This document summarizes key events from 1850-1860 that led to increasing sectional tensions between the North and South and eventually the secession of southern states and onset of the Civil War. It discusses the Compromise of 1850, Kansas-Nebraska Act, Dred Scott decision, Lincoln-Douglas debates, John Brown's raid, and the elections of 1856 and 1860 which saw the Republican Party gain power in the North on an anti-slavery platform leading the South to secede after Lincoln's election in 1860.