The document discusses the challenge of unlocking the potential of the unparalleled generation of human genomic and genetic data in a way that allows global data sharing. It introduces the Global Alliance for Genomics and Health, an international organization working to catalyze responsible data sharing through establishing interoperable standards and approaches. Key activities of the Global Alliance include several data sharing projects and working groups focused on clinical data, data representation, and ethics. The document encourages further international collaboration and participation to realize the benefits of genomic data sharing.