This document proposes a model-based framework for developing engineering tool-chains that support cyber-physical systems modeling and simulation. It presents the SPIT framework, which takes a systems approach to support MBSE tool-chain development. The framework addresses functionalities of MBSE tool-chains from a systems engineering perspective. Demo tool-chains are developed to support co-simulation of CPS using MBSE. Future work includes extending tool integration languages to formalize co-simulation tool-chains and analyzing the functional dynamics of MBSE enterprise transitioning.