The document is a lecture on respiratory physiology that covers several topics:
1. It describes the anatomy and functions of the respiratory system, including gas exchange, lung volumes, and respiratory muscles.
2. Respiration is explained as the process of inspiration and expiration, which is driven by changes in pressures within the lungs and chest cavity.
3. Other concepts covered include diffusion of gases, transport of oxygen and carbon dioxide in the blood, and regulation of breathing.
Hypoxia :types , causes,and its effects Aqsa Mushtaq
hypoxia :oxygen defecincy at tissue level.in these slides you are going to in touch with its types ,causes effects.share whatever you wanted to say comment us .
these notes are provided by our loving mam MAM SANIA .thanks to teach us mam :)
Random motion of molecules
Movement in both directions through the membranes & fluids of the respiratory structure
Mechanism & rate of molecule transfer dependant on physics of gas diffusion and partial pressures of gases involved
Hypoxia :types , causes,and its effects Aqsa Mushtaq
hypoxia :oxygen defecincy at tissue level.in these slides you are going to in touch with its types ,causes effects.share whatever you wanted to say comment us .
these notes are provided by our loving mam MAM SANIA .thanks to teach us mam :)
Random motion of molecules
Movement in both directions through the membranes & fluids of the respiratory structure
Mechanism & rate of molecule transfer dependant on physics of gas diffusion and partial pressures of gases involved
These slides will help you know about the physiology of the respiratory system. These slides are the simplest version on how to know about the Physiology Of Respiratory System with its applied physiology.
The epithelium lining the respiratory tract from the nasal fossa through the bronchi is called the respiratory mucosa and is characterized by a pseudostratified ciliated epithelium with abundant non-ciliated cells known as goblet cells. - [Source: medcell.med.yale.edu/histology/respiratory_system_lab.php]
These slides will help you know about the physiology of the respiratory system. These slides are the simplest version on how to know about the Physiology Of Respiratory System with its applied physiology.
The epithelium lining the respiratory tract from the nasal fossa through the bronchi is called the respiratory mucosa and is characterized by a pseudostratified ciliated epithelium with abundant non-ciliated cells known as goblet cells. - [Source: medcell.med.yale.edu/histology/respiratory_system_lab.php]
Introduction to respiration and mechanics of ventilation (the guyton and hall...Maryam Fida
Respiration is the process by which oxygen is taken in and carbon dioxide is given out.
Respiration is classified into two types:
1. External respiration
It involves exchange of respiratory gases, i.e. oxygen and carbon dioxide between lungs and blood.
2. Internal respiration
It involves exchange of gases between blood and tissues.
Respiration occurs in two phases:
Inspiration during which air enters the lungs from atmosphere.
2. Expiration during which air leaves the lungs.
During normal breathing, inspiration is an active
process and expiration is a passive process.
Respiratory tract is divided into two parts:
1. Upper respiratory tract that includes all the
structures from nose up to vocal cords; vocal cords are the folds of mucous membrane within larynx that vibrates to produce the voice
2. Lower respiratory tract, which includes Larynx, trachea, bronchi and lungs.
RESPIRATORY UNIT
Respiratory unit is defined as:
“The structural and functional unit of lung”. Exchange of gases occurs only in this part of the respiratory tract.
STRUCTURE OF RESPIRATORY UNIT
1. Respiratory bronchioles
2. Alveolar ducts
3. Alveolar sacs
4. Antrum
5. Alveoli
Between the trachea and alveoli airways divide 23 times
Out of 23 divisions first 16 are just to conduct air and these divisions of airways are up to terminal bronchioles.
The last 7 divisions are for the exchange of gases and these divisions which are for exchange of gases includes respiratory bronchioles, alveolar ducts and alveoli.
There are 300 million alveoli in the lungs and the alveolar surface form s an area of 70-100 square meters
Common medication used for anesthesia, there action; dosage; adverse effect; duration of action.
They Include {inhalation + Induction + Muscle relaxant + Anticholinergic + Analgesic + Resuscitation}
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When the pituitary Gland it' s function is increased whether the cause are?
Both anterior and Posterior gland secretions are increased the most causes are ADENOMAS
in this presentation you will be learn the different drug form that all medical health workers prescribing the medication.
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Medical equipment and tools are crucial to saving a person's life or performing any procedure.
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This note paper is short notes of general physiology for medical students who which to understand the concept of the physiology, physiology is the mother of medicine.
A summary of skeletal muscle contraction and relaxationAyub Abdi
it consist for 4 pages and cover all the steps that occur during muscle contraction and relaxation, I does not take a time just 5 minute is enough to read. I hope it's interesting.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
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The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
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Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
2. Dr: Ayub Abdulcadir Sheikh:
Postgraduate MBBS, at University of Somalia.
Resident physician at Sureya Medical Center.
A lecturer physiology at Frontier University.
Dedication:
To all my family especially may parents (Allah may bless you), also my student
in frontier university.
3. TABLE OF CONTENTS
1. Introduction to Respiratory system ……………………...……………..…………. 1 - 2
2. Mechanism of Respiration …………………………………………………….…… 3 - 4
3. Lung Volume and capacity changes ………………………………………………...… 5
4. Pulmonary Circulation ……………………………….……………………………...… 6
5. Diffusion of gases across respiratory membrane …….………………………...…..… 7
6. Transport of Gases (O2 & CO2) …………………………………………….…….. 8 - 10
7. Regulation Of Respiration …………………………………………...……….… 11 – 15
8. High altitude, Avian, Space physiology …………………………………...……. 16 - 17
9. Deep Sea Physiology ………………………………………………...…………… 17 - 18
4. Page 1 of 18
The respiratory system starts from the nose and ends to the alveoli
The lungs are contained in a space with a volume of approximately 4 L (~ 6-8L).
The respiratory system dividedinto:
1. Upper respiratory system: includes all
structures from nose to larynx.
2. Lower respiratory system: includes
trachea, bronchi, and lungs.
The Types Of Respiration:
1. External respiration: that involvesexchange of respiratory gases,
i.e. (oxygen and carbon dioxide between lungs and blood).
2. Internal respiration: that involves exchange of gases between
blood and tissues).
3.
The Phases Of Respiration:
1. Inspiration: air enters the lungs
from atmosphere.
2. Expiration: air leaves the lungs.
The Stages Of Respiration:
1. Ventilation stage.
2. Transport stage.
3. Exchange stage.
4. Tissue stage.
The Respiratory zone:
1. Conductive zone: no gas
exchange, but humidified
air and prevent foreign
substance.
2. Respiratory zone: site for
gas exchange.
Respiratory Protective
Reflexes:
1. Cough reflexes.
2. Sneezing reflex.
3. Swallowing reflex.
Autonomic nervous system on bronchial conductive zone:
1. Sympathetic “Adrenergic receptor”: Adrenaline (relaxation and
dilation of smooth muscle cells) – Nor adrenaline (decrease
mucosal secretion).
2. Parasympathetic “Cholinergic Muscarinic receptor”:
Acetylcholine (Contraction and Constriction of smooth muscle
cell) – Acetylcholine (increase mucosal secretion).
Mechanism of Cough Reflexes:
1. Pick up to 2.5 liters of air are rapidly
inspired.
2. The epiglottis closes, and the vocal
cords shut tightly to entrap the air
within the lungs.
3. The abdominal muscles contract
forcefully, pushing against the
diaphragm while other expiratory
muscles, such as the internal
intercostals, also contract
forcefully.
4. The vocal cords and the epiglottis
suddenly open widely, so that air
under this high pressure in the lungs
explodes outward.
4.
5. Page 2 of 18
Pleura layer:
1. Inner Visceral Layer: that attached
firmly to the surface of the lungs.
2. Outer Parietal Layers: that attaches to
the wall of thoracic cavity.
A. Intrapleural Space or Pleural Cavity:
the narrow space in between the two
layers of pleura.
B. Intrapleural Fluid: thin film of serous
fluid, which is secreted by the visceral
layer.
B 1. Serve as lubricant to prevent
friction between two layers of pleura
(during respiration).
B2. Serve creating the negative
pressure called intrapleural pressure
within intrapleural space.
Alveolar Cells or Pneumocytes:
A. Type I alveolar cells: Site of gaseousexchange between the
alveolus and blood.
B. Type II alveolar cells: Secrete alveolar fluid and surfactant.
6. Page 3 of 18
Inspiration & Expiration depends:
A) Changes of these Pressures:
Atmospheric pressure.
1. intrapleural or intrathoracic pressure.
2. Alveolar or intrapulmonary pressure.
3. Transpulmonary pressure.
B) Respiratory Muscles:
1. Primary & accessory inspiratory muscle.
2. Primary & accessory expiratory muscle.
Two recoils of respiratory system:
1. The Lungs recoil.
2. The chest wall recoils.
Three ways to increase lung volume:
1- Anterioposterior diameter.
2- Vertical diameter.
3- Transverse diameter.
Dalton Law: is the sum of all partial pressure of
gasses equal total pressure.
Atmospheric pressure = 760 mmHg or 1 Atm.
Pressure gradient: is movement of gases from
highest pressure to lowest pressure.
Boyle’s law: whenlung volumes increase the
pressure decrease and vice verse.
Pressure
gradient
Atmospheric pressure = 760 mmHg or 1 Atmosphere.
Intrapulmonary or (intra-alveolar) pressure: during
inspiration less than Atmosphere (-1mmHg), during
expiration more than Atmosphere (=1mmHg).
Intrapleural or (intrathoracic) pressure: normally less
than atmosphere (-4mmHg), during inspiration (-7
mmHg), during expiration (-4mmHg).
Transpulmonary pressure: intrapulmonary pressure –
intra-alveolar pressure.
During normal quiet breathing:
Inspiration is the “active process”.
Expiration is the “passive process”.
7. Page 4 of 18
Process of Inspiration (quite or heavy state):
1- Contraction of diaphragm, external intercostals
mus., and accessory muscles leads
2- Increases lung volume & decrease pressure.
3- Then the intra-pleural pressure becomes more
negatively from (-4 mmHg to -7mmHg) and
4- The intrapulmonary pressure also decreases
(760 mmHg - 1 mmHg = 759 mmHg) means less
than atmospheric pressure.
5- Due to these changes the air in the
atmosphere will enter the lungs.
Process of Expiration(quite or heavy state):
1. Relaxation of diaphragm, & contraction of internal
intercostals mus., and accessory muscles leads
2. Decrease lung volume & increase pressure.
3. Then the intra-pleural pressure becomes back to
its normal (-4 mmHg) and
4. The intrapulmonary pressure also increase (760
mmHg +1 mmHg = 760 mmHg) means more than
atmospheric pressure.
5. Due to these changes the air in the lungs will exit
to the atmosphere.
Compliance: is the ability of the lungs and thorax
to expand or it is the expansibility of lungs and
thorax.
A. Static and Dynamic compliance.
B. Old age & emphysema increases lung compliance.
C. Kyphosis, pleural fibrosis, paralysis of respiratory
muscles, pleural effusion all will decrease lung
compliance.
Collapsing Tendency of Lungs:
Factors CausingCollapsing
Tendency of Lungs:
1. Elastic property of lung tissues.
2. Surface tension.
Factors Preventing Collapsing
Tendency of Lungs:
1. Intrapleural pressure.
2. Surfactant.
About Surfactant:
1. Mixture of several
phospholipids, proteins,
and ions.
2. Reduces the surface
tension of water.
3. Defense within the
lungs against infection
and inflammation.
WORK OF BREATHING: Is work done by respiratory
muscles during breathing (inspiration) to
overcome the resistance in thorax and respiratory
tract.
Three types of resistance:
1. Airway resistance.
2. Elastic resistance of lungs and thorax.
3. Non-elastic viscous resistance.
8. Page 5 of 18
DEAD SPACE: is some of the air a person
breathes never reaches the gas exchange areas
but simply fills respiratory passages where gas
exchange does not occur, such as the nose,
pharynx, and trachea. Normal range = 150 mL.
Lung volumes:
1. Tidal volume (TV) = 500ml.
2. Inspiratory reserve (force) volume (IRV) = 1.9 -3.3ml.
3. Expiratory reserve (force) volume (ERV) = 0.7–
1.2ml.
4. Residual volume (RV) = 1.1 -1.2ml.
Factors that affects lung
volume andlung capacities are:
A. Age.
B. Gender.
C. Built.
D. Height.
E. Level of physical training.
RESPIRATORY MINUTE VOLUME:
Also called; Pulmonary ventilation or
minute ventilation.
Is the volume of air breathed in and out
of lungs every minute.
ALVEOLAR VENTILATION:
Is the amount of air utilized for gaseous
exchange every minute.
TYPES OF DEAD SPACE :
1- Anatomical Dead Space:
It includes nose, pharynx, trachea,
bronchi and branches of bronchi up to
terminal bronchioles.
Gaseous exchange does not take place in
these structures.
2- Physiological Dead Space:
Air in the alveoli, which are non-
functioning.
Air in the alveoli, which do not receive
adequate blood flow
These two types of respiratory diseases are determined by
lung functions tests; particularly Force Expiratory Volume
FEV (has great diagnostic value).
1- Restrictive respiratory disease: difficulty in inspiration (FEV-
slightly reduced), but expiration not affected.
2- Obstructive respiratory disease: difficulty inexpiration
(FEV- very much decreased).
9. Page 6 of 18
Lung (pulmonary) vessels:
1- Bronchial artery (High-pressure, low-flow
circulation):
A. Branch of aorta,
B. Less than aortic pressure.
C. Supplies: trachea bronchus, supportive
connective tissue of lung,& outer coat of vessels.
2- Pulmonary artery (low-pressure, high-flow
circulation):
A. 1/3 thickness of that aorta.
B. Large compliance, larger diameters.
C. Carries deoxygenated blood from heart to lungs.
3- Lymphatic vessels:
A. Present in all the supportive tissues of the lung.
B. Empties to right thoracic lymph duct
C. Prevent pulmonary edema.
Physiological shunt: A diversion through which the venous blood is
mixed with arterial blood (1-5% of cardiac output).
The Lungs Serve as a Blood Reservoir.
Cardiac Pathology May Shift Blood From the
Systemic Circulation to the Pulmonary Circulation
Lung zones
Pulmonary edema:
Increases fluid filtration out of
the pulmonary capillaries.
Impedes pulmonary lymphatic
function.
10. Page 7 of 18
Diffusion: is simply the random motion of molecules in all directions through
the respiratory membrane and adjacent fluids.
Respiratory (Pulmonary) Membrane:
1) A layer of fluid containing surfactant.
2) The alveolar epithelium.
3) An epithelial basement membrane.
4) A thin interstitial space.
5) A capillary basement membrane.
6) The capillary endothelial membrane.
7) Blood plasma.
8) Red blood cell membrane.
9) Red blood cell cytoplasm.
10) Hemoglobin.
• For diffusion to occur these factors mast be done:
A. A source of energy provided by the kinetic motion of the molecules.
B. A constant temperature.
“Partial Pressures” of Individual Gases: Is the pressure
of a single type of gas in a mixture of gases.
Henry’s law: is the solubility of gases in a liquid and
depends on:
Solubility.
Temperature.
Factors that affect the rate of gas diffusion
through the respiratory membrane:
1. The thickness of the membrane.
2. The surface area of the membrane.
3. The diffusion coefficient of the gas
4. The partial pressure difference of the gas
between the two sides of the membrane.
Multiple breaths are required to
exchange most of the alveolar air.
11. Page 8 of 18
• Transport of oxygen from alveoli to the tissue:
1. As simple physical solution(3%).
2. In combination with hemoglobin (97%) as Oxyhemoglobin.
Poor solubility of oxygen in water content of plasma as in simple
physical solution.
Oxygen Carrying Capacity of Hemoglobin & Blood:
Each Hb can carry 4 oxygen.
One RBC contains 250 million Hb molecules: 250 X 4 =
1 billion oxygen (one RBC).
1g of Hb combines 1.34ml of Oxygen.
100ml of blood contains 15g of Hb, so
15g X 1.34ml/g = 20 ml of oxygen.
OXYGEN-HEMOGLOBIN DISSOCIATION CURVE:
Hemoglobin’s affinity for oxygen.
Under normal conditions, oxygen-hemoglobin
dissociation curve is ‘S’ shaped or sigmoid shaped.
A. Upper part of the curve indicates the uptake of
oxygen by hemoglobin depending upon partial
pressure of oxygen (shift to left).
B. Lower part of the curve indicates dissociation of
oxygen from hemoglobin (shift to right).
Bohr Effect:
Christian Bohr in 1904.
Is the effect by which presence of carbon
dioxide decreases the affinity of hemoglobin
for oxygen.
Due to continual metabolic activity in the
tissue there is high P co2 and Low P o2 in
tissue.
Oxygen dissociation curve is shifted to right.
12. Page 9 of 18
• Transport of carbon dioxide from tissue to the alveoli:
1. As dissolved form (7%)
2. As carbonic acid(negligible)
3. As bicarbonate (63%)
4. As carbamino compounds (30%).
Carbonic acid is very unstable immediately dissociates into
bicarbonate and hydrogen ions.
CARBON DIOXIDE DISSOCIATION CURVE:
Is the curve that demonstrates the
relationship between the 1) partial pressure
of carbon dioxide and the 2) quantity of
carbon dioxide that combines with blood.
Haldane Effect:
John Scott Haldane in 1860.
Is the effect by which combination of
oxygen with hemoglobin displaces carbon
dioxide from hemoglobin.
Excess of oxygen content in blood & Highly
acidic hemoglobin has low tendency to
combine with carbon dioxide
Carbon dioxide dissociation curve is
shifted to right.
14. Page 11 of 18
Regulation of Respiration:
Nervous or neural
mechanism
Chemical mechanism
Nervous or neural
mechanism
Afferent nerves Respiratory centers Efferent nerves
A. Medullary centers:
1. Dorsal respiratory group of
neurons (DRGN)
2. Ventral respiratory group of
neurons (VRGN)
B. Pontine centers:
3. Apneustic center
4. Pneumotaxic center.
1. Phrenic nerve fibers (C3,
C4, C5), which supply the
diaphragm.
Phrenic nerve: motor,
sensory, sympathetic.
2. Intercostals nerve fibers
(T1 to T11), which supply
the intercostals muscles.
Intercostals nerve: Right
& Left internal
intercostals , Right & Left
external intercostals
1. Peripheral chemoreceptors
and baroreceptors via
branches of glossopharyngeal
and vagus nerves.
2. Stretch receptors of lungs via
vagus nerve.
3. Others
15. Page 12 of 18
A= MEDULLARY CENTERS:
1. Dorsal Respiratory Group of Neurons:
a) Situated in the nucleus of tractus solitarius
(NTS).
b) Inspiratory neurons and generate inspiratory
ramp.
c) During quite breathing (2 second inspiration
followed 3 second expiration).
2. Ventral Respiratory Group of Neurons:
a) Present in nucleus ambiguous and nucleus
retroambiguous.
b) Earlier, expiratory center.
c) Both inspiratory and expiratory neurons.
d) During forced breathing.
B= PONTINE CENTERS:
1. Apneustic Center:
a) Situated in the reticular formation of lower
pons.
b) Increases depth of inspiration.
2. Pneumotaxic Center:
a) Situated in the dorsolateral part
of reticular formation.
b) Neurons of medial parabrachial and
subparabrachial (kölliker-fuse) nuclei.
c) Inhibits the apneustic center, so inspiration
stops and expiration starts.
17. Page 14 of 18
CHEMICAL MECHANISM:
Changesin Chemical Constituents of
Blood which Stimulate Chemoreceptors:
1. Hypoxia (decreased pO2)
2. Hypercapnea (increased pCO2)
3. Increased hydrogen ion concentration.
A) Central Chemoreceptors:
Present in the brain.
Deeper part of medulla oblongata,
close to the (DRGN).
In close contact with blood and
cerebrospinal fluid (CSF).
Sensitive for CO2 , H+
.
B) Peripheral Chemoreceptors:
Carotid and aortic region (glomus cells).
Sensitive for Oxygen.
• Mechanism action OfGLOMUS CELLS:
Decreased PO2 in blood.
Activation of O2 sensor and closure of K
channel.
Entrance of Ca+2
ions and depolarization of
Glomus cell.
Release of neurotransmitter in synaptic cleft
then taking by sensory fiber to respiratory
center.
Peripheral
Chemoreceptors
18. Page 15 of 18
• Mechanism action OfCentral Chemoreceptors:
CO2 enters the extracellular fluid of the brain.
CO2also is permeable across the brain-CSF barrier and enters the CSF.
CO2 is converted to H+ and HCO3−, thus increases in arterial PCO2
produce increases in the PCO2 of CSF, which results in an increase in H+
concentration of CSF (decrease in pH).
The central chemoreceptors are in close proximity to CSF and detect the
decrease in pH. A decrease in pH then signals the inspiratory center to
increase the breathing rate (hyperventilation).
Central
Chemoreceptors
19. Page 16 of 18
High altitude: Is the region of earth located at an altitude of above
8,000 feet from mean sea level.
Partial pressure of gases, particularly oxygen proportionally
decreases.
Carbon dioxide in high altitude is very much negligible and it does
not create any problem.
CHANGES IN THE BODY AT HIGH ALTITUDE:
a) Hypoxia.
b) Expansion of gasesin Alveoli, and Gastrointestinal.
c) Fall in atmospheric temperature (-400
C).
d) Injury from Light rays especially (skin, eye).
MOUNTAIN SICKNESS (Condition characterized by adverse
effects of hypoxia at high altitude) like:
a) Loss of appetite, nausea and vomiting
b) Heart rate and force of contraction of heart increases.
c) Increase pulmonary blood pressure & pulmonary edema.
d) Headache, depression, disorientation, irritability, lack of sleep,
weakness and fatigue (cerebral edema).
ACCLIMATIZATION:
Adaptations or the adjustments by
the body in high altitude despite a
low oxygen tension.
Changes during cclimatization:
RBC count increases and packed
cell volume rises from normal
value of 45% to about 59% (Hb15g-
20g).
Increase in rate and force of heart
contraction & vascularity.
Pulmonary ventilation increases
and pulmonary hypertension.
Elevation both cellular oxidative
enzymes and mitochondria.
does not create any
AVIATION PHYSIOLOGY: Is the study of physiological
responses of the body in aviation environment.
Flyingexerts great effects on the body through accelerative
forces (velocity) and gravitational forces.
GRAVITATIONAL FORCE: Is the major factor that develops
accelerative force.
Increase inG unit is called positive G (acceleration).
Decrease inG unit is called negative G (deceleration).
EFFECTS OF GRAVITATIONAL FORCES ON THE BODY:
Effects of Positive G:
When G unit increases to about 4 to 5 G, blood is pushed toward
the lower parts of the body including abdomen.
Reduced blood supply to the brain and eyes leads:
1. Graying of vision that occurs when blood flow to eyes starts
diminishing.
2. Complete loss of vision.
3. Loss of consciousness.
4. When force increases to about 20 g, bones, particularly the spine,
becomes susceptible for fracture even during sitting posture.
Effects of Negative G:
Negative G develops while flying downwards (inverted flying).
1. The blood is pushed towards head.
2. Blurring of vision and sudden reddening of visual field.
3. Loss of consciousness (it increases the pressure in the blood
vessels of chest and neck).
20. Page 17 of 18
SPACE AND SPACECRAFTS: Is the study of physiological
responses of the body in space and spacecrafts.
Major differences between the environments of earth and space are:
a) Atmosphere.
b) Radiation.
c) Gravity.
Astronauts also wear launch and entry suit (LES: is a pressurized suit)
that protects the body from space environment.
Another factor which affects the body in the space is
WEIGHTLESSNESS due to absence of gravity.
EFFECTS OF WEIGHTLESSNESS IN SPACECRAFT ARE:
1. Accumulation of blood and other fluid in the head and upper trunk,
firstly the heart enlarged and after a while times it become gradually
shrinking and small in size.
2. The kidney compensate the excess fluid in the body by excreted the
fluid and electrolyte, so the person not feel thirst.
3. Space anemia due to decrease both blood volume and RBC.
4. Suppression of immune system in the body.
5. Decrease in muscle mass and muscle strength, also osteoclast
activity increased. Astronauts move by floating instead of using their
legs.
6. Abnormal stimulation of vestibular apparatus and fluid shift causes
space motion sickness - It is characterized by nausea, vomiting,
headache and malaise.
Deep Sea Physiology:
In deepsea or mines, the problem is with high barometric
pressure.
Increased pressure creates two major problems:
1. Compression effect on the body and internal organs.
2. Decrease in volume of gases.
21. Page 18 of 18
NITROGEN NARCOSIS:
As the person going more depth in the sea his may suffer a
condition knowing as nitrogen narcosis which is means
“nitrogen intoxication”.
Nitrogen narcosis is common in deep sea divers, who breathe
compressed air (air under high pressure).
Mechanism of nitrogen narcosis:
Nitrogen is soluble in fat.
Nitrogen escapes from blood vessels and gets dissolved in
neuronal membranes and act like anesthetic agent.
Nitrogen narcosis can be prevented by mixing helium with
oxygen
Nitrogen narcosis may be prevented by limiting the depth of
dives.