The document provides details about the anatomy and physiology of swallowing. It describes the four stages of swallowing as oral preparatory, oral, pharyngeal, and esophageal. Key points include that swallowing involves passage of food from mouth to stomach through coordinated voluntary and involuntary contractions. The pharynx and esophagus are described in terms of layers, segments, nerve supply, and functions during swallowing. Causes and characteristics of dysphagia in the oropharyngeal and esophageal regions are also summarized.
short description of the process of deglutation with all the stages and their complete description and graphic view of all the things that are undergoing during the process of swallowing including an animated summary of whatever goes in the mouth for ease of understanding.
short description of the process of deglutation with all the stages and their complete description and graphic view of all the things that are undergoing during the process of swallowing including an animated summary of whatever goes in the mouth for ease of understanding.
details the deglutition or swallowing
phases and all process
theories of deglutition
components of deglutition,
stages of deglutition
deglutition reflex
features of swallow
physiology applied
details the deglutition or swallowing
phases and all process
theories of deglutition
components of deglutition,
stages of deglutition
deglutition reflex
features of swallow
physiology applied
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This seminar gives brief description about introduction, normal anatomy of velopharyngeal structure, different closure pattern of velopharynx, diagnostic aids used, VPI in cleft patients
Is a phenomenon of reflex sequence of muscle contractions that propels the ingested materials and pooled saliva from the mouth to the stomach.
PATTERNS
Infantile (visceral) swallow
Adult/mature swallow
ADULT SWALLOWING
Is composed of 4 stages
Voluntary
Preparatory phase
Oral or buccal
Involuntary: Controlled By Medulla and Lower Pons
Pharyngeal
b. Oesophageal
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
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- GENE THERAPY
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- ETHICAL CHALLENGES IN LIFE SCIENCES
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
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This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
2. Definition- Normal deglutition involves a complex
series of voluntary and involuntary neuromuscular
contractions proceeding from the mouth to the
stomach and is commonly divided into
oropharyngeal and esophageal stages.
Swallowing by definition involves passage of
bolus of food (solid / liquid) from the oral cavity to
stomach via the pharynx and esophagus, passing
over the entrance to laryngeal vestibule
3.
4. 12-14cm
4 layers :
Mucous membrane : ciliated columnar in
nasopharynx, stratified squamous in the rest
Pharyngeal aponeurosis : fibrous layer lining the
muscular layer
Muscular
Extrinsic : superior, middle and inferior constrictors
Intrinsic : stylopharyngeus, salpingopharyngeus and
palatopharyngeus
Buccopharyngeal fascia : lines outer surface.
5. Nasopharynx : base
of skull to soft
palate, c1 vertebra
Oropharynx :
junction of hard and
soft palate to floor of
vallecula, 2nd and 3rd
cervical vert
Hypopharynx : floor
of vallecula to lower
border of cricoid
cartilage, 3rd, 4th, 5th
and 6th cervical vert
6.
7. Sensory Nerve Supply:
• Nasopharynx: Maxillary nerve
• Oropharynx: Glossopharyngeal nerve
• Laryngopharynx: Internal laryngeal branch of the vagus nerve
Motor Nerve Supply:
• All the muscles of pharynx, except the stylopharyngeus, supplied by
the pharyngeal plexus
• The stylopharyngeus is supplied by the glossopharyngeal nerve
• Cricopharyngeus ms has additional supply frm external laryngeal N
& parasympathetic vagal fibres frm RLN ( relaxation ), postganlionic
sympathetic fibres frm sup cervical ganglion ( contrction ).
8. Esophagus
25cm long
Layers : mucosa, submucosa, muscularis propria
and adventia
Muscles : upper 1/3rd : skeletal
middle 1/3rd : mixed
lower 1/3rd : smooth
LES : 2-4cm tonically contracted thickened
smooth muscle
9. Teeth-grinding & reducing food
Elevators & depressors of jaw helps in bolus
formation
Tongue
Intrinsic muscles-changes shape of tongue
Extrinsic muscles-alters position of tongue
Lips maintain a seal preventing spilling of food
Buccinator returns food from the vestibule to the
oral cavity
Soft palate prevents nasal regurgitation &
premature movement of food into oropharynx
10. 3 components
Passage of bolus from oral cavity to stomach
Airway protection
Inhibition of air passing into stomach
4 stages
Oral preparatory Phase-voluntary
Oral phase - voluntary
Pharyngeal Phase-reflexive
Oesophageal Phase-reflexive
11. Food is readied for swallowing by reducing & mixing
with saliva
Jaw closed by jaw elevators masseter, temporalis &
medial pterygoid
Chewing occurs with the help of both elevators &
depressors
Lip maintains a tight seal under the action of orbicularis
oris
Buccinator returns food from vestibule during
mastication
Soft palate lowered by the action of palatoglossus &
palatopharyngeus which approximates the respective
arches to dorsal aspect of posterior part of tongue
12. Lateral rolling of tongue
: most important ,
manipulation and
mastication of food
At the end : tongue pulls
food together into a
bolus at the floor of
mouth or against hard
palate : preparation for
beginning of oral stage
Respiration: normal
through the nose (mouth
closed
13. Involves moving food from front of oral cavity to
the pharynx
Tongue plays a vital role in this phase : shapes, lifts
and squeezes the bolus upward and backward along
the hard palate
At this time lateral margins of tongue sealed
against alveolar ridge
Soft palate elevated by tensor and levator veli palati
When bolus crosses the tongue base : pharyngeal
swallowing reflex triggered.
14. Bolus accumulates in
the oropharyngeal
surface of tongue due
to repeated cycles of
upward and downward
movement of tongue
Time taken
Bolus preparation-
variable
Oral phase proper : 1-
2sec
15. This phase is reflexive in nature
Ventilatory & alimentary streams cross each other
during this phase
PROTECTION OF AIRWAY
Inhibition of diaphgramatic contraction making
swallow & breathing impossible simultaneously
Soft palate elevation closing the nasopharynx by
the action of tensor & levator veli palatini
Closure of larynx
16. Opening of cricopharyngeal sphincter
Airway closure
Pharyngeal closure to clear residues
Tongue base retraction to propel bolus through pharynx
Velopharyngeal closure
Pharyngeal swallow triggered
17. ELEVATION OF SOFT PALATE
ELEVATION OF LARYNX
CLOSURE OF LARYNX-3 TIER MECHANISM
*EPIGLOTTIS & ARYEPIGLOTTIC FOLDS
*FALSE CORDS
*TRUE CORDS
18. Pharyngeal closure
Food passes the tongue base
Immediately tongue base
retracts, moves backwards
Increase in pressure in
pharynx
Lateral and ppw move
inward( constrictor action )
19. Cricopharyngeus relaxes at
the time when pharyngeal
contraction occus
Allow food bolus to pass
Immediately closes to
prevent reflux of food into
pahrynx
21. 21
Stimulation of trigger
points present in the
oropharynx starts off the
pharyngeal reflexive
stage of swallowing
present at the faucial
arches & mucosa of the
posterior pharyngeal wal
innervated by
glossopharyngeal nerve
Stimulation of these
trigger points causes
dilatation of pharynx due
to relaxation of the
constrictors, and elevation
of pharynx & larynx due
to contraction of
longitudinal muscles
The pharynx constricts
behind the bolus thereby
propelling it
Contraction of the inferior
constrictor moves the
bolus towards the
oesophagus
22. Involuntary in nature
Starts with the relaxation of cricopharyngeus
The anterosuperior movement of laryngohyoid
complex opens the upper oesophageal sphincter
Bolus is then conducted from oesophagus to
stomach
23. Primary peristalsis
Continuation of peristalatic wave initiated in pharynx
Secondary peristalsis
Initiated due to distension of oesophagus with food
These waves will continue till all the food is emptied into stomach
Produced due to intrinsic neural circuits and partly by vagal reflex
Tertiary peristalsis
Irregular, non propulsive contractions involving long segments
which occur during emotional stress.
Time taken-
7-8sec (solids)
3sec (liquids)
24.
25.
26. Swallow is initiated in trigger area. Afferent is the
glossopharyngeal nerve
Efferents involve several cranial nuclei which
include
Nucleus ambiguus supplying muscles of palate,
pharynx & larynx
Hypoglossal nucleus supplying muscles of tongue
Motor nuclei of trigeminal nerve & facial nerve
which supply muscles of face,jaw & lips
27. Nucleus tractus solitarius, Trigeminal nuclei, Afferents from jaw,
muscles of mastication, lips and tongue
Triggering of swallow reflex
Pharynx
Food bolus in oral cavity
28. Muscles of pharynx and esophagus
Cranial nerve motor nuclei
Nucleus ambiguus : muscles of palate, pharynx and larynx
Hypoglossal : muscles of tongue
Motor nuclei of trigeminal and facial for muscles of jaws and lips
Medulla( dorsal and ventral group of neurons )
Dorsal : convergence of sensory input
Vnetral : output to cranial motor nuclei
Frontal cortex through ventral and lateral corticobulbar tracts
29.
30. DYSPHAGIA{Greek:dys-difficulty, phagia-to eat}
Refers to difficulty in swallowing affecting any part
from mouth to stomach
ODYNOPHAGIA
Painful swallowing
GLOBUS HYSTERICUS
Sensation of a lump lodged in throat
PHAGOPHAGIA
Fear of swallowing as in rabies, tetanus, pharyngeal
paralysis due to fear of aspiration
PRESBYDYSPHAGIA
Refers to swallowing difficulties due to ageing
31. Lack of coordination or strength of muscles
Mechanical obstruction
If contractions fail to develop progress bolus
distends the oesophageal lumen & causes
discomfort
Low amplitude of primary & secondary peristaltic
activity is insufficient to clear oesophagus as in
elderly individuals
32. Mechanical narrowing of oesophageal lumen
obstructs passage of bolus despite adequate
contractions
Minimal obstructing lumen; large bolus
Lesions occluding lumen; liquids & solids
Abnormal sensory perception in oesophagus may
cause sensation of dysphagia even after bolus is
cleared
33. Oropharyngeal
Difficulty in preparing
and transfferring food
bolus through oral
cavity
Difficulty in initiation
of swallow
Aspiration/
nasopharyngeal
regurgitation
Oesophageal
dysphagia
patients complain of
food sticking in their
lower throat, neck,
retro-sternal
discomfort or
epigastrium
34. Inability to initiate the act of swallowing.
It is a transfer problem caused by
impaired ability to transfer food from mouth to upper
esophagus
impaired oral preparatory phase
Clinical presentation:
food sticking in the throat
difficulty initiating a swallow
nasal regurgitation
coughing during swallowing
They may also complain of
dysarthria
nasal speech because of associated muscle weaknesses
Other Neurological clinical findings
36. Likely causes: reflux, certain cancers
Characteristics:
Structural abnormalities in esophagus
Decreased esophageal motility or contraction
Inadequate opening of lower esophageal sphincter
(bolus cannot move into stomach)
Excessive opening of the lower esophageal sphincter,
allowing backward flow of contents from stomach to
esophagus (reflux)
44. X-RAY SOFT TISSUE NECK
Lateral view
AP view
LATERAL VIEW(taken in full inspiration with neck
extn)
Examine patency of airway
Examine soft tissues of neck
Examine the cervical vertebra
Foreign body
45. AP VIEW
For glottic & subglottic areas
CHEST X-RAY
PA View
Lateral View
To detect general conditions of lung
Rule out aspiration,chest infection,pulmonary
neoplasm,achalasia cardia
Patency of airway
48. PROCEDURE
Patient is given liquid barium(barium sulfate)to
swallow while bolus is followed fluroscopically
COMPONENTS
Static: Provides information on structural
abnormalities eg-zenker’s diverticulum, cervical
osteophytes
Dynamic: Oesophageal motility assesed with multiple
single swallows in different positions(including
recumbent)
49. Continuous & single swallows are observed
separately as second swallow obliterates the
peristalsis of first swallow
Look for
Filling defects
Obliterative lesions
Spill over
Extrinsic compression
50. BARIUM SUPHATE
Contrast used in barium studies
ADVANTAGES:
Inert
Suspendable in water
very minimal absorption in GIT
DISADVANTAGES:
Outside the lumen of GIT acts as foreign body
Contrast leak in mediastinum leads to
inflammatory reaction
57. Performed like barium swallow but with addition
of effervescent granules to barium
Advantages:
Better anatomical details especially edge contrast
Disadvantages:
Irradiation
Documented on plain film
61. Procedure
Bolus(Barium sulfate) of all consistencies (liquid,
semi-solid, solid) incorporated with special
contrast materials in increasing volume to
minimize risk of aspiration.
Patient in upright position
Start with 1 ml
Simultaneous viewing of oral, pharyngeal &
laryngeal areas
Images recorded on videotapes in lateral & AP
views
62. Analysis
Subjective
Flow, misdirection & residue of bolus
Aspiration
Objective
Kinematics of swallowing
Capturing & manipulating digital images to make
exact timing of bolus flow & movements of
structures
Spatial measurement of distance & area
63.
64. ADVANTAGES DISADVANTAGES
ALL STAGES OF SWALLOWING
ASSESSED COMPREHENSIVELY
ANATOMY OF STRUCTURES
BETTER UNDERSTOOD
DIFFERENT POSITIONS
ASSESSED
ALL RANGE OF CONSISTENCIES
TESTED
DIAGNOSING SILENT
ASPIRATION SYMPTOMS
ESTIMATING THE AMOUNT OF
ASPIRATION
EASY TO VIDEOTAPE
IRRADIATION
HIGH COST
PATIENT INCOMPATIBILITY
LIMITED INFERENCE ABOUT
SENSATION,MUCOSA,GLOTTIC
CLOSURE,INTER BOLUS
PRESSURE
65. Contraindictations :
Patients without a pharyngeal swallow
Uncooperative, drosy patient
h/o adverse reactions to contrast media
Caution in pts with h/o respiratiory distress/ arrest
due to aspiration
66. CT used to stage the disease in malignant
dysphagia-both intrinsic & extrinsic
MRI used to detect intracranial lesions and
vascular abnormalities
Disadvantages
Expensive
Patient has to be in supine which does not reflect
stages of swallowing
68. Definition
Technique used to measure intraluminal pressure &
coordination of pressures in 3 regions
Lower esophageal sphinchter(LES)
Oesophageal body
Upper esophageal sphinchter(UES)
To assess oesophageal peristalsis & oesophageal
motor dysfunction
69. Technique
Performed with water
infusion catheters
They contain several
small caliber lumens
perfused with water
These are inserted into
oesophagus via nares
70. Mechanism
Oesophageal contraction occludes catheter
Water pressure builds in catheter exerting a
force,conveyed to external transducer
Electrical signals from transducers reflected in
computer which produces graphic record
71. Catheter advanced to approx.60cm to enter the
stomach
Patient placed in left supine position & catheter
calibrated
Catheter slowly withdrawn through LES,oesophagus
& UES
72. Basal LES pressure 10-45mm Hg
LES relaxation with swallow Complete
Wave progression Peristalsis
Distal wave amplitude 30-180 mm Hg
73. High resting LES Pressure
Absent or incomplete LES
Relaxation
Loss of peristalsis
75. Advantages Disadvantages
Actual test of pressure wave
pathology
Assessment of pressur events only
Due to movement of larynx difficult
to reading from middle transducer
measuring cricopharyngeus muscle
activity
76. Solid probe with 36 sensors
spaced at 1cm intervals,
having12 circumferential sectors
measuring pressure over 2.5mm
length
Average of pressure detected by
each sensor taken
Advantage
Simple
Precise
Accurate
Faster
77. Similar to videofluroscopy & manometry
Advantages
Combines pressure & bolus information
simultaneously
Disadvantages
Not widely used
Costly
78. Done under general anaesthesia
Used to visualize the pharynx & upper oesophagus
To take biopsy and staging tumors of pharynx &
upper oesophagus
To examine postcricoid area
79. Done in acute stages of dysphagia
Persistent dysphagia
Assesment of pharyngeal and laryngeal anatomy
and physiology with normal food and drink
Equipment
Flexible nasal endoscope, camera, monitor,
digital/video recorder, microphone
80. Procedure
Patient sits upright,nose examined for any septal
deviation
Decongestants & lubrication of nasal passages
along with topical anaesthesia
Scope passed between inferior turbinate & floor of
nose
Examine nasopharynx for nasal reflux, oropharynx
and hypopharynx
81.
82.
83. Advantages Disadvantages
Good view of anatomical variations
Visualization of secretion & pooling
of secretions
Observation of swallowing with a
range of normal food and drink
Can assess swallow when patient is
nil orally
Lengthy assessments-enables
assessment throughout meals
Portable
No view of oral phase
Loss of view due to pharyngeal
constriction around endoscope lens
Cannot measure structure
displacement
Cannot measure the amount of
aspirate
84. Short lived isoptope mixed with single swallow bolus
Gamma camera registers the radiation
Bolus transit & aspiration assessed
Advantages
Aspiration assessed
Disadvantages
Oropharyngeal anatomy not assessed
Cannot perform multiple swallows
Technical expertise needed
85.
86. Submental transducers used to image
Structures
Mobility of bolus transit
Vallecular status
Advantages
Avoids irradiation
Normal food used(no barium)
Disadvantages
Cannot be used to visualize larynx & pharynx due
to skeletal interference
Not effective for esophageal phase
87. 24hrs ambulatory Ph monitoring –reliable for GERD
Procedure
Proximal probe placed below UES
Distal probe placed 5cm above LES(position
detected by manometry)
Reflux measured along entire length of esophagus
Disadvantage
Invasive
Provokes relux
Editor's Notes
-passage of bolus from oral cavity to stomach
- airway protection
- inhibition of ingestion of air into stomach