Self-ligating brackets incorporate a locking mechanism such as a ring, spring, or door that holds the archwire in the bracket slot. The document discusses and compares active and passive self-ligating brackets. It notes that while active brackets may provide more complete initial tooth alignment with smaller archwires due to their clip design, they also generate more friction. Passive self-ligating brackets produce lower forces and friction, which may facilitate tooth movement. However, evidence suggests torque control is similar between active and passive designs. Overall, the evidence is mixed as to whether self-ligating brackets provide faster treatment times or better outcomes compared to conventional brackets.
Comparison of The Roth prescription,Alexander prescription & MBT prescription...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Roth philosophy /certified fixed orthodontic courses by Indian dental academy Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
lingual appliance in orthodontics.
a recent advancement in orthodontics.
invisible orthodontics.
invisible braces.
invisible braces for adults.
adult orthodontics.
braces for adults.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Controversies in orthodontics /certified fixed orthodontic courses by Indian Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Comparison of The Roth prescription,Alexander prescription & MBT prescription...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Roth philosophy /certified fixed orthodontic courses by Indian dental academy Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
lingual appliance in orthodontics.
a recent advancement in orthodontics.
invisible orthodontics.
invisible braces.
invisible braces for adults.
adult orthodontics.
braces for adults.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Controversies in orthodontics /certified fixed orthodontic courses by Indian Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
MBT system in orthodontics /certified fixed orthodontic courses by Indian den...Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy has a unique training program & curriculum that provides students with exceptional clinical skills and enabling them to return to their office with high level confidence and start treating patients
Andrew’s straight wire appliance /certified fixed orthodontic courses by Indi...Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy has a unique training program & curriculum that provides students with exceptional clinical skills and enabling them to return to their office with high level confidence and start treating patients
State of the art comprehensive training-Faculty of world wide repute &Very affordable.
Loops in orthodontics /certified fixed orthodontic courses by Indian dental ...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
00919248678078
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
PG Retraction Spring for Canine & Incisor /certified fixed orthodontic cours...Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy has a unique training program & curriculum that provides students with exceptional clinical skills and enabling them to return to their office with high level confidence and start treating patients
State of the art comprehensive training-Faculty of world wide repute &Very affordable.
Elastics and Elastomeric are routinely used as a active component of orthodontic therapy.
Elastics have been a valuable adjunct of any orthodontic treatment for many years.
There use combined with good patient cooperation provides the clinician with the ability to correct both
Antero-posterior and vertical discrepancies. The latex elastics have become integral part of orthodontics after being first discussed by Calvin. S. case in 1893 at the Columbia dental congress but the credit goes to Henry A. Baker for the use of these elastics in clinical practice to exert a class II intermaxillary forces.
Both natural rubber and synthetic elastomers are widely used in orthodontic therapy. Naturally produced latex elastics are used in the Begg technique to provide intermaxillary traction and intramaxillary forces. Synthetic elastomeric materials in the form of chains find their greatest application with edgewise mechanics where they are used to move the teeth along the arc
Maxillomandibular elastics (or intermaxillary elastics) are commonly used because of their simplicity; however, a lack of understanding of their force system can lead to many serious problems.
Elastics are usually classified by the direction of the force (eg, Class II or Class III elastics).
Sometimes force magnitude is considered, but point of force application is left out. Therefore, many different types of Class II elastics can be applied. There are short or long elastics.
Often too many elastics are used when a single resultant elastic at the correct location would work better. However, sometimes more than a single elastic is needed when the attachment point is not directly accessible.
All maxillomandibular elastics and their actions should be analyzed in three dimensions.
Friction less mechanics in orthodontics /certified fixed orthodontic course...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
00919248678078
Elastics in orthodontics /certified fixed orthodontic courses by Indian denta...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Straight wire appliance /certified fixed orthodontic courses by Indian dental...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Self ligatingbrackets /certified fixed orthodontic courses by Indian dental a...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
MBT system in orthodontics /certified fixed orthodontic courses by Indian den...Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy has a unique training program & curriculum that provides students with exceptional clinical skills and enabling them to return to their office with high level confidence and start treating patients
Andrew’s straight wire appliance /certified fixed orthodontic courses by Indi...Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy has a unique training program & curriculum that provides students with exceptional clinical skills and enabling them to return to their office with high level confidence and start treating patients
State of the art comprehensive training-Faculty of world wide repute &Very affordable.
Loops in orthodontics /certified fixed orthodontic courses by Indian dental ...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
00919248678078
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
PG Retraction Spring for Canine & Incisor /certified fixed orthodontic cours...Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy has a unique training program & curriculum that provides students with exceptional clinical skills and enabling them to return to their office with high level confidence and start treating patients
State of the art comprehensive training-Faculty of world wide repute &Very affordable.
Elastics and Elastomeric are routinely used as a active component of orthodontic therapy.
Elastics have been a valuable adjunct of any orthodontic treatment for many years.
There use combined with good patient cooperation provides the clinician with the ability to correct both
Antero-posterior and vertical discrepancies. The latex elastics have become integral part of orthodontics after being first discussed by Calvin. S. case in 1893 at the Columbia dental congress but the credit goes to Henry A. Baker for the use of these elastics in clinical practice to exert a class II intermaxillary forces.
Both natural rubber and synthetic elastomers are widely used in orthodontic therapy. Naturally produced latex elastics are used in the Begg technique to provide intermaxillary traction and intramaxillary forces. Synthetic elastomeric materials in the form of chains find their greatest application with edgewise mechanics where they are used to move the teeth along the arc
Maxillomandibular elastics (or intermaxillary elastics) are commonly used because of their simplicity; however, a lack of understanding of their force system can lead to many serious problems.
Elastics are usually classified by the direction of the force (eg, Class II or Class III elastics).
Sometimes force magnitude is considered, but point of force application is left out. Therefore, many different types of Class II elastics can be applied. There are short or long elastics.
Often too many elastics are used when a single resultant elastic at the correct location would work better. However, sometimes more than a single elastic is needed when the attachment point is not directly accessible.
All maxillomandibular elastics and their actions should be analyzed in three dimensions.
Friction less mechanics in orthodontics /certified fixed orthodontic course...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
00919248678078
Elastics in orthodontics /certified fixed orthodontic courses by Indian denta...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Straight wire appliance /certified fixed orthodontic courses by Indian dental...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Self ligatingbrackets /certified fixed orthodontic courses by Indian dental a...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Space closure /certified fixed orthodontic courses by Indian dental academy Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Efficiency of newer generation edge wise applience /certified fixed orthodont...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Optimal orthodontic force /certified fixed orthodontic courses by Indian dent...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Optimal orthodontic force /certified fixed orthodontic courses by Indian dent...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Orthodontic implants /certified fixed orthodontic courses by Indian dental ac...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Self ligating brackets /certified fixed orthodontic courses by Indian dental ...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Torquing in orthodontics /certified fixed orthodontic courses by Indian dent...Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy has a unique training program & curriculum that provides students with exceptional clinical skills and enabling them to return to their office with high level confidence and start treating patients
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists
self ligation
1.
2. “Brackets that incorporate a locking mechanism (such as a ring,
spring, or door mechanism) that holds the archwire in the bracket
slot”
3. Historical Aspects and
Evolution of Ligation
and Appliances
• Archwire ligation
• Stainless steel ligatures
• Elastomeric ligatures
• Begg pins
• Self ligation
4. They are cheap, robust,
essentially free from deformation
and degradation and
to an extent they can be applied
tightly or loosely to the archwire.
They also permit ligation of the
arch-wire at a distance from the
bracket.
This distant ligation is
particularly useful if the
appliance tends to employ high
forces from the archwires,
The length of time required to
place and remove the ligatures.
additional 11 minutes was
required to remove and replace two
archwires
Additional potential hazards
include those arising from puncture
wounds from the ligature ends and
trauma to the patients’ mucosa if the
ligature end becomes displaced.
5. fail to fully engage an archwire
‘figure of 8’
substantial degradation of their mechanical
proper-ties in the oral environment.
more than 50% degradation in force in the first
24 hours5
The higher temperature in the mouth,
enzymatic activity and lipid absorption by
polyurethanes are all cited as in vivo sources of
force relaxation.
loss of rotational control
Lam et al. reported substantial variation in the
range and tensile strength of elastomerics from
different manufacturers and for different colours of
elastomeric from the same manufacturer.
much higher friction between bracket and
archwire in vitro with elastomeric ligation
compared to wire ligatures. Hain et al.8
greatly reduced time required
to place and remove them
when compared with steel
wire ligatures.
It was also easier to learn the
skills required to place these
ligatures,
Intermaxillary elastics-
Calvin S. Case and H.A.
Baker.
6. • Faster ligation
• Secure archwire engagement
• Low friction
• Assistance to good oral hygiene?
• More comfortable treatment?
• Secure archwire engagement and low friction as a
combination
7. Have a slide that
opens and closes vertically and
creates a passive labial surface
to the slot with no intention to
invade the slot.
Have a sliding spring clip,
which encroaches on the slot
from the labial aspect,
potentially placing an active
force on the archwire.
e.g: Damon,
Smartclip,
Praxis Glide,
Carriere LX,
vision LP,
Lotus.
e.g: Speed,
In-Ovation,
Nexus,
Quick, Time
8. Year Developer/company Name Ligation principle Design
1935 Stolzenberg Russell Passive Metal
1972 Wildman/Ormco EdgeLok Passive Metal
1973 Sander/Forestadent Mobil-Lock Passive Metal
1980 Hanson/Strite Industries SPEED Active Metal
1986 Plechtner/A-Company Activa Passive Metal
1994 Heiser/Adenta Time Active Metal
1996 Damon/A-Company Damon Passive Metal
1997 Voudouris/GAC In-Ovation Active Metal
1998 Wildman/Ormco TwinLock Passive Metal
1999 Damon/A-Company/Ormco Damon 2 Passive Metal
2002 Voudouris/GAC In-Ovation R Active Metal
2004 Abels/Ultradent Opal Passive Aesthetic
2004 3M Unitek SmartClip Passive Metal
2004 Damon/Ormco Damon 3 Passive Aesthetic
2005 Adenta Flair Active Metal
2005 Forestadent Quick Active Metal
2005 American Orthodontics Vision LP Passive Metal
2007 Abels/Ultradent Opal M Passive Metal
2007 GAC In-Ovation C Active Aesthetic
2007 3M Unitek Clarity SL Passive Aesthetic
2008 Dentaurum Discovery SL Passive Metal
2008 Forestadent QuicKlear Active Aesthetic
9. Try to treat without extractions in all cases which appear to
have the necessary potential
• If treatment objectives cannot be accomplished without
extractions, extract second bicuspids to minimize any tendency
toward unattractive reduction in the prominence of the
dentition
• Use preliminary functional appliances to favorably alter jaw
growth patterns wherever it is desirable and feasible
• Employ intra-oral distalization mechanics instead of headgear
when conditions permit
• Expand arches which have failed to develop to their full
potential
• Intrude upper anterior teeth in patients who exhibit a lot of
gingival tissue
• Correct tooth rotations to ideal alignment without any over-
correction and rely upon interproximal reshaping and
circumferential supracrestal fiberotomies to enhance retention
• Overcorrect class II or class III buccal segment relationships
where a strong relapse tendency is expected
Treatment should be planned to optimize facial appearance as
maturation and aging occur
• Treat non-extraction where biologically possible and
compatible with dental and facial treatment goals
• Use light forces, in an appliance where direct transmission of
archwire energy to bracket can be achieved without modifi
cation or absorption by ligatures, in order to move teeth with
adaptation of the alveolar bone by ensuring the orthodontic
forces do not impede blood supply in the periodontium
• Use functional appliances to obtain anteroposterior
correction of class II malocclusions
• Do not use rapid palatal expansion appliances or headgear
• Utilize the oral musculature to assist in correction of the
malocclusion by:
Allowing the orbicularis oris and mentalis muscles to provide a
‘lip bumper’ effect which minimizes anterior movement of the
incisors during non-extraction treatment
Expanding the posterior buccal segments with light archwires
thus allowing the tongue position to elevate and move forward
producing a new force equilibrium between it and the facial
muscles
Dr Hanson’s
treatment
philosophy
for the SPEED
appliance
Dr Dwight
Damonfor
the Damon
System
appliance
Treatment philosophies
10. Active clip or passive slide ?
• with thin aligning wires smaller then 0.018" diameter
• The potentially active clip will be passive
• For teeth which were initially placed lingual to their
neighbours, the active clip can bring the tooth more
labially (up to a maximum of 0.027 - 0.018 = 0.009
inches) with a given wire.
• Pandis et al (2010) found no difference in the rate of
alignment when comparing the passive Damon MX
with the active In-Ovation R brackets.
11. for wires > 0.018" diameter
• The active clip will place a continuous lingual force on the wire even when the
wire has gone passive.
• On teeth which are in whole or in part lingual to a neighbouring tooth, the
active clip will again bring the tooth (or part of the tooth if rotated) slightly more
labial than would have been the case with a passive clip at 0.027" slot depth.
• The maximum difference will be the difference between the labiolingual
dimension of the wire and 0.027".
• 0.016" x 0.022" -maximum difference of 0.005".
• 0.016" x 0.025" or 0.014” x 0.025” nickel titanium wires are recommended as
the intermediate aligning wire for Damon and this wire reduces this potential
difference to 0.002".
• Lingually placed teeth would have a slightly higher initial force with an active
clip and wires of this intermediate size.
• With an active clip, an active lingually-directed force will remain on the wire
even when it is passive
12. with thick rectangular wires
• An active clip will probably make a labiolingual
difference in tooth position of 0.002" or less which
is very small.
• An active clip places a lingually directed force on
the wire in all circumstances which results in a
higher friction and resistance to sliding.
14. Archambault et al 2010-concluded that the
reduced slop angle with an active clip ( 5 degrees
less) did not in fact produce a clinically significant
difference in torque forces.
Exploring this in more detail Major et al, 2011
again concluded that from a clinical perspective
the torque plays were essentially identical for
Damon Q, In-Ovation R and SPEED brackets.
The torque plays for these three bracket types
were 11.3°, 11.9°, and 10.8°, respectively.
These conclusions support the finite element
analysis work by Huang et al.
15. Major et al 2011-has reinforced the conclusion that the delivery of torquing
forces is very similar for Damon, Speed and In-Ovation brackets.
They found that all brackets had torque play between approximately −12° and
10.5°.
Brauchli et al (2012) found that the range of ‘slop’ (zero torquing force) was
larger - from minus 15 to plus degrees for a number of brackets.
They too found no difference in the torque performance of passive and active
self-ligating brackets.
By measuring brackets with the clip open and shut, they found that the
contribution to torque from the active clip was 1Nmm which is a small
percentage of the torquing force thought to be clinically effective.
Key point: Active and passive self-ligating brackets do not inherently differ in
their ability to apply torquing forces. An active clip contributes little to torquing
force. Play or ‘slop’ in the torque dimension is greater than frequently
appreciated and should influence our choices of prescription accordingly.
16. Hisham Badawi and the team at the
University of Alberta.
The resulting friction and binding produced a
labially directed force on the central incisors
which was reduced by between 73% and
82% when Damon 3MX brackets with their
passive slide were used instead of In-Ovation
brackets with an active clip.
These results agree with those of Baccetti et
al (2009) and (Franchi et al 2009)
17.
18. Pandis et al (2007) who retrieved spring
clips from SPEED and In-Ovation R
brackets following a course of treatment
and compared the stiffness and range of
action of these spring clips with unused
spring clips.
The two types of bracket had spring clips
of very different initial stiffness and the
In-Ovation clips lost an average of 50% of
their stiffness during the treatment,
whilst the SPEED clips had very little
change in their performance.
19. • alignment: in theory, it is probable that with an active clip, initial
alignment is more complete for a wire of given size to an extent which is
potentially clinically useful.
• friction: overall, an active clip will generate higher forces and higher
friction. The increased clearance between a given wire and a passive slide
will generate lower forces and may facilitate dissipation of binding forces
and the ability of teeth to push each other aside as they align. It may also
lead to qualitative differences in the direction and amount of tooth
movement but this is yet to be established.
• robustness and ease of use: in any specific bracket these factors are
frequently related to the type of clip or slide.
• torque control: there is good evidence that the presence of an active clip
does not contribute significantly to torque control.
20. (Harradine 2001), (Eberting et al 2001), (Tagawa 2006), found that self-ligation with earlier versions
of Damon brackets was quicker, with less visits and good or better final alignment and occlusion than
with conventional appliances used by the same operator/s.
A retrospective study by Vajaria et al (2011) also found a reduction of two months in treatment time.
Several other (but not all) presented but unpublished consecutive case series have also found more
efficient treatment with self-ligation, whilst Ong (2010) compared alignment, arch widths and
spontaneous extraction space closure after 20 weeks of treatment in a retrospective study and found
no difference in these parameters between Damon MX and conventional brackets.
Ollivere (2012) published the results of two studies of consecutively treated premolar extraction
cases and in both instances, found no significant difference in treatment time with his switch to
active self-ligation and changes in treatment protocol.
21. (Miles 2005), (Miles et al 2006), (Pandis et al 2007b), (Scott et al 2008),
(Fleming et al 2009), (Fleming 2009b), (Fleming et al 2010) have not found
any overall benefit in the alignment phase, although Pandis et al found
that mild crowding was eliminated 2.7 times more rapidly with Damon 2
than with conventional brackets. Only one of these studies has to date
reported data for the whole of the treatment period.
Another study by Miles (2007), found no improvement in the rate of en
masse space closure with SmartClip self-ligating brackets.
Two prospective split mouth studies (Burrow 2010) and (Mezomo 2011) of
the rate of canine retraction on 0.018” stainless steel wires have also failed
to find faster retraction with self-ligation, in fact Burrow found that with
conventional brackets, the rate averaged 0.17 mm per month faster than
with Damon 3 or Smartclip. The better rotational control with self-ligating
brackets in the study by Mezomo has already been noted.
Two systematic reviews (Fleming and Johal 2010) and Chen et al (2010),
have concluded that there is insufficient evidence to support the view that
treatment with self-ligating brackets is more or less efficient than with
conventional ligation.
22. (Scott et al 2008b) found no difference between Damon 3 and Synthesis in the first
week of treatment and
(Fleming 2009c), found no difference in pain levels comparing SmartClip and
conventional brackets and also that the actual process of archwire changes with
SmartClip brackets was significantly more uncomfortable than with conventional
ligation.
Tagawa (2006) in a case series found a substantial reduction in reported pain with Damon SL brackets.
Miles (2006) in a split mouth study found lower pain levels with Damon 2 brackets during the alignment
phase, although opening the brackets was more uncomfortable than removing elastomerics.
Pringle et al (2009) in an RCT found significantly less pain during the initial 7 days of treatment with Damon 3
brackets when compared with elastomerics tied in an ‘O’ configuration.
The systematic review by (Fleming and Johal 2010) concluded that the balance of evidence from the three
publiched RCTs on this topic just favoured a reduction of pain with self-ligation.
A very interesting paper by Yamaguchi et al (2009) examined the question via a different measure of pain.
They measured the level of the neuropeptidase substance P in gingival crevicular fluid. This substance is a
marker of the inflammation and associated pain resulting from orthodontic forces. They found that treatment
with Damon brackets significantly lowered the levels of this marker of pain and inflammation when compared
with conventional ligation at 24 hours after archwire placement.
23.
24. self-ligation – and particularly passive self-ligation – enables tooth-moving
forces to be sufficiently light that forces from the soft tissues can compete
with them.
It has been proposed that the lips can restrain labial movement of the
incisors and that the alignment of crowded teeth on a non-extraction basis
will result in more lateral arch expansion and less labial incisor movement
than would be the case with heavier forces and higher resistance to sliding –
the “lip bumper” concept.
Further, it has been claimed that expansion brought about by such light
forces is more likely to achieve an archform which is in balance with the
tongue and cheeks and can establish a wider arch which will be relatively
stable because of altered tongue position.
25. • wider arches which may be more
aesthetic
• wider arches which have better periodontal
health than those resulting from more rapid
and forceful expansion
• wider arches which may be more
stable
• less incisor proclination for a given
amount of crowding
• less need for extractions
• easier class 2 correction through a
‘lip-bumper’ effect
26. Self - ligation Conventional
Esthetics Some designs permit significant miniaturization Limited miniaturization
Force level Permits use of lighter forces Require heavier force level
Force density Limited initial force Higher initial force
Friction Predictable, very low S/s: high
Elastomeric: very high
Infection control Significantly reduced risk of percutaneous injury Increased risk of percutaneous injury
Instrumentation Fewer instrument required during arch wire change Many instruments
Ligation Movable,integral part creates outer fourth wall S/s or elatomeric ligatures
Ligation stability Retains original throughout t/t Loses initial shape & tightness
Office visit Shorter, less frequent Longer more frequent
Oral hygiene Wingless designs easy to clean Difficulty to treat food straps
Patient comfort Slight discomfort Teeth usually sore after ligation
Sliding mechanics Ideally situated for tooth translation slow
t/t time Reduced by 4 months Longer esp. in extraction cases
27. • Self ligation systems have been gaining popularity in recent years with a host of claimed
advantages over conventional appliance systems relating to reduced overall treatment
time, less associated subjective discomfort, promotion of periodontal health, superior
torque expression, and more favorable arch -dimensional change.
• Other claimed advantages include possible anchorage conservation, greater amounts of
expansion, less proclination of anterior teeth, less need for extractions, and better
infection control.
• However, many of these claims were based on retrospective studies which are potentially
biased as there are many uncontrolled factors which may affect the outcome.
• These include greater experience, differing archwires, altered wire sequences, changes in
treatment mechanics, and modified appointment intervals.
• While Advocates claim that low-friction SL brackets coupled with light forces enhance the
treatment efficiency and address the clinical superiority of self-ligating brackets, other
team believes that bracket type does not appear to have a significant influence on
treatment efficiency.
Editor's Notes
In self-ligation, the bracket itself contains a clip or other mechanism, which is used instead of either elastic or metal ligatures.
The elastomeric ligature was, however, in many respects a retrograde step in ligation technology. It often did not achieve full bracket engagement, particularly on displaced teeth, had higher friction than wire ligatures and absorbed oral fluids with time resulting in loss of elastic properties, discoloration, dimensional and color instability and plaque accumulation. However, it was less time consuming to place and remove than wire ligatures and patients liked the ability to cus-tomize the appearance of fixed appliances by select-ing different colored ligatures.