This document discusses different types of taxonomic characters that can be used to distinguish between taxa. There are 5 main kinds of characters: 1) Morphological characters related to external features, structures, internal anatomy, development stages, and karyology. 2) Physiological characters like growth rates, temperature tolerances, and biochemical processes. 3) Ecological characters like habitat, food preferences, breeding seasons. 4) Ethological characters regarding behavior like mating calls and web patterns. 5) Geographical characters about distribution patterns that can help clarify taxonomy. A wide variety of observable attributes can serve as taxonomic characters to differentiate between species and other taxonomic levels.
Iczn(The International Commission on Zoological Nomenclature )Al Nahian Avro
The International Commission on Zoological Nomenclature (ICZN) acts as adviser and arbiter for the zoological community by generating and disseminating information on the correct use of the scientific names of animals. The ICZN is responsible for producing the International Code of Zoological Nomenclature - a set of rules for the naming of animals and the resolution of nomenclatural problems.
1.Definition and basic concepts of Biosystematics, , Historical perspectives of Biosystematics and Taxonomy, Stages of taxonomic procedures-alpha taxonomy, Beta taxonomy and Gamma taxonomy,
Neo taxonomy.
Iczn(The International Commission on Zoological Nomenclature )Al Nahian Avro
The International Commission on Zoological Nomenclature (ICZN) acts as adviser and arbiter for the zoological community by generating and disseminating information on the correct use of the scientific names of animals. The ICZN is responsible for producing the International Code of Zoological Nomenclature - a set of rules for the naming of animals and the resolution of nomenclatural problems.
1.Definition and basic concepts of Biosystematics, , Historical perspectives of Biosystematics and Taxonomy, Stages of taxonomic procedures-alpha taxonomy, Beta taxonomy and Gamma taxonomy,
Neo taxonomy.
ORIGIN OF CHORDATES
Animal kingdom is basically divided into two sub kingdoms:
Non-chordata- including animals without notochord.
Chordata- This comprising animals having notochord or chorda dorsalis.
Chordates were evolved sometime 500 million years ago during Cambrian period (invertebrates were also began to evolve in this period) .
Chamberlain (1900) pointed out that all modern chordates possess glomerular kidneys that are designed to remove excess water from body.
It is believed that Chordates have originated from invertebrates.
It is difficult to determine from which invertebrate group the chordates were developed.
Chordate ancestors were soft bodied animals. Hence they were not preserved as Fossils.
However, early fossils of chordates have all been recovered from marine sediments and even modern protochordates are all marine forms.
Also glomerular kidneys are also found in some marine forms such as myxinoids and sharks. That makes the marine origin of chordates more believable.
Chordates evolved from some deuterostome ancestor (echinoderms, hemichordates, pogonophorans etc.) as they have similarities in embryonic development, type of coelom and larval stages.
Many theories infers origin of chordates, hemichordates and echinoderms from a common ancestor.
Taxonomic Collections, Preservation and Curating of InsectsKamlesh Patel
Taxonomy: Taxonomy is the science of defining and naming groups of biological organisms on the basis of shared characteristics.
The classification of organisms is according to hierarchal system or in taxonomic ranks (eg; domain, kingdom, phylum class, order, family, genus and species) based on phylogenetic relationship established by genetic analysis.
Taxonomic Collection : Biological collection are typically preserved plant or animals specimens along with specimen documentations such as labels and notations.
Dry Collection - Dry collections consist of those specimens that are preserved in a dry state.
Wet Collection - Wet collections are specimens kept in a liquid preservative to prevent their deterioration.
The process by which a new species develops from the existing species is known as speciation.
Charles Darwin was the first to describe the role of natural selection in speciation in his 1859 book On the Origin of Species. He also identified sexual selection as a likely mechanism, but found it problematic.
A species can be defined as one or more populations of interbreeding organisms that are reproductively isolated in nature from all other organisms.
When populations no longer interbreed, they are thought to be separate species.
There are four geographic modes of speciation in nature, based on the extent to which speciating populations are isolated from one another: allopatric, peripatric, Parapatric, and sympatric.
Speciation may also be induced artificially, through animal husbandry, agriculture, or laboratory experiments.
Allopatric speciation: It is regarded as the most common type of speciation. It involves the physical separation of a species into two groups. This may occur due to climatic changes, movement of tectonic plates leading to the fragmentation of a mass of land, or eruption of a land mass, formation of waterways, or due to the presence of an impassable mountain range.
Parapatric mode of speciation: It occurs due to partial spatial isolation of populations, and is characterized by a small overlap in their ranges as well as significant gene flow amongst the populations. However, the gene flow reduces due to changes in the local conditions, and the two populations become reproductively isolated.
Sympatric mode of speciation: It involves the formation of new species due to a genetic divergence among a few members of the species inhabiting a single geographic area. Unlike the other modes of speciation, here genetic divergence does not arise due to increase in geographic distance, but occurs within the same niche.
Peripatric speciation was Proposed by Ernst Mayr. In this type of speciation, a small group of members inhabiting a peripheral region of the range undergo reproductive isolation to form a new species. Many a time, it is considered to be a variation of allopatric speciation.
Organisms are classified into a hierarchical classification that groups closely related individuals.
The species is the basic biological unit around which classifications are based.
ORIGIN OF CHORDATES
Animal kingdom is basically divided into two sub kingdoms:
Non-chordata- including animals without notochord.
Chordata- This comprising animals having notochord or chorda dorsalis.
Chordates were evolved sometime 500 million years ago during Cambrian period (invertebrates were also began to evolve in this period) .
Chamberlain (1900) pointed out that all modern chordates possess glomerular kidneys that are designed to remove excess water from body.
It is believed that Chordates have originated from invertebrates.
It is difficult to determine from which invertebrate group the chordates were developed.
Chordate ancestors were soft bodied animals. Hence they were not preserved as Fossils.
However, early fossils of chordates have all been recovered from marine sediments and even modern protochordates are all marine forms.
Also glomerular kidneys are also found in some marine forms such as myxinoids and sharks. That makes the marine origin of chordates more believable.
Chordates evolved from some deuterostome ancestor (echinoderms, hemichordates, pogonophorans etc.) as they have similarities in embryonic development, type of coelom and larval stages.
Many theories infers origin of chordates, hemichordates and echinoderms from a common ancestor.
Taxonomic Collections, Preservation and Curating of InsectsKamlesh Patel
Taxonomy: Taxonomy is the science of defining and naming groups of biological organisms on the basis of shared characteristics.
The classification of organisms is according to hierarchal system or in taxonomic ranks (eg; domain, kingdom, phylum class, order, family, genus and species) based on phylogenetic relationship established by genetic analysis.
Taxonomic Collection : Biological collection are typically preserved plant or animals specimens along with specimen documentations such as labels and notations.
Dry Collection - Dry collections consist of those specimens that are preserved in a dry state.
Wet Collection - Wet collections are specimens kept in a liquid preservative to prevent their deterioration.
The process by which a new species develops from the existing species is known as speciation.
Charles Darwin was the first to describe the role of natural selection in speciation in his 1859 book On the Origin of Species. He also identified sexual selection as a likely mechanism, but found it problematic.
A species can be defined as one or more populations of interbreeding organisms that are reproductively isolated in nature from all other organisms.
When populations no longer interbreed, they are thought to be separate species.
There are four geographic modes of speciation in nature, based on the extent to which speciating populations are isolated from one another: allopatric, peripatric, Parapatric, and sympatric.
Speciation may also be induced artificially, through animal husbandry, agriculture, or laboratory experiments.
Allopatric speciation: It is regarded as the most common type of speciation. It involves the physical separation of a species into two groups. This may occur due to climatic changes, movement of tectonic plates leading to the fragmentation of a mass of land, or eruption of a land mass, formation of waterways, or due to the presence of an impassable mountain range.
Parapatric mode of speciation: It occurs due to partial spatial isolation of populations, and is characterized by a small overlap in their ranges as well as significant gene flow amongst the populations. However, the gene flow reduces due to changes in the local conditions, and the two populations become reproductively isolated.
Sympatric mode of speciation: It involves the formation of new species due to a genetic divergence among a few members of the species inhabiting a single geographic area. Unlike the other modes of speciation, here genetic divergence does not arise due to increase in geographic distance, but occurs within the same niche.
Peripatric speciation was Proposed by Ernst Mayr. In this type of speciation, a small group of members inhabiting a peripheral region of the range undergo reproductive isolation to form a new species. Many a time, it is considered to be a variation of allopatric speciation.
Organisms are classified into a hierarchical classification that groups closely related individuals.
The species is the basic biological unit around which classifications are based.
Species are groups of actually or potentially interbreeding populations which are reproductively isolated from other such groups. The biological species concept has been prevalent in the evolutionary literature for the last several decades and is emphasized in many college-level biology courses. It is probably the species concept most familiar to biologists in diverse fields, such as conservation biology, forestry, fisheries, and wildlife management. Species defined by the biological species concept have also been championed as units of conservation. The species concept for most phycologists is based on the morphological characters and hence the term ‘species’ means morphospecies. On the other hand, for evolutionary biologists, the term means biological species that can be defined as a reproductive community of populations (reproductively isolated from others) that occupy a specific niche in Nature.
What are homologous traits Similar traits in different organisms bas.pdfjaronkyleigh59760
What are homologous traits? Similar traits in different organisms based on common function.
Traits only found in the genus Homo. i.e. living humans and their extinct ancestors. Similar traits
resulting from independent evolution in different groups of organisms. Similar traits in different
organisms based on common descent. How does cladistics differ from evolutionary systematic?
Only cladistics traces evolutionary relationships and constructs classification that reflect these
relationships. Only evolutionary systematics recognizes that organisms must be compared using
specific characters. Only cladistics rigorously defines the kinds of homologies that yield the most
useful information. Only cladistics uses homologous traits to trace evolutionary relationships.
Why is the paleo species concept more difficult to apply to organisms than the biological and the
ecological species concepts? Because reproductive isolation cannot be stuffed directly. Because
ecological distinctions are difficult to impossible in past environments. Because neither exclusive
mating nor ecological niche separation are usually accessible in fossil specimens. Because
homologous traits are rarely expressed in fossil specimens. speciation is characterized by?
Complete reproductive isolation of two populations. Partial reproductive isolation of two
populations. No reproductive isolation of two populations. Complete ecologic niche separation
of two species. What is the age of the oldest known fossils found on Earth: 3.8 billion years. 3.5
billion years. 2 billion years. 520 million years. is the study of: What happens to organic matter
after death. How bones mineralize during fossilization. The rules of classification. Ancestral
traits in closely related species. When general and specialized traits of organisms are considered
in evolution it is important to recognize that only a generalized ancestor can profit from the
flexible evolutionary basis for rapid diversification. Which of the following animals is an
appropriate example for a highly specialized placental mammal that is structurally adapted to a
narrow, rodent/woodpecker-like corniche: The duck billed platypus. The wallaby. The white-
tailed deer. The aye-aye of Madagascar.
Solution
38 d.
Homologous traits are are shared by different species that share a common ancestor. Similar in
structure or genetics, but may have very different functions and appearances. Example: bones in
the wing of a bird and the hand of a primate are homologous.
Scientific evidences I would give in support of evolution1. Paleo.pdfarwholesalelors
Scientific evidences I would give in support of evolution:
1. Paleontological evidence: Fossils are those remains of plants and animals that could not be
degraded. Some of them bear resemblances to present day animals and serve as connecting links,
eg. Duck billed platypus is connecting link between reptiles and mammals. Some of them
represent extinct organisms, eg. dinosaurs. Cross sections of the earth\'s crust from where the
fossils have been isolated determines the geological time scale during which the organism
existed.
2. Comparative anatomy/physiology: Homologous organs of animals such as forelimb bones of
humans, tigers, whales and bats share similar type of arrangement and indicates common
ancestry. Such type of evolution is called \"divergent\". Analogous organs are opposite to
homologous organs, such as wings of butterfly and birds. Although they perform the same
function, they are not anatomically similar. Thus, these are results of \"convergent \"evolution.
3. Similarities in genes and proteins among genetically different organisms also support for the
existence of common ancestry.
4. Natural selection/Industrial melanism: The dominance of dark coloured moths in industrial
areas compared to the white forms is an example of industrial melanism. This type of selection
resulted in the dark coloured moths from becoming a prey of birds compared to the paler ones as
the darker forms camouflage in the dark coloured soots. Another example of natural selection is
antibiotic resistance in bacteria. The resistant bacteria can be isolated by plating the organisms in
a LB agar plate containing the corresponding antibiotic.
5. Adaptive radiation: Darwin\'s finches in Galapagos island is an example of adaptive radiation.
It was found that the different species of finches (with different beak structure) arose from an
initial seed eating finch, enabling them to become vegetarian and insectivorous finches.
Solution
Scientific evidences I would give in support of evolution:
1. Paleontological evidence: Fossils are those remains of plants and animals that could not be
degraded. Some of them bear resemblances to present day animals and serve as connecting links,
eg. Duck billed platypus is connecting link between reptiles and mammals. Some of them
represent extinct organisms, eg. dinosaurs. Cross sections of the earth\'s crust from where the
fossils have been isolated determines the geological time scale during which the organism
existed.
2. Comparative anatomy/physiology: Homologous organs of animals such as forelimb bones of
humans, tigers, whales and bats share similar type of arrangement and indicates common
ancestry. Such type of evolution is called \"divergent\". Analogous organs are opposite to
homologous organs, such as wings of butterfly and birds. Although they perform the same
function, they are not anatomically similar. Thus, these are results of \"convergent \"evolution.
3. Similarities in genes and proteins among genetically different o.
Lab 12 Building Phylogenies Objectives .docxDIPESH30
Lab 12
Building Phylogenies
Objectives
In this laboratory exercise, you will examine six species of agaricomycetes and predict the evolutionary
relationships among them. After completing this exercise you will be able to
• define ancestral characteristics, derived characteristics, branch point, and phylogeny.
• predict ancestral and derived characteristics for agaricomycetes.
• construct a phylogeny (phylogenetic tree).
• support the phylogeny with data.
• explain how evolutionary biologists discover evolutionary relationships.
Introduction
One of the most compelling pieces of evidence for evolution is that organisms have amazing similarities. An
example that almost everyone has heard before is that the limbs of birds, bats, horses, moles, cats, frogs,
humans, turtles, and other vertebrates have virtually the same skeletal plan. Furthermore, even snakes and
whales show structural remnants of the limbs of their ancestors. The evolutionary interpretation of these
similarities is that the vertebrate limb has been modified by natural selection to perform different functions
(for example, running, digging, flying). Another commonly used example is that the embryos of turtles,
mice, humans, chickens, and many other vertebrates are amazingly similar. Furthermore, the proteins and
DNA of organisms are remarkably similar. Why, do you suppose, can human diabetics use insulin extracted
from pigs to control their blood sugar levels? Well, the reason is that the chemical structure of human and
pig insulin is very similar.
In addition to these similarities, we discover that organisms that appear similar in one respect are often
similar in other respects (we can say the patterns are “concordant”). For example, organisms that are
similar morphologically (in shape) have similar protein structures. Organisms that are less similar
morphologically have less similar protein structures. This pattern holds for traits that are not easily
modified by evolution, but not so often by traits that are easily modified by selection. For example, flower
color might not be a good trait to use when looking for concordance because it is easily changed
genetically.
The concordance of traits is an important support of evolution. Imagine that we saw that organisms similar
in one set of characteristics were very different in a second set of characteristics and different again in a
third set of characteristics. This situation would be chaotic and we would be forced to question the reality
1
of evolution. The development of methods of DNA and protein analysis has shown dramatically that
organisms that are similar morphologically are also similar at the genetic level.
So, similarity among organisms provides evidence for evolution. We can then turn around and use the
similarities to try to reconstruct evolutionary relationships. That is the purpose of today’s lab: to construct a
hypothes ...
Classical and molecular taxonomic parameters, species concept, systematic gradation of animals, nomenclature, modern scheme of animal classification into sub-Kingdom, division, section, phyla and minor phyla
what is a shared derived charterer and how is it useful for construc.pdfmichaelazach6427
what is a shared derived charterer and how is it useful for constructing a phylogeny ?
Solution
Phylogeny can be understood as the science of developmental history of an organism with
respect to other organisms. Since the origin of an individual remains unknwon and
developmental characters can be measures only relative to other known organisms, the science of
phylogeny is based upon relavance of the features of a developing organism with respect to other
organisms whose features have been already well studied. For this purpose, the extent of
relatedness and differences between two or more organisms are generally studied. There are
some features which remain exclusive for a species whereas some features are common in
different species. These common features are termed as \'shared derived characters\' because it is
supposed that owing to their presence, anatomical relavance and similarities in physiological
function in different species, these features must have been orginated from a common ancestor
and gradually shared by different species for development. Thus, the more is the number of
shared derived characters between two or more species, the more likely is their evolutionary
relatedness.
For example, while constructing a phylogeny tree, the index of these shared derived characters
remains highly useful. It helps in grouping and clssifying organisms based upon their
evolutionary history and evident relatedness based upon number of shared characters. For
example, all organisms with jointed feet are placed under phylum arthropoda. After that,
organisms with paired feet and un-paired feet are differentiated either as millipeds or centipeds.
After that, organisms are differentiated based upon their mouth structures and so on. Thus, the
occurence of jointed feet, nature of feet and distribution of body plates on mouth cavity represent
shared derived characters. These characters can be further elaborated at anatomical and
molecular levels.
Thus, this clearly explains the role of shared derived charterer and its usefullness for
constructing a phylogeny tree..
This presentation elaborates the economic crisis in Sri Lanka. It explains the causes of economic instability in Sri Lanka and the factors worsening it. Such miserable economic situation is presenting valuable lessons for other sister asian countries to counter their economic instability. Pakistan, a sister country of Sri Lanka is facing severe political and economic instability these days. Pakistan is learning from the Sri Lankan economic situation and tending to improve its economy but the extreme political instability is hurdling and exacerbating the economic crisis. However, policies are underway to counter the economic crisis and more probably Pakistan will escape the Sri Lankan experience.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
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2. TAXONOMIC CHARACTERS
Definition: A taxonomic character is any attribute of a
member of a taxon by which it differs or may differ from
a member of a different taxon.
A characteristic by which members of two taxa agree but
differ from members of a third taxon is a taxonomic
character.
5. b . Special structures(e.g Genetalia):
- Difference in genetalic structure has been used to delimit
species.It is very effective in insects where lock and key
relationship exists between male and female copulatory organs.
- Color pattern and other aspect of coloration are among the
most easily recognized and thus the most convenient characters
in certain groups of animals e.g birds.
6. C.Internal morphology:
- Both the soft as well as hard parts of practically all groups of
higher animals have been used as taxonomic characters.
d.Larval stages and embryology:
- Various immature or larval stages,the embryology and
sometimes even the eggs may provide taxonomic information.
e.g the various sibling species of the Anopheles maculipenis
complex were discovered owing to differences in egg structure.
- The classification of white flies is based primarily on the
pupae.
- Comparative studies of embryological characters like cleavage
pattern,blastulation,gastrulation are also useful in certain phyla.
7. E.Karyology: karyology is the description of chromosome
structure,size,shape and number etc.
Chromosomes are particularly useful on two different levels
- On the one hand ,they aid in the comparison of closely related
species,including sibling species.These are often far more
different chromosomally than in their external morphology.
- on the other hand,chromosomal patterns are of extreme
importance in establishing phyletic lines.
8. 2.PHYSIOLOGICAL
CHARACTERS
This group of character is hard to define.
All structures are the products of physiological processes
and are thus physiological characters.
By physiological characters one generally means growth
constants,temperature tolerances and the various
processes studied by comparative physiologist.
These characters cannot be studied in preserved
material.
9. Serology:The proteins of one organism will react more strongly
with antibodies to the proteins of a closely related organism
than to those of one more distantly related.
Sibley analysed the egg-white proteins of more than 100 species
of birds and was able to establish relationship among them.
10. 3.ECOLOGICAL CHARACTERS
Every species has its own niche in nature,differing from
its nearest relatives in food prefrence,breeding
season,tolerance to various physical factors,resistance to
predators,competitors and pathogens and in other
ecological factors.
E.g the larvae of both Drosophila mulleri and aldriachi
live simultaneously in the decaying pulp of the fruits of
the cactus Opuntia lindheimeri.
The two species are markedly specialized in their
preference for certain yeast and bacteria.
11. Similarly tapeworms of man and rodents and ascaris of man and
pigs though differ very slightly but can be identified by their
host specificity.
Each genus of galapagos finches is characterized by its
utilization of the environment,Geospiza is a ground finch while
Camarhynchus is a tree finch.
12. 4.ETHOLOGICAL
CHARACTERS
Behaviour is one of the most important soures of
taxonomic characters.
They are clearly superior to morphological characters in
the study of closely related species.
13. Similarly bioacoustics like matting calls of frogs and toads and
crickets are used for species delimitation.
Similarly the pattern of the webbing constructed by spiders can
be used at various level in classification.
14. 5.GEOGRAPHICAL
CHARACTERS
Geographical characters are among the most useful tools
for clarifying a confused taxonomic picture and for
testing taxonomic hypothesis.
The taxonomist is primarily interested in two kinds of
geographical characters
(1)general biogeographic patterns ,which are especially
useful in the arrangement of higher taxa.
(2) the allopatric-sympatric relationship,which is most
helpful in determining whether or not two populations
are conspecific.