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RESPIRATORYSYSTEM
By
H.Khorrami Ph.D.
http://scribd.com/khorrami4
khorrami4@yahoo.com
Respiration
• Mechanic of respiration
• Physical principles of gas exchange
• Carriage of blood gases
• Control of respiration
• https://www.youtube.com/watch?v=kacMYexDgHg
Physiology of respiration
Respiratory system functions
• Oxygen transfer
• Co2 expel
• Primary barrier
• Metabolic organ
• Produces sounds
• Olfaction
• Temperature and water control
• Enhances strength of power
Nasal Mucus, trap particles larger than 10micron
Branching of airways
Each bronchus branches 16-22 times
Alveolus
Alveolar structure
Surfactant
• Reduce surface tension
• To increase pulmonary Compliance
• To prevent atelectasis (collapse of the lung) at the end of
expiration
• To facilitate recruitment of collapsed airways
• Helps keep alveoli dry
• Helps prevent edema
• Expansion of lungs at birth
Surfactant
Innervations
Pump handle
Mechanic of Breathing/ Muscles
Breathing
• Shallow
• Deep
Spirometry
Respiratory disorders
• Emphysema
• Cancer
• Asthma
• Laryngitis/ bronchitis
• Cystic fibrosis ( genetic disorder)
• TB
• Scoliosis
• SIDS
• Pneumonia
• Carbon monoxide poisoning
• Pneumothorax
Pneumothorax
Pneumothorax
Some terms
• Compliance
• Pneumothorax
• Anatomical shunt
1mmHg=1.36 CmH2O
Ventilation / Perfusion
Shunt
Control of breathing
Hyperventilation
• Hypoxia
• High altitude
• Metabolic acidosis
• Panic attack, anxiety
• Seizure
• Stroke
• High fever, pain
• Voluntary
• Respiratory alkalosis
• Nausea
• Numbness
• Prolonged muscle
spasms
• Muscle twitching
• Hand tremor
• Dizziness
• Confusion
• Coma
Methemoglobinemia
• Symptoms are proportional to the fraction of methemoglobin. A
normal methemoglobin fraction is about 1% (range, 0-3%).
• At methemoglobin levels of 3-15%, a slight discoloration (eg,
pale, gray, blue) of the skin may be present
• Patients with methemoglobin levels of 15-20% may be
relatively asymptomatic, apart from mild cyanosis
• Signs and symptoms at levels of 25-50% include:
• Headache
• Dyspnea
• Lightheadedness, even syncope
• Weakness
• Confusion
• Palpitations, chest pain
Methemoglobinemia
• Methemoglobin levels of 50-70% can cause:
• Cardiovascular - Abnormal cardiac rhythms
• CNS - Altered mental status; delirium, seizures, coma
• Metabolic - Profound acidosis
• At methemoglobin fractions exceeding 70%, death usually
results
Exercise
s
Respiratory system
Respiratory system
Respiratory system
Respiratory system
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Respiratory system

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Respiratory system