This document provides definitions and explanations of key terms and metrics used in interpreting polysomnography tests. It describes signs and symptoms that indicate the need for a polysomnogram and defines measurements of sleep periods, stages, efficiency, and latency. It also defines the various types of respiratory events that can be observed, such as apneas, hypopneas, and arousals, and how they are calculated and classified. Finally, it outlines the process for reviewing sleep study results and making a diagnosis.
What are the main sleeping disorders and what are the sleeping disorders related to respiratory system ? how to deal with it and how to diagnose and treat?
Brief explanation about all the essential parameters monitoring during polysomnography or sleep study with corresponding images for better understanding.Also explain briefly about the split night study.I hope this may be helpful for those who are related to this field.
What are the main sleeping disorders and what are the sleeping disorders related to respiratory system ? how to deal with it and how to diagnose and treat?
Brief explanation about all the essential parameters monitoring during polysomnography or sleep study with corresponding images for better understanding.Also explain briefly about the split night study.I hope this may be helpful for those who are related to this field.
OSA is an entity that is increasingly being managed by otolaryngologists...Hope this presentation helps to clear any doubts regarding its diagnosis and management!
ECochG is a variant of brainstem audio evoked response (ABR) where the recording electrode is placed as close as practical to the cochlea. We will use the abbreviation ECOG and ECochG interchangeably below. ECOG is preferable to us as it is shorter.
ECOG is intended to diagnose Meniere's disease, and particular, hydrops (swelling of the inner ear). ECOG may also be abnormal in perilymph fistula, and in superior canal dehiscence. The common feature connecting these illnesses is an imbalance in pressure between the endolymphatic and perilymphatic compartment of the inner ear.
ECOG can also be used to show that the cochlea is normal, in persons who are deaf. The cochlear microphonic of ECOG may be normal in auditory neuropathy (Santarelli and Arslan 2002) as well as other disorders in which the cochlea is preserved but the auditory nerve is damaged (Yokoyama, Nishida et al. 1999).
Finally, ECOG's have also been used to as a indicator of the temporary threshold shift that may follow noise injury (Nam et al, 2004).
OSA is an entity that is increasingly being managed by otolaryngologists...Hope this presentation helps to clear any doubts regarding its diagnosis and management!
ECochG is a variant of brainstem audio evoked response (ABR) where the recording electrode is placed as close as practical to the cochlea. We will use the abbreviation ECOG and ECochG interchangeably below. ECOG is preferable to us as it is shorter.
ECOG is intended to diagnose Meniere's disease, and particular, hydrops (swelling of the inner ear). ECOG may also be abnormal in perilymph fistula, and in superior canal dehiscence. The common feature connecting these illnesses is an imbalance in pressure between the endolymphatic and perilymphatic compartment of the inner ear.
ECOG can also be used to show that the cochlea is normal, in persons who are deaf. The cochlear microphonic of ECOG may be normal in auditory neuropathy (Santarelli and Arslan 2002) as well as other disorders in which the cochlea is preserved but the auditory nerve is damaged (Yokoyama, Nishida et al. 1999).
Finally, ECOG's have also been used to as a indicator of the temporary threshold shift that may follow noise injury (Nam et al, 2004).
Analysis on parameters affecting sleep apnea & control measures using low...eSAT Journals
Abstract Sleep apnea is a potentially serious sleep disorder in which breathing repeatedly stops and starts for at least ten seconds. Apnea may occur 5 to 30 times or more in patients during sleep. Sleep apnea is diagnosed with an overnight sleep test called a polysomnogram, or "sleep study". More than eighteen million Americans suffer from sleep apnea (ASAA), and it is estimated conservatively that ten million remain undiagnosed. There are many ways to control sleep apnea i.e., through respiratory devices (CPAP, Bi-PAP), surgery on mouth and throat, Oral Appliance Therapy (OAT) etc. These respiratory devices are not self controlled which disturbs the patients sleep and should be turn ON throughout the night continuously In this Research, the objective is to develop a Bi-PAP device (Automatic Bi-level Positive Airway Pressure machine) for the purpose of detection and controlling of sleep apnea disease using Atmel 89c51 Microcontroller programming. Here, a new methodology is followed to detect the sleep apnea condition in a patient by using active Infrared source and Infrared detector. The program is specifically to control the functioning of the Bi-PAP and is shown to be effective at responding to a patient’s breathing cycle. Central sleep apnea can also be detected and alarmed such that this ability could prove critic during emergency situations. In particular, the current Bi-PAP machine operates depending up on the patient’s necessity for positive air pressure. Therefore the BiPAP acting time on a patient can be reduced and hence, BiPAP side effects can be minimized. A Humidifier is also engaged along with saturated oxygen line to clear patients’ airway. Based on the results, the Automatic BiPAP system is shown to be more effective at responding sleep apnea condition by giving alarm signal. It is economically good and maintenance free. Exclusively, in this system Apneas both in infants and adults are detected by the adjustable sensing time. Current design acts positively on demerits of existing methodologies. The system has been validated on a single live subject in the Sleep Research Laboratory. Finally, it is found that this fully functional Bi-PAP is compatible for both home & hospital usage. Development of this device in several aspects will be a great achievement.
Analysis on parameters affecting sleep apnea & control measures using low cos...eSAT Publishing House
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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2. Signs and Symptoms
The signs and symptoms(EDS associated
with fatigue or impaired concentration
,unrefreshing sleep,choking or gasping
during sleep,recurrent awakenings from
sleep) helps in determining the patient’s
overall need for the polysomnogram as
well as their chief complaint.
3. Time in bed
Time in bed is the total number of minutes
that a patient spends in bed. This amount
varies for different age groups and can
also vary on an individual patient basis.
This is important because it gives a basic
idea as to whether or not the patient is
spending enough time attempting to sleep.
4. Total Sleep Time
Total sleep time is the actual amount of sleep
time in a sleep period ; equal to total sleep
period less movement and awake time. Total
sleep time is the total of all REMS and NREMS
in a sleep period. This is important because it
gives a basic idea as to whether or not the
patient is achieving enough sleep for the time
they are in bed.
5. Sleep Efficiency
Sleep efficiency is the proportion of sleep
in the period potentially filled by sleep, that
is, the ratio of total sleep time to time in
bed.
Normal is >80%This is important because
it displays the patients overall quality of
sleep as it pertains to any sleep disorder
they exhibit.
6. Sleep Latency
Sleep latency is the period of time measured
from “lights out”, or bedtime, to the
commencement of sleep. This is important
because it can show the level of sleepiness by
how fast the patient gets to sleep or their sleep
latency (<30 minutes)
It can also help to determine insomnia in
patients that displays signs of excessive daytime
sleepiness but do not achieve sleep in a timely
manner.
7. REM Latency
Is the period of time measured from “lights
out”, or bedtime, to the commencement of
REM sleep (70-120 minutes)
8. Wake Percentage
Wake percentage is the percentage of
wake scored from lights out to the final
wake-up. This is important because it will
help determine how much any sleep
disorder is affecting the patient’s sleep
architecture.
9. Stage 1
Stage 1 is a stage of NREM sleep that ensues
directly from the awake state. It’s criteria
consists of a low-voltage EEG with slowing to
theta frequencies, alpha activity less than
50%,EEG vertex spikes, and slow rolling eye
movements. Stage 1 percentage is the total time
spent in stage1 sleep from lights out to the final
wake-up. Stage 1 generally constitutes about 4-
5% of sleep.
10.
11. Stage 2
Stage 2 is a stage of NREM sleep characterized
by the advent of sleep spindles and K
complexes against a relatively low-voltage,
mixed-frequency EEG background, high-voltage
delta waves may compromise up to 20% of
stage 2 epochs. Stage 2 percentage is the total
time spent in stage 2 from lights out to the final
wake-up. Stage 2 generally constitutes 45-55%
of sleep.
12.
13. Stage 3
Stage 3 is a stage of NREM sleep defined by at
least 20% of the epoch consisting of EEG waves
less than 2 Hz and more than 75 Micro V , it
constitutes deep NREM sleep. Stage 3
percentage is the total time spent in stage 3 from
lights out to final wake-up. Stage 3 sleep is
usually constitutes 12-18% of sleep.
14.
15.
16. REM Sleep
REM sleep consists of low-voltage, mixed
frequency EEG which may be accompanied by
both saw-tooth waves and rapid eye
movements. REM percentage is the total time
spent in REM sleep from lights out to the final
wake-up. REM sleep usually constitutes 20-25%
of sleep in 4 to 6 episodes.
17.
18. REM latency
REM latency is the period of time from
sleep onset to the first appearance of REM
sleep. This is important in showing a short
onset of REM sleep, which is a sign of
Narcolepsy.
20. Obstructive Apneas
Obstructive apneas are respiratory episodes where there
is a complete cessation of airflow lasting greater than 10
seconds associated with thoracic and abdominal efforts
21. Hypopneas
Hypopneas are a respiratory episode where
there is partial obstruction of the airway lasting
greater than 10 seconds (30% fall in nasal
flow)and accompanied by a 4% desaturation
22. Central Apneas
Central Apneas are respiratory episodes
where there is no airflow and no effort to
breathe lasting greater than 10 seconds.
Atleast >5 events per hour
23. Mixed Apneas
Mixed Apneas are respiratory episodes
where there are features of both
obstructive and central apneas in the
same event.
24. Total events
Total events is the total number of
Obstructive apneas, Hypopneas, Central
apneas, and mixed apneas from lights out
to the final wake-up.
25. RERA
characterized by marked decreased in
airflow for at least 10 secs with increased
respiratory effort, no significant
desaturation and which leads to an
arousal from sleep.
28. Cyclical crescendo and decrescendo
breathing pattern for 3 consecutive cycles
associated with
A.5 or more Central sleep apnoea or
hypopnoea per hour or
B.Cyclical crescendo and decrescendo
breathing pattern has duration of atleast
10 minutes
29. RDI
RDI is an abbreviation for Respiratory
Disturbance Index. This number is the average
number of respiratory events per hour of sleep.
APNOEA+HYPOPNOEA+CENTRAL APNOEA+
RERA
Any RDI lower than 5/hr is considered to be
within normal limits.
30. REM RDI
REM RDI is the total number of respiratory
episodes per hour of REM sleep.
31. Supine RDI
Supine RDI is the number of respiratory
episodes per hour of supine sleep. This is
important because the patient may have
only positional apnea and therefore can be
treated with positional therapy.
32. Oxygen (SaO2)
Baseline = the baseline oxygen level for
the entire polysomnogram.
Low = the lowest oxygen level recorded
during the polysomnogram.
34. Arousals
Abrupt change of EEG from a deeper stage of
NREM sleep to a lighter stage, or from REM
sleep toward wakefulness, with the possibility of
awakening as the final outcome
An arousal may be accompanied by increased
chin (EMG) activity and heart rate, as well as by
an increased number of body movement
35. Minimum duration is 3 secs
Types: respiratory, PLMs, spontaneous
Increased arousals are associated with
increased daytime sleepiness and
decreased performance, similar to that
seen in sleep deprivation
36. EKG abnormalities during sleep
Heart rate too fast (tachycardia) or too
slow (bradycardia)
Heart rhythm irregular
Pauses
38. Periodic Limb Movements
No of PLMS = the total number of periodic limb
movements during the polysomnogram.
Limb movement should be of atleast 0.5 to 10
seconds and > 75 MicroVolts
4 successive limb movements separated by
duration of least 5 to 90 seconds between each
movement
PLMS Index = the average number of PLMS per
hour of sleep.
39. Arousals
# of arousals = the total number of
arousals recorded during the
polysomnogram.
Arousal index = the average number of
arousals per hour of sleep.
<20 years is 10-20/hour
50-60 years 20-22/hr
40. Technical impression
The technical impression is the overall
breakdown and comments for the entire
polysomnogram.
41. Review of Sleep Study Times,
formulas and calculations:
Sleep statistics – Lights Out – Light On –
Total Recording Time – Total Sleep Time
– Sleep Latency – Sleep Efficiency – Rem
Latency – WASO (wake after sleep onset)
– Time and percentage in each sleep
stage
42. Respiratory Events
Number of obstructive apneas – Number
of mixed apneas – Number of central
apneas – Number of hypopneas –
Respiratory effort related arousals
(RERAs)
43. Oxygen saturation
Baseline oxygen saturation (at the start of
the study)
Lowest oxygen saturation during sleep
44. Diagnosis
The diagnosis portion is where the diagnosis for
this polysomnogram are listed. The diagnosis of
Obstructive sleep apnea is based upon the RDI.
Mild RDI 5/hr. to 15/hr.
Moderate RDI 15/hr. to 30/hr.
Severe RDI >30/hr.
-Split Night Study:in patients with moderate to high
probabity of OSA at least 3 hours of Diagnostic
portion followed by atleast 4 hours for titration