The document discusses different types of isomerism including structural isomerism, stereoisomerism, and constitutional isomerism. It explains that stereoisomers have the same molecular formula and connectivity but different spatial orientations of bonds. Specifically, it defines enantiomers as stereoisomers that are non-superimposable mirror images, and diastereomers as stereoisomers that are not mirror images. The document also discusses restricted rotation of double bonds leading to cis-trans isomers and the use of Fischer projections to represent stereoisomers.
…….. “DRUGS” do something in our body as a result of their molecular structure, which determines:
1. Physicochemical properties
2. Chemical / biochemical reactivity
3. Shape
4. STEREO-CHEMISTRY
…….. “DRUGS” do something in our body as a result of their molecular structure, which determines:
1. Physicochemical properties
2. Chemical / biochemical reactivity
3. Shape
4. STEREO-CHEMISTRY
Cyclohexane exists in different conformations viz chair, boat, twist boat and half chair. These conformations possess different energies. Therefore they differ in energy.
Here you will find about optical isomerism...
To know about more optical isomerism download it and then you will find a link... open this and go through..
Unit i.Optical Isomerism as per PCI syllabus of POC-III Ganesh Mote
Unit I optical isomerism which is included in PCI syllabus of Sem IV of POC-III subject
This Unit Includes all points of Unit I such as nomenclature, R& S, d&l, D& L isomerism, Meso compounds, diastereomers, chirality, resolution of racemic mixture, enantiomers, Asymmetric synthesis,
STEREOSPECIFIC REACTION, STEREOSELECTIVE REACTION, OPTICAL PURITY, ENANTIOMERIC EXCESS.. all these topics are explained in this slide with examples and formula.
Biphenyl derivatives & Atropisomerism:Optical activity in Biphenyls, Stereochemistry of biphenyl derivatives, rules and assigning RS configuration to biphenyls
5 membered heterocyclic compound Furan. it is complete powerpoint presentation who want to learn from basics of heterocyclic chemistry. I have referred from various books and done my best so that view can get all they can without scroll many books. Kindly give your feedback after viewing powerpoint presentation
Cyclohexane exists in different conformations viz chair, boat, twist boat and half chair. These conformations possess different energies. Therefore they differ in energy.
Here you will find about optical isomerism...
To know about more optical isomerism download it and then you will find a link... open this and go through..
Unit i.Optical Isomerism as per PCI syllabus of POC-III Ganesh Mote
Unit I optical isomerism which is included in PCI syllabus of Sem IV of POC-III subject
This Unit Includes all points of Unit I such as nomenclature, R& S, d&l, D& L isomerism, Meso compounds, diastereomers, chirality, resolution of racemic mixture, enantiomers, Asymmetric synthesis,
STEREOSPECIFIC REACTION, STEREOSELECTIVE REACTION, OPTICAL PURITY, ENANTIOMERIC EXCESS.. all these topics are explained in this slide with examples and formula.
Biphenyl derivatives & Atropisomerism:Optical activity in Biphenyls, Stereochemistry of biphenyl derivatives, rules and assigning RS configuration to biphenyls
5 membered heterocyclic compound Furan. it is complete powerpoint presentation who want to learn from basics of heterocyclic chemistry. I have referred from various books and done my best so that view can get all they can without scroll many books. Kindly give your feedback after viewing powerpoint presentation
This is for UG students. In this unit concept of stereochemistry is explain in easy way. The content are shown below:
-Stereochemistry
-Isomerism and their classification
-stereochemistry and their classification
-Geometrical Isomerism
-Optical isomerism
-Confirmational Isomerism
Geometric isomerism of alkenes, cyclic compounds: cis-trans and (E)-(Z) system of
nomenclature
b) Conformational isomers: Open chain and cyclic system
c) Chirality of molecules: Enantiomers, diastereomers, racemic modification, Meso
compound, R & S configuration, sequence rule, Optical rotation
d) Asymmetric synthesis: Preparation of enantiomers by asymmetric synthesis & optical
resolution method
e) Stereo selective and stereo specific reaction
f) Pharmaceutical importance of studding stereochemistry
Currently pi network is not tradable on binance or any other exchange because we are still in the enclosed mainnet.
Right now the only way to sell pi coins is by trading with a verified merchant.
What is a pi merchant?
A pi merchant is someone verified by pi network team and allowed to barter pi coins for goods and services.
Since pi network is not doing any pre-sale The only way exchanges like binance/huobi or crypto whales can get pi is by buying from miners. And a merchant stands in between the exchanges and the miners.
I will leave the telegram contact of my personal pi merchant. I and my friends has traded more than 6000pi coins successfully
Tele-gram
@Pi_vendor_247
The European Unemployment Puzzle: implications from population agingGRAPE
We study the link between the evolving age structure of the working population and unemployment. We build a large new Keynesian OLG model with a realistic age structure, labor market frictions, sticky prices, and aggregate shocks. Once calibrated to the European economy, we quantify the extent to which demographic changes over the last three decades have contributed to the decline of the unemployment rate. Our findings yield important implications for the future evolution of unemployment given the anticipated further aging of the working population in Europe. We also quantify the implications for optimal monetary policy: lowering inflation volatility becomes less costly in terms of GDP and unemployment volatility, which hints that optimal monetary policy may be more hawkish in an aging society. Finally, our results also propose a partial reversal of the European-US unemployment puzzle due to the fact that the share of young workers is expected to remain robust in the US.
how to sell pi coins on Bitmart crypto exchangeDOT TECH
Yes. Pi network coins can be exchanged but not on bitmart exchange. Because pi network is still in the enclosed mainnet. The only way pioneers are able to trade pi coins is by reselling the pi coins to pi verified merchants.
A verified merchant is someone who buys pi network coins and resell it to exchanges looking forward to hold till mainnet launch.
I will leave the telegram contact of my personal pi merchant to trade with.
@Pi_vendor_247
Even tho Pi network is not listed on any exchange yet.
Buying/Selling or investing in pi network coins is highly possible through the help of vendors. You can buy from vendors[ buy directly from the pi network miners and resell it]. I will leave the telegram contact of my personal vendor.
@Pi_vendor_247
how to sell pi coins in all Africa Countries.DOT TECH
Yes. You can sell your pi network for other cryptocurrencies like Bitcoin, usdt , Ethereum and other currencies And this is done easily with the help from a pi merchant.
What is a pi merchant ?
Since pi is not launched yet in any exchange. The only way you can sell right now is through merchants.
A verified Pi merchant is someone who buys pi network coins from miners and resell them to investors looking forward to hold massive quantities of pi coins before mainnet launch in 2026.
I will leave the telegram contact of my personal pi merchant to trade with.
@Pi_vendor_247
Falcon stands out as a top-tier P2P Invoice Discounting platform in India, bridging esteemed blue-chip companies and eager investors. Our goal is to transform the investment landscape in India by establishing a comprehensive destination for borrowers and investors with diverse profiles and needs, all while minimizing risk. What sets Falcon apart is the elimination of intermediaries such as commercial banks and depository institutions, allowing investors to enjoy higher yields.
US Economic Outlook - Being Decided - M Capital Group August 2021.pdfpchutichetpong
The U.S. economy is continuing its impressive recovery from the COVID-19 pandemic and not slowing down despite re-occurring bumps. The U.S. savings rate reached its highest ever recorded level at 34% in April 2020 and Americans seem ready to spend. The sectors that had been hurt the most by the pandemic specifically reduced consumer spending, like retail, leisure, hospitality, and travel, are now experiencing massive growth in revenue and job openings.
Could this growth lead to a “Roaring Twenties”? As quickly as the U.S. economy contracted, experiencing a 9.1% drop in economic output relative to the business cycle in Q2 2020, the largest in recorded history, it has rebounded beyond expectations. This surprising growth seems to be fueled by the U.S. government’s aggressive fiscal and monetary policies, and an increase in consumer spending as mobility restrictions are lifted. Unemployment rates between June 2020 and June 2021 decreased by 5.2%, while the demand for labor is increasing, coupled with increasing wages to incentivize Americans to rejoin the labor force. Schools and businesses are expected to fully reopen soon. In parallel, vaccination rates across the country and the world continue to rise, with full vaccination rates of 50% and 14.8% respectively.
However, it is not completely smooth sailing from here. According to M Capital Group, the main risks that threaten the continued growth of the U.S. economy are inflation, unsettled trade relations, and another wave of Covid-19 mutations that could shut down the world again. Have we learned from the past year of COVID-19 and adapted our economy accordingly?
“In order for the U.S. economy to continue growing, whether there is another wave or not, the U.S. needs to focus on diversifying supply chains, supporting business investment, and maintaining consumer spending,” says Grace Feeley, a research analyst at M Capital Group.
While the economic indicators are positive, the risks are coming closer to manifesting and threatening such growth. The new variants spreading throughout the world, Delta, Lambda, and Gamma, are vaccine-resistant and muddy the predictions made about the economy and health of the country. These variants bring back the feeling of uncertainty that has wreaked havoc not only on the stock market but the mindset of people around the world. MCG provides unique insight on how to mitigate these risks to possibly ensure a bright economic future.
how can I sell my pi coins for cash in a pi APPDOT TECH
You can't sell your pi coins in the pi network app. because it is not listed yet on any exchange.
The only way you can sell is by trading your pi coins with an investor (a person looking forward to hold massive amounts of pi coins before mainnet launch) .
You don't need to meet the investor directly all the trades are done with a pi vendor/merchant (a person that buys the pi coins from miners and resell it to investors)
I Will leave The telegram contact of my personal pi vendor, if you are finding a legitimate one.
@Pi_vendor_247
#pi network
#pi coins
#money
USDA Loans in California: A Comprehensive Overview.pptxmarketing367770
USDA Loans in California: A Comprehensive Overview
If you're dreaming of owning a home in California's rural or suburban areas, a USDA loan might be the perfect solution. The U.S. Department of Agriculture (USDA) offers these loans to help low-to-moderate-income individuals and families achieve homeownership.
Key Features of USDA Loans:
Zero Down Payment: USDA loans require no down payment, making homeownership more accessible.
Competitive Interest Rates: These loans often come with lower interest rates compared to conventional loans.
Flexible Credit Requirements: USDA loans have more lenient credit score requirements, helping those with less-than-perfect credit.
Guaranteed Loan Program: The USDA guarantees a portion of the loan, reducing risk for lenders and expanding borrowing options.
Eligibility Criteria:
Location: The property must be located in a USDA-designated rural or suburban area. Many areas in California qualify.
Income Limits: Applicants must meet income guidelines, which vary by region and household size.
Primary Residence: The home must be used as the borrower's primary residence.
Application Process:
Find a USDA-Approved Lender: Not all lenders offer USDA loans, so it's essential to choose one approved by the USDA.
Pre-Qualification: Determine your eligibility and the amount you can borrow.
Property Search: Look for properties in eligible rural or suburban areas.
Loan Application: Submit your application, including financial and personal information.
Processing and Approval: The lender and USDA will review your application. If approved, you can proceed to closing.
USDA loans are an excellent option for those looking to buy a home in California's rural and suburban areas. With no down payment and flexible requirements, these loans make homeownership more attainable for many families. Explore your eligibility today and take the first step toward owning your dream home.
how to sell pi coins effectively (from 50 - 100k pi)DOT TECH
Anywhere in the world, including Africa, America, and Europe, you can sell Pi Network Coins online and receive cash through online payment options.
Pi has not yet been launched on any exchange because we are currently using the confined Mainnet. The planned launch date for Pi is June 28, 2026.
Reselling to investors who want to hold until the mainnet launch in 2026 is currently the sole way to sell.
Consequently, right now. All you need to do is select the right pi network provider.
Who is a pi merchant?
An individual who buys coins from miners on the pi network and resells them to investors hoping to hang onto them until the mainnet is launched is known as a pi merchant.
debuts.
I'll provide you the Telegram username
@Pi_vendor_247
If you are looking for a pi coin investor. Then look no further because I have the right one he is a pi vendor (he buy and resell to whales in China). I met him on a crypto conference and ever since I and my friends have sold more than 10k pi coins to him And he bought all and still want more. I will drop his telegram handle below just send him a message.
@Pi_vendor_247
Latino Buying Power - May 2024 Presentation for Latino CaucusDanay Escanaverino
Unlock the potential of Latino Buying Power with this in-depth SlideShare presentation. Explore how the Latino consumer market is transforming the American economy, driven by their significant buying power, entrepreneurial contributions, and growing influence across various sectors.
**Key Sections Covered:**
1. **Economic Impact:** Understand the profound economic impact of Latino consumers on the U.S. economy. Discover how their increasing purchasing power is fueling growth in key industries and contributing to national economic prosperity.
2. **Buying Power:** Dive into detailed analyses of Latino buying power, including its growth trends, key drivers, and projections for the future. Learn how this influential group’s spending habits are shaping market dynamics and creating opportunities for businesses.
3. **Entrepreneurial Contributions:** Explore the entrepreneurial spirit within the Latino community. Examine how Latino-owned businesses are thriving and contributing to job creation, innovation, and economic diversification.
4. **Workforce Statistics:** Gain insights into the role of Latino workers in the American labor market. Review statistics on employment rates, occupational distribution, and the economic contributions of Latino professionals across various industries.
5. **Media Consumption:** Understand the media consumption habits of Latino audiences. Discover their preferences for digital platforms, television, radio, and social media. Learn how these consumption patterns are influencing advertising strategies and media content.
6. **Education:** Examine the educational achievements and challenges within the Latino community. Review statistics on enrollment, graduation rates, and fields of study. Understand the implications of education on economic mobility and workforce readiness.
7. **Home Ownership:** Explore trends in Latino home ownership. Understand the factors driving home buying decisions, the challenges faced by Latino homeowners, and the impact of home ownership on community stability and economic growth.
This SlideShare provides valuable insights for marketers, business owners, policymakers, and anyone interested in the economic influence of the Latino community. By understanding the various facets of Latino buying power, you can effectively engage with this dynamic and growing market segment.
Equip yourself with the knowledge to leverage Latino buying power, tap into their entrepreneurial spirit, and connect with their unique cultural and consumer preferences. Drive your business success by embracing the economic potential of Latino consumers.
**Keywords:** Latino buying power, economic impact, entrepreneurial contributions, workforce statistics, media consumption, education, home ownership, Latino market, Hispanic buying power, Latino purchasing power.
2. CHAIN ISOMERISM
STRUCTURAL ISOMERISM POSITION ISOMERISM
Same molecular formula but
different structural formulae FUNCTIONAL GROUP
ISOMERISM
GEOMETRICAL ISOMERISM
Occurs due to the restricted
STEREOISOMERISM rotation of C=C double bonds...
two forms… CIS and TRANS
Same molecular
formula but atoms
occupy different
positions in space. OPTICAL ISOMERISM
Occurs when molecules have a
chiral centre. Get two non-
superimposable mirror images.
4. In alkenes
CIS TRANS
Groups/atoms are on the Groups/atoms are on OPPOSITE
SAME SIDE of the double bond SIDES across the double bond
5. RESTRICTED ROTATION OF C=C BONDS
Single covalent bonds can easily rotate. What appears to be a different structure is
not. It looks like it but, due to the way structures are written out, they are the same.
ALL THESE STRUCTURES ARE THE SAME BECAUSE C-C BONDS HAVE ‘FREE’ ROTATION
6. RESTRICTED ROTATION OF C=C BONDS
C=C bonds have restricted rotation so the groups on either end of the bond are
‘frozen’ in one position; it isn’t easy to flip between the two.
This produces two possibilities. The two structures cannot interchange easily
so the atoms in the two molecules occupy different positions in space.
8. Isomerism
• Constitutional Isomers: Same atoms but
linked (bonded) together differently.
Spatial orientation not important.
hexane 3-methylpentane
cyclohexane
No, different molecular
Are these constitutional isomers of isomers of hexane?
Are these constitutional cis but-2-ene?
formulae!!
Not this one! It is 2-butene. Cis / trans
does not matter.
9. Stereoisomerism
• Stereoisomers: Same molecular
formulae, same connectivity; same
constitutional isomer. Different spatial
orientation of the bonds.
Are these stereoisomers of cis but-2-ene?
How does the connectivity differ between these two?
10. Enantiomers and Diastereomers
Two kinds of Stereoisomers
– Enantiomers: stereoisomers which are mirror
objects of each other. Enantiomers are
different objects, not superimposable.
– Diastereomers: stereoisomers which are not
mirror objects of each other.
If a molecule has one or more tetrahedral carbons
having four different substituents then enantiomers will
occur. If there are two or more such carbons then
diastereomers may also occur.
11. Summary of Isomerism Concepts
Isomers, contain same atoms, same formula
Constitutional isomers, different Stereoisomers, same
connectivities, bonding. connectivity, different three dimensional
orientation of bonds
Enantiomers, mirror objects Diastereomers, not mirror objects
12. Mirror Objects – Carbon with 4 different substituents. We
expect enantiomers (mirror objects).
Reflect!
The mirror plane still relates the two structures. Notice that we can
characterize or name the molecules by putting the blue in the back, drawing
a circle from purple, to red, to green. Clockwise on the right and
counterclockwise on the left. Arbitrarily call them R and S.Notice how the reflection
is done, straight through
the mirror!
Arrange both
structures with the
light blue atoms
towards the rear….
These are mirror objects. Are they the same thing just viewed
differently ?? Can we superimpose them?
We can
superimpose two
atoms. but not all
S R
four atoms.
13. Recap: Tetrahedral Carbon with four
Different Substituents. Enantiomers
Mirror objects.
Different, not
superimposable.
Simple Simple
Rotation, Sa Enantiomers Rotation, Sa
me me
14. But the reflection might have been done
differently. Position the mirror differently….
Reflection can give
any of the following…
Again. all three objects on the
right Can the mirror object of the
are you locate the mirror
structure above. They eachthe
which would transform
What is common to are of
different reflectionthe into each
original molecule
these views of operations?
In themirror object?
enantiomer. of each
course
reflection, two substitutents are
A swap of two substituents is
swapped.be equivalent to a
seen to The other two remain All three of these structures are the same, just made by
unchanged.at the carbon atom. different mirrors. The structures are superimposable.
reflection
What rotations of the whole molecules are needed to
superimpose the structures?
15. Now Superimposable mirror objects:
Tetrahedral Carbon with at least two identical
substituents.
Reflection can interchange the two red substituents.
Clearly interchanging the two reds leads to the same
structure, superimposable! Remember it does not
make any difference where the mirror is held for the
reflection.
This molecule does not have an enantiomer; the
mirror object is superimposable on the original, the
same object.
16. Polarized light vibrates in one plane only, in
contrast to ordinary light, which vibrates in
all planes.
What causes such a rotation of the plane of polarized liight?
According to the van’t Hoff theory, such an effect on the plane polarized light
is due to the presence of one or more chiral carbon atoms.
17. Fischer projection
A two-dimensional method of indicating the structure of an enantiomer.
Horizontal lines indicate bonds extending forward from the paper and the
vertical lines indicate bonds extending backward from the paper.
The formulas are always written with the aldehyde(or ketone) group)-the
most highly oxidized-at the top.
convert to
CHO a Fischer CHO
projection
H C OH H OH
CH2 OH
CH2 OH
18. Glyceraldehyde
(an aldotriose)
H H O
O
C C
H C OH HO C H
CH2 OH CH2 OH
D (+) L (-)