The document discusses the three states of matter - solids, liquids, and gases. It describes their characteristics at a microscopic level. Solids have a fixed shape and volume, with particles tightly packed in a repeating pattern that can only vibrate in place. Liquids have a fixed volume but changing shape as particles can move past each other while being attracted. Gases have volumes and shapes that change as particles are always pushing outward and spreading to fill their containers. The document also discusses intermolecular forces such as dispersion forces, dipole-dipole forces, induced dipole forces, and hydrogen bonding that influence the behavior of matter in different states.
State of matter and properties of matter (Part-7)(Solid-crystalline, Amorpho...Ms. Pooja Bhandare
CRYSTALLINE SOLID, Types of Crystalline solid, AMORPHOUS SOLID, Difference between crystalline solid and amorphous solid, Why does the amorphous form of drug have better bioavaibility that crystalline couterpaerts?, Polymorphism,
TYPES OF POLYMORPHISM, PROPERTY OF POLYMORPHS, Methods of preparation of Polymorphs, Methods to determine Polymorphism Characterization of Polymorphs, Pharmaceutical Application
State of matter and properties of matter (Part-2) (Latent Heat, Vapour pressu...Ms. Pooja Bhandare
Latent Heat, Vapour pressure, Factor affecting vapour pressure, Surface area, Types of molecule, Temperature and Intermolecular forces, Sublimation Critical point
Solubility of drugs: Solubility expressions, mechanisms of solute solvent interactions, ideal solubility parameters, solvation & association, quantitative approach to the factors
influencing solubility of drugs, diffusion principles in biological systems. Solubility
of gas in liquids, solubility of liquids in liquids, (Binary solutions, ideal solutions)
Raoult’s law, real solutions. Partially miscible liquids, Critical solution temperature . Distribution law, its limitations and applications
State of matter and properties of matter (Part-7)(Solid-crystalline, Amorpho...Ms. Pooja Bhandare
CRYSTALLINE SOLID, Types of Crystalline solid, AMORPHOUS SOLID, Difference between crystalline solid and amorphous solid, Why does the amorphous form of drug have better bioavaibility that crystalline couterpaerts?, Polymorphism,
TYPES OF POLYMORPHISM, PROPERTY OF POLYMORPHS, Methods of preparation of Polymorphs, Methods to determine Polymorphism Characterization of Polymorphs, Pharmaceutical Application
State of matter and properties of matter (Part-2) (Latent Heat, Vapour pressu...Ms. Pooja Bhandare
Latent Heat, Vapour pressure, Factor affecting vapour pressure, Surface area, Types of molecule, Temperature and Intermolecular forces, Sublimation Critical point
Solubility of drugs: Solubility expressions, mechanisms of solute solvent interactions, ideal solubility parameters, solvation & association, quantitative approach to the factors
influencing solubility of drugs, diffusion principles in biological systems. Solubility
of gas in liquids, solubility of liquids in liquids, (Binary solutions, ideal solutions)
Raoult’s law, real solutions. Partially miscible liquids, Critical solution temperature . Distribution law, its limitations and applications
State of matter and properties of matter (Part-6)(Relative humidity, Liquid ...Ms. Pooja Bhandare
RELATIVE HUMIDITY, Humidity, Wet and Dry Hygrometer, LIQUID COMPLEX, LIQUID CRYSTALS, Types of liquid crystals, GLASSY STATES, Characteristics glassy state, Types of glassy state, What is the Glass Transition Temperature?
4th (30.10.2014) on eutectic mixture by Diptarco SinghaDiptarco Singha
this ppt is very simple and has immence importance in physical pharmacy. it has been prepared based on the syllabus of WBUT & consists of informations of elimentary label...
When phases exist together, the boundary between two of them is known as interface.
When the phase is in contact with atmosphere it is termed as surface.
States of matter and properties of matterJILSHA123
States of matter and properties of matter, latent heat, vapour pressure, aerosols - inhalers, sublimation critical point, eutectic mixtures, gas laws, Gibbs phase rule, crystalline structures, 3rd b.pharmacy, sanjo college of pharmaceutical studies, palakkad, kerala
State of matter and properties of matter (Part-6)(Relative humidity, Liquid ...Ms. Pooja Bhandare
RELATIVE HUMIDITY, Humidity, Wet and Dry Hygrometer, LIQUID COMPLEX, LIQUID CRYSTALS, Types of liquid crystals, GLASSY STATES, Characteristics glassy state, Types of glassy state, What is the Glass Transition Temperature?
4th (30.10.2014) on eutectic mixture by Diptarco SinghaDiptarco Singha
this ppt is very simple and has immence importance in physical pharmacy. it has been prepared based on the syllabus of WBUT & consists of informations of elimentary label...
When phases exist together, the boundary between two of them is known as interface.
When the phase is in contact with atmosphere it is termed as surface.
States of matter and properties of matterJILSHA123
States of matter and properties of matter, latent heat, vapour pressure, aerosols - inhalers, sublimation critical point, eutectic mixtures, gas laws, Gibbs phase rule, crystalline structures, 3rd b.pharmacy, sanjo college of pharmaceutical studies, palakkad, kerala
QMS SOP [QUALITY MANAGEMENT SYSTEM - STANDARD OPERATING PROCEDURE]Nabeela Moosakutty
Standard Operating Procedure (SOP)
A Standard Operating Procedure (SOP) is a set of written
instructions that documents routine or repetitive activity followed by
an organization.
The development and use of SOPs are an integral part of a
successful quality system as it provides individuals with the information
to perform a job properly, and facilitates consistency in the quality and
integrity of a product or end-result. To ensure quality control, all
procedures are standardized, So SOPs are integral part of Quality
assurance process.
Purpose
SOPs detail the regularly recurring work processes that are to be
conducted or followed within an organization. They document the way
activities are to be performed to facilitate consistent conformance to
technical and quality system requirements and to support data quality.
They may describe, for example, fundamental programmatic actions and
technical actions such as analytical processes, and processes for
maintaining, calibrating, and using equipment. SOPs are intended to be
specific to the organization or facility whose activities are described and
assist that organization to maintain their quality control and quality
assurance processes and ensure compliance with governmental
regulations.
If not written correctly, SOPs are of limited value. In addition, the
best written SOPs will fail if they are not followed. Therefore, the use of
SOPs needs to be reviewed and re-enforced by management, preferably the
direct supervisor. Current copies of the SOPs also need to be readily
accessible for reference in the work areas of those individuals actually
performing the activity, either in hard copy or electronic format, otherwise
SOPs serve little purpose.
SOP-Benefits
a) The development and use of SOPs minimizes variation and promotes
quality.
b) SOPs can indicate compliance with organizational and governmental
requirements through detailed work instructions and can be used as
apart of a personnel training program.
c) It minimizes opportunities form is communication and can address
safety concerns. SOP-Writing Styles
SOPs should be written in a concise, step-by-step, easy-to-read format.
Information should not be overly complicated.
SOP Process
a) Preparation
The organization should have a procedure in place for
determining what procedures or processes need to be documented. Those
SOPs should then be written by individuals knowledgeable with the
activity and the organization's internal structure. These individuals
are essentially subject-matter experts who actually perform the work
or use the process.
SOPs should be written with sufficient detail so that someone with
limited experience with or knowledge of the procedure, but with a basic
understanding, can successfully reproduce the procedure when
unsupervised
b) Review and Approval
SOPs should be reviewed (that is, validated) by one or more
individuals with appropriate training and experience with the process.
Introduction
The pericardium is a fibrous sac that encloses the heart and great vessels. It keeps the heart in a stable location in the mediastinum, facilitates its movements, and separates it from the lungs and other mediastinal structures. It also supports physiological cardiac function.
Structure and Function
The pericardium consists of two layers: the fibrous and the serous. The fibrous pericardium is a conical-shaped sac. Its apex is fused with the roots of the great vessels at the base of the heart. Its broad base overlies the central fibrous area of the diaphragm with which it is fused. Weak sterno-pericardial ligaments connect the anterior aspect of the fibrous pericardium to the sternum. The serous pericardium is a layer of serosa that lines the fibrous pericardium (parietal layer), which is reflected around the roots of the great vessels to cover the entire surface of the heart (visceral layer). Between the parietal and visceral layers is a potential space that may be filled with a small amount of fluid. The part of the visceral layer that covers the heart, but not the great vessels is called the epicardium.
As the serous pericardium reflects off various cardiac structures, it forms two sinuses: the transverse sinus and the oblique sinus. The oblique sinus is a cul-de-sac extending superiorly from the inferior vena cava between the two left pulmonary veins on one side and the two right pulmonary veins on the other. Its anterior wall is formed by the posterior wall of the left atrium, between the four pulmonary veins. The oblique sinus provides expansion space for the left atrium. The transverse sinus is open at both ends and formed by the reflection of visceral serosal pericardium from the posterior aspects of the aortic and pulmonary trunks over to the anterior aspect of the atrium. Thus, a finger in the transverse sinus will pass behind the aortic and pulmonary trunks, in front of the superior vena cava on the right, and the left atrial appendage on the left.
The pericardial sac positions the heart in the mediastinum and limits its motion while providing a lubricated slippery surface for the heart to beat inside and the lungs to move outside. The pericardium prevents the excessive dilatation of the heart, and in pathological states, it can limit the overfilling of the heart, which would result in low cardiac output. It also influences the pressure-volume relationships of cardiac chambers by providing limited space for the heart as a whole. The pericardium also equalizes hydrostatic, inertial, and gravitational forces maintain the geometry of the left ventricle, and acts as a mechanical barrier to infection.
Pericarditis
Inflammation of the pericardium is called pericarditis. Its origin can be infectious, immunologic, metabolic, neoplastic, traumatic, or idiopathic. A myocardial infarction can also cause localized pericarditis of the area overlying the infarct.
Heart Anatomy
Location
Outlook
Components:
Layers
Chambers
Valves
Great vessels
Small brief Anatomy of the heart
Your heart is located between your lungs in the middle of your chest, behind and slightly to the left of your breastbone (sternum). A double-layered membrane called the pericardium surrounds your heart like a sac. The outer layer of the pericardium surrounds the roots of your heart’s major blood vessels and is attached by ligaments to your spinal column, diaphragm, and other parts of your body. The inner layer of the pericardium is attached to the heart muscle. A coating of fluid separates the two layers of membrane, letting the heart move as it beats.
Your heart has 4 chambers. The upper chambers are called the left and right atria, and the lower chambers are called the left and right ventricles. A wall of muscle called the septum separates the left and right atria and the left and right ventricles. The left ventricle is the largest and strongest chamber in your heart. The left ventricle’s chamber walls are only about a half-inch thick, but they have enough force to push blood through the aortic valve and into your body.
The Heart Valves
Four valves regulate blood flow through your heart:
The tricuspid valve regulates blood flow between the right atrium and right ventricle.
The pulmonary valve controls blood flow from the right ventricle into the pulmonary arteries, which carry blood to your lungs to pick up oxygen.
The mitral valve lets oxygen-rich blood from your lungs pass from the left atrium into the left ventricle.
The aortic valve opens the way for oxygen-rich blood to pass from the left ventricle into the aorta, your body’s largest artery.
The Conduction System
Electrical impulses from your heart muscle (the myocardium) cause your heart to contract. This electrical signal begins in the sinoatrial (SA) node, located at the top of the right atrium. The SA node is sometimes called the heart’s “natural pacemaker.” An electrical impulse from this natural pacemaker travels through the muscle fibers of the atria and ventricles, causing them to contract. Although the SA node sends electrical impulses at a certain rate, your heart rate may still change depending on physical demands, stress, or hormonal factors.
The Circulatory System
The heart and circulatory system make up your cardiovascular system. Your heart works as a pump that pushes blood to the organs, tissues, and cells of your body. Blood delivers oxygen and nutrients to every cell and removes the carbon dioxide and waste products made by those cells. Blood is carried from your heart to the rest of your body through a complex network of arteries, arterioles, and capillaries. Blood is returned to your heart through venules and veins. If all the vessels of this network in your body were laid end-to-end, they would extend for about 60,000 miles (more than 96,500 kilometers), which is far enough to circle the earth more than twice
Emulsions
Definition
These are homogenous, transparent and thermodynamically stable dispersion of water and oil stabilized by surfactant and co-surfactants
Consists of globules less than 0.1 μm in diameter
Types
Oil dispersed in water (o/w) - oil fraction low
Water dispersed in oil (w/o) - water fraction low
Bicontinuous (amount of oil and water are same)
Advantages
Thermodynamically stable, long shelf life
Potential reservoir of lipophilic or hydrophilic drug
Enhance the absorption and permeation of drugs through biological membranes
Increased solubility and stability of drugs
Ease and economical scale-up
Greater effect at lower concentration
Enhances the bioavailability of poorly soluble drugs
Theories of microemulsion
Interfacial or mixed film theory
Microemulsions are formed spontaneously due to formation of complex film at the interface by a mixture of surfactant and co-surfactant, As a result of which the interfacial tension reduces
Solubilization theory
Microemulsions are considered to be thermodynamically stable solutions of water swollen (w/o) or oil swollen (o/w) spherical micelles
Thermodynamic theory
The free energy of microemulsion formation is dependent on the role of surfactant in lowering the surface tension at the interface and increasing the entropy of the system
Multiple emulsions are complex polydispersed systems where both oil in water and water in oil emulsion exists simultaneously which are stabilized by lipophilic and hydrophilic surfactants respectively
The ratio of these surfactants is important in achieving stable multiple emulsions
They are also known as “Double emulsion” or “emulsion-within-emulsion”
Types
Oil-in-water-in-oil (O/W/O)
An o/w emulsion is dispersed in an oil continuous phase
Water-in-oil-in-water (W/O/W)
a w/o emulsion is dispersed in a water-continuous phase
MONOMOLECULAR ADSORPTION THEORY
MULTIMOLECULAR ADSORPTION THEORY
SOLID PARTICLE ADSORPTION THEORY
ELECTRICAL DOUBLE LAYER THEORY
ORIENTED WEDGE THEORY
Surfactants adsorb at the oil-water interface and form a monomolecular film
This film rapidly envelopes the droplets
They are very compact, elastic, flexible, strong and cannot be easily broken
For getting better stable emulsions combination of surfactants [surfactant blend] are used rather than a single one
The surfactant blend consists of both water soluble and oil soluble surfactants in order to approach the interface from aqueous and oil phase sides
At interface the surfactant blend interact to form a complex and condense a monomolecular film
Ex: A combination of Sodium cetyl sulfate (hydrophilic) and Cholesterol (lipophilic) forms a close packed complex film at the interface that produces an excellent emulsion
Dispersion system
suspensions
interfacial properties of suspensions
zeta potential
Sedimentation parameters
Settling in suspension
Formulation of suspension
Preparation of suspension
factors affecting protein drug binding
significance of protein binding
drug related factors
protein related factors
drug interactions
patient related factors
Controlled drug delivery system part 2
mechanism and different approaches of controlled drug delivery system
diffusion-controlled drug delivery
dissolution controlled drug delivery
ion-exchange resin system
Introduction, Definitions, Advantages and Disadvantages, Selection of drug candidates for designing controlled drug release systems and rationale biological and medical rationale
5th B.Pharm Pharmaceutical Jurisprudence
Import of Drugs: Classes of drugs and cosmetics prohibited from import, import license and registration certificate, import under license or permit, Offenses and Penalties
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
This is a presentation by Dada Robert in a Your Skill Boost masterclass organised by the Excellence Foundation for South Sudan (EFSS) on Saturday, the 25th and Sunday, the 26th of May 2024.
He discussed the concept of quality improvement, emphasizing its applicability to various aspects of life, including personal, project, and program improvements. He defined quality as doing the right thing at the right time in the right way to achieve the best possible results and discussed the concept of the "gap" between what we know and what we do, and how this gap represents the areas we need to improve. He explained the scientific approach to quality improvement, which involves systematic performance analysis, testing and learning, and implementing change ideas. He also highlighted the importance of client focus and a team approach to quality improvement.
The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
For more information, visit-www.vavaclasses.com
How to Split Bills in the Odoo 17 POS ModuleCeline George
Bills have a main role in point of sale procedure. It will help to track sales, handling payments and giving receipts to customers. Bill splitting also has an important role in POS. For example, If some friends come together for dinner and if they want to divide the bill then it is possible by POS bill splitting. This slide will show how to split bills in odoo 17 POS.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
MARUTI SUZUKI- A Successful Joint Venture in India.pptx
States of matter 1 matter and types converted
1. STATES OF MATTER
Matter and Types
PART-I
Nabeela Moosakutty
Lecturer
Dept. of Pharmaceutics
KTN College of Pharmacy
2. States of Matter
• Different forms of matter:
• Solid
• Liquid
• Gas
•
State depends on 2 things:
• Particle (atoms/molecules) arrangement
• Particle motion
4. Solid Matter
•
•
Particles vibrate in place
• remember – matter is always in motion!
Want to separate the particles in a solid?
BREAK it!
5. Liquid Matter
•
•
•
•
•
Fixed volume, changing
shape
Particles can move
from place to place
Particles attracted to
each other, but more
easily separate
Take the shape of the
container its put in
Examples: milk, oil,
honey, water
6. Gas Matter
•
•
•
Volume changes, shape
changes
Examples: air, oxygen,
water vapor
Particles always push
outward on container
• Spread to fill
container if there is
more space
• Or pack closer
together when there
is less space =
PRESSURE from the
pushing!
7.
8. • THREE STATES OF MATTER
Some Characteristics of Gases, L iquids and Sol ids and the
M icroscopic E xplanation for the B ehavior
Gas Liquids Solids
assumes the shape and
volume of its container
particles can move past one
another
assumes the shape of the
part of the containerwhich
it occupies
particles can move/slide
past one another
retains a fixed volume and
shape
rigid - particles locked into
place
compressible
lots of free space between
particles
not easily compressible
little free space between
particles
not easily compressible
little free space between
particles
flows easily
particles can move past one
another
flows easily
particles can move/slide
past one another
does not flow easily
rigid - particles cannot
move/slide past one
another
9. • TYPES OF I NTERMOLECULAR FORCES
Dispersion forces
or London forces
Itis theweakestintermolecularforce
It is a temporary at ractiveforcethat
results whentheelectronsin two
adjacent atoms occupy positions that
make theatoms form temporarydipoles
This forceis sometimescal edan
induceddipole- induceddipole at
raction
Theseatractiveforces that cause
nonpolar substances to condenseto
liquids and tofreezeinto solids when
thetemperatureis loweredsuf iciently
10. DIPOLE- DIPOLEFORCES
Dipole-dipole forces are at ractiveforces betweenthepositive end
of onepolar
molecule and the negative end of another polar molecule. Dipole-
dipole forces havestrengthsthatrange from5 kJ to20 kJ per
mole.They aremuchweaker
than ionic or covalent bonds and have a significant ef ect
only whenthe moleculesinvolvedareclose
together(touching oralmost touching).
11. INDUCED-DIPOLEFORCES
Ion–induceddipoleforces
An ion-induceddipole at ractionis
a weak at ractionthatresults
whentheapproach of an ion
induces a dipole in an atom or in
a nonpolar molecule by
disturbing the arrangement of
electrons in thenonpolar species.
• Dipole–InducedDipoleForces
A dipole-induced dipole at raction
is a weak at raction that results
when a polar moleculeinducesa
dipole inan atomorina nonpolar
molecule by disturbing the
arrangement of electrons in
thenonpolar species.
12. • HYDROGENBOND
The hydrogen bond is a special dipole-dipole interaction
betweenthe hydrogenatomina polar N-H, O-H orF- H
bondand an electronegative O, N or F atom.
A – H ----B
A and B
or
are O, N
A – H ----A
and F
13. Pressure: Gases andTemperature
Particles speed up (more
energy)
= Volume increases!
• Decreased temperature
• (remove heat)
Particles slow down (less
energy)
= Volume decreases!
Increased temperature
(add heat)