, bones, teeth, intestines, kidneys, thyroid gland
reproductive and nervous systems represent its main targets
• High affinity for SH groups toxic to multiple enzymes systems
• Affect Ca requiring cell function by binding to CaBP
• Anemia due to inhibition of chain reaction for haem synthesis
• Toxic effect on renal tubules
• Inhibit 5-pyrimidine nucleotides (Active precursor of DNA and RNA)
• Affect motors nerves ultimately CNS (Affect CPK II system)
15. • Affects virtually every system in the body
Central nervous system
Blood (Inhibition of heam synthesis)
Endocrine
Cardiovascular
Renal
Gastrointestinal
Musculoskeletal
Immune and reproductive system
17. Treatment of lead Toxicity
• Dimercaprol (also referred to as British antilewisite [BAL])
• Chelating agent Removes intra cellular and extracellular lead
• Recommended as an agent of first choice for patients with lead
toxicity.
• With high BLLs (i.e, > 70 µg/dl), it is used in conjunction with EDTA
• Allows extracellular lead to be eliminated through renal system
18. Arsenic (As)
• 20th most Abundant mineral in earth crust
(1.5-3.0 mg /kg)
• Arsenic exists in the environment in major
three forms,
Organic (arsine)
Inorganic arsenic compounds (arsenite)
Elemental form
19. • “King of poisons, poison of kings”
• Odorless and taste less properties inorganic
compounds makes it ideal poison i.e.
arsenic tri-oxide (white arsenic)
• Tiberius Britannicus in 55 CE poisoned by his
step brother Nero, who later secured
position of emperor of Rome
20. Exposure to arsenic
• Inorganic arsenic poisoning can be related to human activities such as
mining and smelting
• Dissolved naturally in ground water and soil
• Marine food like fish (less toxic organic form)
• Herbicides, fungicides contain arsenic
• In cosmetics 19th to early 20th century for whitening and rosy cheeks
• Common source of accidental poisoning
21.
22. Absorption
• Many arsenic compounds (especially inorganic arsenic) are readily
absorbed through the GI tract when delivered orally in humans
• Absorption within the lungs is dependent upon the size of the arsenic
compound, and it is believed that much of the inhaled arsenic is later
absorbed through the stomach after (respiratory) mucociliary
clearance
• After the absorption of arsenic compounds, it accumulate in tissues
and body fluids
liver, kidneys, lung, spleen, aorta, and skin
Arsenic compounds are also deposited in the hair and nails
23. Tolerable levels of arsenic in Diets
Diet Level
Human beings Tolerable Daily Intake (PTDI) for inorganic arsenic is
0.002 mg/kg bodyweight
Goats 30 mg/kg BW
Horses 6.5 mg/kg BW
Sheep 11 mg/kg BW
Fish 10 mg/Kg BW
24. Toxicity
• In blood bind to the globulin portion of hemoglobin
• Impair cellular respiration by inhibiting mitochondrial enzymes and
oxidative phosphorylation
• Block pyruvate dehydrogenase in Kreb's cycle
• Binds to SH- containing proteins thus reacts with a variety of
structural and enzymatic proteins leading to inhibition of their activity
(like glutathione reductase and thioredoxin reductase)
• Trivalent arsenic inhibits cellular glucose uptake, gluconeogenesis,
fatty acid oxidation
25. • It can replace phosphate in many reactions can replace the stable
phosphate ester bond in ATP and produce an arsenic ester stable
bond which is not a high energy bond
• Arsenic has very high carcinogenic potential. The mechanisms
responsible for this may be inhibition of DNA repair and alterations in
the status of DNA. Due to inactivation of DNA-binding proteins,
transcription factors and DNA-repair proteins by interaction of arsenic
with –SH group.
• Arsenic has irritant effect and has the ability to induce endothelial
damage, loss of capillary integrity, and capillary leakage
26.
27.
28. Treatment
• Normal values
Spot urine ~ 11 µg/L
Whole blood < 7 µg/dl
• BAL (British Anti lewisite) or Dimercaprol @ 3-5 mg/Kg I/M every 4 to
6 hrs
lewisite is arsenic containing vesicant gas
• DMSA (Succimer)
29. Mercury (Hg)
• Mercury is rarely occurring free element in
earth's crust
• Silvery, heavy, mobile, liquid phase
• Only liquid metal at room temp.
• Occurs in three forms (elemental, inorganic
salts, and organic mercurial compounds)
• Contamination results from mining,
smelting, and industrial discharges
• Almandine mine in Spain having Cinnabar
ore (HGs) is in operation from 400 BC
30. Sources of exposure
• Elemental: Barometers, batteries,
electroplating, fingerprinting products,
Fluorescent and mercury lamps, thermometers,
silver and gold production
• Organic: Insecticidal, fungicidal, bactericidal
products, aquatic products like fish (have
deposited mercury from industrial waste
deposited in water)
• Inorganic: Cosmetics, mirror silvering,
photography, tattooing inks, wood preservation
31.
32. Absorption
• Elemental
Liquid at room temperature that volatizes readily
Inhalation is the main source of toxication, rapid distribution in body
by vapor, poor in GI tract. Can affect CNS. Skin contact may also
considered.
• Inorganic
Poorly absorbed in GI tract, but can be caustic
Dermal exposure has resulted in toxicity
33. • Organic
Lipid soluble and well absorbed via GI, lungs and skin. Cross BBB and
affects CNS
Can cross placenta and into breast milk
The organic form is readily absorbed in the GIT (90-100%); lesser but
still significant amounts of inorganic mercury are absorbed in the
GIT(7-15%). Target organs are mostly the nervous system and kidneys
34. Toxicity
• Mercury reacts with sulphahydryl groups (SH), resulting n enzymes
inhibition and pathologic alteration of cellular membranes
• Methyl mercury affects CNS
• Target specific sites in brain especially cerebral cortex (visual cortex),
motor and sensory centers, auditory center and cerebellum
Typical neurological symptoms i.e. mental distortion, ataxia, hearing
loss, confusion, movement disorder, anorexia, memory loss,
uncontrolled perspiration
• Mercury vapors affects pulmonary tract
• Corrosive to the skin, eyes and GIT
35.
36. Out breaks of mercury toxicity
• Japan - 1952, chemical co.
dumped Hg into Minamata
harbor; residents of local fishing
villages contaminated; 100s
affected and 68 died
• Iraq – 1971, poison grain
disaster
Utilization of mercury treated
grains never indented to eat
Imported from Mexico and US
37. Treatment
• Allowable blood level is 5 ng/mL (nanograms per milliliter)
• urine - 20 ng/mL
• Gastric lavage if the compound is observed on abdominal radiograph series
• Activated charcoal is indicated for GI decontamination because it binds
inorganic and organic mercury compounds
• Whole bowel irrigation until rectal effluent is clear and void of any
radiopaque material
38. • Hemodialysis is used in severe cases of toxicity when renal function has declined.
However, hemodialysis with L-cysteine compound as a chelator has been
successful
• Chelating therapy for acute inorganic mercury poisoning can be done with
Dimercaptosuccinic acid (DMSA), DPCN, or BAL.
• Only DMSA is approved for treating mercury poisoning in children, organic
mercury poisoning, and poisoning due to mercury vapor
• Exchange transfusion has been used as a treatment of last resort
39. Cadmium (Cd)
• Occurs naturally in the environment in its
inorganic form as a result of volcanic emissions
and weathering of rocks
• Anthropogenic sources have increased the
background levels of cadmium in soil, water and
living organisms
• Maximum allowable contamination levels
Air 0.1-0.2 mg/cubic m
Soil 85 mg/kg
Drinking water 0.005 mg/l
Water supporting aquatic life 0.008
40. Exposure
• Small particles exist in air as result of smelting, soldering and other
industrial processes
• By-product of zinc, copper, lead ores
• Metal plating, color pigments, batteries, plastic
41. • McDonald’s Shrek glasses were
contaminated with cadmium
• Tobacco smoke important source
of cadmium
• Low levels found in grains,
cereals, leafy vegetables
42. Absorption
• Inhalation:
18-50 % inhaled absorbed through lungs
Cigarette smoke, smelters etc.
• GIT:
Liver and kidney of meat animals are rich source
6% is absorbed
43. • Absorbed Cd bound to albumin in plasma and red blood cells
• Transported to liver, pancreas, prostate and kidney, with eventual
transfer to kidney
• 50-75% of total body Cd is found in liver and kidney
• Metallothionein: protein rich in cysteine
Traps Cd especially in kidney
Synthesis induced by Cd
• Half-life in humans is 22 - 30 years
44. Toxicity
• Bind to –SH groups
• Competing with Zn and Se for inclusion into metalloenzymes
• Competing with calcium for binding sites
• Kidney toxicity:
Free Cd binds to kidney glomerulus
Proximal tubule dysfunction
• Lung toxicity:
Edema and emphysema by killing lung macrophages (dust cells)
45. • Skeletal effects:
Osteoporosis and osteomalacia (pseudofractures)
• Cancer:
Carcinogenic in animal studies
~8% of lung cancers may be attributable to Cd
46.
47. Outbreak of Cd toxicity in history
• Itai-itai disease ("it hurts-it hurts disease") was the name given to the
mass cadmium poisoning of Toyama Prefecture, Japan, starting
around 1912
• Increased demand for raw material during Russo-japanese war and
world war 1 increased mining output
• Mining industry waste polluted the river
• Rice fields irrigated with the water of that river results in the
accumulation of toxic minerals in the crop
48. • Induced toxicity in many people
living in that region
• Victims felt severe pain in spine
and joints
• Softening of bones
• Kidney failure
49. Treatment
• The allowable blood level of cadmium is 0.315 µg/L
• Elements like calcium and selenium are shown to have protective
effect against cadmium-induced toxicity
• Adequate levels of zinc in the body helps to displace cadmium from
the tissues
• Potent antioxidants like Vitamin C, E, glutathione, methionine,
glycine, cysteine has great protective efficiency
• chelation therapy is ineffective so only treatment is to remove source
Structural
Component of body organs and tissues i.e Ca and P in bones
Physiological
Osmotic pressure, Acid-base balance, membrane permeability, transmission of nerve impulse
Catalytic
Act as enzymes and co-enzymes
Regulatory
Regulate cell replication and differentiation