Choline and sorbitol are lipotropic agents used to treat hepatic disorders by combating fatty degeneration of the liver. Choline increases biliary secretions to overcome digestive issues caused by liver insufficiency, while sorbitol increases liver glycogen and favors bile and pancreatic juice excretion. The combination of choline and sorbitol widens their individual therapeutic ranges and provides excellent clinical results in treating chronic constipation, hepatic disorders, gall bladder issues, migraines, and dyspepsias. Trichtoline Citrate Sorbitol Solution combines these two agents and is indicated for hepatobiliary disturbances and various functional alimentary tract issues.

1. The introduction of lipotropes, in particular choline
therapeutics was a decisive step in the treatment of
hepatic disorders.
Choline :- the most powerful lipotropic agent,
extensively utilised to combat fatty degeneration of the
liver Choline, into parenchyma which leads to cirrhosis.
By virtue of its parasympathomimetic action, Choline
increases the volume of glandular secretions, especially
biliary, thereby overcoming digestive disturbances due to
hepatic insufficiency.

2. Sorbitol:- increases the glycogen content of the liver.
It exerts moistening and osmotic properties on the
digestive mucosa and by modification of the intestinal
flora enhances the synthesis of the B- complex vitamins.
The essential functions of Sorbitol are to stimulate biliary
contraction, favour exudation of bile and pancreatic juice
and by its action on the intestinal musculature to
favourably influence the passage of intestinal bolus.
The action of Choline has been reinforced and made more
comprehensive by Sorbitol. therefore, widens the range
of indications covered by Choline and Sorbitol
individually. The excellent clinical results obtained which
makes it an ideal preparation in the treatment of chronic

3. constipation, hepatic disorders, gall bladder atonia, certain
forms of migraine and varieties of dyspepsia.
INDICATIONS:
For hepatobiliary disturbances, functional disturbances of
the alimentary tract, atonic constipation, hyperlipemia and
hyper cholestramia, and hyper- cholesterolemia.
DOSAGE PROPOSED:-
Adults: Two teaspoonful in a little water at the beginning
of lunch and/or dinner.
Children: One to two teaspoonful with a little water daily
with lunch.
CONSTIPATION:
Adults: Two to four teaspoonful in a glass of water, in the
morning before breakfast.

4. Children: One to two teaspoonful in a glass of water, in
the morning before breakfast.
Combination Proposed :-
TRICHOLINE CITRATE
SORBITOL SOLUTION (70%) I.P.