NeuroMed7 is a topical anesthetic containing 4% lidocaine that provides rapid onset of anesthesia within 15-20 minutes. It is designed to improve skin absorption and provide a medium duration of efficacy of around 60 minutes. NeuroMed7 can be used for minor procedures like injections, laser treatments, and hair removal. It is applied as a thin layer to the skin and rubbed in until fully absorbed to block nerve impulses and reduce pain. When used as directed, NeuroMed7 is a safe and cost-effective option to reduce pain from minor medical procedures.

1. NeuroMed7®
Rapid-onset Topical Anesthetic (Lidocaine HCl 4%)
A time saving & cost effective solution
Peak onset begins 15 – 20 minutes after application

2. Background
Clinicians are increasingly using topical
anesthetics to decrease the pain
associated with minimally invasive
dermatologic, aesthetic, injection,
cannulation and laser procedures (among
others).
Numerous lidocaine-containing products
are available, but comprehensive studies
are lacking regarding their relative safety
and appropriate dermatologic uses.

3. Concept
Lidocaine-containing products play an
integral role in cutaneous anesthesia by
providing patient comfort with minimal side
effects. Careful attention must be paid to
the particular anatomic location, the total
surface area covered, active ingredient
concentration and the duration of
anesthetic skin contact.

4. Awareness
Topical anesthetics decrease pain during
superficial cutaneous procedures. As the
number of in-office dermatologic
procedures continues to grow, clinicians
will benefit from awareness of the
indications, pharmacologic mechanisms,
appropriate methods of application, and
safety profiles of the currently available
prescription and over-the-counter (OTC)
topical anesthetics.

5. Mechanism of Action
Once inside the dermis, ester and amide
anesthetics possess the same mechanism
of action. The anesthetic binds the voltage-
gated sodium ion channel of the free nerve
endings and blocks sodium influx. The
blockade of sodium influx inhibits nerve cell
depolarization and prevents propagation of
nerve cell impulses along the nerve. Meechan
JG. Intraoral topical anesthesia. Periodontal 2000 2008;46:6 - 79

6. NeuroMed7® OTC Rapid Onset
Topical Anesthetic can be used
for:
• Superficial aesthetic procedures
• Hair and tattoo removal
• Minimally invasive excisions
• Injections
• Cannulation procedures
• Other minimally invasive procedures
and uses as directed by a licensed
physician

7. Proprietary formulation
• Designed to improve absorption
• Rapid-onset of action – 15 – 20 minutes
• Medium duration of efficacy –
approximately 60 minutes
• Safe and effective
• Patent-pending

8. Designed to improve absorption
• Rapid-onset – 15 to 20 minutes
• Medium duration – 60 minutes
• Safe and effective
• Easy to apply and remove
• Free of oily or gritty residue

9. A time saving & cost effective solution
• Save time - peak onset of action – 15 –
20 minutes
• Save money – only $23 per 2.2 ounce
(63 gram) tube – as low as $19 per tube
for bulk orders
• Increase practice revenue – can be
dispensed as a retail item for clinician-
directed, patient self-application – at
high margins
• Increase efficiency– reduced onset of
action time can increase patient flow
efficiency

10. Proper application
• Clean treatment area with mild cleanser and
damp, clean cloth to remove any dirt, make-
up or other material that may impede
absorption.
• Use approximately a “US quarter
dollar”(or one packet) size amount per
4”x4” area 15 - 20 minutes prior to
procedure (recommended dose – 0.75 –
2.0 grams – or milliliters – per 1”X1”
square area
• Dosage will depend on the skin type,
aggressiveness of procedure, known
patient pain tolerance and surface area.
• Use the least amount of product necessary
to achieve the required amount of local
anesthesia

11. Proper application – cont’d
• Avoid use on open wounds, broken
skin, eyes, ears, in the nostrils and
mouth
• With a gloved hand, evenly distribute
the cream and rub vigorously in a
circular motion for at least 30 – 60
seconds to each area of the
treatment surface
• Apply more aggressively to
known pain-sensitive “hot spot”
areas on the face and body
• The peak action begins in
approximately 15 – 20 minutes

12. Proper application – cont’d
• Some clinicians use an occlusive
dressing for an improved efficacy –
occlusion should be determined by a
licensed physician.
• It is important to note that applying a
hot or warm compress to the treatment
area prior to application of
NeuroMed7® will increase cutaneous
absorption. While this method will
enhance the effect of the anesthetic,
special care should be exercised in
recognition of the potential for
increased systemic entry of the active
ingredient, lidocaine HCL 4%
• Do not exceed 10 grams
(milliliters) per application
• Physician should take into account
total anesthetic dose when using
this product in combination with
other anesthetic products

13. Contact Sambria
Pharmaceuticals or your local
representative
1075 Peachtree Street NE, Suite 3650
Atlanta, Georgia 30309
888.246.6601 | info@sambriapharma.com |
www.sambriapharma.com

14. THANK YOU!