1) The study investigated signaling pathways involved in formation of the porcine inner cell mass (ICM) and methods to increase pluripotency in porcine embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). 2) They found that inhibiting MEK and GSK3β signaling pathways in porcine embryos and iPSCs, combined with LIF treatment, promoted a naive pluripotent state similar to mouse ESCs. 3) Naive piPSCs expressed genes associated with naive pluripotency and showed higher germline differentiation potential than non-naive piPSCs. The study provides insights into regulating pluripotency in