Total knee replacement (TKR) involves replacing the weight-bearing surfaces of the knee joint to relieve pain and correct deformities. The document discusses the anatomy of the knee joint, common conditions requiring TKR such as osteoarthritis and rheumatoid arthritis, the evolution of TKR implant designs, surgical approaches, the procedure, goals of alignment and balancing, and potential complications. Computer-assisted technology can provide real-time feedback on bony cuts and alignment during surgery. While TKR successfully relieves pain in most patients, some may still experience complications such as stiffness, infection, or loosening of implants.