This document discusses the physiological and biochemical basis of hyperbilirubinemia or jaundice. It covers the etiology, pathophysiology including prehepatic, hepatic and posthepatic phases, epidemiology, classification, symptoms, evaluation and treatment of hyperbilirubinemia. The pathophysiology section describes the metabolic pathway of bilirubin from heme degradation to conjugation and excretion. Evaluation involves tests to determine if the cause is hepatocellular or cholestatic. Treatment focuses on addressing the underlying disease causing jaundice.