Heat exhaustion and heat stroke are dangerous conditions that can occur in hot weather. Heat exhaustion involves feeling weak, dizzy, and nauseous with a normal or elevated temperature under 104°F, while heat stroke can be life-threatening with very high body temperature over 104°F and symptoms like confusion and loss of consciousness. To prevent these conditions, it is important to drink plenty of water, take breaks in the shade, and avoid strenuous activity during the hottest parts of the day. Thunderstorms and lightning can also be dangerous, with an average of 80 lightning deaths per year in the US. It is safest to go indoors when thunderstorms threaten and to avoid contact with electrical equipment or plumbing until
This gives you an insight into thunderstorms, what they are and how they occur. It also gives you some safety precautions in case you are actually stuck in one of them! It includes a small Case Study of two thunderstorms too.
This gives you an insight into thunderstorms, what they are and how they occur. It also gives you some safety precautions in case you are actually stuck in one of them! It includes a small Case Study of two thunderstorms too.
Thunderstorms are most likely to occur in the spring and summer months and during the afternoon and evening hours, but they can occur year-round and at all hours. Thunderstorms frequently occur in the late afternoon and at night in the Plains states. This module highlights the basics of thunderstorms.
A document tackling about the basis of Thunderstorms:
-What is Thunderstorm?
-How do the Thunderstorms form?
-What is the difference between thunder and lightning?
Between a water spout and a tornado?
-What are the types of Lightning? of a Thunderstorm?
-What are some signs of an approaching thunderstorm?
-What are some precautionary measures to do before and during a thunderstorm?
-Case of Thunderstorms in the Philippines and on Planes
Weather safety is important as it affects everyone, both inside and outside of the office setting. Thunderstorms, lightning, flodding, and tornadoes can impact us all. This presentation is to bring awareness to my colleagues at ERM.
This is a sample lightning policy for sports fields and outdoor event venues.
For more sports event planning resources, visit us at: https://sportspaces.io/resources/
A brief yet comprehensive description of a very common problem faced in KSA especially during hajj season. It is meant to enhance the awareness among ER and ICU physicians.
Thunderstorms are most likely to occur in the spring and summer months and during the afternoon and evening hours, but they can occur year-round and at all hours. Thunderstorms frequently occur in the late afternoon and at night in the Plains states. This module highlights the basics of thunderstorms.
A document tackling about the basis of Thunderstorms:
-What is Thunderstorm?
-How do the Thunderstorms form?
-What is the difference between thunder and lightning?
Between a water spout and a tornado?
-What are the types of Lightning? of a Thunderstorm?
-What are some signs of an approaching thunderstorm?
-What are some precautionary measures to do before and during a thunderstorm?
-Case of Thunderstorms in the Philippines and on Planes
Weather safety is important as it affects everyone, both inside and outside of the office setting. Thunderstorms, lightning, flodding, and tornadoes can impact us all. This presentation is to bring awareness to my colleagues at ERM.
This is a sample lightning policy for sports fields and outdoor event venues.
For more sports event planning resources, visit us at: https://sportspaces.io/resources/
A brief yet comprehensive description of a very common problem faced in KSA especially during hajj season. It is meant to enhance the awareness among ER and ICU physicians.
Basic data about heat stroke uncluding: Definition, forms, exertional and non exertional, epidemiology, risk factors, characteristics, ettiology, pathophysiology, clinical presentation in all body systems, management, cooling tools, assisting procedures, complications, prevention, and patient education
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We analyzed all the recruiting activity on LinkedIn this year and identified the Top Skills employers seek. Starting Oct 24, learn these skills and much more for free during the Week of Learning.
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Hi friends, I have created a small presentation on Air pressure and Wind systems chapter that also has some info on types of disasters and the precaution to be taken..... Hope this will be helpful to you all. Thank you
Are You Prepared? Winter Storms & Extreme Coldntoscano50
While the amount of danger from winter weather varies across the country, nearly all Americans, regardless of
where they live, are likely to face some type of severe winter weather at some point in their lives. Winter storms
can range from a moderate snow over a few hours to a blizzard with blinding, wind-driven snow that lasts for
several days. Many winter storms are accompanied by dangerously low temperatures and sometimes by strong
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A presentation for Incarnation Catholic Schools for grade 6 students on the topic of meteorology. Ms. Hernandez is a meteorologist at the National Weather Service Phoenix.
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
1. Think Abel – Think Safety
Summer 2010
Welcome to another issue of our Safety Heat Exhaustion vs. Heat Stroke:
Bulletin. Since the summer of 2010
arrived most of us have experienced very Knowing The Difference!
warm temperatures. Over the last few
With the hot weather upon us, heat stroke and heat exhaustion play an everyday part in
months we have had some record break-
today’s workforce, but do you know the difference?
ing heat: combine that with the high
humidity and you have very uncomfort- Heat Exhaustion – This condition often Heat Stroke – This medical condition is
able conditions. occurs when people exercise (work or life-threatening. The person’s cooling sys-
In this issue we would like to address a play) in a hot, humid place and body fluids tem, which is controlled by the brain, stops
few points regarding summertime condi- are lost through sweating, causing the body working and the internal body temperatures
tions such as, heat exhaustion and heat to overheat. The person’s temperature may rises to the point where brain damage or
stroke, driving in heavy rain, and light- be elevated, but not above 104°F. damage to other internal organs may result
ning storms. Signs & Symptoms for Heat Exhaustion: (temperature may reach 105+°F).
• Normal, low, or elevated body Signs & Symptoms for Heat Stroke:
Amazing Weather temperature • Very high temperature (104°F or
• Cool, clammy, pale skin. Sweating higher)
Facts • Dry mouth. Thirst • Hot, dry, red skin. No sweating
One inch of rain over one square mile • Fatigue. Weakness. Feeling Dizzy • Deep breathing and fast pulse. Then
equals to 17.4 million gallons (66 mil- • Headache shallow breathing and weak pulse
lion liters) of water. • Nausea - Vomiting can occur • Confusion. Hallucinations
The weight of one inch of water over • Muscle cramps • Convulsions
one square mile equals over 145 million • Weak or rapid pulse • Loss of consciousness
pounds (66 million kg).
Prevention
145 million pounds of water is almost • Drink lots of liquids. Drink water and drinks that replenish electrolytes and salt
73,000 tons or the weight of 241 loco- (Gatorade, Powerade, etc.) If you have clear, pale urine, you are probably drinking
motives. This is a lot of water held up enough fluids. Dark-colored urine is an indication that you're dehydrated.
by wind. • Drink plenty of water before starting an outdoor activity.
Clouds are made of trillions of tiny • During an outdoor activity, take frequent breaks. Drink water or other fluids every 15
droplets of water (or when cold enough, to 20 minutes, even if you don't feel thirsty.
ice crystals)! • Do not stay in or leave anyone in a closed, parked vehicle during hot weather.
There is so much water in the air that if • Do not have drinks with caffeine or alcohol.
it all fell as rain at the same time, it • Use caution when you are in the sun. At the first sign of heat exhaustion, get out of
could fill enough buckets to reach from the sun. If you can, avoid midday heat. Do not do vigorous activity during the hottest
the earth to the sun 57 million times! part of the day (11:00 AM to 4:00 PM).
You can tell the temperature by count- • Wear light, loose-fitting clothing, such as cotton, so sweat
ing the clicks a cricket makes in 15 sec- can evaporate. Wear a wide-brimmed hat with vents. Use
onds and adding 37! an umbrella for shade.
The air in the core of a lightning bolt • If you feel very hot, try to cool off. Open a window, use
has been estimated to be heated to as a fan, go to an air conditioned place.
much as 54,000 degrees Fahrenheit. • Use sunscreen with a sun protection factor (SPF) of
That happens to be about six times hot- 15 or more.
ter than the surface of the sun! • Check with your doctor about sun exposure if are taking
medication; some have adverse reactions to sun exposure.
2. Thunderstorms and Lightning Stormy Weather
All thunderstorms are dangerous. Every life and property to those in the path of Driving
thunderstorm produces lightning. In the the storm. As long as we have the heat and humidi-
US, an average of 300 people are injured What to Do Before a Thunderstorm ty, we all know that the chance of having
and 80 people are killed each year by To prepare for a thunderstorm, you should heavy pop-up thunderstorms caused by
lightning. Although most lightning victims do the following: cold fronts moving across the area will
survive, people struck by lightning often no doubt cause havoc for some motorists
• Remove dead or rotting trees and
report long-term, debilitating symptoms. and create hazardous driving conditions.
branches that could fall and cause injury
Other associated dangers of thunderstorms
or damage during a severe thunderstorm. In stormy conditions, it is more difficult to
include tornadoes, strong winds, hail, and
• “If thunder roars, go indoors” because see other vehicles, road signs and the road
flash flooding. Flash flooding is responsi-
no place outside is safe when lightning is itself. Make sure you can be seen and, by
ble for more fatalities than any other thun-
in the area. Stay indoors until 30 minutes the way, it’s the law: headlights on when
derstorm-related hazard.
have passed after you hear the last clap wipers are in use.
Facts About Thunderstorms of thunder. Slow down! Hydroplaning is very likely
• They may occur without notice, appear • Have flashlights handy in case of to happen with just a small amount of
in individual or as multiple storms. power failure, avoid using candles due water on the roadway, not to mention the
• Some of the most severe occur when a to risk of fire. oil mixed with it.
single thunderstorm affects one location Summary of Lightning Safety Tips for Hydroplaning is when your car’s tires can-
for an extended time. not channel the water out of the grooves
Inside the Home
• Thunderstorms typically produce heavy fast enough, therefore your car actually
• Avoid contact with corded phones.
rain for a brief period, anywhere from 30 becomes airborne on top of the wet road
• Avoid contact with electrical equipment
minutes to an hour. surface and you will not have control of
or cords. If you plan to unplug any elec-
• Warm, humid conditions are highly steering or braking at that point.
tronic equipment, do so well before the
favorable for thunderstorm development. Stay toward the middle lane of the road;
storm arrives.
Facts About Lightning • Avoid contact with plumbing. Do not: running water tends to pool up in the out-
• Lightning’s unpredictability increases the wash your hands, take a shower, wash side lane of the road or median, and when
risk to individuals and property. dishes, and do not do laundry. you hit that, it’ll stop your car dead.
• Lightning often strikes outside of heavy • Stay away from windows and doors, and Increase your stopping distance from the
rain and may occur as far as 10 miles stay off porches. vehicle in front of you by two car lengths.
away from any rainfall. • Do not lie on concrete floors and do not Watch the vehicle ahead of you closely; if
• “Heat lightning” is actually lightning lean against concrete walls. that car hits a wall of water so will you.
from a thunderstorm too far away for The following are guidelines for what you Avoid driving on the sides or directly
thunder to be heard. should do if a thunderstorm is likely in behind a truck or bus; the spray from them
• Most lightning deaths and injuries occur your area: reduces your visibility significantly.
when people are caught outdoors in the • Postpone any outdoor activities. Avoid hard braking to avoid skidding, and
summer months during the afternoon • Get inside a home, building, or hard top pump your breaks periodically to dry
and evening. automobile (not a convertible). Although them off.
Know Your Thunderstorms and Lightning you may be injured if lightning strikes One last reminder - never use your cruise
Familiarize yourself with these two terms your car, you are much safer inside a control during a rainstorm. When your
to help identify a thunderstorm hazard: vehicle than outside. tires loose connection with the road,
Severe Thunderstorm Watch • Remember, rubber-soled shoes and rub- cruise control will continue to make your
Tells you when and where severe thunder- ber tires provide NO protection from wheels spin, making it more likely to lose
storms are likely to occur. Watch or listen lightning. However, the steel frame of a control of your vehicle.
to weather bulletins for your area. A bat- hard-topped vehicle provides increased
tery operated radio is recommended in case protection if you are not touching metal.
of power failure. • Secure outdoor objects that could blow
away or cause damage.
Severe Thunderstorm Warning
• Avoid showering or bathing. Plumbing
Issued when severe weather has been and bathroom fixtures can conduct
reported by spotters or indicated by radar. electricity.
Warnings indicate imminent danger to
2 Corporate Drive, Cranbury, New Jersey, 08512-3604
t: 609-860-0400 f: 609-860-0440 safety@ThinkAbel.com www.ThinkAbel.com