- Retrosynthetic analysis, also known as disconnection approach or retrosynthesis, is a logical method for designing organic syntheses by breaking down target molecules into simpler precursor molecules through imaginary bond breaking or functional group interconversions. - The process involves envisioning the synthetic route in reverse, starting from the target molecule and identifying immediate precursor molecules that could be transformed into the target molecule in one step. - This is repeated backwards until arriving at readily available starting materials. Guidelines for effective disconnections include corresponding to known reaction reversals and avoiding chemoselectivity problems.