This document provides guidelines for the insertion and management of peripheral intravenous catheters (PIVCs) to prevent healthcare-associated infections. It outlines best practices for choosing catheter type and site, skin preparation, insertion procedure, dressings, flushing, and monitoring. Key points include using chlorhexidine for skin preparation, sterile technique for insertion and dressing changes, reviewing PIVC need daily, and flushing after each use to maintain patency and prevent incompatibilities between fluids. The goal is to support facilities in adopting evidence-based practices for invasive device use and reduce infections.