Artificial sweeteners are used as sugar substitutes that provide sweetness with fewer calories than sugar. Some are produced naturally while others like aspartame, saccharin, acesulfame-K, sucralose, and neotame are synthesized. They are used by those watching their sugar intake, managing diabetes, or concerned with weight gain. While safe for most in moderation, artificial sweeteners come with restrictions for those with rare conditions like phenylketonuria. They are many times sweeter than sugar but provide no calories, making them a popular sugar substitute.