This presentation by Dr. Jerry Bouquot covers soft tissue tumors including fibrosarcoma, malignant fibrous histiocytoma, pyogenic granuloma, peripheral ossifying fibroma, peripheral giant cell granuloma, hyperparathyroidism, and hemangioma. It provides information on the etiology, histopathology, clinical features, and treatment for each tumor type. The presentation is intended for dental students in Dr. Bouquot's class and permission is not given for publishing the photos.
pathology of round cell tumours of osseo articular system like ewings sarcoma, mesenchymal chondrosarcoma,small cell osteosarcoma, plasma cell neoplasms and other hematopoietic malignancies. how immunochemistry os playing pivotal role in differential diagnosis.
pathology of round cell tumours of osseo articular system like ewings sarcoma, mesenchymal chondrosarcoma,small cell osteosarcoma, plasma cell neoplasms and other hematopoietic malignancies. how immunochemistry os playing pivotal role in differential diagnosis.
Benign connective tissue tumors 1/ dental implant courses by Indian dental ac...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
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The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Peripheral ossifying fibroma (POF) is a non-neoplastic enlargement of the gingival, which is one of the main
benign, reactive hyperplastic inflammatory lesions of the gingiva occurring in young adults. It has a very high
recurrence rate of around 7-45%. For this reason, a longer patient follow-up is very important in POF. Peripheral
ossifying fibroma comprises about 9% of all gingival growths. POF has similar clinical presentations with different
lesions which makes it difficult to reach at a correct diagnosis. In this article, we are reporting a case of peripheral ossifying fibroma (POF) in a 16-year-old female patient.
Key Words: Fibrous hyperplasia, Peripheral ossifying fibroma,
Benign connective tissue tumors 2/ dental implant courses by Indian dental ac...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
this ppt is about malignant tumours of connective tissue origin. classifications, clinical features, radiological features and histological features of all tumors are discussed with pictures.
Childhood mumps, certain bacterial infections (for example, of the tonsils or teeth), and other diseases that are typically more common among adults (such as AIDS, Sjögren syndrome, diabetes mellitus, sarcoidosis, and bulimia) often cause swelling of the major salivary glands.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
Tích hợp xương trong nha khoa
Jan Lindhe, Niklaus P. Lang, Thorkild Karring. Clinical Periodontology and Implant Dentistry, 5th edition, 2008, Blackwell Munksgaard.
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
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This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
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A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
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Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
1. Oral & Maxillofacial Pathology II
DB 3702
Topic: Soft Tissue Tumors
Course Director: Dr. J. E. Bouquot
Room 3.094b; 713-500-4420
Jerry.Bouquot@uth.tmc.edu
Thursdays, 10:00 – 11:50 am
Room DB 132
2. This presentation created by
Dr. J. E. Bouquot
This presentation is intended for students of Dr. Jerry Bouquot.
Designated owners of the photographic images in this lecture
retain the copyrights for those images but have agreed to allow
their photos to be used for teaching. You are welcome to use this
presentation for your learning, alone or with other dental students,
but permission is not given for the publication of these photos in
electronic or any other format.
Disclaimer: Dr. Bouquot is Professor & Chair,
Department of Diagnostic Sciences,
University of Texas Dental Branch at Houston.
The information and opinions provided herein are,
however, his own and do not represent official opinion
or policy of the University of Texas.
4. Fibrosarcoma
Malignant neoplasm of fibroblasts
Etiology = unknown
GALP:
– None
– Children, teenagers, young adults
– Palate > tongue > buccal
– 10% of all are in H&N
Painless, firm mass
Often lobulated
May have surface ulceration
Slow-growing in beginning
Moderate growth speed
-- May be rapid
5. Fibrosarcoma
Histopathology
Spindle cells in collagen
Spindle cells may be dysplastic
Grade is important for prognosis
-- Grades I - IV
Not encapsulated
Grade I
Mitotic figures
Herring bone pattern
Grade III
6. Fibrosarcoma
Pathophysiology, Treatment
Can grow rapidly toward end
--Especially high grade lesions
Destroys underlying bone
Fibrosarcoma of bone
-- Perforates through cortex
Treatment:
-- Radical surgical removal
-- Including affected bone
5-year survival = 50%
8. Malignant Fibrous Histiocytoma
Fibroxanthoma; Dermatofibroma
Malignant neoplasm of histiocytes
-- With fibrous differentiation
GALP:
– None
– Middle-age and older (but skin lesions: young adults)
– Buccal< vestibule
-- Rare in mouth
Painless, firm mass
May be lobulated
May be ulcerated
11. Pyogenic Granuloma
Pyogenic Granuloma Type Hemangioma
Lack of reduction of granulation tissue
during normal healing process
-- Not an infection, no pus
but “pyogenic” = pus producing
-- Not a granulomatous infection
GALP:
– None (although strong female predilection in biopsied cases)
– Children & young adults
– Gingiva (75%), lips, tongue, buccal
– 50th most common mucosal lesion
-- Prevalence = 1/10,000 adults
“Proud flesh”
13. Pyogenic Granuloma
Painless erythematous mass
Often hemorrhagic
Often lobulated surface
Often ulcerated
Often pedunculated
14. Pyogenic Granuloma
Special Variants
Pregnancy tumor:
-- PG of gingiva
-- In pregnant woman
Pregnancy tumor
-- Papilla involved
-- May be multiple
-- Poor oral hygiene
Epulis granulomatosum:
-- PG within poorly healed Epulis granulomatosum
extraction socket
-- Curette thoroughly
Parulis (gum boil):
-- PG at opening of dental fistula
-- Check for abscess in bone
-- Treat the tooth
Parulis
15. Pyogenic Granuloma
May shrink over time
May become irritation fibroma
-- Fibrotic pyogenic granuloma
Pregnancy tumor:
-- Often disappears after
birth of baby
Treat: Surgical excision
-- Remove cause
For pregnancy tumor:
-- Wait until after birth
May recur
-- If original cause
is not removed
-- More infection, trauma
18. Peripheral Ossifying Fibroma
Peripheral Cementifying/Ossifying Fibroma
Inflammatory proliferation of
fibrous tissue
From periodontal fibers
Primitive stroma
Bone or cementum
GAL:
– 2/3 females
– Teenagers and young adults
– Gingival papilla
(must be in this location)
-- Edentulous alveolus also
19. Peripheral Ossifying
Fibroma
Histopathology
Primitive spindle cells
in fibrous stroma
Immature bone formation
-- Often with active osteoblasts
Maybe cementoid globules
-- Few cementoblasts
-- Almost no cementocytes
20. Peripheral Ossifying
Fibroma
Painless mass of papilla
Firm, red/pink
May be lobulated
May be ulcerated
May show radiopacities
Can separate teeth
May develop in socket
22. Peripheral Ossifying Fibroma
Usually < 2 cm.
-- Occasionally up to 3 cm.
Treat:
-- Conservative surgical excision
-- With curettage of base
– Cleaning/scaling adjacent teeth
15% recur
29. Peripheral Giant Cell Granuloma
Clinical Features
Painless mass
Perhaps hemorrhagic
Often red/bluish/brown
Somewhat soft to palpation
May cup out underlying bony cortex
-- Saucerization (from pressure)
Maybe calcifications on radiograph
-- Near lower border
Often ulcerated
In socket =
epulis granulomatosum
30. Peripheral Giant Cell Granuloma
Pathophysiology; Treatment
Generally remain less than 2 cm.
May become more than 4 cm.
No malignant transformation
Treat: Conservative surgical excision
--With curettage of base
– And cleaning/scaling of adjacent teeth
10% recur
Caution: large or multiple or recurring lesions
might be brown tumor of hyperparathyroidism
31. Hyperparathyroidism
↑ PTH >> ↑ calcium taken from bone
Primary: ↑PTH from tumor
-- 90%: from parathyroid adenoma
-- 10% from parathyroid hyperplasia
-- Rare: from parathyroid carcinoma Ground glass skull
Secondary: chronic ↓ calcium >> ↑PTH
-- Usually: chronic renal disease
-- ↓ vitamin D made by kidney >>
-- ↓ calcium GI absorption >>
-- ↓ serum calcium (hypocalcaemia)
-- Severe: renal osteodystrophy
GALP:
-- 1:4 male:female ratio
-- >60 y/o Osteitis
-- Kidneys, bone fibrosa
cystica
32. Hyperparathyroidism
“Bones, moans and abdominal groans”
Renal calculi (kidney stones, nephrolithiasis)
-- From ↑ serum calcium
Metastatic calcification
-- Dystrophic calcification of soft tissues
-- From ↑ serum calcium
Subperiosteal resorption of phalanges
-- Index & middle fingers
Ground glass bone
-- ↓ trabeculae
-- Blurred radiograph
Loss of lamina dura (early sign)
Brown tumor
Osteitis fibrosa cystica
-- Severe variant of bone change
-- Marrow degeneration
-- Fibrosis of brown tumors
36. Hemangioma
Cavernous Hemangioma; Capillary Hemangioma
Benign developmental growth of vessels
Benign neoplasm of blood vessels
GALP:
– 3x females
– Children and teenagers
– Seldom congenital, but develop shortly after birth
– Tongue > buccal > lips
– 6th most common mucosal lesion
– Prevalence = 6/1,000 adults
– Head and neck:
most common location
37. Hemangioma
Histopathology
Dilated vessels:
cavernous hemangioma
Small vessels:
capillary hemangioma
Endothelium-lined channels
Endothelial nuclei are enlarged
-- Plump; bulge into lumen
-- If flat: inactive lesion
Blood-filled lumina
Without blood:
lymphangioma
No encapsulation
Port wine stain =
capillary hemangioma
39. Hemangioma
Clinical Characteristics
Sessile, lobulated
Soft red mass
Often lobulated
Painless
Smooth-surface
Fluctuates and blanches
Blue color if venous blood
Red if arterial
Deep lesions: no surface color
On skin: port wine stain,
-- Berry angioma
-- Sturge-Weber syndrome
41. Hemangioma
Pathophysiology
Infancy lesions:
-- Often spontaneously regress
-- Later lesions do not
Some lesions continue to enlarge
-- Until adulthood
-- Perhaps even after
– No cancer development
Problems:
-- Hemorrhage
-- Clots (from stagnant blood)
46. Traumatic Angiomatous Lesion
Venous Pool; Venous Lake;
Venous Aneurysm
Acute trauma to subepithelial vein
-- With focal dilation or “aneurysm”
GAL:
– None
-- Middle-aged and older
-- Lips, buccal
Small, painless red bleb
– Blanches
Micro: single dilated venous structure
Perhaps with thrombus (may calcify)
Remains indefinitely
– Usually remains less than 4 mm
– No malignant development
Treat: conservative surgical removal
OK to leave alone, except for esthetics
48. Sturge-Weber Angiomatosis
Sturge-Weber Syndrome,
Encephalotrigeminal Angiomatosis
Vascular plexus forms around cephalic
part of neural tube at six weeks
-- Regresses after the ninth week
-- Doesn’t regress with S-W syndrome
– Not inherited
GALP:
– None
– Congenital
– Face, buccal, maxilla
-- Rare
49. Sturge-Weber Angiomatosis
Sturge-Weber Syndrome,
Encephalotrigeminal Angiomatosis
Purple/red macule(s) of face
-- Port wine stain
-- Nevus flammeus
-- Trigeminal nerve distribution, usually
Often with involvement of oral mucosa
Angiomas of ipsilateral leptomeninges
-- May cause seizures
--May cause mental retardation
Calcifications of gyri
53. Kaposi Sarcoma
In AIDS
Vascular proliferation (neoplasm?)
-- Usually in AIDS
-- Non-AIDS cases usually in old me
Stimulated by herpesvirus 8
-- Kaposi’s sarcoma-associated herpesvirus
GAL:
– Strong male predilection
– Young adults and middle-aged
– Tongue, lips, gingiva
Soft-to-firm red or purple nodule
-- May be macular
– Painless
– Nonhemorrhagic
-- May be multiple
-- May be lobulated or granular
54. Kaposi Sarcoma
Histopathology, Pathophysiology,
Treatment
Combination of proliferating
spindled &endothelial cells
– Extravasated erythrocytes
– Staghorn clefts (veins)
Slowly enlarge
New lesions developing over time
Treat: lesions disappear with
successful AIDS treatment
-- Protease inhibitors, antivirals, etc.
57. Lymphangioma
Benign neoplasm of lymph vessels
Hamartoma of lymph vessels
GAL:
– None
– Children and teenagers
– Tongue (produces macroglossia)
Soft painless cluster of clear blebs
Often with outlying or satellite blebs
-- Several mm from main mass
May be scattered clear blebs
58. Lymphangioma
Histopathology
Same appearance as hemangioma,
but without blood in the lumina
Cavernous type, usually
Plump endothelial nuclei
-- If flat: inactive lesion
May be admixed with blood vessels
No encapsulation
59. Lymphangioma
Pathophysiology, Treatment
Slowly enlarges with body growth
No spontaneous regression
-- As with hemangioma
No cancer development
Treat: conservative surgical removal
– Usually deliberately leave tumor behind
(debulking)
Repeat surgery is not uncommon
-- Congenital cases: average = 4
66. Lipoma
Benign neoplasm of fat cells
Some are developmental
GALP:
–None
– Middle-aged
– Buccal, vestibule
– Most common soft tissue tumor in the body,
but not so common in the mouth
– 38th most common mucosal lesion in adults
– Prevalence = 3/10,000
67. Lipoma
Clinical Features
Sessile, yellowish mass
Very soft
Painless
Encapsulated: freely movable
68. Lipoma
Histopathology
Micro: mature adipocytes
-- With collagen trabeculae
May or may not be encapsulated
May “infiltrate” great distances
into surrounding stroma
Sometimes admixed with fibrous tissue (fibrolipoma)
Problem: herniated buccal fat pad
69. Lipoma
Pathophysiology, Treatment
Slowly enlarge
Usually remain < 3 cm.
No malignant transformation
Treat: conservative surgical excision
– Usually do not recur, except the infiltrating types
72. Traumatic Neuroma
Reactive proliferation of neural tissue
-- After nerve injury
GAL:
-- None
-- Middle-aged
-- Mental foramen
Smooth-surfaced nodule
Soft, nonulcerated
Less than half are tender or painful, may be burning
Micro: Intertwining, tortuous nerve fibers in a fibrous stroma
Usually remain less than 1 cm.; no malignant transformation
Treat: conservative surgical excision
-- With small part of affected nerve
May lead to paresthesia and pain
May recur
74. Neurofibroma
Benign neoplasm of Schwann cells
-- And perineural fibroblasts
GALP:
– None
– Young adults
– Tongue, buccal
– The most common peripheral nerve tumor
-- 1/1,000 adults
Smooth-surfaced soft, nonulcerated nodule
Painless
May be huge and pendulous
75. Neurofibroma
In Inferior Alveolar Canal
Photo: Dr. J. Bouquot, University of Texas, Houston, Texas
76. Neurofibroma
Well circumscribed interlacing bundles
of spindle-shaped cells with wavy nuclei
-- In a fibrous stroma
Usually < 2 cm.
-- May become huge
Oral lesions seldom become malignant
-- Less likely than skin lesions
Treat: conservative surgical excision
– Recurrence is rare
78. Schwannoma
Neurilemmoma
Benign neoplasm of Schwann cells
GALP:
– None
– Young adults and middle-aged
– Tongue, hard palate
– Up to half occur in head and neck area
Smooth, soft nodule
Nonulcerated
Painless
Moveable
Normal color or yellowish white
79. Schwannoma
Histopathology
Encapsulated
Two tissue types:
– Antoni A: streaming fascicles of spindle
Schwann cells forming Verocay bodies
– Antoni B: disorganized neurites in
loose fibrous stroma
80. Schwannoma
Pathophysiology, Treatment
Usually remain less than 2 cm
Oral lesions seldom become malignant
Skin lesions can but it is uncommon
Treat: conservative surgical excision
– Recurrence is rare
84. von Recklinghausen Neurofibromatosis
Multiple Endocrine Neoplasia I (MEN I)
Multiple neurofibromas
-- Some schwannomas
-- Throughout body
-- Maybe hundreds
-- Oral lesions in 1/4 of cases
Autosomal dominant inheritance
-- Gene is on chromosome 17
85. von Recklinghausen Neurofibromatosis
Multiple Endocrine Neoplasia I (MEN I)
Café au lait spots (brown skin patches)
Abnormal bone development
Lisch nodules (brown spots on iris)
5-10% chance of malignant development
-- Usually neurofibrosarcoma
(malignant peripheral nerve sheath tumor)
87. Multiple Endocrine Neoplasia IIB
Multiple Mucosal Neuroma Syndrome; MEN III
Autosomal dominant inherited disease
-- Multiple tumors or hyperplasias of
neuroendocrine tissues
Mutation of RET protooncogene
-- On chromosome 10
GALP:
– None
– Teenagers and young adults
– Tongue, lips
-- Rare
88. Multiple Endocrine Neoplasia IIB
Clinical Features
Sessile, soft nodules
-- Smooth-surfaced
-- Painless
-- Yellowish white
-- Moveable
Oral signs: often first evidence of disease
Narrow face
89. Multiple Endocrine Neoplasia IIB
Clinical Features
Long extremities
Abraham Lincoln appearance
Weak muscles
Pheochromocytomas (50%)
Medullary thyroid carcinomas (90%)
Elevated serum and urinary calcitonin
-- From thyroid tumor
Elevated urinary vanillylmandelic acid (VMA)
Increased epinephrine-to-norepinephrine ratio
-- From adrenal tumor
90. Multiple Endocrine Neoplasia IIB
Histopathology, Pathophysiology, Treatment
Micro: intertwining, tortuous nerve fibers
-- Thick perineurium
-- Spaces (artifactual) around nerves
Oral neuromas remain small
-- Less than 5 mm
Oral neuromas do not become malignant
Treat: no treatment needed for oral lesions
-- Except for esthetics
Treat systemic problems and tumors prn
92. Neuroectodermal Tumor of Infancy
Progonoma; Retinal Anlage Tumor
Neoplasm of neural crest cells
GALP:
– None
– Infancy; newborns
– Anterior maxillary alveolus
– Very rare
Rapidly expanding blue/black painless mass
Usually destroys underlying bone
Elevated urinary vanillylmandelic acid (VMA)
-- From oral tumor
93. Neuroectodermal Tumor of Infancy
Histopathology
Micro: two cell types:
– Small dark round neuroblastic cells
– Large epithelioid cells with melanin
94. Neuroectodermal Tumor of Infancy
Pathophysiology, Treatment
May reach alarming size
May destroy anterior alveolar bone
Malignant variants (very rare)
Treat: Moderately severe surgical excision
– 15% recurrence
96. Granular Cell Tumor
Granular Cell Myoblastoma
Benign neoplasm of Schwann cells
Originally thought to be from
striated muscle cells
GALP:
– 2x females
– Fourth-sixth decades
– Tongue
-- 50% of all body cases
are oral
Sessile mass
-- Painless
-- Firm
-- Pale
98. Granular Cell Tumor
Histopathology
Large, polygonal cells
-- Like histiocytes
-- Granular cytoplasm
-- Small nuclei
In sheets and globules
May be spindled cells
Not encapsulated
99. Granular Cell Tumor
Histopathology
May infiltrate between muscle fibers
Problem:
-- Pseudoepitheliomatous hyperplasia
-- Mimics squamous cell carcinoma
100. Granular Cell Tumor
Pathophysiology, Treatment
Usually remain 1-2 cm.
Seldom enlarge after initial notice
No malignant transformation risk
Treat: conservative surgical excision
-- Recurrence is very rare
102. Granular Cell Epulis
Congenital Epulis
Developmental tumor of unknown histogenesis
GAL:
– 90% females
– Newborn
– Anterior maxillary alveolus
Pedunculated, soft, nodule
Smooth-surfaced
Pink or pale
103. Granular Cell Epulis
Histopathology
Large, polygonal cells
-- Granular cytoplasm
Like cells in granular cell tumor
-- But different immunohistochemistry
Atrophic epithelium
-- No pseudoepitheliomatous hyperplasia
104. Granular Cell Epulis
Pathophysiology, Treatment
Usually remains less than 2 cm
-- May become up to 9 cm
Treat: conservative surgical excision
-- As soon as baby can tolerate surgery
– Does not recur
If left untreated: small lesions shrink
-- Often disappear
-- Does not interfere with tooth eruption
106. Leiomyoma
Benign neoplasms of
smooth muscle
GALP:
– None
– Infancy or childhood
– Tongue, lips
– Very rare
Usually sessile, firm, painless mass
Normal surface color and smooth surface
Micro: cellular proliferations of smooth muscle cells
Usually encapsulated
Usually remain less than 2 cm.
No cancer transformation
Treat: conservative surgical removal
– Few recurrences
108. Leiomyosarcoma
Malignant neoplasm of
smooth muscle
Etiology: unknown
GALP:
-- None
-- Young adults & middle age
-- No location predilection
-- Rare
Lobulated mass
Relatively firm
May be ulcerated
111. Rhabdomyoma
Benign neoplasm
of striated muscle
Etiology: unknown
GAL:
– None
– Infancy or childhood
– Tongue, lips
– Very rare
Usually sessile, firm, painless mass
Normal surface color and smooth surface
112. Rhabdomyoma
Micro: cellular proliferations
of striated muscle cells
-- Usually encapsulated
Usually remain less than 2 cm.
No cancer transformation
Treat: conservative surgical removal
– Few recurrences
117. Cartilaginous Choristoma
Soft Tissue Chondroma
Tumor-like proliferation of normal cartilage
-- But in wrong place
GAL:
– None
– Teens and young adults (probably started much earlier)
– Tongue
Sessile, firm, painless mass with normal surface color or pallor
Micro: Normal cartilage (hyaline or fibrous) in a fibrous stroma
118. Cartilaginous Choristoma
Soft Tissue Chondroma
Usually remain 1-2 cm
No cancer transformation
Treat: conservative surgical removal
– No recurrence
Special variant: Cutright tumor:
– Presumably secondary to continuing, low-level trauma
– Older persons
– Anterior maxillary alveolar midline
– Firm, sessile nodule under denture
– Treat: conservative surgical removal and fix denture
(seldom recurs)
119. Osseous Choristoma
Soft Tissue Osteoma
Tumor-like proliferation of normal bone
-- But in wrong place
GALP:
– None
– Teens and young adults (probably started much earlier)
– Tongue
-- Rare
Sessile, firm mass
Normal surface color or pallor
Painless
Micro: Normal but immature bone
-- Perhaps with marrow
-- In fibrous stroma
Usually remain 1-2 cm
No cancer transformation
Treat: conservative surgical removal
– No recurrence
121. Metastasis to the Mouth
Metastatic spread from extraoral source
-- Almost always carcinoma
Usually from lung, breast and GI
GALP:
– Moderate male predilection
– Middle-aged and older
– Gingiva, tongue
-- 1-2% of all oral cancers
Firm, smooth-surface nodule
-- Often with normal color
Often ulcerated
May be painful
May destroy bone
122. Metastasis to the Mouth
Micro: same appearance as primary cancer
Enlarge rapidly
Eventually with surface ulceration, pain
Treat:
-- Radical surgical excision
-- Radiotherapy
-- Chemotherapy
– Depends on condition of the primary tumor
-- Depends on other metastases