The primary treatment for schizophrenia is psychopharmacology. Antipsychotic medications, also known as neuroleptics, are prescribed to decrease psychotic symptoms. Conventional antipsychotics target positive symptoms like delusions and hallucinations by blocking dopamine, while atypical antipsychotics also target negative symptoms by blocking serotonin. Common side effects of antipsychotics include extrapyramidal symptoms like dystonia, akathisia, and tardive dyskinesia. Clozapine is effective but carries the risk of the potentially fatal agranulocytosis if white blood cell counts are not regularly monitored. Long-acting injectable forms of fluphenazine and haloperidol can be used for maintenance therapy
ANTIDEPRESSANTS: All you need to know...by RxVichu! :)RxVichuZ
This is my 50th powerpoint.......
Deals with Important tips while using ANTIDEPRESSANTS, their special precautions, ADRs and differential mechanisms.
Will be worthwhile for a precise insight!!
Thanking all viewers who have supported me all my ways to reach this 50th milestone!!
Regards,
Vishnu. :)
ANTIDEPRESSANTS: All you need to know...by RxVichu! :)RxVichuZ
This is my 50th powerpoint.......
Deals with Important tips while using ANTIDEPRESSANTS, their special precautions, ADRs and differential mechanisms.
Will be worthwhile for a precise insight!!
Thanking all viewers who have supported me all my ways to reach this 50th milestone!!
Regards,
Vishnu. :)
TREATMENT RESISTANT DEPRESSION IS A AREA THAT IS NOT EXPLORED MUCH, BUT IT REALLY NEEDS LOT OF ATTENTION AS IT IS ONE OF THE MOST COMMON OBSTACLE IN ACHIEVING COMPLETE REMISSION IN DEPRESSION
antipsychotics history, managment of psychosis,side effect of antipsychotics, mechanism of antipsychotics, atypical antipsychotics,2nd generation antipsychotics.
TREATMENT RESISTANT DEPRESSION IS A AREA THAT IS NOT EXPLORED MUCH, BUT IT REALLY NEEDS LOT OF ATTENTION AS IT IS ONE OF THE MOST COMMON OBSTACLE IN ACHIEVING COMPLETE REMISSION IN DEPRESSION
antipsychotics history, managment of psychosis,side effect of antipsychotics, mechanism of antipsychotics, atypical antipsychotics,2nd generation antipsychotics.
New treatment for Schizophrenia/Nuevo tratamiento para la Esquizofreniabraincosm
BRAINco Biopharma Schizophrenia Drug Discovery project brochure. Licensing opportunity.
Folleto descriptivo del proyecto de búsqueda y desarrollo de fármacos en Esquizofrenia. Oportunidad de licencia.
Update on Risperdal Mass Tort Litigation with Robert MosierLarry Bodine
Hosted by The National Trial Lawyers, the program "Update on Risperdal Mass Tort Litigation" is presented Robert Mosier, a trial lawyer with the law firm of Sanders Phillips Grossman, LLP in Irvine, California.
Risperdal is a very powerful antipsychotic developed by Janssen Pharmaceuticals to treat schizophrenia in adults. However Janssen illegally marketed and sold it to one of the most vulnerable segments of our society – our children – and hid a disfiguring side effect that caused a generation of young boys and men to grow female breasts.
Mr. Mosier discusses cases pending in Philadelphia, Los Angeles, and St. Louis, and rulings by the courts in those jurisdictions.
More than 5,000 cases have been filed across the country, which may be the tip of the spear, because hundreds of thousands of young boys took Risperdal and suffered gynecomastia.
Mr. Mosier’s practice is focused on representing plaintiffs harmed by pharmaceutical and medical device companies. He also maintains an active medical malpractice caseload. He serves as Plaintiff’s Co-Lead Counsel in the Risperdal and Invega Product Liability Cases JCCP 4775. Mr. Mosier is an AV Preeminent Attorney, a member of the Million Dollar Advocates Forum, an Arizona Top Rated Attorney – Top Trial Lawyers in America and National Trial Lawyers – Top 100.
Medication-induced movement disorder (Extra-Pyramidal Side Effects, EPSE) occurs due to treatment with antipsychotic medications. It can also be defined as physical symptoms, including tremor, slurred speech, akathesia, dystonia, anxiety, distress, paranoia, and bradyphrenia, that are primarily associated with improper dosing of or unusual reactions to neuroleptic (antipsychotic) medications.
Though they are commonly caused by the typical antipsychotics, but can also be caused by the atypical.
The adverse consequences of these syndromes can be minimized by vigilant clinicians who systematically examine patients at risk for these disorders and who manage them properly when discovered.
The best management is, of course, prevention, which starts with the judicious prescription of neuroleptics, and an awareness of the potential for certain nonpsychiatric medications to cause the same movement disorders.
Antipsychotics, also known as neuroleptics, are a class of medications primarily used to manage symptoms of psychosis, a mental state characterized by impaired thinking, emotions, and behaviors, often seen in conditions like schizophrenia, schizoaffective disorder, and certain mood disorders. These medications work by modulating neurotransmitters in the brain, particularly dopamine, to alleviate or reduce the severity of symptoms associated with psychosis. this ppt contains information regarding antipsychotics
Chapter 4 Pharmacology Diploma in Pharmacy Part -1 .pdfSumit Tiwari
Drugs Acting on the Central Nervous System
Definition, classification, pharmacological actions, dose,
indications, and contraindications of
General anaesthetics
Hypnotics and sedatives
Anti-Convulsant drugs
Anti-anxiety drugs
Anti-depressant drugs
Principles and Practice of Sedation in Intensive Care Unit (ICU)Apollo Hospitals
Distress is common amongst critically ill patients in ICU, especially those who are intubated or have difficulty communicating with their caregivers [1]. Distress in ICU generally presents as agitation. It needs to be treated for patient comfort & if left untreated increases sympathetic tone with untoward physiologic effects [2].
Before a sedative agent is initiated to manage agitation, the cause of distress should be identified & treated. Common causes of distress in critically ill patients include:-anxiety, pain, delirium, dyspnoea and neuromuscular paralysis. These etiologies may occur separately or in combination.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
2. Psychopharmacology
The primary medical treatment for
schizophrenia is PSYCHOPHARMACOLOGY.
In the past:
Electroconvulsive therapy
Insulin Shock therapy
Psychosurgery
6. Antipsychotic medications
( Neuroleptics)
Chlorpromazine ( Thorazine ) , are
prescribe primarily to for their efficacy in
decreasing psychotic symptoms . They do
not cure schizophrenia rather they are used
to manage symptoms.
Conventional antipsychotic medications are
DOPAMINE antagonist.
7. Conventional Antipsychotics
These drugs are dopamine antagonists. They target positive
signs of schizophrenia such as delusions, hallucinations,
disturbed thinking and other psychotic symptoms.
Thioridazine
Mellaril, Melleril, Novoridazine, Thioril
Mesoridazine
Serentil
Levomepromazine
Nosinan, Nozinan, Levoprome
Loxapine
Loxapac, Loxitane
Molindone
Moban
Perphenazine
Trilafon
Thiothixene
Navane
Trifluoperazine
Stelazine
Haloperidol
Haldol
Fluphenazine
Prolixin
Droperidol
Droleptan, Dridol, Inapsine, Xomolix, Innovar (+Fentanyl)
Zuclopenthixol
Clopixol
Prochlorperazine
Compazine, Stemzine, Buccastem, Stemetil, Phenotil
8. Atypical Antipsychotics
These drugs are dopamine and serotonin antagonists, they not
only diminish positive symptoms but also lessen the negative signs
of lack of volition and motivation, and social withdrawal.
Clozapine
Clozaril
Iloperidone
Fanapt
Lurasidone
Latuda
Mosapramine
Cremin
Olanzapine
Zyprexa, Ozace
Paliperidone
Invega
Perospirone
Lullan
Quetiapine
Seroquel
Remoxipride
Roxiam
Risperidone
Risperdal, Zepidone
Sertindole
Serdolect
Sulpiride
Sulpirid, Eglonyl
Ziprasidone
Geodon, Zeldox
9. Maintenance Therapy are available in
depot injection forms.
Two medications are available in depot injection
forms for maintenance therapy:
Fluphenazine (PROLIXIN) in decanoate
Haloperidol (HALDOL)in decanoate
The effects of medications are absorbed slowly over time
in the client’s system, the depot injection is sesame oil.
The effects of these medications last for 2-4 weeks,
eliminating the need for daily oral antipychotic medication.
The duration of action is 7-28 days for FLUPHENAZINE
4 weeks for HALOPERIDOL.
10. SIDE EFFECTS:
Serious neurologic side effects include :
Extrapyramidal side effects
Acute dystonic reactions
Akathisia
Parkinsonism/ Pseudo parkinsonism
Tardive Dyskinesia
Seizures
Neuroleptic Malignant Syndrome
12. Extrapyramidal Side effects:
EPS are reversible movement disorders induced by
neuroleptic medication.
DYSTONIC reactions to antipsychotic medications appear
early in the course of treatment and are characterize by
spasms in discrete muscle groups such as the neck
muscles (Torticollis) or eye muscles (oculogyric crisis).
These spasms also may be accompanied by protrusion of
the tongue, dysphagia, laryngeal, pharyngeal spasms
that can compromise the client’s airway, causing medical
emergency.
Acute treatment consists of diphenhydramine (Benadryl)
given either IM or IV, or Benzotropin (Cogentin) given IM.
14. AKATHISIA
Characterized by restless movement,
pacing, inability to remain still, and the
client’s report of inner restlessness.
Clients are very uncomfortable with
these sensations and may stop taking
the antipsychotic medication to avoid
these side effects.
Treatment: Betablockers such as
propanolol have been the most
effective in treating akathisia,
whereas Benzodiazepines have
provided some success as well.
15. Tardive Dyskinesia
A late appearing side effect of
antipsychotic medications, is
characterized by abnormal,
involuntary movements such as lip
smacking, tongue protrusion,
chewing, blinking, grimacing and
choreiform movements of the
limbs and feet.
These movements are
embarrassing for the clients and
may cause them to become more
socially isolated, decreasing or
discontinuing the medication can
arrest the progression.
16. Tardive Dyskinesia
Clozapine (Clozaril),
an atypical
antipsychotic drug
has not been found to
cause this side effect,
so it often
recommended for
clients who have
experienced tardive
dyskinesia while
taking conventional
antipsychotic drugs.
18. ABNORMAL INVOLUNTARY MOVEMENT SCALE
* The client is observed for several positions
and the severity of symptoms is rated from 0-4.
* The AIMS can be administered every 3-6
months.
If the nurse detects an increase in score on the
AIMS, indicating increased symptoms of tardive
dyskinesia, he or she should notify the physician
so that the client’s dosage of the drug can be
changed to prevent advancement of tardive
dyskinesia.
19. Seizures are an SEIZURE
infrequent side effect
associated with the
antipsychotic drugs.
Seizures may be
associated with higher
doses of the
medication.
Treatment is a lowered
dosage or a different
antipsychotic
medications.
20. Neuroleptic Malignant Syndrome
Is a serious and frequently
fatal condition seen in those
being treated with
antipsychotic medications.
Characterized by muscle
rigidity, high fever, increased
muscle enzymes(particularly
creatine phosphokinase), and
leukocytosis (increased
leukocytes)
This can be treated by
stopping antipsychotic
medications. The clients ability
to tolerate other antipsychotic
medications after NMS varies
but use of another
antipsychotic appears possible
in most instances.
21. Agranulocytosis
Clozapine has the potentially fatal
side effect of agranulocytosis
(failure of the bone marrow to
produce adequate white blood
cells).
Agranulocytosis suddenly develops
characterized by fever, malaise
ulcerative sore throat and
leukopenia.
The drug must be discontinued
immediately.
Must have weekly WBC counts.
22. Agranulocytosis
• WBC must be assessed
weekly for the first 6
months of clozapine
therapy and every 2 weeks
thereafter.
• Clozapine is dispensed every
7-14 days only and evidence
of the WBC above
3000cells/mm3 is required
before a refill is furnished.