The document discusses automation in the pharmaceutical industry. It describes how automation involves using machines to perform manufacturing processes instead of human workers. Automation can increase production rates and quality while improving safety. However, it also requires high capital costs and maintenance. The document then focuses on how automation improves compliance with regulations by connecting instruments to electronic systems and embedding rules to ensure data is valid. It provides examples of automated processes in tablet manufacturing, such as material handling and combining or eliminating steps. Finally, it discusses the role of robotics in research and development processes.

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2.  Introduction
 Advantages
 Disadvantages
 Automation and compliance
 Benefits of automation in pharmacy
 Automation in tablet manufacturing
 Automation and robotics
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3.  Automation means the use of machines and
equipments for performing physical and
mental operations in a production process in
place of human being.
 Pharmaceutical automation involves the
mechanical processes of handling materials,
distributing medications and manufacturing
and packaging formulations in industries.
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4.  Higher production rates and increased
productivity
 Efficient use of materials
 Better product quality
 Improved safety
 Shorter workweeks for labour
 Reduced factory lead times
 Less variability
 Greater control and consistency of product
quality.
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5.  High capital expenditure
 Higher level of maintainance
 Lower degree of flexibility
 Worker displacement- major demerit
 Emotional stress condition for workers
 Relocation of worker to find other work
 Workers become slaves of machines
 Society will become dependent on
automation for its economic well being
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6.  The pharmaceutical industry recognizes the
value of automation.
 Om May 16, The International Society of
Automation (ISA) invited top pharmaceutical
executives to their Food and Pharmaceutical
Industries Division (FPID) symposium to
explore and examine solutions to automation
challenges in food processing and drug
manufacture and distribution.
 Automation improves compliance and
minimizes deviations by connecting instruments
to electronic systems, so users don’t have to
manually enter data.
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7.  Organizations learned the importance of
protecting the validity of data generated and,
in a regulated environment, that deviations
from processes should be investigated and
removed.
 The Micro Therapeutic Research Labs
incident in March 2017 highlighted the
necessity for pharmaceutical organizations
to ensure the data associated with their
organization- including data produced by a
third party-is compliant with industry
regulations.
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8.  By automating processes and embedding
rules, organizations can ensure the data
produced, and associated with them, is
compliant
 From a regulatory perspective, automation is
a positive step to improving compliance.
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9.  Dispensing of prescriptions
 Filling , inspection and packaging
 Personalised medicines
 Structural protein analysis
 Measurement of molecular vibration and
rotational energy changes of each tablet.
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10.  Benefits of automation in tablet production.
 1.Improve material handling
 2.Improve specific unit operations
unit operations in tablet manufacturing:
• particle size reduction
• Sieving
• Mixing
• Particle size enlargement
• Drying
• Compression
• Sorting
• Coating
• Packaging
3. Eliminate or combine processing steps
4.Incorporated automated process control of unit operation and processes
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11.  Risks
1.Customer dissatisfication
2. Increased production rate
3. Employees safety liabilties
Principles of material handling
 Short distance
 Short terminal times
 Two way pay load
 Avoid partial load
 Avoid manual loading
 Move scrap cheaply
 Move in straight lines
 Unit loads
 Label thoroughly
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12.  Examples of material handling improvement
 Granulation and tabletting sections of the computer
controlled tablet manufacturing process by Merck Sharp
and Dohme (MSD) and Eli lily and company.
 Processing step combination or elimination
A] Direct compression (new process)
 Raw materials
 Weighing and measuring (automatic weigher and
recording system)
 Gravity feeding
 Compression (high speed rotary press)
 Aqueous coating (Hi coater)
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13.  Wet granulation: standard processing steps
1) Load processor weigh ingredients mix,
mass agglomerates, dry lubricate
2) Transfer( store)
3) Compress
4) Continuous batch powder mixing and
massing equipment
5) Eg. Dionsa mixer and granulator is a high-
shear powder mixer and processor
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14.  In the world of pharmaceuticals, there is a vital
role for robotics to play in the complicated
processes of research and development.
 Commonly used robots in pharmaceutical
industry :
1. Cylindrical robot for high throughput screening
2. Pharmaceutical container replacement robots
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15.  Tirelessness
 Accuracy
 Reliability
 Safety
 Redeployment
 Less chances of contamination
 Suitable to all environment
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16.  Costly
 Dangers and fear
 Safety
 Trained employee is needed
 Tough to installed
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17.  Research and development
 Laboratory Robots
 Control systems
 Vision system
 Sterilization and clean rooms
 Flexible feeding
 Biopharma and diagnostic application
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18.  Internet sources
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19. Thank you
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