TOPICAL ANESTHETIC FOR COSMETIC PROCEDURES
NeuroMed7 is a topical, local anesthetic that can be used for a variety of procedures to improve patient comfort and satisfaction
NeuroMed7 is a rapid onset of action OTC topical anesthetic that contains a combination of lidocaine HCl 4% with trans-dermal penetration/absorption enhancers
It can be used as a topical anesthetic prior to a variety of medical procedures including:
Injections
Trigger point injections
immunizations
Myo-facial paralyzing injections (BOTOX therapy)
Dermal fillers
Minimally invasive procedures
Venipuncture
Can also be used for post procedural analgesia
Can be used to mitigate pain, itch and burn related to cutaneous manifestations of a variety of conditions
Safe and effective concentration of lidocaine HCl
Rapid onset of action
trans-dermal penetration/absorption enhanced
OTC
Affordable pricing
NeuroMed7 is an OTC Topical Anesthetic with uses that include local anesthesia prior to:
Injections
Immunizations
Venipuncture
Minimally invasive procedures
Cosmetic/aesthetic procedures
Also post procedural analgesia
NeuroMed7 is a formula combination of the topical anesthetic, lidocaine HCl 4% and trans-dermal penetration enhancers created to promote a rapid onset of action and trans-dermal penetration
Benefits include:
Rapid onset of action
trans-dermal penetration
Affordable cost
Clinical size and multi-dose packaging
Dosage forms (also called unit doses) are pharmaceutical drug products in the form in which they are marketed for use, with a specific mixture of active ingredients and inactive components (excipients), in a particular configuration (such as a capsule shell, for example), and apportioned into a particular dose. For example, two products may both be amoxicillin, but one is in 500 mg capsules and another is in 250 mg chewable tablets. The term unit dose can also sometimes encompass non-reusable packaging as well (especially when each drug product is individually packaged
NeuroMed7 is an OTC Topical Anesthetic with uses that include local anesthesia prior to:
Injections
Immunizations
Venipuncture
Minimally invasive procedures
Cosmetic/aesthetic procedures
Also post procedural analgesia
NeuroMed7 is a formula combination of the topical anesthetic, lidocaine HCl 4% and trans-dermal penetration enhancers created to promote a rapid onset of action and trans-dermal penetration
Benefits include:
Rapid onset of action
trans-dermal penetration
Affordable cost
Clinical size and multi-dose packaging
Dosage forms (also called unit doses) are pharmaceutical drug products in the form in which they are marketed for use, with a specific mixture of active ingredients and inactive components (excipients), in a particular configuration (such as a capsule shell, for example), and apportioned into a particular dose. For example, two products may both be amoxicillin, but one is in 500 mg capsules and another is in 250 mg chewable tablets. The term unit dose can also sometimes encompass non-reusable packaging as well (especially when each drug product is individually packaged
Semisolid Dosage Form: Ointment, creams & Gel.
Learn more with me Asst. Prof. Mr. Manohar D. Kengar, Nootan College of Pharmacy, Kavathemahankal.
Suppository Dosage Form: Type of Suppository, Preparation method, Evaluation
https://youtu.be/NUgFoLuT3cs
Liquid dosage forms are effective pharmaceutical products containing a mixture of active pharmaceutical ingredients (API/Drug) and non drug components (excipients). It is a dose of a drug used as a medicine for consumption or administration. Many liquid dosage forms are used in the pharmacy, but the most commonly used are syrup, suspension, and elixirs. The general category of liquid oral doses includes a broad range of dosage forms, broadly classified as monophasic and biphasic. Whereas dosage forms in both types comprise at least one drug, monophasic forms are homogeneous and completely dissolve in liquid, whereas biphasic forms in a vehicle do not dissolve.
NeroMed7 is a rapid-onset topical anesthetic. It can be used as a pre-procedural, local, topical anesthetic for injections, veni-puncture and other minimally invasive dermal instrumentation procedures.
Semisolid Dosage Form: Ointment, creams & Gel.
Learn more with me Asst. Prof. Mr. Manohar D. Kengar, Nootan College of Pharmacy, Kavathemahankal.
Suppository Dosage Form: Type of Suppository, Preparation method, Evaluation
https://youtu.be/NUgFoLuT3cs
Liquid dosage forms are effective pharmaceutical products containing a mixture of active pharmaceutical ingredients (API/Drug) and non drug components (excipients). It is a dose of a drug used as a medicine for consumption or administration. Many liquid dosage forms are used in the pharmacy, but the most commonly used are syrup, suspension, and elixirs. The general category of liquid oral doses includes a broad range of dosage forms, broadly classified as monophasic and biphasic. Whereas dosage forms in both types comprise at least one drug, monophasic forms are homogeneous and completely dissolve in liquid, whereas biphasic forms in a vehicle do not dissolve.
NeroMed7 is a rapid-onset topical anesthetic. It can be used as a pre-procedural, local, topical anesthetic for injections, veni-puncture and other minimally invasive dermal instrumentation procedures.
Compound pharmacies sell clinicians multi-use containers of compounded BLT to be used for many patients but prescribed for one. The legal risk is transferred to the prescriber who ordered the compound not the pharmacy providing it. STOP THE INSANITY! It is your practice and your good name. Here is your fix!
Silospheres™ is the unique silicone base used in our innovative line of creams and lotions. Due to the nature of silicones, numerous aesthetic and efficacy benefits have been revealed in our topical products.
Transdermal drug delivery system was introduced to overcome the difficulties of drug delivery through oral route. A transdermal patch is medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. Often, this promotes healing to an injured area of the body. An advantage of a transdermal drug delivery route over other types of medication delivery such as oral, topical, intravenous, intramuscular, etc. is that the patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive. The main disadvantage to transdermal delivery systems stems from the fact that the skin is a very effective barrier; as a result, only medications whose molecules are small enough to penetrate the skin can be delivered in this method.
Video Lecture is available at https://www.youtube.com/watch?v=DXu_CLgB4q0
Introduction, terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates. Approaches to design-controlled release formulations based on diffusion, dissolution and ion exchange principles. Physicochemical and
biological properties of drugs relevant to controlled release formulations.
INTRODUCTION :
Ophthalmic dosage are the preparation designed for application to the eye:-
For treatment,
For symptomatic release of symptoms,
For diagnostic purpose,
As aid to surgical procedures.
They are the sterile products meant to instillation in to the eye in the space between eye lid and the eye ball
They are also prepared as parenteral product.
Example :Eye drops, Eye lotion, Eye ointment, Eye suspension, Contact lens solution
Skin topical medicine is a kind of preparation that can act as local or systemic treatment. The semi-solid
topical preparation, which is a type of common preparation for skin medicine, is multiphase,
thermodynamically unstable, and complex in composition. It is classified as a complex preparation and
has applications in the field of innovative drugs, improved new drugs and generic drugs. Medicilon
offers a professional formulation technology platform, keeping up with the pace of innovation in drug
research and development, and meeting the diverse requirements of our clients. Medicilon supported a
number of innovative drugs to complete the R&D and receive approval for clinical use.https://www.medicilon.com/platform/skin-topical-preparation-rd/
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
2. Our Mission
Sambria Pharmaceuticals is a developer of
differentiated, highly effective topical pain relief
consumer healthcare products and medications.
Our primary goals are to develop topical
formulations that provide clinicians, patients and
consumers with effective methods to mitigate
pain singularly or in conjunction with other
effective therapies in a regulatory compliant
manner.
Assist healthcare clinicians in improving patient
comfort, satisfaction and overall doctor/patient
experience
3. Our Approach
We have developed a proprietary topical pain relief
formula that combines the active ingredient,
lidocaine HCl with a blend of trans-dermal
penetration enhancers widely used in
pharmaceutical compounding.
Clinical applications of our launch product include
topical anesthesia particularly for the
dermatological, aesthetic/cosmetic, pediatric,
podiatric and other specialties where rapid onset of
local anesthesia is medically warranted and desired
Clinical studies being conducted around the globe
demonstrate the high degree of efficacy applying
transdermal delivery of topical lidocaine
applications in a safe manner when applied
responsibly.
4. Current and Potential
Applications
We are researching a broad range of current and potential future uses in
an effort to expand applications of this historically effective
anesthetic/analgesic.
Dermatologic conditions
Pre-and post-cosmetic/aesthetic procedure applications
Minor surgical procedures
IPL and LASER procedures
Venipuncture
Injections
Immunizations
Cutaneous allergy reactions
Pediatric
Neuropathic pain
Musculoskeletal pain
5. NeuroMed7TM
A topical anesthetic/analgesic cream that
combines the active ingredient lidocaine HCl 4%
with a proprietary blend of ingredients known in
pharmaceutical compounding to enhance
transdermal absorption of a variety of medicinal
therapies
In a topical cream formulation, lidocaine HCl 4% is
applied externally as a local analgesic/anesthetic
medication.
When used properly topical lidocaine
demonstrates a very low amount of lidocaine
entering the blood, limiting its systemic effects.
6. NeuroMed7TM
It can be used to reduce pain locally when applied externally directly to
the skin.
Typically will not cause profound, uncomfortable numbing of the skin
(lidocaine is known to cause numbing when applied by injection or to
mucous membranes),
However, its action is known to desensitize the affected area where
applied.
In combination with Sambria’s proprietary penetration enhancement
blend, NeuroMed7™ is demonstrating a rapid onset of action and
may serve physician needs for trans-dermal and sub-dermal
penetration
It is free of counter irritant materials sometimes known to cause localized
skin irritation. On the contrary its uses include relief from pain caused by
skin irritations.
This product is also free of topical acetaminophen or salicylates,
mitigating the risk of reactions in people with sensitivities to those
compounds.
7. Lidocaine HCL 4%
The active ingredient in NeuroMed7™ falls under a class of
medication known as OTC Topical Analgesics and
Anesthetics. See US FDA Monograph CFR 21 348 OTC Topical
Anesthetics and Analgesics
Medications in this class can be used for local pain relief
when applied externally.
When applied topically, Lidocaine HCl 4% has analgesic and
anesthetic properties.
In accordance with Federal Regulations, products in its
category can be used by children and adults 2 years of age
and older without prior consent of a licensed physician when
applied externally as an analgesic/anesthetic.
8. Product differentiators
Rapid onset of action (typically 3 to 5 minutes)
Proprietary blend that includes transdermal
penetration enhancers
Safe concentration of topical anesthetic –
lidocaine HCl 4%
Clinical use dose and patient retail size
packaging availability
Cost effective – affordable price points
throughout the distribution chain; from distributor
to end user
Co-branding
9. Facility Costs and Margins
Sambria wholesales its product for $17.50 per tube.
Tubes contain a blend of materials that include lidocaine HCl 4% in a
cream form. Tubes contain 2.2 ounces of cream per tube.
Tubes are sold wholesale in cases of 48 units per case. The case
Wholesale Acquisition Cost (WAC) is $840 per case ($17.50 per tube)
By special request, Sambria can package tubes in a 24 units case
box WAC is $445 per case ($18.54 per tube)
The manufacturer suggested retail price (MSRP) is $34.95 per tube.
When sold at the MSRP, Neuromed7™ has a nearly 100% markup.
Sambria also produces one use packaging for clinical setting
applications – Wholesale Acquisition Cost (WAC) is $1.70 per
application dose packet (package includes 3 milliliters of product– 1
milliliter = 40 mgs lidocaine HCl – total application per package = 120
mgs)
Clinic use individual packets are packaged in 100, 500, 1000 and
5000 unit boxes
10. Regulatory Compliance
NeuroMed7™ is manufactured and marketed in
accordance with United States Food and Drug
Administration (US FDA or FDA) regulations.
Regulation policies are governed by the US FDA
CFR 21 Monograph 348 OTC Topical Analgesic and
Anesthetics.
Monograph policy specifically directs marketers of
medications in this class to list the uses “topical
analgesic”, “topical anesthetic”, “external
analgesic”, “external anesthetic” or “for the
temporary relief of pain” on its product packaging.
¹ Monograph CFR 21 348.50(a).1
USA FDA NDC# 54723-175-22
11. Dermatological Safety and Efficacy
References Supporting the Use of OTC
4% Topical Lidocaine
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923950/
http://www.the-dermatologist.com/article/7737
http://www.skinlaser.com/wp-
content/uploads/2011/07/2012AnestheticReviewDermSurg
-AlsterSobanko.pdf
http://www.hospitalpharmacyeurope.com/featured-
articles/topical-anaesthetics-dermatology
http://archderm.jamanetwork.com/article.aspx?articleid=
407139
http://www.drugs.com/cdi/lidocaine-cream.html
http://www.iacdworld.org/legal/lidocaine.htm
http://otcsafety.org/en/treatments/topical-pain-relievers/
http://www.webmd.com/drugs/mono-9170-LIDOCAINE+-
+TOPICAL.aspx?drugid=8532&drugname=Lidocaine+Top