Presentation summer 2011

Ibrahim khidir ibrahim osman

This document provides an overview of the coagulation system. It begins with an introduction to the coagulation cascade and hemostasis. It then discusses the intrinsic and extrinsic pathways in more detail, focusing on the complexes formed and the factors involved such as tissue factor and thrombin. The document also covers anticoagulation processes mediated by the endothelium like heparan sulfate and protein C. It concludes with explanations of fibrinolysis and the role of vitamin K in carboxylating coagulation factors.

Clotting factors

binipsamuel25

Cascade theory

Raissa Guldam

The cascade theory describes blood coagulation as a series of biochemical reactions that converts soluble fibrinogen into insoluble fibrin clot. It involves the intrinsic and extrinsic pathways that activate coagulation factors in a cascade-like manner, culminating in a common pathway where thrombin converts fibrinogen to fibrin. Feedback mechanisms tightly regulate clot formation to prevent excessive coagulation.

platelets therapy

FREE EDUCATION FOR ALL

Platelets play a key role in hemostasis and thrombosis. They become activated when endothelial cells are damaged, adhering to exposed collagen and releasing substances like ADP and thromboxane A2 that amplify recruitment and activation of additional platelets. Activated platelets undergo conformational changes and secrete procoagulant factors from granules, promoting fibrin formation and stabilization of thrombi. Strong agonists like thrombin and collagen induce intracellular signaling leading to aggregation, while weaker agonists like ADP stimulate secondary pathways. Platelets also release inflammatory mediators that can promote endothelial dysfunction. Antiplatelet drugs inhibit pathways of platelet activation to reduce thrombosis.

Coagulation Cascade

Secondary Haemostasis involves the formation of fibrin clots via the blood coagulation cascade. This involves complex sequential reactions between coagulation factors. The coagulation factors are classified based on their physical properties like molecular weight or functional properties like being substrates, cofactors, or enzymes. Vitamin K plays an important role by allowing coagulation factors to bind to phospholipid surfaces. The coagulation cascade is tightly regulated by naturally occurring inhibitors like antithrombin III and protein C to prevent excessive clotting.

Secondary hemostasis - coagulation cascades and lab tests

harveenbhusari

This document provides an overview of coagulation factors and mechanisms involved in secondary hemostasis. It describes the intrinsic and extrinsic pathways, key coagulation factors such as fibrinogen, prothrombin, thromboplastin, and von Willebrand factor. It also discusses the fibrinolytic system, natural inhibitors of coagulation, and common laboratory tests used to evaluate coagulation, including specimen collection methods.

coagulation system

The coagulation system involves a cascade of enzymatic reactions that ultimately result in fibrin clot formation. The cascade can be initiated through either the intrinsic or extrinsic pathway, both of which involve a series of coagulation factor zymogens being activated into active enzyme forms. This leads to thrombin generation and conversion of fibrinogen into fibrin. A number of processes also act to regulate coagulation and prevent excessive clotting, including antithrombin III, protein C, and fibrinolysis.

Coagulation: In medicine, the clotting of blood. The process by which the blood clots to form solid masses, or clots. More than 30 types of cells and substances in blood affect clotting. The process is initiated by blood platelets. Platelets produce a substance that combines with calcium ions in the blood to form thromboplastin, which in turn converts the protein prothrombin into thrombin in a complex series of reactions. Thrombin, a proteolytic enzyme, converts fibrinogen, a protein substance, into fibrin, an insoluble protein that forms an intricate network of minute threadlike structures called fibrils and causes the blood plasma to gel. The blood cells and plasma are enmeshed in the network of fibrils to form the clot.

Blood Coagulation , ABO blood group & Rh factor

SusmitaShaw3

1) The document summarizes blood coagulation, ABO blood group system, and Rh factor. It describes the process of haemostasis including vascular constriction, platelet plug formation, and blood clotting via the intrinsic and extrinsic pathways. 2) It explains the ABO blood group system which is based on the presence or absence of A and B antigens. The four blood groups are A, B, AB, and O depending on which antigens are present. It also describes the corresponding agglutinins (antibodies) found in each blood group. 3) The genetic inheritance of blood groups is discussed where the A, B, and O genes determine the antigens present. The Rh factor, a

Labman in-IS & BB

Medina College

This document discusses immunology, serology, and blood banking. It provides information on specimen collection and storage, the roles of antigens, immunogens, and antibodies, and various immunological tests including agglutination, lateral flow tests, and blood typing. It also covers blood banking procedures such as blood collection and storage, blood component preparation, and donor selection and deferral criteria. Key aspects of blood grouping and crossmatching are explained.

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Physiologyof Coagulation

Flavio Guzmán

The document summarizes the physiology of blood coagulation, including the five main components (vessels, platelets, coagulation factors, inhibitors, fibrinolysis) and how they work together in a complex system. It describes platelet activation and aggregation to form a platelet plug, coagulation factors that amplify to form a fibrin mesh to strengthen the clot, and fibrinolysis to prevent excessive clotting and allow blood to flow again. A balance is needed between coagulation and anticoagulation/fibrinolysis to control clotting.

update on blood product alternatives

This document discusses the treatment of anemia and the need for red blood cell substitutes. It begins by outlining the reasons to treat anemia and discusses the mortality risk of anemia versus the morbidity of red blood cell transfusions. Current possibilities for red blood cell substitutes are then summarized, including hemoglobin-based oxygen carriers (HBOCs) such as Hemopure, Polyheme, and Sanguinate. Toxicities of HBOCs like vasoconstriction and nitric oxide depletion are also noted. The document concludes by discussing protocols for managing severe anemia in the interim before fully developed red blood cell substitutes, and the potential of in vitro production of red blood cells as a future option.

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Factor Viii Hemophilia

faysalahmed35

Cell based model of coagulation

Arjuna Samaranayaka

This document summarizes the cell-based model of coagulation. It describes coagulation as occurring in three overlapping phases: initiation, amplification, and propagation. In initiation, tissue factor activates factors VII and X. Amplification involves platelet activation and formation of complexes that generate a burst of thrombin. Propagation uses this thrombin to rapidly form a stable fibrin plug through fibrin and factor XIII. Control mechanisms like TFPI and natural anticoagulants prevent excess coagulation. Deficiencies help understand the model, as factor VII deficiency causes bleeding despite an intact intrinsic pathway, implicating its role in initiation.

Heart & Circulation

raj kumar

The circulatory system transports blood throughout the body to deliver oxygen and nutrients to tissues and remove waste. It has three main functions: transportation, regulation, and protection. The circulatory system consists of the heart, blood vessels, and blood. The heart pumps blood through a closed system of arteries, capillaries and veins. Blood is composed of plasma and formed elements including red blood cells, white blood cells and platelets.

Blood component therapy and blood substitutes

Himanshu Jangid

This document summarizes different types of blood products and transfusions. It discusses whole blood and its shelf life of 35 days when stored with CPDA-1. It also describes the production and storage of blood components like packed red blood cells, platelet concentrates, granulocytes and plasma derivatives. Key elements covered are donor screening, testing, storage conditions and guidelines for transfusion thresholds.

Blood transfusion in pediatrics part1

Pramod Sarwa

BLOOD TRANSFUSION

Anusree k

This document provides a summary of the history and process of blood transfusion from the 15th century to present day. It describes key historical figures and advances such as the discovery of blood groups by Landsteiner in 1901. The document outlines donor criteria, components of blood like red blood cells, plasma, platelets, and derivatives. It discusses transfusion indications, testing, and potential immune and non-immune mediated transfusion reactions.

5thsembloodtransfusion

Tanuj Bhatia

1. Blood transfusions can be indicated for both elective and emergency situations such as anemia, hemorrhage, surgery, and trauma. 2. The ABO and Rh blood group systems are the most important to screen for due to the risk of hemolytic transfusion reactions from naturally occurring antibodies. 3. Whole blood can be stored for 35 days while components like packed red blood cells and platelets have shorter storage times and are preferred to minimize changes during storage.

Blood

Pawan Kumar Sahu

Maha Reddy

Blood coagulation, also known as hemostasis, is the process by which blood changes from a liquid to a solid gel-like substance. It involves three stages: vasoconstriction, formation of a platelet plug, and coagulation of blood. When a blood vessel is injured, a series of reactions are initiated through the intrinsic and extrinsic pathways, ultimately resulting in a cross-linked fibrin mesh that traps blood cells to form a clot. Coagulation is tightly regulated by several mechanisms to prevent excessive clotting. Deficiencies or defects in the coagulation cascade can result in bleeding disorders.

Fibrinolysis

Muhammad Helmi

This document discusses the processes of hemostasis, thrombosis, and fibrinolysis. It defines key terms like blood clot, platelet, fibrin, coagulation cascade, and anticoagulants. The document describes the steps of primary hemostasis which involves platelet adhesion and activation at the site of injury. It also outlines the secondary hemostasis process known as the coagulation cascade that generates thrombin and ultimately forms a fibrin clot to stop bleeding. The roles of fibrinolysis and anticoagulant pathways in regulating clot formation are also summarized.

Blood component preparation

SUNIL KUMAR PEDDANA

Blood can be separated into components to meet most transfusion needs while minimizing risks. Effective separation requires centrifugation based on differences in specific gravity of components. Common components prepared include packed red blood cells, platelet concentrates, fresh frozen plasma, and granulocyte concentrates. Preparation of blood components allows for optimal use of donated blood by providing only the required constituent to the patient in need.

Lymphatic System

000 07

The lymphatic system collects fluid that leaks from blood vessels into tissues and returns it to the circulatory system. Lymph vessels carry this fluid through lymph nodes, which filter the fluid and produce white blood cells, before returning it to the circulatory system via veins near the collarbone. Blood transports nutrients, oxygen, waste products, and more throughout the body. It is composed of plasma and blood cells including red blood cells, white blood cells, and platelets, each with distinct functions like oxygen transport, waste removal, and clotting. A person's blood type is determined by antigens on red blood cells, and the Rh factor is another important antigen that can cause complications during pregnancy if mother and child are incompatible.

Basciano platelets fellows 2013

This document discusses platelet function and disorders. It begins by describing platelet production, structure, and the key roles of platelets in hemostasis and thrombosis. It then examines the processes of platelet activation and aggregation. The document reviews methods to assess platelet function including bleeding time, aggregometry, and thromboelastography. It details several inherited disorders of platelet function like Bernard-Soulier syndrome and Glanzmann thrombasthenia. Finally, it covers acquired platelet dysfunctions from medications and treatments for platelet disorders.

Timelin present day timeline ppt dr. carr

This document discusses several books and concepts related to organizational leadership and structure in education. It summarizes Jim Collins' book "Good to Great" which identifies leadership styles of humility and discipline. It also discusses the importance of professional learning communities that allow teachers to collaborate. Additionally, it outlines John Maxwell's "21 Irrefutable Laws of Leadership" and the key rules around building relationships and developing future leaders. Finally, Edie Holcomb's book "Asking the Right Questions" is mentioned, focusing on implementing change through strategic planning.

Declaring independence

The colonists achieved their goal of independence from Great Britain through several key events: the First Continental Congress organized militias in response to the crisis, the battles of Lexington and Concord marked the beginning of the Revolutionary War, and the Second Continental Congress appointed George Washington as commander and declared that war with Britain was necessary. Thomas Paine's influential pamphlet "Common Sense" encouraged declaring independence, and the Declaration of Independence was finally signed on July 4, 1776.

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Lecture 2, fall 2014 pdf

Shabab Ali

Blood Coagulation , ABO blood group & Rh factor

SusmitaShaw3

Labman in-IS & BB

Medina College

Erythropoietin- Kokate

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Physiologyof Coagulation

Flavio Guzmán

update on blood product alternatives

6.shockblood transfusion)

nazimjat

Factor Viii Hemophilia

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Cell based model of coagulation

Arjuna Samaranayaka

Heart & Circulation

raj kumar

Blood component therapy and blood substitutes

Himanshu Jangid

Blood transfusion in pediatrics part1

Pramod Sarwa

BLOOD TRANSFUSION

Anusree k

5thsembloodtransfusion

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Fibrinolysis

Blood component preparation

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Lecture 2, fall 2014 pdf

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Factor Viii Hemophilia

Cell based model of coagulation

Heart & Circulation

Blood component therapy and blood substitutes

Blood transfusion in pediatrics part1

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Blood

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Lymphatic System

Basciano platelets fellows 2013

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RC Vasco da gama - TRF

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This document provides information about packaged grants available through The Rotary Foundation's Future Vision Plan. It discusses strategic partnerships that have been established with organizations like Aga Khan University, Mercy Ships, Oikocredit, and UNESCO-IHE to fund pre-designed global grant projects in areas like health, education, economic development, and water/sanitation. It provides details on applying for two packaged grant opportunities - one through Oikocredit to develop local entrepreneurs, and one for scholarships through the UNESCO-IHE partnership. Clubs must submit proposals for packaged grants that are reviewed on a first-come, first-served basis.

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Space decoder-v3 preassessment game

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Chapter 9 the progressive era

Progressive era reformers in the early 20th century sought to address social problems through four main goals: protecting social welfare, promoting moral improvement, creating economic reform, and fostering efficiency. Reform efforts included regulating working conditions, limiting child labor, securing worker's compensation, and directly electing U.S. senators to make government more responsive to citizens. Journalists known as "muckrakers" also exposed corruption in big business to promote reform.

The revolution begins

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The document summarizes the economic development of the post-Civil War New South from the late 1800s to early 1900s. It describes the growth of industries like textiles, coal, steel production in Birmingham, and tobacco in Durham, North Carolina. It also discusses the rise of sharecropping and tenant farming, as well as the emergence of Jim Crow laws that enforced racial segregation and disenfranchisement of African Americans in the Southern states in this period.

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The rise of african age of reform

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