The document discusses renal trauma, providing details on:
1) The anatomy, embryology, and blood supply of the kidneys.
2) Classification of renal injuries from Grade I to V based on severity.
3) Evaluation of renal trauma patients including history, exam, laboratory tests, ultrasound, IVU, CT, and angiography.
4) Management approaches including non-operative for lower grades and exploration for higher grades or hemodynamic instability.
Please find the power point on Urinary Tract Injury (Kidney Injury). I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
Please find the power point on Urinary Tract Injury (Kidney Injury). I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
Consensus on GU Trauma
Evaluation and management of renal
injuries: consensus statement of the
renal trauma subcommittee
BJU International
Volume 93 Issue 7 Page 937-954, May 2004
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
3. Embryology
• Three sets of structures
appear and then regress
in succession ; the
pronephros, the
mesonephros and the
metanephros which
persists to form the
definitive kidney.
Clinically Oriented Anatomy “MOORE” 6th edition
4. • measures 10 to 12 cm in
length(2 & half vertebral
body length)
• 5.0 to 7.5 cm in width
• 2.5 to 3.0 cm in
thickness
• weighs approximately
125 to 170 gm(in males)
and 10 to 15 gm smaller
in females.
Clinically Oriented Anatomy “MOORE” 6th edition
18. Function of Kidney
• Excretory function
• Homeostatic function
• Endocrine function
• Metabolic function
19. Introduction to Trauma
• Trauma is defined as a physical injury or a
wound to living tissue caused by an
extrinsic agent.
• sixth leading cause of death worldwide
• 10% of all mortalities
• Mostly 15-45 age group and mostly male
EAU guidelines 2018
20. 1. Intentional
• either interpersonal violence related, war-
related or self-inflicted injury
2. unintentional injury
• mainly motor vehicle collisions, falls, and
other domestic accidents
EAU guidelines 2018
21. Genito-Urinary Trauma
• seen in both sexes and in all age groups, but is
more common in males
• kidney is the most commonly injured organ
• 5% of all trauma cases
• 10% of all abdominal trauma cases
EAU guidelines 2018
28. Etiology
• Penetrating
- gunshot wounds
- stab wounds
• Blunt
- Rapid deceleration (eg, motor vehicle crash
fall from heights)
- direct blow to the flank (eg, physical assault,
sports injury)
Campbell and Walsh Urology 101h edition
29. Etiology
Iatrogenic
- endourologic procedures
- extracorporeal shock-wave lithotripsy
- renal biopsy and percutaneous renal procedures
- Intraoperative
Other
- renal transplant rejection
- Childbirth [may cause spontaneous renal lacerations]
Campbell and Walsh Urology 101h edition
30. Pathology
• Lacerations from blunt trauma usually occur in the
transverse plane of the kidney.
• The mechanism of injury is thought to be force
transmitted from the center of the impact to the
renal parenchyma.
31. Pathology
• In injuries from rapid deceleration the kidney moves
upward or downward, causing sudden stretch on the
renal pedicle and sometimes complete or partial
avulsion
• Acute thrombosis of the renal artery may be caused
by an intimal tear from rapid deceleration injuries
owing to the sudden stretch.
32. Presentation and Diagnosis
• History – mode /mechanism,
• The diagnosis of renal injury begins with a high
index of clinical awareness
• Pain may be localized to one flank area or over
the abdomen
• Retroperitoneal bleeding may cause abdominal
distention, ileus, and nausea and vomiting.
EAU guidelines 2018
33. • Examination
– General Condition - feature of shock heavy
retroperitoneal
– Ecchymosis in the flank or upper quadrants of
the abdomen
– Lower rib fractures are frequently found
EAU guidelines 2018
34. Per abdomen
• Pelvic compression -- tender
• Diffuse abdominal tenderness may be found on
palpation;
Post Trauma an “acute abdomen” usually indicates
free blood in the peritoneal cavity.
• A palpable mass may represent a large
retroperitoneal hematoma or perhaps urinary
extravasation.
EAU guidelines 2018
35. Per abdomen
• If the retroperitoneum has been torn, free blood
may be noted in the peritoneal cavity but no
palpable mass will be evident.
• The abdomen may be distended and bowel
sounds absent.
• visible evidence of abdominal trauma
EAU guidelines 2018
38. Criteria for radiologic imaging
• Penetrating trauma patients with a likelihood of renal injury
(abdomen, flank, or low chest) who are hemodynamically stable
• Blunt trauma with significant mechanism of injury, specifically
rapid deceleration as wound occur in a motor vehicle accident or
a fall from heights
• Blunt trauma with gross hematuria
• Blunt trauma with hypotension defined as a systolic pressure of
less than 90 mm Hg at any time during evaluation and
resuscitation
Campbell and Walsh Urology 101h edition
39. Criteria for radiologic imaging
Pediatric patients
• with greater than 5 red blood cells (RBCs)/HPF.
Patients who are hemodynamically unstable after
initial resuscitation require imaging
Campbell and Walsh Urology 101h edition
40. • Imaging
• Xray without contrast-
– associated pelvic fracture
– Obliteration of psoas shadow
– Associated rib fractures
41. • Intravenous urography
– determine the presence of two functioning renal
units
– the presence and extent of any urinary
extravasation, in penetrating injuries
42. One shot IVP
• Unstable patients with blunt trauma selected
for immediate operative intervention (and thus
unable to have a CT scan) should undergo one-
shot IVP in the operating theatre.
• The technique consists of a bolus intravenous
injection of 2mL/kg of radiographic contrast
followed by a single plain film taken after 10
minutes.
EAU guidelines 2018
43. Advantages of IVP are as follows:
–Allows functional and anatomic assessment
of both kidneys and ureters
–Establishes the presence or absence of two
functional kidneys
–May be performed in the emergency
department or operating room
EAU guidelines 2018
44. Disadvantages of IVP are as follows:
–Multiple images are required for maximal
information, although a one-shot technique
can be used
–The radiation dose is relatively high (0.007-
0.0548 Gy)
–A full IVP usually requires a trip to the
radiology suite
EAU guidelines 2018
45. Standard IVP
• Standard IVP should be used only if other imaging
modalities are not available.
– Non-functioning kidney suggests extensive trauma or
renalpedicle injury.
• Other features noted are
- Extravasation
- Delayed excretion
- incomplete filling
- distortions of pelvicalyceal system
46. USG
• First imaging modalities
–it does not provide information about renal
function or urine leak.
–Some of these limitations are overcome if
contrast enhanced ultrasonography is used.
–Ultrasonography is useful in follow-up of
stable renal injury patients
EAU guidelines 2018
47. Advantages of USG
– Noninvasive
– May be performed in real time in concert with
resuscitation
– May help define the anatomy of the injury
48. Disadvantages of USG
– Optimal study results related to anatomy require
an experienced sonographer
– The focused abdominal sonography for trauma
(FAST) examination does not define anatomy and, in
fact, looks only for free fluid
– Bladder injuries may be missed.
49. CECT
• Gold standard for evaluation of stable patients
with renal trauma.
• Absence of enhancement on contrast
administration or presence of parahilar
hematoma suggests renal pedicle injury
• difficult to directly visualize renal vein injury
• Standard CECT scans may miss collecting system
injury which is best detected by repeating the
scan 10-15 minutes after contrast injection
EAU guidelines 2018
50. CECT
• CT imaging is both sensitive and specific
– for demonstrating parenchymal lacerations and urinary
extravasations
– delineating segmental parenchymal infarcts
– determining the size and location of the surrounding
retroperitoneal hematoma and/or associated intra-
abdominal injury (spleen, liver, pancreas, and bowel)
• Renal artery occlusion and global renal infarct are noted on
CT scans by lack of parenchymal enhancement or a
persistent cortical rim sign
51. CECT
• To complete the proper evaluation and staging of renal
injuries, later imaging in the nephrogram phase is needed to
detect renal parenchymal and venous injury
• Delayed images (2-10 min) are often required to detect urine
and blood extravasation.
• On delayed CT images
– extravasated urine can be distinguished from blood in that it
accumulates
– while extravasated arterial contrast dilutes out after the bolus of
contrast is stopped.
52. Magnetic resonance imaging
• accurate in detecting
- peri-renal hematomas
- Renal lacerations and pre-existing anomalies
BUT
- does not detect urine extravasation.
• MRI is not the first choice in managing patients with
trauma because
- it requires a long imaging time and
- limits access to patients when they are in the magnet during
the examination
EAU guidelines 2018
53. Angiography
• most common indication for arteriography is non-
visualization of a kidney on IVP after major blunt renal
trauma when a CT is not available
• It is the test of choice for evaluating renal venous injury.
• Angiography is also indicated in stable patients
to assess pedicle injury if the findings on CT are
unclear
for those patients who are candidates for
radiological control of hemorrhage
EAU guidelines 2018
55. Non-operative management
• Grade 1-4 blunt renal trauma, stable patients
should be managed conservatively with
bed rest
prophylactic antibiotics, and
continuous monitoring of vital signs until
hematuria resolves
EAU guidelines 2018
56. Indications for exploration
• Hemodynamic instability due to renal
hemorrhage is an absolute indication for renal
exploration
• Grade 5 renal injury in a stable patient
• Expanding or pulsatile peri-renal hematoma seen at
laparotomy for associated injuries are other
indications for renal exploration.
EAU guidelines 2018
57. Surgery
• Goal of renal exploration following renal trauma is
control of hemorrhage and
renal salvage.
• approach is trans-peritoneal
– early control of renal pedicle bleeding
– Temporary occlusion of the pedicle during the
exploration of kidney reduces blood loss without
increasing post-operative morbidity
EAU guidelines 2018
58. Surgery
• Renorraphy or partial nephrectomy is used to
manage parenchymal laceration.
–Attempt should be made for a water tight
closure of collecting system.
–Raw areas should be minimized by using renal
capsule, omentum or fibrin glue.
EAU guidelines 2018
59. • Repair of Grade 5 renal injury is rarely
successful and nephrectomy is usually the
best option, except in case of a solitary
kidney.
• Retroperitoneum should be drained
following renal exploration.
EAU guidelines 2018
60. Post-trauma care and follow up
• Repeat imaging is recommended for all
hospitalized patients within 2-4 days of
significant renal trauma, especially in cases of
fever, flank pain, or falling hematocrit.
• Nuclear scintigraphy before discharge from the
hospital is useful for documenting functional
recovery.
UpToDate.com
61. Post-trauma care and follow up
• Within 3 months of major renal injury, patients’follow-up
should involve
physical examination
urinalysis
individualized radiological investigation
serial blood pressure measurement and
serum determination of renal function.
• Long-term follow-up should be decided on a case-by-case
basis but should at the very least involve monitoring for
renovascular hypertension.
UpToDate.com
62. Late pathologic findings
Urinoma
• Deep lacerations that are not repaired
may result in persistent urinary
extravasation
• late complications of a large
perinephric renal mass,
• hydronephrosis and abscess
formation
63. Late pathologic findings
Hydronephrosis—
– Large hematomas in the retroperitoneum and
associated urinary extravasation may result in
perinephric fibrosis engulfing the
ureteropelvic junction, causing
hydronephrosis.
– Follow-up excretory urography is indicated in all
cases of major renal trauma
65. Late pathologic finding
•Renal vascular hypertension
– The blood flow in tissue rendered nonviable by
injury is compromised
– this results in renal vascular hypertension in less
than 1% of cases.
– Fibrosis from surrounding trauma has also been
reported to constrict the renal artery and cause
renal hypertension.
66. Complications
• Early complications occur within the first month
after injury and can be
Bleeding
infection
peri-nephric abscess
sepsis
urinary fistula
hypertension
urinary extravasation, and
urinoma
67. • Delayed complications include
calculus formation
chronic pyelonephritis
hypertension
arteriovenous fistula
hydronephrosis, and
pseudoaneurysms
68. Special cases
• Pediatric renal trauma
• Children are more prone to renal trauma as the kidneys are
lower in the abdomen.
• less well-protected by the lower ribs and muscles of the flank
and abdomen.
• Kidney is more mobile, have less protective peri-renal
fat and are proportionately larger in the abdomen than
in adults.
• Hypotension is a less reliable sign and significant injury can be
presentdespite stable blood pressure.
UpToDate.com
69. Pediatric renal trauma
Indications for radiographic evaluation of
children suspected of renal trauma include
blunt and penetrating trauma patients with
any level of hematuria
patients with associated abdominal injury
regardless of the findings of urinalysis
patients with normal urinalysis who
sustained a rapid deceleration event,
direct flank trauma or a fall from a height.
UpToDate.com
70. • Procedures like percutaneous nephrostomy,
percutaneous nephrolithotomy and renal biopsy are
occasionally associated with significant complications
such as
- Hematuria
- arteriovenous fistula and
- urinary leak
• most often be managed by
arterial embolization and
stenting.
Percutaneous renal procedures:
72. Take Home Message
• Most GU injuries involve the kidney, most are due
to blunt mechanisms, and most are low grade.
• Begin urologic testing with urinalysis and Hct.
• Obtain contrast-enhanced CT for suspected
moderate or severe injury (eg, mechanism or
findings suggesting severe injury, gross
hematuria, hypotension).
• Consider surgery or therapeutic angiographic
intervention for persistent bleeding, expanding
perinephric hematoma, renal pedicle avulsions,
and significant renovascular injuries.
Editor's Notes
kidneys are paired ovoid or bean shaped reddish-brown in color.
the mesonephros forms male reproductive duct (duct of the epididymis, the vas deferens and the ejaculatory duct, the efferent ductules of the testis, the appendix of the epididymis)
and gives rise to the ureteric bud in both sexes.
superiorly it forms the ureter, the pelvis of the ureter, the major and minor calyces and the collecting ducts
Inferiorly to become the trigone of bladder and part of the urethra
measures 10 to 13 cm in length
5.0 to 7.5 cm in width
2.5 to 3.0 cm in thickness
weighs approximately 125 to 170 gm(in males) 10 to 15 gm smaller in females.
Each kidney is of a characteristic shape, having a superior and an inferior pole, a convex border placed laterally, and a concave medial border. The medial border has a marked depression or vertical cleft, the renal hilum, where the renal artery enters and the renal vein and renal pelvis leave the renal sinus.
•At the hilum, the renal vein is anterior to the renal artery, which is anterior to the renal pelvis. Superomedial aspect of each kidney normally contact with suprarenal gland. Right kidney is approxamitely 2.5cm lower then left kidney probably due to presence of liver on right side . superior poles are closer to midline than inferior
Kidney is retroperitoneal organs situated in the posterior part of the abdomen on each side of the vertebral column
Kidney lies between T12 to L3 of vertebral column and superior part of kidney is protected by 11 and 12 rib on left and only 12th rib on right.
Psoas major and quadratus lumborum muscle are behind the kidney
Kidney, suprarenal gland vessels and renal sinus is covered by true renal capsule, perinephric fat and renal fascia ( gerota’s fascia).
Outside the renal fascia there is paranephric fat. The collagen bundles, renal fascia, and perinephric and paranephric fat along with teethering provided by the renal vessels and ureter hold the kidney in relatively fix position and protect from injury.
However movement of kidneys occurs during respiration and changes from supine and errect position.
Parenchyma of kidney is divided into cortex and medulla
Cortex: On a longitudinal section, forms the external layer of renal parenchyma.
(The layers of cortical tissue between adjacent pyramids are named renal cortical columns of Bertin.)
The renal medulla is formed by several inverted cones, surrounded by a layer of cortical tissue on all sides (except at the apexes).
Thus forming a renal pyramid. The apex of a pyramid is the renal papilla.
Functional unit of kidney is nephrons
Regulation of inorganic ions (Na+, K+, Ca++, Cl-, Pi, Mg++)
Regulation of water balance & osmolality
Excretion of nitrogenous wastes (urea, creatinine)
Excretion of foreign chemicals (drugs, pollutants, etc.)
Regulation of pH, and HCO3-
Synthesis of renin
Synthesis of erythropoietin; activation of vitamin D3
Gluconeogenesis (liver much more important)
incidence of urological tract injury following abdominal trauma is
approximately 10%
Renal trauma 1-5% of all trauma cases
kidney m/c injured genitourinary organ in all ages
male-to-female ratio 3:1
Both kidneys are at equal disposition for injury
blunt trauma 90-95%
penetrating injuries comprise 40%
Most injuries can be managed conservatively as advances in imaging and treatment strategies have decreased the need for surgical intervention and increased organ preservation
It is based on abdominal CT or direct renal exploration.
It correlates well with preservation or removal of the injured kidney as well as post-injury mortality and morbidity.
Grade 1 – the most common
contusion or Nonexpanding subcapsular hematomas Microscopic hematuria is common, but gross hematuria can occur rarely
Grade 2
Nonexpanding perinephric hematomas confined to the retroperitoneum Superficial cortical lacerations less than 1 cm in depth without collecting system injury
Grade 3Renal lacerations greater than 1 cm in depth that do not involve the collecting system
May extending through the cortex and into the renal medulla.
Bleeding can be significant in the presence of large retroperitoneal hematoma
Grade 4Renal lacerations extending through the kidney into the collecting system Injuries involving the main renal artery or vein with contained hemorrhage Segmental infarctions without associated lacerations Expanding subcapsular hematomas compressing the kidney
Grade 5Shattered or devascularized kidney Ureteropelvic avulsions Complete laceration or thrombus of the main renal artery or vein