Peptic ulcer disease is caused by Helicobacter pylori infection in about 60% of stomach ulcers and 90% of duodenal ulcers. Symptoms include epigastric or retrosternal pain associated with meals. Treatment involves stopping NSAIDs, taking a PPI or H2RB to heal 90% of ulcers, and treating any H. pylori infection with a PPI and antibiotics. Complications include bleeding, perforation, penetration into adjacent organs, and gastric outlet obstruction.