1) tiamo is Metrohm's new control and database software for titration systems and laboratory automation. It allows for titration, dosing, and complete automation of analytical workflows. 2) tiamo offers a modern user interface, powerful report generation, flexible method editor, real-time parallel titrations, client-server database, and export of data to LIMS systems. 3) As tiamo can integrate existing Titrino and new Titrando systems, it protects customers' investments while offering compatibility across different Metrohm instruments.

1. I o n a n a l y s i s
Networked Titration Data System

2. Networked Titration Data System
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3. • tiamo points the way 4/5
• tiamo at a glance 6
• tiamo makes work a pleasure 7
• tiamo brings you more... 8/9
• ... and more... 10/11
• ... and even more 12/13
• Future-proof thanks to client-server option 14/15
• Unlimited flexibility 16/17
• Further innovative features of tiamo 18/19
• Prepared for the audit 20/21
• Ordering information 22
• System requirements 23
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4. tiamo points
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5. tiamo – titration and more
tiamo is a control and database software for titrators and
dosing devices as well as for complete laboratory auto-
mation up to a client-server system. This is why the name
tiamo stands for «titration and more» – tiamo can do
more than just titrate. tiamo is a titration network (NTDS
= Networked Titration Data System).
tiamo is the result of Metrohm’s largest and most modern
software project. With its numerous innovations, user
friendliness and flexibility, tiamo is the leading software
package for titrations.
the way
Bringing together what belongs together
tiamo is the successor to TiNet and Workcell. Metrohm
now offers you worldwide a uniform software package
for laboratory automation. This means that, as an interna-
tionally operating company, all your subsidiaries can use a
single software platform in their laboratories for titrations.
Your benefits: data and methods can be exchanged
without any losses.
tiamo brings together the world of Titrinos and the new
Titrando system generation. In the software sector such
compatibility with existing Metrohm instruments is not just
a matter of course. The whole Titrino family, which was
previously also controlled by TiNet, can continue to be
operated under tiamo, and this after being on the market
for more than ten years! That's how Metrohm protects
your investments!
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6. tiamo at a glance
tiamo is easy to use
• New, progressive software interface
• Freely configurable desktop thanks to new Layout Manager
• Powerful report generator
• Automatic database backup
• Graphical method editor
tiamo communicates
• Real client-server database software
• Real parallel titrations
• Data export in XML, etc.
• E-Mail function for results and messages
tiamo overcomes boundaries
• Titrando and Titrino can be used in one system
• Central user administration
• Complete traceability of all results
• Extended method commands
• Developed and validated for cGxP
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7. tiamo makes work a pleasure
Your new workplace
The modern user interface makes it easy for
you to familiarize yourself with tiamo. All the
commands and controls are to be found where
you expect them to be.
The tiamo bar allows direct access to the four
program parts of tiamo:
• Workplace
• Database
• Methods
• Configuration
These buttons may be visible or concealed,
depending on the user’s access rights.
The information windows are in the center. In
the run window you can comfortably enter all
the sample data, whether for a single sample
or for a whole sample series.
The live display window informs you about
freely definable method instructions and shows
the live curve during the titration. The method
window provides information about the cur-
rent method status. If necessary, you have live
access to the method parameters. In the report
window you can view the current reports of
the last determinations.
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8. tiamo brings you more...
Layout Manager – each user gets his or her own tiamo
With the novel Layout Manager the user interface can be arranged so that each user only sees
those windows that are really necessary. This saves time; cluttered-up screens are now a thing of
the past.
You can also freely define what information is to be shown in the windows.
Making four from one – parallel titrations
You can subdivide the user interface even further to create up to four independent workplaces.
In this way you can elegantly control different titration systems that are all connected to the same
PC. And all this in parallel – and, if necessary, with different users. This means that tiamo offers
maximum utilization of the analytical system.
tiamo carries out tedious routine work
Do you enter your sample data manually or do you use a barcode reader? In both cases tiamo
helps you to fill in the sample table. Continually repeated sample identifications can be saved as
text templates. tiamo also takes care of the sequential numbering. Importing the sample table?
Just let your LIMS draw up the sample table for tiamo! Avoid surprises when using a sample
changer – let tiamo check the sample table for sample weights that are too high. You can use
the sample assignment table to link sample numbers with methods. This makes your tiamo the
easiest to operate routine system in your lab!
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9. 9

10. ... and more...
Database
The database is a further trump from tiamo.
Not only your determinations, but all the
settings, methods and user information are
stored in the tiamo database and protected
against manipulation and loss.
Data Manager
Manage your data in the determination over-
view, where you can obtain the most important
information about any sample in tabular and
freely configurable form. Powerful search and
filter tools provide support. Even among thou-
sands of titrations you are sure to find your own
particular determination – in just a few seconds.
Curve window
The titration curve is shown for each
determination. The curve layout can be
freely defined. Do you want to include
the titration curve in a Word document?
No problem.
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11. Total traceability Immediately recognize what matters
Who carried out a determination and when? Provide yourself with a quick overview in
What titrator was used? What alterations the results window. No long searching
have been made to the determination and by for the result – here you will find all the
whom? The unique traceability of the tiamo important results and calculation details
system leaves no questions unanswered. in compact form.
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12. ... and even more
Determination reprocessing
Wrong sample weight? No problem. With the reprocessing function the sample weight can be
quickly corrected or a calculation formula adapted. Endpoint not recognized correctly? tiamo
can help here as well. You can evaluate the curve again. And you do not have to worry about
the documentation. tiamo automatically records all alterations.
History
tiamo manages all the versions of a determination. The history function provides you with the
necessary overview.
Signatures
You can provide digital signatures for the determinations. tiamo offers signatures at two levels. As
soon as a determination has a level 2 signature, the data are protected against further alterations.
Report generator
The unique report generator allows you to
arrange your analytical report layout as you
want. You can adapt one of the many report
templates to suit your particular requirements.
There is no limit to what you can do; you can
include any imaginable information in your
tiamo report.
Do you need an analysis report? Just mark the
determination in the database, select a report
template and off it goes. You can even send
your analytical reports comfortably by E-Mail!
Data export
Do you want to process your data further in
Excel or are you planning to include tiamo
in a LIMS? No problem – tiamo offers you a
wide range of export formats, including the
modern XML format. All imaginable office
applications, databases and long-term
archiving programs are available for your
data. tiamo's flexibility is unbeatable!
Control chart
tiamo can produce a control chart for your
determinations at the touch of a button.
Present your measured values in chrono-
logical order. Print them out, save them
as a pdf document or use them in Office
applications. Ready!
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14. Future-proof thanks
to client-server option
Client-server database
In the simplest case you just install the database on your local computer. tiamo will grow together
with your requirements. As soon as data security and central data management make it necessary,
you can set up tiamo in a client-server configuration.
Install the database on a server and all measuring and office computers will act as clients. All
results are stored centrally and can be viewed and reprocessed by all client PCs. In addition, all
clients access the same pool of methods.
Data security
tiamo supports you in safeguarding your data. Activate the automatic backup function; tiamo
will then automatically make complete copies of all determinations and configurations. This means
that if the worst comes to the worst you can recover all your settings, system configurations and
determinations within a very short time.
Central control
In addition to data security, the client-server version provides you with the possibility of central
user administration. From your office you can activate new users, assign rights of access to data
and methods or implement security policies. The administration of titration systems has never
been so simple.
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15. Example of a client-server system comprising four lab workplaces and two office PCs.
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16. Unlimited flexibility
Method editor – clarity creates order
The block-by-block presentation of a method is clear and tidy. This makes operation child’s play.
You just make a selection from the list of method templates provided, quickly insert a calculation
template, add a report template and you can start the titration. It’s as easy as that!
Quick access to details
The detailed parameters can be accessed quickly with a double-click on the particular method
block.
You regard increased flexibility as being the key to solving your future problems?
Then tiamo is the ideal tool for you. Flexibility is one of the main advantages of this software
package. You can compile measuring commands, titrations, queries, calculations, database entries,
export instructions and sample changer commands, and this in any sequence, according to the
motto: «Nothing is impossible».
START EXIT SERIES START SERIES END
Main track Exit track Series start track Series end track
MOVE CALC CAL LOOP pH MOVE
Move to sample Calculations Calibration Cond beaker
DET pH REPORT MOVE LIFT
DET pH Report Buffer Work position
PUMP DATABASE CAL MEAS pH END
Rinse electrode Database CAL MEAS pH Series end track
END EXPORT MOVE
Main track Export Move rinse beaker
END PUMP
Exit track Rinse buffer
LIFT
Shift position
END
Series start track
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17. Titration and more
In addition to the commands that are necessary to control the measuring, dosing, titrating and
automation devices, tiamo also lets you:
• Show messages on the screen to guide the user through a sample preparation procedure.
• Ask for the sample size and monitor result limits.
• Assign the results to different databases.
• Print out a result report and send it by E-Mail.
• Inform your colleagues automatically by E-Mail about any interference to the titration system.
• Program recurring sequences and decisions.
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18. Further innovative features of tiamo
Configuration
All the tiamo settings are made in the configuration section.
Plug and play
Our modern USB devices ensure that all connected devices appear in the devices window.
Connect up – ready! All device data are adopted automatically.
Titrants under control
Simple organization of your titrants and solutions:
• In addition to the basic information, tiamo manages all the data required for traceability.
• tiamo even checks the working life and titer validity for you.
• If you use our uniquely intelligent dosing systems with the new «Chip on board» technology,
tiamo will prevent mix-ups.
Sensor Organizer
tiamo also manages your sensors perfectly. In this way you can ensure that all calibration intervals
are observed and only perfectly functioning electrodes are used. The calibration history of each
sensor is saved to ensure complete traceability.
Safely managed
If a computer crash should occur then your system will be quickly ready for use again if you have
automatically saved all your configuration settings. This means that «disaster recovery» poses no
problems.
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19. Networked Titration Data System
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20. Prepared for the audit
tiamo guarantees data security
Whether GMP or GLP rules, regulations on the security of electronic data (e.g. 21 CFR Part 11)
or the requirement that all results are traceable – tiamo has been developed from the very start to
meet all these requirements and therefore sets new standards.
Security has priority
Protect your data with the comprehensive security functions of tiamo. Let tiamo or Windows
monitor the passwords. Define the rules for assigning digital signatures and control access to your
data.
User administration
Add new users to the list from your office computer – tiamo assists you in doing this. Arrange the
access rights of each user in accordance with your company’s security policy. tiamo sets no limits,
but will convince you with its unique flexibility.
Complete Audit Trail
Each action performed by a tiamo user is stored automatically in the Audit Trail. This means that
you can obtain a detailed protocol about who did what and when. Data for an audit can be
prepared by pressing a button.
Version check
All data records are stored in tiamo together with their version. Protect your results against
accidental or deliberate manipulation. Use the history function to show each version of your data.
All alterations to electronic data are documented automatically – audits can no longer worry you.
Traceability
Be absolutely certain and place your confidence in the complete traceability of Metrohm software
and hardware for your titrations. Each data record contains all the raw data necessary to ensure
traceability. Unique in the world is the fact that each component used to generate the data is
documented.
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22. Ordering information
tiamo is available in different versions and offers a suitable system for every application.
tiamo 1.0 light tiamo 1.0 full tiamo 1.0 multi
Order number 6.6056.101 6.6056.102 6.6056.103
Max. no. of devices per PC 21) Unlimited Unlimited
Supported devices See2) See2) See2)
Dialog languages English, German English, German English, German
Meets the requirements • •
of FDA 21 CFR Part 11
User administration • • •
Security policy • •
Audit Trail • •
Client-server support •
Licenses 1 1 3
Additional licenses (optional) •3)
Data export to LIMS • •
Parallel titration • •
Upgrade available •4) •5)
1) Please note that a balance or a barcode reader also counts as a connected device.
2)
Titrandos 808, 809, 835, 836, 841
Titrinos 702, 716, 718, 719, 720, 721, 736, 751, 758, 784, 785, 794, 795,
798, 799
Measuring instruments 712
KF Coulometers 756, 831
Sample changers 730, 774, 778, 789, 814, 815
Others 846, balance, barcode reader...
3) 6.6056.001 tiamo multi: 1 additional license
6.6056.002 tiamo multi: 5 additional licenses
6.6056.003 tiamo multi: 10 additional licenses
The serial no. of the tiamo multi version is required for ordering additional licenses!
4) 6.6056.106 tiamo 1.0 light upgrade to full (1 license)
6.6056.107 tiamo 1.0 light upgrade to multi (3 licenses)
5) 6.6056.108 tiamo 1.0 full upgrade to multi (3 licenses)
License policy for the client-server version
Metrohm offers you a favorable license program. tiamo multi uses runtime licenses, i.e. a license
is only required for those tiamo installations that are in use at the same time. In practice this
means that you do not need to purchase a separate license for your office computer. As a result,
when you have finished making measurements in the laboratory you can continue to use tiamo
in your office without needing a further license.
Free-of-charge updates!
You really should choose tiamo. As a Metrohm customer you will receive all future tiamo
software updates free of charge. You will also profit from new and extended tiamo functions.
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23. System requirements
Minimum system requirements
• Processor Pentium 4; clock rate 1 GHz
• Working memory 512 MB
• Free hard disk memory 150 MB for program
• Free data memory 2 GB (for approx. 5000 determinations)
• Operating system Windows 2000 SP1, Windows XP Professional
• Connections free USB connection and/or free serial connection (RS 232C)
Additional system requirements for tiamo server
• Data line 10 MBit/s
• Operating system Windows 2000 SP1, Windows XP Professional, Windows
2000/2003 Server
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24. I o n a n a l y s i s
Metrohm Ltd.
CH-9101 Herisau/Switzerland
Phone +41 71 353 85 85
Fax +41 71 353 89 01
www.metrohm.com
info@metrohm.com
www.titration-and-more.com
Layout Ecknauer+Schoch ASW, printed in Switzerland by Metrohm AG, Herisau
Subject to modifications
8.032.6003 – 2004-12