The document discusses several STEMI mimics that can present with ST segment elevation on ECG but are not actually caused by an acute myocardial infarction. These include early repolarization, left bundle branch block, electrolyte abnormalities, left ventricular hypertrophy, pulmonary embolism, left ventricular aneurysm, Brugada syndrome, pericarditis, and hypothermia. It provides details on the characteristic ECG patterns and clinical features that can help differentiate these conditions from a true STEMI.
How to read ECG systematically with practice strips Khaled AlKhodari
This lecture simplifies the steps of reading ECG systematically. It starts with a simple heart anatomy and the logical steps that should be followed to perfect ECG reading without missing any abnormality. Finally, there are some practice ECG strips that include but not only MI, STEMI, Wellens syndrome, Pulmonary embolism, LVH, arrhythmias... and others
ECG in Athletes is common facing problem in primary care and emergency. clinician must be aware and able to differentiate between normal changes and abnormal ECG that need further investigations
How to read ECG systematically with practice strips Khaled AlKhodari
This lecture simplifies the steps of reading ECG systematically. It starts with a simple heart anatomy and the logical steps that should be followed to perfect ECG reading without missing any abnormality. Finally, there are some practice ECG strips that include but not only MI, STEMI, Wellens syndrome, Pulmonary embolism, LVH, arrhythmias... and others
ECG in Athletes is common facing problem in primary care and emergency. clinician must be aware and able to differentiate between normal changes and abnormal ECG that need further investigations
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
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The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
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Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
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The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
2. WHY IS THIS IMPORTEANT ?
Chest pain is a common cause of ED visits.
In patients with ECG findings consistent with a STEMI, the primary goal is t
o salvage myocardium through rapid reperfusion.
However, before activating the cardiac catheterization lab for ECG changes
,
it is important to consider non-ischemic causes of ST-segment elevation
3.
4.
5. Early repolarization was initially associated with young healthy athletes,
but increasingly is found in a wider variety of individuals.
The dramatic appearance of ST segment in multiple contiguous leads results in early repolarization being cited as the most
common cause of false-positive catheterization laboratory activations in patients without elevated cardiac biomarkers.
Over the years, different authors have used different criteria for the diagnosis of early repolarization. To provide consistency, in
2015, Hancock et al proposed three criteria that are required for the diagnosis of benign early repolarization:
• The QRS slur or notch (termed a J wave) must be on the downslope of the R wave and be above the isoelectric
line.
• The peak of the J point must be elevated ≥ 0.1 mV in two or more contiguous leads, except V1-V3.
• The QRS duration must be < 120 ms.
Early Repolarization
6. ST segment / T wave morphology
The ST segment-T wave complex in ER has a characteristic appearance:
• There is elevation of the J point
• The T wave is peaked and slightly asymmetrical
• The ST segment and the ascending limb of the T wave form an upward concavity (smiley
-shaped )
• The descending limb of the T wave is straighter and slightly steeper than the ascending li
mb
7. J-point morphology
One characteristic feature of ER is the presence of a notched or irregular J-point so-called
“fish hook” pattern.
This is often best seen in lead V4.
8. a healthy 17-year old female who was admitted to hospital following a benz
odiazepine overdose.
She had no chest pain, and cardiac biomarkers were normal.
12. Left Bundle Branch Block
ECG Diagnostic criteria of LBBB:
• QRS duration ≥ 120ms
• Dominant S wave in V1
• Broad monophasic R wave in lateral leads (I, aVL, V5-6)
• Absence of Q waves in lateral leads
• Prolonged R wave peak time > 60ms in leads V5-6
In hemodynamically stable patients with a presumed new LBBB, evaluation of their sympt
oms requires both measurement of cardiac biomarkers and observation.
In patients with hemodynamic compromise (including acute heart failure), revascularizatio
n should be emergently considered.
13.
14. Sgarbossa criteria for LBBB
The Sgarbossa criteria can help guide the decision for emergent catheterization and coronary intervention in the
presence of both new and old LBBBs.
• Concordant ST elevation > 1mm in leads
with a positive QRS complex (score 5)
• Concordant ST depression > 1 mm in V1-V3 (score 3)
• Excessively discordant ST elevation > 5 mm in leads
with a -ve QRS complex (score 2)
These criteria are specific, but not sensitive (36%)
for myocardial infarction
. A total score of ≥ 3 is reported to have a specificity of 90%
for diagnosing myocardial infarction.
18. Electrolyte derangements of potassium, calcium, magnesium, and sodium alter the cardiac action po
tential,
resulting in ECG changes.
Hyper K
Hyperkalemia frequently can cause ST elevation, most commonly in leads V1 and V2 and s
hould be suspected when there is any QRS widening, especially when associated w
ith some symmetric
peaking of the T waves
(“T waves that will poke you if you touch them”)
Short QT, PR
Flat P wave
Loss of SA conduction <<< wide QRS <<< V Fib and asystole
Electrolyte
19.
20. Hypercalcemia
Characteristic ECG changes include shortening of the QT interva
l.
This shortening of the QT interval is what may mimic ST elevatio
n.
Electrolyte
21.
22. Sodium channel blocker (SCB) toxicity
Sodium channel blocker (SCB) toxicity may manifest as ST elevation,
particularly in lead aVR.
SCB TOXICITY Like ??
Electrolyte
23.
24. Left ventricular hypertrophy (LVH)
Left ventricular hypertrophy (LVH) is known to cause many false-positive cardiac catheterization lab activation
s.
Voltage Criteria
Limb Leads
• R wave in lead I + S wave in lead III > 25 mm
• R wave in aVL > 11 mm
• R wave in aVF > 20 mm
• S wave in aVR > 14 mm
Precordial Leads
• R wave in V4, V5 or V6 > 26 mm
• R wave in V5 or V6 plus S wave in V1 > 35 mm The most specific and widely used criteria are the So
kolow-Lyon criteria, which confer a specificity of almost 100%
• Largest R wave plus largest S wave in precordial leads > 45 mm
Non Voltage Criteria
• Increased R wave peak time > 50 ms in leads V5 or V6
• ST segment depression and T wave inversion in the left-sided leads: AKA the left ventricular ‘str
25.
26.
27.
28. Acute Pulmonary Embolism
ECG findings compared to Acute Coronary Syndrome
• ACS is rarely associated with tachycardia
• Rt Axis deviation rarely seen in STEMI
• Bedside echo may be useful in differentiating the two, demonstrating features of RV dilatation and
pulmonary
arterial hypertension
• Kosuge et al have shown that simultaneous inversion in III and V1 are diagnostically significant:
Negative T waves in leads III and V1 were observed in only 1% of patients with ACS compared with 88% of patient
s with Acute PE (p less than 0.001). The sensitivity, specificity, positive predictive value, and negative predictive
value of this finding for the diagnosis of PE were 88%, 99%, 97%, and 95%, respectively. In conclusion, the presen
ce of negative T waves in both leads III and V1 allows PE to be differentiated simply but accurately from ACS in p
atients with negative T waves in the
precordial leads.
31. When a transmural infarct is not aborted by therapeutic intervention and the AMI completes itself, the
myocardium is replaced by a thin, fibrous layer, which is called an LV aneurysm.
On the ECG, a left ventricular aneurysm may manifest as persistent ST elevation in the territory of a p
rior infarct,
commonly concomitant with Q waves.
The rule states that when the differential diagnosis is acute LAD occlusion vs. anterior LV aneurysm,
if any of
leads V1-V4 has a T wave amplitude to QRS amplitude ratio of > 0.36, then STEMI is likely.
In general, aneurysm is favored by prominent Q waves in leads V1-V4 with corresponding diminishe
d T wave
amplitudes.
• T-wave/QRS ratio < 0.36 in all precordial leads favours LV aneurysm
• T-wave/QRS ratio > 0.36 in any precordial lead favours anterior STEMI
Aneurysm
32.
33.
34. Brugada syndrome
Brugada Syndrome is an ECG abnormality with a high incidence of sudden death in patient
s with structurally normal hearts.
Brugada syndrome is due to a mutation in the cardiac sodium channel gene.
• Diagnosis depends on a characteristic ECG finding AND clinical criteria.
• Further risk stratification is controversial.
• Definitive treatment = ICD.
• Brugada sign in isolation is of questionable significance.
35. Diagnostic Criteria
This ECG abnormality must be associated with one of the following clinical criteria to make
the diagnosis:
• Documented ventricular fibrillation (VF) or polymorphic ventricular tachycardia (VT).
• Family history of sudden cardiac death at <45 years old .
• Coved-type ECGs in family members.
• Inducibility of VT with programmed electrical stimulation .
• Syncope.
• Nocturnal agonal respiration.
36. TYPES
Type 1
• Coved ST segment elevation >2mm in >1 of V1-V3 followed by a negative
T wave.
• This is the only ECG abnormality that is potentially diagnostic.
• It is often referred to as Brugada sign.
37. TYPES
Type 2
• Brugada Type 2 has >2mm of saddleback shaped ST elevation.
Type 3
• Brugada type 3: can be the morphology of either type 1 or type 2, but with
<2mm of ST segment elevation.
38.
39. Look for features of STEMI first:
• Search for ST depression in leads other than aVR and V1
• Look for ST elevation in lead III > II
• Search for horizontal or convex upward ST elevation
• New Q wave
pericarditis
42. Hypothermia
Hypothermia is defined as a core body temperature of < 35 °C
The Osborn wave (J wave) is a positive deflection
at the J point (negative in aVR and V1).
• It is usually most prominent in the precordial leads.
• The height of the Osborn wave is roughly proportional
to the degree of hypothermia
Early repolarization showing J-point elevation in multiple contiguous leads and slurring and/or notching on the downstroke of the R wave in leads II, III, aVF, V5, and V6.
ST elevation and J-point notching are more prominent at a slower heart rate.
There is concordant ST depression in V2-5 (= Sgarbossa positive).
The morphology in V2-5 is reminiscent of posterior STEMI, with horizontal ST depression and prominent upright T waves.
This patient had a confirmed posterior infarction, requiring PCI to a completely occluded posterolateral branch of the RCA.