Singapore grouper iridovirus (SGIV) induces a type of programmed cell death called parapotosis in host cells. This document summarizes research finding that SGIV activates mitogen-activated protein kinase (MAPK) signaling pathways, including ERK, JNK, and p38 MAPK, to induce parapotosis and facilitate viral replication. Inhibition of the ERK and JNK pathways can delay cytopathic effects and reduce virus production, indicating their role in the viral life cycle. JNK activation in particular promotes viral transcription and protein synthesis. MAPK signaling also modulates the expression of immune genes during infection. Therefore, SGIV utilizes MAPK pathways to induce parapotosis in host cells and