Platelets are small non-nucleated cell fragments that originate from megakaryocytes in the bone marrow. They have a lifespan of 8-12 days and function to form blood clots to stop bleeding from damaged blood vessels. Platelets adhere to sites of injury in blood vessels and aggregate together to form a platelet plug. They release chemical signals that recruit additional platelets and activate the coagulation cascade to form a stable blood clot. Platelet structure includes a cell membrane, microtubules, and cytoplasm containing granules of proteins and enzymes involved in clotting and wound healing. Common platelet function tests include platelet count, bleeding time, and platelet aggregation assays. Abnormal platelet counts or function can occur in various medical conditions.