This document provides guidance on spill management in hospitals. It discusses the types of spills that can occur, including blood, body fluids, chemicals, mercury and radioactive materials. It outlines the contents and use of spill kits for different spill types. Protocols are provided for cleaning small and large volume blood and body fluid spills, as well as for neutralizing acid and alkali chemical spills, handling solid and liquid chemical spills, and managing mercury and radioactive spills. The document stresses the importance of spill prevention through proper chemical storage and having appropriate spill response equipment and protocols displayed in the hospital.