This review paper discusses the seismic responses of multistoried RCC buildings with mass irregularity, using various time history analysis methods to assess their structural safety during earthquakes. It emphasizes the identification of irregularities that contribute to structural failures and highlights the importance of ductility in the design of earthquake-resistant buildings. Through extensive literature review and analysis using ETABS software, the paper concludes that effective seismic analysis techniques and structural modifications, such as shear walls and base isolators, can mitigate earthquake impacts.