Suppositories are solid or semi-solid dosage forms that are inserted into body cavities like the rectum, vagina, or nose. They have several advantages including ease of administration for certain patients and avoidance of first-pass metabolism. Suppositories are classified based on the cavity they are inserted into and include rectal, vaginal, nasal, urethral, and ear suppositories. They are prepared using methods like rolling, fusion, or compression and involve incorporating medications into a suppository base before molding and cooling. Proper storage, labeling, and container selection is important after preparation.

2. SUPPOSITORIES

3. SUPPOSITORIES
 CONTENTS
1. Definition.
2. Advantages and disadvantages.
3. Classifications.
4. Bases used in suppositories.
5. Classification of bases.
6. Method of preparation of suppositories.
7. Storage, container and labling.

4. SUPPOSITORIES
 Definition of suppositories.
Suppositories can be defined as
suppositories is a Solid or Semisolid dosage
form containing medicament or
medicaments installed into body cavity
other than mouth cavity such as nasal,
rectal and vaginal cavity is called as
suppositories.

5.  Advantages of suppositories.
1. They are to administration for geriatric patient.
2. They are to administration for Pediatric
patient.
3. They are to administration for Unconscious
patient.
4. It avoid first pass metabolic effect (Hepatitis
effect).
5. Suppositories are also used for promote
evacution bowl.
6. Avoid irritant effect GIT.
7. It gives sustain release.

6.  Disadvantages of suppositories.
1. Suppositories required specific
temperature range 10-20 degree
centigrade.
2. Irritant drug can not be design as
suppositories formulation.
3. Difficult preparation of suppositories.

7. Classification of suppositories.
 Classified based on installation into body
cavities.
1. Rectal suppositories.
2. Vaginal suppositories.
3. Nasal suppositories.
4. Urethral suppositories.
5. Ear cone.

8. 1. Rectal suppositories.
- This suppositories installed into rectum for
some local action.
- It is made with oil of Theobroma.
- Around 1 to 2 gram in size available in
market.
- It may be cone or torpedo in shape.

9. 2. Vaginal suppositories.
- its installed into vagina.
- Its also known as pessaries.
- Around 4 to 8 gram in weight available in
market.
- It may be available in conical and rod
shape.
- Its lager than rectal suppositories.

10. 3. Nasal suppositories.
- Its installed into nose.
- Its also known as nasal bougies.
- It may be 9-10 cm in size as well as
around 1 gm in weight.

11. 4. Urethral suppositories.

12. 4. Urethral suppositories.
- Its installed in urethra.
- It may be available in 2 to 4 gm of
weight as well as it’s a thin.
- Its also known as urethra boogies.
- It may be available in cylindrical shape.

13. 5. Ear cones.
- Its installed into ear.
- Around 1 gm in weight.
- They are cylindrical in shape, long and
thin.

14. Preparation of suppositorities.
 Types of methods.
1. Rolling method.
2. Hot process or fusion method.
3. Cold compression method.

15. 1. Rolling method.
- The rolling method is a old method used for
the preparation of suppositories.
- The suppository base rolled and desired
shape is given by hand.
2. Hot process or fusion method.
- Melt the base selected for preparation of
suppositories.
- Medicament or medicament are
incorporated.
- Filled in lubricant mold.
- Cool for make suppositories

16. Mold

17.  Lubrication of mold.
- They different types of lubricant used in
lubricants mold.
1. Cocoa butter- Soft soap, glycerin, alcohol
90%.
2. Glycero-geletin- liquid paraffin or arachis
oil.
3.Emulsifying base- No lubricant is used.
How to applied lubricant’s- brush or swab of
gauze
Cotton wool should not be used.
Do not excess amount of lubricant.

18.  Suppository mold-
- Suppository mold are made with stainless
steel, nickel, copper, brass, aluminum or
plastic.
- They are available in various size.
- Mold may open longitudinally with screw
present in centre.

19.  Displacement value-

39. 1.
2.
3.
4.
5.
REFERENCES
https://www.google.com/search?q=suppository+mould&tbm=isch&source=iu&ictx=1&fir
=GADe-4Y4Z6smaM%252CBxmydjBlBnCCeM%252C_&vet=1&usg=AI4_-
kTEii2H_oeGuihQL2Sca9GGhC_qnA&sa=X&ved=2ahUKEwjLu_3T_azwAhVDjuYKHd
F5AhIQ_h0wAXoECBUQBQ&biw=1422&bih=677#imgrc=GADe-4Y4Z6smaM
https://www.google.com/search?q=aurinaria+ear+cone+&tbm=isch&ved=2ahUKEwjOhK
nt9azwAhVVMLcAHfJBDcYQ2-
cCegQIABAA&oq=aurinaria+ear+cone+&gs_lcp=CgNpbWcQA1D3oQtYosALYNHDC2
gAcAB4AIABAIgBAJIBAJgBAKABAaoBC2d3cy13aXotaW1nwAEB&sclient=img&ei=
BJ2PYM7yL9Xg3LUP8oO1sAw&bih=677&biw=1422#imgrc=JqorQFMad6QoVM
google.com/search?q=urethral+suppositories+formulation&source=lnms&tbm=isch&sa=X
&ved=2ahUKEwiq6cOR8azwAhWV7XMBHaAHCXwQ_AUoAXoECAIQAw&biw=142
2&bih=677#imgrc=prD7T-Y8Q8D5AM&imgdii=thrJLIPUycE0IM
https://www.google.com/search?q=Nasal+suppositories+formulation&source=lnms&tbm=i
sch&sa=X&ved=2ahUKEwinstLW7qzwAhXrIbcAHf6zB6cQ_AUoAXoECAIQAw&biw=
1422&bih=677#imgrc=JV8bY2U8qATyBM
https://www.google.com/search?q=Nasal+suppositories+formulation&source=lnms&tbm=i
sch&sa=X&ved=2ahUKEwinstLW7qzwAhXrIbcAHf6zB6cQ_AUoAXoECAIQAw&biw=
1422&bih=677#imgrc=JV8bY2U8qATyBM

40. 6. https://www.philadelphia.edu.jo/academics/aadnan/uploads/SUPPOSITORIE.pdf
7. https://www.google.com/search?q=rectal+suppositories+formulation&source=ln
ms&tbm=isch&sa=X&ved=2ahUKEwiwxLf66qzwAhU673MBHUGzA64Q_A
UoAXoECAIQAw&biw=1422&bih=677#imgrc=lDnF8KcIFsHhAM
8. https://www.google.com/search?q=SUPPOSITORIES+DOSAGE+FORM&sourc
e=lnms&tbm=isch&sa=X&ved=2ahUKEwjd1-
3v3qzwAhXQXCsKHSn5C4oQ_AUoAXoECAEQAw&biw=1422&bih=741#im
grc=RSPXgEH6v21tNM
9. https://www.youtube.com/watch?v=HJpp-CtOBH8
10. https://www.youtube.com/watch?v=AX9N6OOEVaI
11. https://www.youtube.com/watch?v=QQl6RpBvZtA