This document discusses a SWOT analysis of data science at the National Institutes of Health (NIH). It outlines opportunities and threats, as well as strengths and weaknesses. Key points include that data science will become more central to biomedical research but the transition is taking longer than needed. Opportunities include open science and patient-centered healthcare, while threats include insufficient resources and issues with data access and privacy. Strengths include large datasets and diverse data types available, as well as collaboration, but weaknesses include gender/race inequality and sustainability challenges. The Big Data to Knowledge (BD2K) program aims to address these through initiatives like the NIH Commons and policy recommendations.