This document describes the development and purpose of PROSPERO, an international database of prospectively registered systematic review protocols. It notes that prospective registration promotes transparency and helps reduce bias. The database was launched in 2011 by the Centre for Reviews and Dissemination and requires authors to register key details about their review such as the objectives, eligibility criteria, and study types. Over 15,000 visitors from 34 countries have utilized PROSPERO, which aims to identify unintended duplication and ensure reviews are based on pre-specified methods.