LAST MINUTE REVISION NOTES MICROBIOLOGY ENVELOPED VIRUS VIRUS TRANSMISSION PATHOGENESIS ANTEMORTEM DIAGNOSIS TREATMENT ZOONOTIC DISEASE BASIC REVISION NOTES BASED ON REVISION NOTES AND LECTURE NOTES AND HIGH YEILD TOPIC MICROBIOLOGY REVISION NOTES NEET PG REVISION NOTES FOR REVISION NOTES

1. RABIES

2. RABIES VIRUS
• ENVELOPED
• RNA (NEGATIVE SENSE ssRNA )
• BULLET SHAPED

3. • G (GLYCOPROTEIN ) Ag
• NUCLEOCAPSID PROTEIN

4. RABIES VIRUS INACTIVATED BY
• ALCOHOL
• PHENOL
• IODINE
• BETA PROPIONOLACTONE
• FORMALIN
• UV RADIATION
• HEAT

6. RABIES
• ZOONOTIC DS
• DEAD INFECTION IN MAN

7. RABIES ABSENT AREAS
• WATER IS AN EFFECTIVE NATURAL BARRIER FOR RABIES
• AUSTRALIA AND ANTARCTICA
• BRITAIN
• ICELAND & IRELAND
• CHINA(TAIWAN), CYPRUS
• JAPAN, MALTA, NEW ZEALAND
• INDIA- ANDAMAN & NICOBAR, LAKSHADEEP

9. RABIES FREE AREA
• ONE IN WHICH NO CASE OF INDIGENOUSLY ACQUIRED
RABIES HAS OCCURRED IN MAN OR ANIMAL SPECIES FOR 2
YEARS

10. TRANSMISSION
• Dog Bite: MC mode of transmission
• Other animal bite- Monkey , horses, sheep, goat, cat, buffalo, horses (EXCEPT
rat bite and human bite)
• Lick on abrasion on mucosa
• Air borne (from bats)
• Corneal transplant,
• Human-to-human transmission is extremely rare

12. • SPREADS CENTRIPETALLY @ 3MM /HR
• FROM CNS CENTRIFUGALLYTO PERIPHERAL
TISSUES
FROM
SITE OF
BITE
CNS
CENTRIPETALLY
3MM/HR
CENTRIFUGALLY PERIPHERAL
TISUES

13. RABIES IS A SEVERE ENCEPHALITIS
• MAINLY INVOLVES
• RHOMBERCEPHALON (BRAINSTEM )
• MIDBRAIN & FLOOR OF 4TH VENTRICLE
• BASAL GANGLIA
• SPINAL CORD
• DORSAL ROOT GANGLIA

14. HYDROPHOBIA
• MOST COMMONLY PRESENTATION OF RABIES
• DESPITE INTENSETHIRST.ATTEMPTSTO DRINK LIQUIDS BRING ON
PAINFUL SPASMS OF MUSCLES OF PHARYNX AND LARYNX
PRODUCING CHOKING OR GAGGING THAT PATIENT DEVELOPS
DREAD OF EVENTHE SIGHT OR SOUND OF WATER.

15. ANTEMORTEM DIAGNOSIS
• FROM HAIRY SKIN BIOPSY @ NAPE OF NECK OR FACE
• ANTIGEN DETECTION BY IMMUNOFLURESENCE
• CORNEAL IMPRESSION SMEAR  LOW DIAGNOSTICYIELD
• FROM SALIVA VIRUS ISOLATION

16. POSTMORTEM DIAGNOSIS
• DEMONSTRATION OF NEGRI BODIES
• IMMUNOFLURESECNCE

17. TRANSMISSION
• INTRACYTOPLASMIC
• INCLUSION BODY INTHE NEURONS
• MOST ABUNDANT INTHE HIPPOCAMPUS
>> CEREBELLUM
• STAINED BY SELLERTECHNIQUE

18. RX
• HRIG
• VACCINATION
• SUPPORTIVE CARE
• MANAGEMENT OF COMPLICATIONS