Pyloric stenosis is a condition in infants where the pyloric sphincter becomes narrowed due to thickening of the muscle, obstructing food passage from the stomach. It typically occurs in males under 6 months, presenting with projectile vomiting. Diagnosis involves abdominal imaging and treatment is pyloromyotomy surgery to divide the thickened muscle. Post-op care focuses on resuming feeding and monitoring for dehydration or wound issues.