The document discusses the importance of dissolution studies in pharmaceutical education, specifically focusing on the Korsmeyer-Peppas model for tablet dissolution. It outlines how dissolution studies can determine drug release rates, ensure uniformity between batches, and evaluate bioavailability. The seminar by Mr. Ramy Saliheen aims to convey the relevance of these studies for controlled drug release design.

1. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 1
Korsmeyer Peppas Plot for Tablet Dissolution
A Seminar as a part of curricular requirement
for I year M. Pham I semester
Presented by
Mr. RAMY SALIHEEN
(Reg. No. 20L81S0311)
Under the guidance
Dr. CH Pavan KumarM.Pharm, Ph.D.
Professor and Head
Dept. of Pharmaceutics

2. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 2
Introduction on Dissolution
Important of dissolution studies
korsmeyer peppas plot for tablet dissolution
Conclusion
References
Contents

3. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 3
The process where
a solute in gaseous,
liquid, or solid
phase dissolves
in a solvent
to form a solution
Introduction on Dissolution

4. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 4
To show that the release of drug from the tablet is close to 100%.
To show that the rate of drug release is uniform batch to batch.
And to show that release is equivalent to those batches proven to be
bioavailable and clinically effective.
Why dissolution studies

5. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 5
• Mathematical models help to design a controlled drug release
• F = (Mt /M ) = Km tn
• F = Fraction of drug released at time ‘t’
• Mt = Amount of drug released at time ‘t’
• M = Total amount of drug in dosage form
• Km = Kinetic constant
• n = Diffusion or release exponent
• t = Time in hours
korsmeyer peppas plot for tablet dissolution

6. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 6
Interpretation of Data

7. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 7

8. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 8
By conducting dissolution studies we can know the batch to batch
quality
We can estimate the solubility profiles of the drug
we can select suitable approach to formulate the API
Conclusion

9. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 9
• [1] Khan, M and Shefeeq. T, J. 2009. J. Sci. Res. 1 (3) 539-550
• [2] Ninama U., Pal J., Chaudhary, S., Bhimani, B., and Dalsaniya, D.
2015. Int. J. Pharm. Res. Bio Sci. 4 (2) 98-114
• [3] Siepmann J, Siepmann F. 2013. Int. J. Pharm. 453 12-24
• [4] Jafari M, Kaffashi B. 2016. Nanomed Res J. 1 (2) 90-96
• [5] Shaikh HK, Kshirsagar R V, Patil SG. 2015. World J. Pharm.
Pharmaceu. 4, 04 324-338
• [6] Bruschi ML. 2015. Woodhead Publishing. (Cambridge:Elsevier)
p 64
• [7] Collins R, Jinuntuya N, Petpirom P and Wasuwanich S. 1998.
Ann. N.Y. Acad. Sci. 858 116-126
Reference

10. RIPER
AUTONOMOUS
NAAC &
NBA (UG)
SIRO- DSIR
Raghavendra Institute of Pharmaceutical Education and Research - Autonomous
K.R.Palli Cross, Chiyyedu, Anantapuramu, A. P- 515721 10
Thank you