- Rumen biotechnology applies knowledge of fore stomach fermentation and management of natural and recombinant microorganisms to improve digestion of fibrous feed by ruminants.
- Ruminants have a four-compartment stomach and digest food in two steps: by initially eating and later regurgitating cud to chew and re-ingest.
- Rumen fermentation by microbes breaks down plant proteins and fibers into volatile fatty acids and microbial protein for absorption. Various microbes digest different nutrients and some produce methane.
etiology, local names, definition, transmission, source of infection, epidemiology, pathogenesis, clinical signs, diagnosis, differential diagnosis, treatment prevention and control
etiology, local names, definition, transmission, source of infection, epidemiology, pathogenesis, clinical signs, diagnosis, differential diagnosis, treatment prevention and control
Presentation 27 June - 1 July 2016. Asaba, Nigeria. Workshop organised by the PAEPARD supported consortium: Knowledge transfer towards cost–effective poultry feeds production from processed cassava products to improve the productivity of small-scale farmers in Nigeria.
Prepared for Delmarva Small Ruminant Conference: All Worms All Day -- by Dr. Niki Whitley. Delaware State University, Dover, Delaware, December 9, 2017.
This slide share revolves around the anatomy and physiology of an udder including the mechanism of milk production in cows and the hormones involved with their role in milk synthesis.Hope its helpful.
Common cattle diseases by Dr.Pavulraj.S, M.V.Sc., Pathology scholar, IVRI (NR...Pavulraj Selvaraj
important bacterial, viral and parasitic diseases of cattle with good quality images for veterinarians in filed and college as well for better diagnosis of diseases in quick review form in presentation mode
This presentation was given at the Delmarva Small Ruminant Conference All Worms All Day on December 8, 2018, in Keedysville, Maryland. The presenter was Susan Schoenian.
Manipulations of rumen function that can augment livestock productivity are;
Correction of concentrate to roughage ratio
Feed bypass or escaped nutrients
Defaunation of rumen
Use of yeast as probiotics
Use of anaerobic fungi
Use of other feed additives
Rdp,udn and kinetics, Rumen undegradable protein, Rumen degradable protein and their kinetics, Sri Venkateswara veterinary university, Animal nutrition, Vishnu Vardhan Reddy
Presentation 27 June - 1 July 2016. Asaba, Nigeria. Workshop organised by the PAEPARD supported consortium: Knowledge transfer towards cost–effective poultry feeds production from processed cassava products to improve the productivity of small-scale farmers in Nigeria.
Prepared for Delmarva Small Ruminant Conference: All Worms All Day -- by Dr. Niki Whitley. Delaware State University, Dover, Delaware, December 9, 2017.
This slide share revolves around the anatomy and physiology of an udder including the mechanism of milk production in cows and the hormones involved with their role in milk synthesis.Hope its helpful.
Common cattle diseases by Dr.Pavulraj.S, M.V.Sc., Pathology scholar, IVRI (NR...Pavulraj Selvaraj
important bacterial, viral and parasitic diseases of cattle with good quality images for veterinarians in filed and college as well for better diagnosis of diseases in quick review form in presentation mode
This presentation was given at the Delmarva Small Ruminant Conference All Worms All Day on December 8, 2018, in Keedysville, Maryland. The presenter was Susan Schoenian.
Manipulations of rumen function that can augment livestock productivity are;
Correction of concentrate to roughage ratio
Feed bypass or escaped nutrients
Defaunation of rumen
Use of yeast as probiotics
Use of anaerobic fungi
Use of other feed additives
Rdp,udn and kinetics, Rumen undegradable protein, Rumen degradable protein and their kinetics, Sri Venkateswara veterinary university, Animal nutrition, Vishnu Vardhan Reddy
Carbohydrate digestion and metabolism in Ruminants Carbohydrate Digestion...Dr. Rahul kumar Dangi
The rumen of such animals will have higher amylolytic bacteria than cellulolytic bacteria present in the rumen of roughage- and pasture-fed animals.
Factors such as the forage:concentrate ratio, the physical form of the diet (ground vs. pelleted), feed additives, and animal species can affect the rumen fermentation process and VFA production.
Molar ratios of VFAs are dependent on the forage:concentrate ratio of the diet. Cellulolytic bacteria tend to produce more acetate, while amylolytic bacteria produce more propionic acid.
Typically three major VFA molar ratios are 65:25:10 with a roughage diet and 50:40:10 with a concentrate-rich diet.
Changes in VFA concentration can lead to several disorders of carbohydrate digestion in ruminants.
Rumen acidosis occurs when animals are fed high-grain-rich diets or when animals are suddenly changed from pasture- or range-fed to feedlot conditions
Very little digestion occurs in the mouth in farm animals.
The small intestine is the site of carbohydrate digestion in monogastrics.
Pancreatic amylase acts on alpha 1,4 links, and other disaccharidases and remove disaccharide units.
The end product (mainly glucose) diffuses into the brush-border using ATP-dependent glucose transporters.
Undigested (fiber, nonstarch polysaccharides [NSP]) in the hindgut can serve as an energy source for hindgut microbes in monogastrics.
Ruminant carbohydrate digestion is very different from monogastrics. First, there is no amylase secreted in the saliva and then most carbs are fermented in the rumen by microbial enzymes.
Carbohydrates are fermented to volatile fatty acids (VFAs) in the rumen. These include acetic acid, propionic acid, and butyric acid.
VFAs are absorbed through the rumen wall into the portal vein and are carried to the liver.
Ratios of the VFAs change with the type of diet. Roughage diets favor microbes that produce more acetic acid, whereas concentrate diets favor microbes that produce more propionic acid.
Carbohydrate fermentation disorders in ruminants include rumen acidosis (grain overload), when cattle are fed high-starch-based cereal or grain-rich diets or when there is a sudden change from pasture to feedlot FIBROUS CARBOHYDRATES
Cellulose and hemicellulose bound with lignin in plant cell walls or fiber. Provide bulk in the rumen. Fermented slowly.
The lignin content of fiber increases with plant maturity and the extent of cellulose and hemicellulose fermentation in the rumen decreases.
Fiber in the form of long particles essential to stimulate rumination. Which enhances the breakdown and fermentation of fiber and stimulates ruminal contraction, and increases the flow of saliva to the rumen.
Saliva contains sodium bicarbonate (baking soda) and phosphate salts which help to maintain pH of the rumen close to neutral.
Rations lacking fiber generally result in a low percentage of fat in the milk and contribute to digestive disturbances (e.g., displaced abomasum, rumen acidosis).
Non-fibrous carbohydrat
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
2. Rumen Biotechnology
Application of knowledge of fore stomach
fermentation and the use and management
of both natural and recombinant
microorganisms to improve the efficiency
of digestion of fibrous feedstuffs by
ruminants.
3. Ruminants …?
A ruminant is any hooved animal that digests its
food in two steps-
a) By eating the raw material and regurgitating a
semi digested form known as cud
b) then eating the cud, a process called
ruminating
Ruminants share another common feature that
they all have an even number of toes.
Examples are: cattle, goat, sheep, camel, giraffe,
buffalo and dear etc.
4. RUMEN FERMENTATION
– Protein
• Digested to amino acids by rumen micro-organisms and resynthesized
into microbial protein.
• This is digested in the small intestine to amino acids which are absorbed
and used for growth (enzymes, immune proteins, muscle protein).
• Some amino acids can be used to make glucose for energy production in
specialized tissues such as brain and formation of rapid energy stores
(liver and muscle glycogen).
– Fibre (cellulose, hemicellulose, lignin).
• Only digested in the rumen by certain micro-organisms. What is
undigested is excreted in the faeces.
• Producing volatile fatty acids (VFAs) such as propionate and butyrate
which are absorbed in the small intestine and used for energy
production and fat synthesis.
– Starch, sugars
• Digested rapidly in the rumen to form lactate or acetate. Excess
fermentation of starch can cause acidosis, particularly in lotfed cattle
receiving grain.
5. RUMEN FERMENTATION
Urea Microbial Urease NH3 + CO2
Carbohydrates Microbial Enzymes FA + Keto Acids
Keto Acids + NH3 Microbial Enzymes Amino Acids
Amino Acids Microbial Enzymes Microbial Protein
Microbial Protein Small Intestine Enzyme Free Amino
Acids
Free Amino Acids Absorbed
Toxic dose generally regarded as 0.5grams/kg LWT in a single feeding
episode.
6. RUMEN FERMENTATION
Sulphate of Ammonia (NH4)2SO4
Supply N as with urea. Contains approx ½ the level of
N as urea
Important source of Sulphur (S)
Sulphur required as a precursor to the production
amino acids
N:S ratio should be in the range of 12-15:1
SO4 often used to control intake (more bitter than urea )
More expensive source of N than urea
13. True gastric stomach
Proteolytic enzymes
Gastric digestion
Decreased pH from 6 to 2.5
– Denatures proteins
– Kills bacteria and pathogens
– Dissolves minerals (e.g., Ca3(PO4)2)
www.vivo.colostate.edu
Abomasum
14. Many Microbial Munchers
The rumen is home to billions and billions of microbes, including
bacteria, protists, fungi, and viruses. These many different
rumen microbes form a complex community of organisms that
interact with one another, helping the animal digest its food.
Microbial Population
15. Fermentation in Ruminants
Rumen is a fermentation chamber filled with
microorganisms (Gregg, 1995).
Anaerobic process-thus host can absorb
energetic by-products from bacteria
fermentation.
Utilizes enzymes produced by rumen
microorganisms to digest the ingested material
.
Benefits two distinguished groups: host
(ruminant) and the microorganisms.
www.esl.ohio-state.edu
16. Rumen Microbes
Protozoa
– Large (20-200 microns) unicellular organisms
– Ingest bacteria and feed particles
– Engulf feed particles and digest carbohydrates,
proteins and fats
– Numbers affected by diet
(Yokoyama and Johnson, 1988)
18. Fungi
– Known only for about 20 years
– Numbers usually low
– Digest recalcitrant fiber
www.animsci.agrenv.mcgill.ca/feed
Rumen Microbes
19. Cellulolytic bacteria (fiber digesters)
– digest cellulose
– require pH 6-7
– utilize N in form of NH3
– require S for synthesis of sulfur-containing amino
acids (cysteine and methionine)
– produce acetate, propionate, little butyrate, CO2
– predominate from roughage diets
Bacterial Populations
20. Amylolytic bacteria (starch, sugar digesters)
– digest starch
– require pH 5-6
– utilize N as NH3 or peptides
– produce propionate, butyrate and lactate
– predominate from grain diets
– rapid change to grain diet causes lactic acidosis
(rapidly decreases pH)
Contd….
21. Methane-producing bacteria
– produce methane (CH4)
– utilized by microbes for energy
– represent loss of energy to animal
– released by eructation
Contd…..
23. Pre-ingestive Methods
Reducing lignin content and increasing
fermentable carbohydrate. Increasing
available proteins.
Reducing concentration of secondary
compounds. (Ulyatt, 1993).
Use of exogenous fibrolytic enzymes to
improve feed utilisation.
24. Post-ingestive Methods
Increasing fibre digestion.
Improving efficiency of nitrogen
metabolism.
Modification of ruminal ecosystems.
Recombinant ruminal Microorganisms.
Hoover and Stokes, 1991; McSweeny et al., 1994.
25. GI Microbes in livestock
development.
Microbial degradation of antinutritional
factors.
Tannins Toxic Non-protein amino acids.
Oxalates
Fluoroacetate
Pyrrolizidine
(Allison et al., 1985; Nelson et al., 1995)
26. GI Microbial enzymes In
Industry
Tannase in food, beverages, in preparation of
instant tea and as clarifier in fruit juices and beer.
Phytase as feed additives in monogastric’s foods
to increase phosphate utilisation.
Source of restriction enzymes for e.g.. Sru I and
Sru4DI from ruminal selenomonades
Lactobacillus species for disease treatment as
probiotics.
(Cheng, 1999).
27. Future Prospect and Conclusion
Provide a natural barrier for controlling the
entry of enteric pathogens into the human
food chain.
Intensive livestock production in the
future.
In various industries apart from the
Livestock production
Easy and economical way to enhance
economy of developing countries.