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Smoking in pregnancy
2015. 10
전임의 최은정
Introduction
In the US : about 16 % of pregnant women smoke
In Korea : 8-10%
Smoking during pregnancy in US
About 910 infant deaths annually from 1997 through 2001
More than $350 million per year for neonatal care costs
In cigarette smoke
Carbon monoxide
Nicotine
Cotinine
Cyanide
Arsenic
Lead
Propylene glycol
Thiocyanate
More than 4,000 chemicals
Fetal high concentrations
of
carboxyhemoglobin
Decrease amount of
oxygen carried to cells
Affects intracellular
processes by impairing
cytochrome enzymes
Carboxyhemoglobin in fetus & adult
or
Acetylcholine (ACh) on embryo
Initiation of axons and dendrites, migration of nerve cells, synaps
function and localization of specific nerve cell populations.
Later, effects on hippocampal, cerebellar, and sensory cortex
development.
Nicotine stimulates nicotine acetylcholine receptor(nAChR)
 Intensity and timing of brain cell development
Programming of neurodevelopmental events on a cellular level
Prenatal nicotine exposure and nervous system development
Adverse effects of smoking during regnancy
Intrauterine growth retardation (2-3 fold)
Low birth weight (200gm light on average)
: DOSE DEPENDENT!!
Stop during the first half of GA : virtually normal
Long-term effects
Physical growth, mental development, and behavioral problem
Mean 8-point decrement in IQ test in heavy smokers
Nicotine dependence in 40 year old daughters (not son)
Malformation : not major teratogen
Club foot
Craniosynostosis : “moderately increased” risk (odds ratio
1.5)
Premature closure of sagittal suture
Facial clefts
Hydrocephaly, microcephaly
Omphalocele, gastroschisis
Hand abnormalites
Placenta previa, placenta abruption and preterm delivery
Spontaneous abortion
Sudden infant death syndrome (SIDS)
After birth : lactation and neonatal period
Nicotine from cigarettes : concentrated in human milk
Nicotine patch vs. smoking : comparable or less
Impeded iodine transport into milk in smoking mother
After birth : childhood
Childhood cancer (leukemia)
Paternal smoking around conception : prior to 5YO child cancer
(leukemias, lymphomas, and brain tumors)
Pulmonary function
With schizophrenic parents(A 2014 study)
Later schizophrenia : double percentage as controls
Higher food allergic sensitization (OR : 2.2)
Reproduction
Male
Erectile function impair by compromising arterial flow to penis
Sperm abnormalities
Female
Greater variation in menstrual cycle
Childhood exposure : adversely affect fecundity
Exposure to cigarette smoking actively or passively
Higher serum FSH concentration
Poorer follicle function when undergoing ART
임신 중 흡연  Smoking in pregnancy

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임신 중 흡연 Smoking in pregnancy

  • 1. Smoking in pregnancy 2015. 10 전임의 최은정
  • 2. Introduction In the US : about 16 % of pregnant women smoke In Korea : 8-10% Smoking during pregnancy in US About 910 infant deaths annually from 1997 through 2001 More than $350 million per year for neonatal care costs
  • 3. In cigarette smoke Carbon monoxide Nicotine Cotinine Cyanide Arsenic Lead Propylene glycol Thiocyanate More than 4,000 chemicals
  • 4. Fetal high concentrations of carboxyhemoglobin Decrease amount of oxygen carried to cells Affects intracellular processes by impairing cytochrome enzymes Carboxyhemoglobin in fetus & adult or
  • 5.
  • 6. Acetylcholine (ACh) on embryo Initiation of axons and dendrites, migration of nerve cells, synaps function and localization of specific nerve cell populations. Later, effects on hippocampal, cerebellar, and sensory cortex development. Nicotine stimulates nicotine acetylcholine receptor(nAChR)  Intensity and timing of brain cell development Programming of neurodevelopmental events on a cellular level Prenatal nicotine exposure and nervous system development
  • 7.
  • 8.
  • 9. Adverse effects of smoking during regnancy Intrauterine growth retardation (2-3 fold) Low birth weight (200gm light on average) : DOSE DEPENDENT!! Stop during the first half of GA : virtually normal Long-term effects Physical growth, mental development, and behavioral problem Mean 8-point decrement in IQ test in heavy smokers Nicotine dependence in 40 year old daughters (not son)
  • 10. Malformation : not major teratogen Club foot Craniosynostosis : “moderately increased” risk (odds ratio 1.5) Premature closure of sagittal suture Facial clefts Hydrocephaly, microcephaly Omphalocele, gastroschisis Hand abnormalites
  • 11. Placenta previa, placenta abruption and preterm delivery Spontaneous abortion Sudden infant death syndrome (SIDS)
  • 12. After birth : lactation and neonatal period Nicotine from cigarettes : concentrated in human milk Nicotine patch vs. smoking : comparable or less Impeded iodine transport into milk in smoking mother
  • 13. After birth : childhood Childhood cancer (leukemia) Paternal smoking around conception : prior to 5YO child cancer (leukemias, lymphomas, and brain tumors) Pulmonary function With schizophrenic parents(A 2014 study) Later schizophrenia : double percentage as controls Higher food allergic sensitization (OR : 2.2)
  • 14. Reproduction Male Erectile function impair by compromising arterial flow to penis Sperm abnormalities Female Greater variation in menstrual cycle Childhood exposure : adversely affect fecundity Exposure to cigarette smoking actively or passively Higher serum FSH concentration Poorer follicle function when undergoing ART

Editor's Notes

  1. about 16 % of pregnant women smoke during their pregnancies
  2. Development of zebrafish embryos exposed to nicotine: gross morphology. A, Photomicrographs of a 66 hpf control zebrafish embryo and a stage-matched embryo exposed to 33 M nicotine beginning at 22 hpf. B, Summary of overall lengths of control embryos (C) and embryos exposed to nicotine (N) measured at 42, 66, and 120 hpf. Scale bar, 200 m. *p 0.001.
  3. Major teratogen으로 여기지는 않음. Cranio : from US National birth defects prevention Study