A 3-day-old female child presented with abdominal distension and inability to pass meconium. Examination revealed a normal anal opening but resistance to passage of a feeding tube beyond 2 cm. An invertogram showed rectal atresia. Endoscopy visualized a distal rectal membrane, which was incised. A fistulogram then revealed a fistula between the upper anal canal and the labia. Key points discussed include techniques for evaluating anorectal malformations like invertograms and classifications of ARM like the Wingspread and PENA systems. Relationship between sacral development and pelvic floor muscle function is also summarized.
A presentation about Intravenous Urography (Also known as Intravenous Pyeography).
The presentation contains 41 slides, and is divided into 4 parts :
1 - Introduction.
2 - The procedure.
3 - Examples for abnormal findings.
4 - Studies comparing IVU accuracy with KUB & USG with CT Scan.
This presentation was prepared and presented by me in the tutorials of the Radiology Department of Sebha Medical Center.
A presentation about Intravenous Urography (Also known as Intravenous Pyeography).
The presentation contains 41 slides, and is divided into 4 parts :
1 - Introduction.
2 - The procedure.
3 - Examples for abnormal findings.
4 - Studies comparing IVU accuracy with KUB & USG with CT Scan.
This presentation was prepared and presented by me in the tutorials of the Radiology Department of Sebha Medical Center.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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2 Case Reports of Gastric Ultrasound
2. • Invertography was first described by Wangensteen
and Rice in 1930.
• Stephens described PC line by dissection of 25
stillborn pelvis in documenting the attachment of
the levator ani to the pelvic wall both
macroscopically and radiologically, with opaque
wires marking the attachment of the levator ani
3. Technique
• Six to eight hours after the birth, a newborn baby
with ARM should be held upside down for at least 3
minutes
• strict lateral view (in this upside down position) is
taken with the thighs of the baby flexed at hip, and
beam accurately centered on the greater
trochanter.
• Anal dimple and the natal cleft should be outlined
by barium paste , Coin, metal pointer
4.
5. • In a correctly taken radiograph:
(i) both the ischial bones would accurately
superimpose
(ii) the terminal blind bowel will be rounded and well-
distended.
Interpretation of an invertogram should be attempted
only, if both these features are present otherwise it
may be fallacious.
6. • During the reading of an invertogram, besides
evaluating the level of bowel gas
• 1. Spine- Congenital anomalies of the spine are
common.
• 2. Presence of gas in the region of urinary bladder
and vagina, which would indicate an underlying
fistula.
7. • Basic purpose of invertography is to identify the
relationship of the gas bubble in the blind pouch to
the bony pelvis, which in turn indicates the relation
to the levator ani muscle complex.
• By using three lines, a concept which was first put
forward by Stephens and Smith (1971)
8. THE THREE LINES ARE:
(i) PC(pubococcygeal) line
(ii) the I (ischial) line or I point
(iii) the anal pit line .
• A gas bubble situated above the PC line is
designated “high” anomaly.
• one located between the PC and I line or point
“Intermediate” anomaly.
• if it extends below the I line (point), then it is called
“low” anomaly .
9. • PC line stretches from the upper border of the
symphysis pubis to the sacrococcygeal junction.
• At the symphyseal end this line is taken as the
center of the “boomerang” shape of the os pubis,
which corresponds with the upper border of the
symphysis.
• The top of the “boomerang” corresponds with the
superior pubic ramus. Ossification of the pubis
begins in the second fetal month and extends along
the superior pubic ramus medially to the body.
13. • The ischial line (I line) and I point are related to the
ossification center of the ischium, which is a comma
shape in the neonate.
• The I point is demarcated on the x-rays at the
inferior end of the ischial comma.
• The I line is drawn through the I point parallel to the
PC line and corresponds to the upper surface of the
bulb of the urethra in the male and the upper limit
of perineal body and the level of the triangular
ligament in the female. The anal pit is normally 1–2
cm caudal to the ossified ischium.
16. • Cremin (1971) did not find PC line very accurate.
• They proposed a “M line” or “M point”, which is
located at the junction of upper two-third and
lower one-third of the ischium .
• Anomalies are then divided into “high” and “low”
types with no intermediate category.
17.
18. Potential Pitfalls Of This Technique In
Order To Avoid Misdiagnosis.
• 1. Insufficient time for the gas to reach the terminal
bowel.
• 2. Meconium blocking the terminal segment.
• 3. In a crying child, puborectalis sling may move
significantly up or down giving erroneous results.
• 4. Gas may escape through a fistula.
• 5. Improper technique—in positioning, centering or
marker placement.
19. NEWER MODIFICATIONS
• 1. Prone cross table lateral view (Narasimharao et
al, 1983).
• 2. CT invertography (Leighton and de Campo, 1989 )
20. • An upside-down inversion x-ray is no longer
performed, having been replaced by a prone, cross-
table lateral examination of the pelvis, with the hips
elevated over a bolster .
• The prone cross-lateral view’ has few advantages
like the baby is comfortable, whereas in
invertogram requires splints and adhesive tapes and
the baby keeps crying due to which puborectalis
sling contracts and hence there is deceptive
obliteration of the lower rectum.
21. • The prone, cross-table lateral x-ray should be delayed
for 12–24 h after birth to allow gas to reach the distal
rectum.
• The baby should be placed in the genupectoral position
for 3 min before taking the film to allow gas to displace
meconium and rise to the termination of the pouch.
• Barium paste or contrast-soaked gauze placed in the
natal cleft is more accurate than a metal marker.
• A catheter may be placed in the urethra to make
delineation of the urethra more obvious, although this
is not essential.
• The greater trochanter should be marked with a marker
pen on the upper thigh and the x-ray beam centered on
this spot.
22.
23.
24. Common causes for erroneous interpretation of prone, cross-table lateral x-ray
include:
1. Insufficient time for gas to reach the terminal bowel.
2. Meconium plug in the terminal gut may produce an erroneously high shadow if the
gas does not displace the meconium.
3. Active contraction of the levator ani/sphincter muscle complex can push the gas
shadow higher.
4. Gas escape through A fistula may confuse the xray.
5. Distortion by x-ray magnification resulting in the appearance of A longer gap
between the gas within the terminal colon and skin.
6. Inappropriate placement of an anal marker may cause an error of assessment of
the exact site of the anus on the skin.
7. Erroneous estimation of level of the lesion inside the sphincter muscle complex
may occur if the pelvic floor muscles are relaxed, or if there is A sacral anomaly.
8. Gas in the vagina may be mistaken for gas in the distal bowel.
25. Ultrasonic examination
• Ultrasonographic examination has been used to know
the pouch perineal distance.
• It can be performed through a transperineal or
infracoccygeal route.
• Infracoccygeal route can directly demonstrate the
puborectalis as a hypoechoic U-shaped band.
•
• The noninvasive nature and no radiation exposure are
the main advantages, but it is highly observer
dependent.
26. Computer tomography and magnetic
resonance imaging
• Computer tomography (CT) and magnetic
resonance imaging (MRI) of pelvis have been
utilized for the direct visualization of the sphincteric
muscles.
• These have been used for the structural evaluation
of pelvic floor muscle and relation to the pouch, for
both the pre- and post-operative evaluation.
• The exact location of fistula and relation to the
pelvic floor muscle provides crucial information
regarding the approach, whether a sagittal
approach or an approach through abdominal route
is required.
27. • MRI and CT can be utilized for the assessment of
structural development following different
procedures for ARM
• MRI is considered superior to CT scan --
excellent soft tissue characterization, multiplanar
imaging, and lack of ionizing radiation
44. • A three-day-old female child was admitted with a
history of not passing meconium since birth.
• On examination, abdomen was distended. Careful
examination revealed normally placed anal opening,
with normal fourchette and small fistulous opening in
the lower third of left labia majora.
• There was no meconium or any type of discharge from
the opening. The anal opening was calibrated with
number 8 infant feeding tube and a resistance was
observed at about 2 cm from the anal opening.
• X-Ray (invertogram along with feeding tube in situ ) was
suggestive of membranous rectal atresia.
• The membrane was perforated blindly by using Hegar's
dilator following which meconium was coming from the
fistulous opening. Fistulogram revealed fistula between
upper anal canal and the labia.
45.
46.
47. Journal of Minimal Access Surgery, Vol.
6, No. 4, October-December, 2010, pp.
114-115• A 3-day-old female child, (full-term, normal delivery) weighing 2.75 kg at
birth with stable vitals, moderate abdominal distension and history of not
being able to pass meconium was referred to us.
• Examination showed normal anal opening but red rubber catheter could
not be passed beyond 3 cm of anal verge. Spine and external genitalia were
normal. X-ray (invertogram with red rubber catheter passed through anal
opening) showed catheter abutting the air column in the bowel)
• An endoscopy was done with a 7.5F cystoscope. About 3 cm from the anal
verge, the anal canal ended blindly and a membrane was visualized at the
blind end. We incised the outer mucosal membrane, i.e. of the distal pouch
with a bugbee, but the vision was lost due to technical reasons. Then anal
retractors were used, and after the incision on the mucosa of the distal
pouch, the inner mucosal membrane was seen bulging significantly due to
meconium within it.
• Transanal membranotomy was done.
48.
49. RECTAL-TAIL SIGN
Invertogram in a
case of ARM with
intact bowel.
Air-filled rectum is
seen as a tail-like
projection into the
pelvic brim
50. Relationship of Sacral Development and
Levator Muscle Development
i. If sacrum is normal then muscle mass and innervation are
also normal;
ii. If S4, S5 are absent then muscle and innervation are usually
still normal;
iii. If S3–S5 are absent then there is variable degree of deficiency
of the muscle mass, and patient is usually incontinent;
iv. If S1–S5 are absent then muscles are markedly hypo-plastic,
and all the patients are incontinent.
• Good indicator of development of the sacrum is by plain
radiographs also but MRI IS GOLD STANDARD
51. • A sacral defect, particularly hemisacrum, in association
with imperforate anus and a presacral mass is known as
the Currarino triad and has a strong familial tendency..
• The sacral ratio is a valuable prognostic tool because it
quantifies the degree of sacral hypodevelopment.
• Patients with ratios less than 0.4 are universally
incontinent.
• Ratios that approach 1.0 usually predict a good
prognosis