Knee Osteoarthritis, a common cause of knee pain and treatment ranges from exercises,tablets,arthroscopy,deformity correction to total knee replacement (TKR).
Complications after surgery can even be corrected if occurs by proper evaluation,planning and execution of the Revision Surgery.
Knee osteoarthritis basics to reconstruction to replacement dr.sandeep c agrawal agraesn hospital gondia india
Deformity: It’s the position of a limb/Joint, from which it cannot be brought back to its normal anatomical position.
Described as abnormalities of :
Length
Angulation
Rotation
Translation
Combination
Deformity: It’s the position of a limb/Joint, from which it cannot be brought back to its normal anatomical position.
Described as abnormalities of :
Length
Angulation
Rotation
Translation
Combination
presentation is about Orthosis and prosthesis. It gives Classification of Orthosis. It describes structure, function, Indication and uses of Orthosis. Also describes different types of Prostheses, their parts and function.
Orthobiologics is a current terminology for the application of various cells, cytokines, growth factors.Tissue Engineering,Gene Therapy,Osteoarthritis,Avascular Necrosis,Sickle Cell Disease,Disc Regeneration,PRP,Autologous Chondrocyte Transplantation,BMAC,Spinal cord Injury paraplegia,Autoimmnune disorders,Diabetic foot,Tendinopathies,Wound Healing,,SCAFFOLDS IN STEM CELL THERAPY.Regenerative medicine is now an recognized specialty which has evolved from degerative diseases of Orthopaedic Surgery.Articular Cartilage : Repair To Regenerate To Replace Dr.Sandeep C Agrawal Agrasen Hospital Gondia India www.agrasenortho.com
presentation is about Orthosis and prosthesis. It gives Classification of Orthosis. It describes structure, function, Indication and uses of Orthosis. Also describes different types of Prostheses, their parts and function.
Orthobiologics is a current terminology for the application of various cells, cytokines, growth factors.Tissue Engineering,Gene Therapy,Osteoarthritis,Avascular Necrosis,Sickle Cell Disease,Disc Regeneration,PRP,Autologous Chondrocyte Transplantation,BMAC,Spinal cord Injury paraplegia,Autoimmnune disorders,Diabetic foot,Tendinopathies,Wound Healing,,SCAFFOLDS IN STEM CELL THERAPY.Regenerative medicine is now an recognized specialty which has evolved from degerative diseases of Orthopaedic Surgery.Articular Cartilage : Repair To Regenerate To Replace Dr.Sandeep C Agrawal Agrasen Hospital Gondia India www.agrasenortho.com
Femoroacetabular impingement in young adults
Dr.sandeep agrawal agrasen hospital,gondia maharashtra
A cause of groin or hip pain in adults other than commoner cause of Avascular necrosis femoral head
Cam mechanism ,Pincer mechanism,Femoral neck head junction Osteochondroplasty
Pelvic osteotomy ,outerbridge classification
Periprosthetic infection is becoming more and more common and devastating.Better treatment modality of two staged antibiotic cement spacer is becoming more and more common with excellent results.Antibiotic Cement Spacer for Infected Hip Joint Replacement (THR) Surgery, Dr.Sandeep Agrawal,Agrasen Hospital,Gondia,Maharashtra,India
Polyethylene Damage Mechanisms
in Total Hip & Total knee Surgeries ,DR.SANDEEP AGRAWAL
Agrasen Fracture Hospital
Gondia
Maharashtra
Cause for Failure or Revision for Joint Replacement surgeries
THR , TKR
Hip Knee Pain
Instability
Stem Cells,BMAC,PRP,Scaffold,Regenerative Medicine,Chondrocytes,Mesenchymal cells,FUTURE ORTHOPEDICS BASICS OF STEM CELLS AND TISSUE ENGINEERING Dr.Sandeep C Agrawal Gondia Maharashtra India
CALCIUM METABOLISM:
VITAMIN D-PARATHYROID-CALCITONIN ROLE
(Rickets,Osteoporosis,Renal Osteodystrophy)
Prevention Dr.Sandeep C Agrawal Agrasen Hospital Gondia India
Metabolic Bone Diseases:phosphorus,magnesium and other minerals ,Calcium and vitamin D rich diets,Sunlight exposure,vitamin D synthesis,Osteoporosis prevention and diet
Herniated disk in the lower back agrasen hospital dr sandeep agrawal gondia v...Dr.Sandeep Agrawal Gondia
Back Pain
Back pain is often a common symptom of many disease conditions and the back pain may range from simple or dull pain to sudden and sharp pain. If the pain persists for few days, it is acute pain whereas if continues for more than 3 months, it is considered as chronic pain. In most cases, back pain may resolve without any treatment however if persists for more than 3 days, medical intervention is necessary.
Neck Pain
The first 7 vertebral bones on the spinal column form the cervical spine and are located in the neck region. The neck bears the weight of the head, allows significant amount of movement, and also less protected than other parts of spine. All these factors make the neck more susceptible to injury or other painful disorders. Common neck pain may occur from muscle strain or tension in everyday activities including poor posture, prolonged use of a computer and sleeping in an uncomfortable position.
Spinal Deformity Surgery
The Spine or backbone provides stability to the upper part of our body. It helps to hold the body upright. It consists of several irregularly shaped bones, called vertebrae appearing in a straight line. The spine has two gentle curves, when looked from the side and appears to be straight when viewed from the front. When these curves are exaggerated, pronounced problems can occur such as back pain, breathing difficulties and fatigue and the condition will be considered as deformity. Spine deformity can be defined as abnormality in the shape, curvature and flexibility of spine.
Spine Injections
Spine injection is a nonsurgical treatment modality recommended for treatment of chronic back pain. Injection of certain medicinal agents relieves the pain by blocking the nerve signals between specific areas of the body and the brain. The treatment approach involves injections of local anaesthetics, steroids, or narcotics into the affected soft tissues, joints, or nerve roots. It may also involve complex nerve blocks and spinal cord stimulation.
Spine Trauma
Spine trauma is damage to the spine caused from a sudden traumatic injury caused by an accidental fall or any other physical injury. Spinal injuries may occur while playing, performing normal activities, operating heavy machines, lifting heavy objects, driving automobiles, or when you suffer a fall. Injury to spine may cause various conditions including fractures, dislocation, partial misalignment (subluxation), disc compression (herniated disc), hematoma (accumulation of blood) and partial or complete tears of ligaments.
Vertebral Fractures
Vertebral compression fractures occur when the normal vertebral body of the spine is squeezed or compressed. The bone collapses when too much pressure is placed on the vertebrae, resulting in pain, limited mobility, loss of height, and spinal deformities. In severe compression fractures the vertebral body is pushed into the spinal canal which will apply pressure on the spinal cord and nerves.
Herniated Disk in the Lower Back
Sometimes called a slipped disc, a herniated disk most often occurs in your lower back. It is one of the most common causes of low back pain, as well as leg pain (sciatica).
Herniated Disc symptoms: sharp, burning or stabbing pain in back, may also run down leg; onset is often sudden.
Condition and Causes
Between 60% and 80% of people will experience low back pain at some point in their lives. A high percentage of people will have low back and leg pain caused by a herniated disk.
Although a herniated disk can sometimes be very painful, most people feel much better with just a few weeks or months of nonsurgical treatment.
http://www.drsandeepagrawal.com/spine.php
There are many different types of conditions that cause back pain. Like most medical conditions, back pain is treatable through several methodologies. Determining what condition you have is the key to determining the right treatment option for you. Back pain comes in many forms, lower back pain, middle back pain, and upper back pain are just a few of the symptoms associated with spinalconditions. You may also have pain or tingling in your extremities that may be indications of spinal conditions. Feel free to browse through our articles about conditions. Contact your doctor to set up an appointment to start your road to recovery.
Every person is different, so symptoms of conditions may present
differently for different people. Symptoms also vary depending on the
condition, its severity, location, and other factors.
Patella dislocation is a common problem in the young. Recurrence of dislocation can be significant problem causing pain and discomfort. The assessment and guidelines towards non-surgical and surgical treatment options are discussed here.
Acl Reconstruction Surgery In Delhi Dr. Shekhar Srivastav 09971192233DelhiArthroscopy
ACL Reconstruction Surgery in Delhi by Dr. Shekhar Srivastav - Dr. Shekhar Srivastav is an Orthopedic Surgeon attached to Sant Parmanand Hospital, Delhi with special interest in Knee & Shoulder surgery. After obtaining his M.S. Orthopedics degree he has undergone training in various centers in India and Abroad which has helped him in understanding the Orthopedics problems and their Management. He did his AO/ ASIF fellowship at University Hospital, Salzburg, Austria in 2006 and recieved training in Arthroscopy & Sports Medicine at TUM, Munich (Germany) & Rush Orthopedics Centre, Chicago( USA). He has an experience of more than fifteen years of diagnosing and treating Orthopedics & Trauma patients.
Check Out Details at http://www.delhiarthroscopy.com
• Arthroplasty / total knee replacement in Delhi is a surgical intervention in which the worn-out joint surfaces of the femur, tibia and often the kneecap are replaced, as they are a source of disabling pain. Metallic and high-density polyethylene components are placed in place of damaged and painful joint surfaces.
Total knee replacement is a salvage procedure in orthopaedic surgery to provide a painless, mobile and stable knee joint to improve quality of life of patients suffering from afvanced painful arthritis commonly osteoarthritis, rheumatoid arthritis and rarely post-traumatic arthritis. Damaged cartilages and bones are carefully removed by measured resection and the collateral ligaments are preserved and balanced for creating a equal gap both in knee flexion as well as in knee extension for restoring anatomy. the main indication for doing total knee replacement is pain relief. The overall functional outcomes in terms of functional results are good after total knee replacement. Wound infection must be prevented by strict aseptic precautions during surgery.
Vertebroplasty is an effective, minimally invasive spine procedure where acrylic bone cement is injected into a painful pathologically compressed vertebral body.
Approach to acute knee injuries (knee injury)mahadev deuja
approach to acute knee injuries include detail history, focused knee exam and imaging/invasive procedure,Diagnosis is made at history most of the times.History should include mechanism of Injury,location of pain, mechanical symptoms like swelling/ effusion...
Failed Back and Neck Surgery Syndromes happen when a surgery to correct pain completely fails to alleviate the pain and in some cases makes the pain worse.
There are many reasons why a surgery could fail to provide results, both related to the patient and the surgeon.
How is it that a patient could cause a surgery to fail. A great example of this would be that a patient has undergone a spinal fusion to correct spinal instability in the lower back. The surgeon has advised the patient that smoking cigarettes which could severely reduce the healing chances and effect the fusion process. The patient ignores the doctor and continues to smoke and the fusion doesn’t heal. This is an example of the patient being at fault.
In what ways could a surgeon be at fault? There are many times that there is fault before the surgery is even performed. If there is an inaccurate diagnoses the surgery will be performed in the wrong area, and possibly the wrong surgery will be done. It is important to seek a second opinion of a specialist before proceeding with surgery of any kind. If two heads can agree on what and where the problem is, it is likely that there will be an accurate diagnosis.
One of the most common reasons for Failed Back and Neck Surgery Syndrome is that the surgeon is just not experienced enough in the technique being performed and he/she doesn’t perform it properly. This is why it is important to ask the right questions to the surgeon before moving forward with the surgery. How long have you been performing back surgeries? How long have you been performing this specific surgical procedure? and how many times a year do you perform this surgery.
Back and neck surgeries are procedures meant to be a permanent fix for a specific problem and correcting failed back or neck surgery is difficult.
Human spine is a complex structure that provides both mobility (so to bend and twist) and stability (so to remain upright). The normal curvature of spine has an “s”- like curve when looked at from the side. This curvature allows even distribution of weight and with stand stress.
Diagnosis of discogenic back pain can be difficult. There are characteristic findings on physical examination, but these same findings are seen in patients with other types of back pain as well. Imaging studies can be performed, such as MRI.
Discogenic pain is pain originating from a damaged vertebral disc, particularly due to denenegrative disc disease
. However, not all degenerated discs cause pain. Disc degeneration occurs naturally with age.
Once a fully degenerated disc no longer has any inflammatory proteins that can cause pain, the disc enters into a stable position. Hence, discogenic pain rarely occurs after 60 years of age.
Discogenic pain can usually be successfully treated with non-surgical treatments, such as pain medication and physical therapy and exercise, but chronic discogenic pain that is severe and limits the individual's ability to function may need to be treated with surgery.
Damage to the disc occurs naturally or through a twisting injury where the inner and/or outer portions of the disc may tear, exposing or irritating the nerves on the outer edge of the annulus.
The injury can also create excessive micro-motion instability at the adjacent vertebrae because the disc cannot hold the vertebral segment together as well as it used to.
The disc itself has very few nerve endings and no blood supply. Without a blood supply the disc does not have a way to repair itself, and pain created by the damaged disc can last for years, either as a chronic condition or with periodic painful flare ups. The symptoms are most common in individuals age 30 to 60 years old.
What is Spondylolisthesis?
Spondylolisthesis is a condition that affects the spine as we age. The condition occurs when one of the vertebras in the spine slips forward onto the one below it. Spondylolisthesis usually develops as we age and is a result of bones, joints, and ligaments in the spine weakening and being less able to hold the structure of the spinal column in proper alignment. Degenerative spondylolisthesis begins to show itself in patients over 50 years of age and becomes much more common in after the age of 65.
Spondylolisthesis can sometimes be treated non-surgically using block or steroid injections. In some cases it is necessary to perform a minimally invasive spinal fusion procedure, and prevent further deterioration.
Treatment
Treatment varies, depending on if the type of slip, the patient's age and symptoms, and whether pressure is being put on nerves. For those whose nerves are not affected by the vertebral slippage, treatment starts with non-surgical treatments like medication and physical therapy. Bracing may also be recommended. If symptoms are manageable and the slip is small, the treatment will likely be observation. Activity restrictions may be necessary for children, like abstaining from certain sports.
If the slip is more severe or symptoms of nerve compression are present, surgery may be recommended. Surgeries for this condition include spinal decompression, where bone is removed to make room for the nerve being compressed, or spinal fusion. These surgeries are often done at the same time.
Magical Facts About Patients Satisfaction and Pearls of Medical Practise:Doctor-Patient Relationship & Medical Professionalism Dr.Sandeep C Agrawal Agrasen Hospital Gondia India www.agrasenortho.com
Patient Listening, Patient guide,Genuine Practise,Patient Satisfaction
Time is previous so one should utilise it to the best of it.
Self management and time management of happy meaningful life,dr.sandeep agrawal,agrasen hospital,gondia maharashtra india
Orthopedic ,fracture and arthritis knowledge Online informations dr.sandeep agrawal agrasen hospital gondia maharashtra
Internet orthopedic information should be from reliable sources.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
How to Give Better Lectures: Some Tips for Doctors
Knee osteoarthritis basics to reconstruction to replacement dr.sandeep c agrawal agraesn hospital gondia india
1. Dr.Sandeep Agrawal
Consultant Orthopedic Surgeon
MS,DNB
Agrasen Hospital
Gondia
Maharashtra
India
www.agrasenortho.com
drsandeep123@gmail.com
09960122234
Knee Osteoarthritis:
Basics to Reconstruction
to Replacement
2. Clinical evaluation
Pain, functional decline : walking,
climbing stairs, arising from low chair.
Deformity
Detailed history
Major source of failure : inability to
live up to unreasonable patient
expectation, documentation.
General health assessment
questionnaires
3. Radiographic evaluation
AP, 45 weight-bearing, lateral, Merchant views
Three joints standing film (split scanogram):
define the mechanical and anatomical axis.
Common mistake : supine image of knee, MRI
(not specific for articular cartilage
abnormality).
MRI for cartilage : T1-weight, fat suppressed
three-dimensional, spoiled gradient echo
technique, T2-weighted fast spin-echo
technique
10. Arthroscopy
Role of arthroscopic surgery in the
treatment of OA knee : controversy
Success in the treatment of OA knee :
proportional to the degree of mechanical
symptoms (loose bodies, meniscal tears,
unstable cartilage flaps), inversely
proportional to the severity of the
underlying arthritis (malalignment)
11. Valgus-Producing Tibia Osteotomy
Ideal patient : age younger than 50 and
active, with high functional demands,
involvement mainly on medial side.
Contraindications : inflammatory arthritis,
poor flexion(<90o), flexion contracture,
ligament instability, tricompartmental
arthritis
Less successful in smokers, patients age
more than 60 y/o, degree of deformity
beyond 10o
12. Valgus-Producing Tibia Osteotomy
Medial lengthening but not lateral
shortening (open wedge).
Advantage : more anatomic
restoration with resultant ligament
stability, ability to more fine tuning
the correction.
Disadvantage : risk of nonunion and
loss of correction.
13. Varus-Producing Femoral
Osteotomy
For younger, active patients with
involvement isolated in lateral
compartment.
Deformity should be less than 15o,
without flexion contracture or
inflammatory disease.
Correction to physiologic valgus (4o
to 6o)
14. Total Knee Arthroplasty
Advanced disease resulting in failure
of the joint to functional
satisfactorily
Key elements
– Debilitating symptoms
– Failure of such symptoms to respond to
less invasive treatment
– Medical suitability of the patient to
respond to surgery
15. Factors Affecting Outcome
TKA : survivorship exceeding 90% at
10 years, 80% at 15 years, 75% at
20 years.
Age, gender, primary diagnosis,
prosthetic design.
Positive factors : age of 70 or older,
RA, cemented fixation.
Adverse factors : younger than 55
y/o, male, OA.
16. Factors Affecting Outcome
Obesity :
– Difficulties of exposure
– Well-aligned, well-fixed implants fare as
well in the heavy patients as in the
general population
– Wound complications are more common
17. Factors Affecting Outcome
Juvenile Rheumatoid Arthritis
– Severe joint destruction and need for
reconstructive surgery at a very young
age.
– High rate of infection
– Post-operative stiffness
18. Factors Affecting Outcome
Hemophilic Arthropathy
– Repeat hemarthrosis secondary to
coagulopathy
– Most commonly affects the knee
– Young and immunodeficiency, high rate
of infection
– At least 10% failing within 5 years
19. Factors Affecting Outcome
Osteonecrosis
– Secondary to steroid or alcohol usage in
younger patients, spontaneous
occurrence in older patients
– Preoperative MRI can assist in
determining the amount of periarticular
bone involvement
20. Factors Affecting Outcome
Patellofemoral Arthritis
– Isolated PF OA that is calcitrant to
treatment can be successfully managed
with TKA in older patients
– Functional results of TKA are superior to
patellectomy or patellofemoral
arhtroplasty and are equal to TKA for 3
compartmental arthritis
21. Impact of Prior Surgery on
Subsequent TKA
Higher complication and higher
revision rates and less satisfactory
outcomes than primary TKA
Previous scar should be incorporated
whenever possible or standard
incision with optimal skin bridge
If hardware is extensive : consider
staged procedure.
22. Impact of Prior Surgery on
Subsequent TKA
Patella baja is common following tibial
osteotomy, lead to increased tension on
the tendon insertion during exposure
TKA after femoral osteotomy : relative
post-opertive varus of the femoral
component, can be reduced with the use
of EM alignment guide
Conversion of fused knee to TKA : hinged
or constrained prosthesis are
recommended
23. Surgical Technique
Optimal success of TKA
– Accurate restoration of the mechanical
axis : intra and extra medullary guide.
– Good fit and fixation of the implant to
host bone
– Careful attention to soft-tissue balance :
equal tibiofemoral space in both flexion
and extension, proper femoral rotation.
Too tight : flexion contracture
Excessive release : instability.
25. Design issues
Fixation
– Methacrylate cement fixation
Early loosening is more common with
cementless fixation
Cementing only the metaphyseal surface of
the tibial component and press fitting the
stem or keel has higher early loosening rate
than full cementing the tibial component
– Biologic fixation
26. Design issues
Posterior Curciate Ligament
– Retention :
Advantage :more physiologic femoral roll back,
accurate joint line restoration, bone preservation,
proprioceptive role of the ligament.
PCL too tight : posterior femoral subluxation,
asymmetric posterior polyethylene wear, osteolysis,
release too much may lead to late failure
– Sacrifice
– Substitution : cam and post mechanism,
increasing the anterior lip of a conforming tibial
polyethylene, risk of dislocation, polyethylene
wear debris from cam and post.
27. Design Issues
Modularity
– Standard design feature of metal-
backed tibial component.
– Advantage : greater intraoperative
flexibility and the potential for simple
revision of a worn PE
– Disadvantage : motion between the
tibial plate and PE back-side wear
28. Design Issues
Mobile Bearing Design
– Allow mobile bearing to rotate,
increased articular conformity,
advantage has yet to be demonstrated,
durable well into 2nd decade.
– Wear and osteolysis
– Unique problems : baring fracture and
dislocation.
29. Patellar Resurfacing
Controversial
Patellar complications remain one of the
most common sources of problems after TKA
Revision rates are either equivalent or
higher following knees without patellar
resurfacing
Consensus : knees without patellar
resurfacing are at a somewhat increased risk
for anterior knee pain, but are at a
decreased risk for serious patellar
complications
30. Unicompartmental Arthroplasty
Alternative to TKA or osteotomy for one
compartment disease.
Survivorship of greater than 90% at 10
years has been documented.
Patient selection and surgical technique
are the key elements.
Contraindications :
– Inflammatory arthritis
– Severe fixed deformity
– Previous opposite compartment menisectomy
– Tricompartmental arthritis
31. Unicompartmental Arthroplasty
Recommended correction: 1o to 5o of
postoperative valgus.
Advantage : quicker recovery, fewer short-term
complications, better functional outcome.
Causes of failure : implant wear, loosening or
subsidence, progression of symptomatic arthritis in
the lateral or patellar compartments.
Revision of uni-knee is less complex than revision
TKR.
Incision size should not be the dominant outcome
measure of this technique.
34. Infection
Attention to careful surgical technique and
soft tissue handling.
Laminar air flow and prophylactic
antibiotics : reduce infection.
Risk factors : immunosuppression,
diabetes, smoking, prior surgery, obesity.
Antibiotic-cementing : lower incidence of
infection, may considered for high risk
patients.
36. Thromboembolic disease
Absence of effective prevention : historical
data, 50%
Controversy remains regarding the optimal
prophylaxis regimen.
Physical modality : useful adjunct
– compression stocking, pneumatic compression
devices, continuous passive motion machines,
early mobilization.
Two agents commonly used
– Low molecular weight heparin
Lower rate of DVT but higher bleeding rate
– Coumadin
37. Medial collateral ligament injury
Conversion to a prosthesis that
provides varus/valgus restraint
Repair of reattachment : equally
viable alternative, wear braces for 6
weeks but are allowed full ROM
Knee scores and ROM at F/U are
equivalent to knees without this
complication
38. Extensor mechanism failure
Rupture of patellar tendon : compromise
in functional outcomes.
– Achilles tendon allograft, technique demanding,
needs good fixation methods.
Fracture of the patella : compromised
circulation, overaggressive resection,
maltracking, overt trauma.
– Incidence less than 1%
– Surgical treatment : marked extensor
mechanism disruption, gross patellar loosening.
39. Arthrofibrosis
Stiff total knee : common source of
failure and remains unsolved.
Best predictor of post-op ROM : pre-
op ROM.
Early suspect : manipulation under
epidural anesthesia and aggressive
physical therapy.
Late treatment : unreliable and high
rate of failure.
40. Periprosthetic fracture
Prevalence : less than 2%
Risk factors :
– Osteoporosis, Stress shielding, Femoral notching,
Osteonecrosis, Wear-related osteolysis
Treatment : maintaining alignment and
fracture stability with early ROM
Key factors of surgical decision making :
fracture displacement, stability of the
prosthesis, quality of bone.
41. Periprosthetic fracture
Implant loosening : revision, allograft for
bone defect, implant is cemented to the
allograft with long stems, preserve
collateral ligament but usually needs
articular constraint.
Displaced fracture :
– Intercondylar open : retrograde nail through
transarticular approach
– Fixed angle device and locked screws : evolving
– Flexible IM rod : less rigid
42. Revision Total Knee Arthroplasty
Evaluation of pain
Preoperative planning
Selective component retention
Patellar failure management of bone
loss
43. Evaluation of pain
Successful revision of a painful, failed TKA
is dependent on accurate evaluation of the
cause of failure.
Intrinsic (knee related) and extrinsic cause
Pain from hip or spine ?
Aspiration : negative culture does not
exclude infection, white blood cell count
higher than 2500 hint chronic low-grade
infection, repeat aspiration can increase
accuracy.
44. Preoperative planning
Challenge of successful outcome :
– Lower level of general patient health
– Decreased soft tissue integrity
– Bone loss
Complication rate : almost 25%
Factors compromise outcome:
infection, extensor mechanism
dysfunction, instability, fixation
failure, periprosthetic fracture
45. Preoperative planning
Indications for revision TKR : gross
loosening, fracture, instability, infection,
malalignment, wear, osteolysis or extensor
mechanism disruption.
Midline incision is preferred, lateral most
incision for multiple old incisions
Collateral ligament integrity, gap
balancing, joint line restoration(1.5 cm
proximal to the tip of fibula)
46. Preoperative planning
Factors impacting the flexion gap :
– Tibial resection level
– Polyethylene thickness
– Tibial slope
– AP dimension of the femoral component
– AP placement of the femoral component
Factors impacting the extension gap:
– Tibial resection level
– Polyethylene thickness
– Distal femoral resection
– Posterior capsule
47. Selective component retention
Significant PE wear with osteolysis :
may consider change PE only but the
failure rate is 30%-40%.
Consider any occult reasons that
lead to excessive wear of PE
– Malalignment
– Inadequate soft-tissue balance
48. Patellar failure
One of the most common indication for
revision TKR.
Revision TKR due to isolated patellar
fracture : high rate of failure due to
unrecognized malalignment, evolving
patellar osteonecrosis, inability to restore
bone stock.
Patellar bone loss (inadequate bone stock):
patellectomy or debridement, extensor lag
and weakness due to loss of patellar height.
49. Management of bone loss
Infection and osteolysis can result in significant
bone loss, often under-estimated.
Metal augment or substitute or bone grafting.
Contained defect : morcellized bone with long
stem prosthesis.
Uncontained defect : structural allograft
Metallic mesh : converting uncontained defect into
contained,
Circumferential defects : allograft prosthesis
composite
50. ThanksPersistence in your presentations, this is one secret to success. After my first
presentation, I got up
and did it again. Even though I was scared to death, I did it again. So
preparation in all areas of life
is so vital to your success. Don’t be lazy in preparing; don’t be lazy in
laying the groundwork that
will make all of the difference in how your life turns out.
What you may be lacking in are the strong feelings
about what you want and what you want to do.
Let these strong feelings help you take a second
look at your life. After all, you’ve only got one life,
at least on this planet. So why not make it an
adventure in achievement? Why not discover what
all
you can do and what all you can have? Why not
now take the Challenge to Succeed!
First you need to succeed to survive. We must take the seasons and learn how to
use them with
the seed, the soil and the rain of opportunity to learn how to sustain ourselves and
our family.
But then second is to then succeed to flourish in every part of your life today than
yesterday, in
our speech, our language, our health, everything we can possibility think of.