This document provides a summary of the history and process of blood transfusion from the 15th century to present day. It describes key historical figures and advances such as the discovery of blood groups by Landsteiner in 1901. The document outlines donor criteria, components of blood like red blood cells, plasma, platelets, and derivatives. It discusses transfusion indications, testing, and potential immune and non-immune mediated transfusion reactions.
It consists of slides about blood, various blood groups , pre-transfusion testing , blood products , conditions where blood transfusion is indicated and the various complications of blood transfusion in the field of oral and maxillofacial surgery.
Blood transfusion - components , procedure , pre transfusion testing and comp...prasanna lakshmi sangineni
blod transfusion- introduction , procedure , pre transfusion tests , complications , characteristics of components and components usually used like packed red cells, FFP, platelet rich plasma, cryoprecipitate, albumin and other plasma derivatives
It consists of slides about blood, various blood groups , pre-transfusion testing , blood products , conditions where blood transfusion is indicated and the various complications of blood transfusion in the field of oral and maxillofacial surgery.
Blood transfusion - components , procedure , pre transfusion testing and comp...prasanna lakshmi sangineni
blod transfusion- introduction , procedure , pre transfusion tests , complications , characteristics of components and components usually used like packed red cells, FFP, platelet rich plasma, cryoprecipitate, albumin and other plasma derivatives
most controversial topic in the field of transfusion medicine, most of the transfusions worldwide are associated with the deleterious effects of immunomodulation, simplified for PG students with latest article support
A PowerPoint presentation outlining the physiology of blood transfusion, and clinical precautions to take in preventing and managing blood transfusion reactions.
Guidelines on massive blood transfusion(lecture-6)charithwg
it is a very short guideline about massive transfusion. please further read about complications about blood transfusions. and all the recommended reading are mentioned in the last slide. please read.
Autologous Blood Transfusion (ABT) means reinfusion of blood or blood products taken from the same patient
ABT is not a new concept, fear of transfusion- transmitted diseases stimulated the growth of autologous programme
Delayed blood transfusion reaction is a reaction too blood transfusion occurring after 24 hours. Can be divided to immune mediated and non-immune mediated. Share about the cause, symptoms, investigations and management.
most controversial topic in the field of transfusion medicine, most of the transfusions worldwide are associated with the deleterious effects of immunomodulation, simplified for PG students with latest article support
A PowerPoint presentation outlining the physiology of blood transfusion, and clinical precautions to take in preventing and managing blood transfusion reactions.
Guidelines on massive blood transfusion(lecture-6)charithwg
it is a very short guideline about massive transfusion. please further read about complications about blood transfusions. and all the recommended reading are mentioned in the last slide. please read.
Autologous Blood Transfusion (ABT) means reinfusion of blood or blood products taken from the same patient
ABT is not a new concept, fear of transfusion- transmitted diseases stimulated the growth of autologous programme
Delayed blood transfusion reaction is a reaction too blood transfusion occurring after 24 hours. Can be divided to immune mediated and non-immune mediated. Share about the cause, symptoms, investigations and management.
dr m laban
Tanta fever hospital scientific activity
sunday
12-8-2018
Blood transfusion
Aims of Transfusion Center
To care for the donor - ensure act of donation does not harm donor.
Provision of Blood of the best possible quality and safety for the patient receiving it.
Safe blood transfusion means:
Compatible and without transmission of infection
The Safest blood transfusion is No
transfusion
Blood donation
Careful donor selection with donor interview.
Age: not less than 17 years.
Pulse: between 50-100 beat / minute without irregularities.
Blood pressure: systole<180mmHg, diastolic <100mmHg.
Temperature: <37.5C
Hemoglobin:>12g/dl, Hct>38%
Site of vein puncture must be free of lesions and infections.
ABO grouping.
Rh typing.
Cross matching
Laboratory screening test for:-
HBsAg.
HCV Ab.
HIV.
HTLV1.
HTLV2.
Blood grouping means:-
the determination of the antigens of a specific group on the red cells
and the antibodies relevant to this group in the normal serum.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
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disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
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from mild to severe. A diagnosis of AUD requires that at least two of
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AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
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This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
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Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
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Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
19. WHOLE BLOOD
PLASMA CELLS
VOLUME EXPANSION OXYGEN CARRYING CAPACITY
ACUTE HAEMORRHAGE
>/=25%
4 DEGREE CELSIUS
DECREASE IN 2,3-BISPHOSPHOGLYCERATE
INCREASE AFFINITY FOR OXYGEN
DECREASE CAPACITY TO DELIVER OXYGEN
20. UNIVERSAL PRE -STORAGE LEUKOCYTE REDUCTION
CYTOKINES ARE GENERATED IN STORED PRODUCT
PRE STORAGE FILTERATION IS SUPERIOR TO BED SIDE
FILTRATION
<5X1000000 DONOR WBC
REDUCES
POST TRANSFUSION FEVER
CMV INFECTIONS
ALLOIMMUNIZATION
22. SPUN DOWN AND CONCENTRATED
1UNIT=330ml
HAEMATOCRIT= 50-70%
Hb=2g/dL
STORAGE:SALINE –ADENINE-GLUCOSE- MANNITOL
STORAGE: 2-8 DEGREE CELSIUS
SHELF LIFE: 42 DAYS
OLDER:CPD(CITRATE-PHOSPHATE-DEXTROSE-SOLLUTION)
SHELF LIFE:35 DAYS
23. PLATELET
REDUCES INCIDENCE OF BLEEDING
THRESHOLD FOR PROPHYLACTIC TRANSFUSION – 10,000/MICRO L
WITHOUT FEVER/INFECTION – 5000/MICRO L
INVASIVE PROCEDURES – 50,000/MICRO L
2 UNIT RD/ SQUARE METER OF BODY SURFACE AREA - 10,000/MICRO L
25. REFRACTORINESS TO PLATELET TRANSFUSION - ALLONIMMUNIZATION
CORRECTED COUNT INCREMENT
CCI
POST TRANSFUSION COUNT PRE TRANSFUSION COUNT
NO. OF PLATELETS TRANSFUSED X 10^-11
BSA
X=
26. FRESH FROZEN PLASMA
RICH IN COAGULATION FACTORS
150-300ml plasma from one donation of whole blood
PLASMA PROTEINS-
FIBRINOGEN,ANTITHROMBIN,ALBUMIN,PROTEINS C AND S
REMOVED FROM FRESH BLOOD AND STORED AT -40 TO -50
DEGREE CELCIUS
2 YEAR SHELF LIFE
FIRST LINE THERAPY FOR TREATMENT OF COAGULOPATHIC
HAEMORRHAGE
27. CORECTION OF COAGULOPATHIES
REVERSAL OF WARFARIN
SUPPLYING DEFICIENT PLASMA PROTEINS
TREATMENT OF THROMBOTIC THROMBOCYTOPENIC
PURPURA
ACELLULAR-DOES NOT TRANSMIT INTRACELLULAR INFECTIONS
29. SUPERNATENT PRECIPITATE OF FFP
PRODUCED BY CONTROLLED THAWING
RICH IN FACTOR VIII,FIBRINOGEN,VWF
POLED UNITS(10 DONATIONS)-RAISE FIBRINOGEN BY 1g/L
STORAGE: -30 DEGREE CELSIUS
2 YEAR SHELF LIFE
INDICATION
ANY FACTOR DEFICIENCY
VWD
HAEMOPHILIA
30. BLOOD COLD CHAIN
DONATED WHOLE BLOOD OR PLASMA
TRANSPORT BOX AT +20 TO +24 FOR MAX.6hrs
PREPARATION OF COMPONENT RED CELL PLASMA PLATELET
QUARANTINE STORAGE BLOOD REFRIDGERATOR
+2 TO +6
BLOOD REFRIDGERATOR
+2 TO +6
PLASMA FREEZER
-30 OR LOWER
PLASMA FREEZER
-30 OR LOWER
PLATELET AGITATOR
+20 TO +24
PLATELET AGITATOR
+20 TO +24
TRANSPORT BOX
+2 TO + 10
TRANSPORT BOX
LESS THAN -20
TRANSPORT BOX
+20 TO +24
STOCK STORAGE
HOSPITAL BLOOD BANK
BLOOD RECIPIENT(PATIENT)
32. BLOOD PRODUCTS
WHOLE BLOOD/PRBC
PLATELET CONCENTRATE
FFP
CRYOPRECIPITATE
START INFUSION
WITHIN 30 MIN OF REMOVING
FROM REFRIDGERATOR
IMMEDIATELY
AS SOON AS POSSIBLE
AS SOON AS POSSIBLE
COMPLETE TRANSFUSION
</=4hrs
WITHIN 30 MINUTES
WITHIN 30 MINUTES
WITHIN 30 MINUTES
DURATION TIMES FOR TRANSFUSION
39. FEBRILE NON HAEMOLYTIC
TRANSFUSION REACTION
Ab to
LEUKOCYTE
HLA ANTIGEN
MULTIPLE TRANSFUSIONS
MULTIPAROUS WOMEN
NON LEUKODEPLETED
BLOOD
LEUCODEPLETED BLOOD
LEUKOREDUCTION BEFORE STORAGE
41. ANAPHYLACTIC REACTIONS
DIFFICULTY IN BREATHING
COUGHING
NAUSEA
VSSOMITING
HYPOTENSION
BRONCHOSPASM
LOSS OF CONSCIOUSNESS
RESPIRATORY ARREST
SHOCK
STOPPING THE TRANSFUSION
MAINTAINING VASCULAR ACCESS
ADMINISTERING EPINEPHRINE
42. GRAFT VERSUS HOST REACTION
T
CELL HLA
D R
+
MARROW
APLASIA
PANCYTOPENIA
43. FETUS-INTRA UTERINE TRANSFER
IMMUNOCOMPETENT INDIVIDUAL
IMMUNO COMPROMISED STATE
BLOOD RELATIVES
H/O MARROW TRANSPLANTATION
IRRADIATION OF CELLULAR COMPONENTS
(MIN 2500cGY) BEFORE TRANSFUSION
44. TRANSFUSION RELATED ACUTE LUNG INJURY
HYPOXIA
CHEST X-RAY- BILATERAL INTERSTITIAL INFILTRATES: During or within 6 hours
of transfusion
HLA CLASS II Ab Vs RECIPIENT LEUKOCYTES
AGGREGATION OF LEUKOCYTES IN PUL VASCULATURE
MEDIATORS
INCREASE CAPILLARY PERMEABILITY