Introduction to Study of consolidation parameter: Effect of dissolution parameters Presented by G. Kavya Department of Pharmaceutics

1. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 1
A Seminar as a part of curricular requirement for
I year M. Pharm I semester
Presented by
G.Kavya
(Reg. No.20L01S0304)
Dept. Of Pharmaceutics
Under the guidance of
Dr. Pavan Kumar Chintamaneni M.Pharm, Ph.D.
Associate Professor & Head
Department of Pharmaceutics
Study of consolidation parameter:
Effect of dissolution parameters

2. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 2
• Study of consolidation
• Effect of dissolution parameters
• References
Contents

3. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 3
• An increase in the mechanical strength of the material resulting from
particle or particle interaction. (increasing in mechanical strength of
the mass)
Consolidation :

4. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 4
• Dissolution is a process in which a solid substance solubilizes in a
given solvent i.e. mass transfer from the solid surface to the liquid
phase
Dissolution parameters :
a) Effect of agitation
b) Effect of dissolution fluid
c) Influence of PH of dissolution fluid
d) Effect of surface tension of the dissolution medium
e) Effect of viscosity of the dissolution medium
Dissolution parameters :

5. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 5
F) Effect of the presence of un reactive and reactive additives in the
dissolution medium
G) Volume of dissolution medium and sink conditions
H) Deaeration of the dissolution medium
I) Effect of temperature of the dissolution medium

6. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 6
The relationship between the intensity of agitation and the rate of
dissolution varies considerably according to the type of agitation
used, the shape and design of the stirrer and the physicochemical
properties of the solid.
 For the basket method, 100 rpm usually is utilized while for the
paddle procedure, a 50 – 75 rpm is recommended.
Effect of agitation

7. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 7
• Selection of proper medium for dissolution testing depends largely on
the physicochemical properties of the drug.
Effect of dissolution fluid :

8. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 8
• Simulated gastric fluid as the test medium for tablets containing
ingredients which reacted more readily in acid solution than in water
( e.g., calcium carbonate)
• For weak acids, the dissolution rate increases with increasing pH,
whereas, for weak bases, the dissolution rate increases with
decreasing pH.
• Therefore for acetylsalicylic acid tablets and capsules, the dissolution
rate would be expected to increase if the pH of the dissolution
medium was higher then 3
Influence of pH of dissolution fluid

9. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 9
• For example , tablets that are formulation with carbon dioxide
producing compounds, such as sodium bicarbonate ,magnesium
carbonate or calcium carbonate , tend to have slightly faster
dissolution rate in acid medium than in water because rapid
disintegration increases the effective surface area.

10. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 10
• If the interaction at the interfaces, occurs much faster than the rate of
transport, such as in the case of diffusion controlled dissolution
processes, it would be expected that the dissolution rate decreases
with an increase in viscosity .
• The rate of dissolution of zine in HCL solution containing sucrose
was inversely proportional to the viscosity of solution.
• The stokes-Einstein equation expresses the diffusion coefficient as a
function of viscosity, as can be seen from the following treatment.
D = µkT
µ = mobility ( velocity at a force of one dyne)
k = Boltzmann constant (1.38 x 10¯¹)
Effect of viscosity of the dissolution medium

11. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 11
• Dissolution , bioavaibility and bioequivalence by Hamed M.
Abdou.
• Biopharmaceutics and pharmacokinetics by D.M Bhramankar and
sunil B. jaiswal
• The theory and practices of industrial pharmacy by Leon lachmann,
Herbert A Liberman.
Reference

12. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 12