Pertussis, or whooping cough, is an infectious disease caused by the bacterium Bordetella pertussis. It is characterized by severe coughing fits that end in a "whooping" sound as the person inhales. The disease progresses through three stages - a catarrhal stage with mild symptoms lasting 1-2 weeks, followed by a paroxysmal stage of severe coughing fits for 2-4 weeks, and finally a convalescent stage of recovery over 1-2 weeks. Pertussis is highly contagious and spreads through respiratory droplets. Treatment involves antibiotics and isolation of infected individuals. Vaccination provides effective protection.
Bordetella pertussis is an aerobic, non-spore forming, Gram negative coccobacillus (Shumilla et al., 2004). It has no known reservoir other than humans and is thought to be unable to survive in the environment for prolonged periods of time (Merkel, 1998). The Bordetella genus of the Alcaligenaceae family is comprised of seven different species, four of which cause upper respiratory tract infections in different host organisms (Babu et al., 2001). Bordetella parapertussis is the most closely related to Bordetella pertussis . It can cause a milder pertussis-like disease in humans, but Bordetella pertussis is the most serious human pathogen in this genus (Babu et al., 2001). B. pertussis invades its human host through entry into the respiratory tract where it colonizes to cause whooping cough, also known as pertussis, which was at one time a very common and potentially life threatening infection for children (Steele, 2004). Today, whooping cough still effects 20-40 million people worldwide each year and causes between 200,000-400,000 fatalities (Shumilla et al., 2004). The image on this slide shows the B. pertussis after Gram staining.
Whooping cough | pertussis ( medical information ) - a detailed studymartinshaji
Whooping cough (pertussis) is a highly contagious respiratory tract infection. In many people, it's marked by a severe hacking cough followed by a high-pitched intake of breath that sounds like "whoop." Before the vaccine was developed, whooping cough was considered a childhood disease.
this chart comprises all the major aspects of whooping cough / pertussis
please comment
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This ppt contains all the information about the epidemiology of Pertussis ( Whooping Cough). It is useful for students of the medical field learning Preventive and social medicine, Swasthavritta (Ayurved), and everyone who is interested in knowing about it
Bordetella pertussis is an aerobic, non-spore forming, Gram negative coccobacillus (Shumilla et al., 2004). It has no known reservoir other than humans and is thought to be unable to survive in the environment for prolonged periods of time (Merkel, 1998). The Bordetella genus of the Alcaligenaceae family is comprised of seven different species, four of which cause upper respiratory tract infections in different host organisms (Babu et al., 2001). Bordetella parapertussis is the most closely related to Bordetella pertussis . It can cause a milder pertussis-like disease in humans, but Bordetella pertussis is the most serious human pathogen in this genus (Babu et al., 2001). B. pertussis invades its human host through entry into the respiratory tract where it colonizes to cause whooping cough, also known as pertussis, which was at one time a very common and potentially life threatening infection for children (Steele, 2004). Today, whooping cough still effects 20-40 million people worldwide each year and causes between 200,000-400,000 fatalities (Shumilla et al., 2004). The image on this slide shows the B. pertussis after Gram staining.
Whooping cough | pertussis ( medical information ) - a detailed studymartinshaji
Whooping cough (pertussis) is a highly contagious respiratory tract infection. In many people, it's marked by a severe hacking cough followed by a high-pitched intake of breath that sounds like "whoop." Before the vaccine was developed, whooping cough was considered a childhood disease.
this chart comprises all the major aspects of whooping cough / pertussis
please comment
thank u
This ppt contains all the information about the epidemiology of Pertussis ( Whooping Cough). It is useful for students of the medical field learning Preventive and social medicine, Swasthavritta (Ayurved), and everyone who is interested in knowing about it
Pertussis : Highly contagious respiratory infection caused by Bordetella pertussis
Outbreaks first described in 16th century
Bordetella pertussis isolated in 1906
Estimated >300,000 deaths annually worldwide
Before the availability of pertussis vaccine in the 1940s, public health experts reported more than 200,000 cases of pertussis annually.
Since widespread use of the vaccine began, incidence has decreased more than 75% compared with the pre-vaccine era.
In 2012, the last peak year, CDC reported 48,277 cases of pertussis.
Extremely contagious-attack rate 100%
Immunity is never complete
Protection begins to wane in 3-5 yrs after vaccination
i dr manish tiwari a tutor department of microbiology SMC medical college unnao, very interested to make ppt of this subject and upload on slide share for benefit of medical(PG) and UG students. if anybody want any ppt of microbiology kindly message me on my mail address and you can contact me too on contact no.that is given on 1st slide.
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Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journey
Pertussis
1. Usually of young children, mild fever and an irritating cough, with characteristic 'whoop',
with cyanosis and vomiting. '100 day Cough'
Agent
B. pertussis 95% vs B. Parapertussis 5%.
Clinical disease is associated with encapsulated, phase 1 strains.
Infects only man. Source of infection is a case. Chronic carrier state doesn't exist.
Infective Material
Nasopharyngeal and Bronchial secretions
Infective Period
most infectious during catarrhal stage.
A week after exposure to about 3 weeks after the onset of paroxysmal stage although
communicability diminshes rapidly after the catarrhal stage.
There is no cross immunity with B. Parapertussis.
Environment
winter and spring season.
Mode of Transmission
droplet infection and direct contact.
Incubation Period
7-14 days, but not more than 3 weeks
Clinical Course
produces a local infection; the organism is not invasive. Multiplies on surface epithelium of
the respiratory tract and causes inflammation and necrosis of the mucosa leading to
secondary bacterial invasion.
Catarrhal stage, lasting for about 10 days. Lacrimation, sneezing, and coryza, anorexia
and malaise.
Paroxysmal stage, lasting for 2-4 weeks. Bursts of rapid , consecutive coughs followed by
'whoop', usually follwed by vomiting.
Convalescent stage, lasting for 1-2 weeks. Illnes genarally lasts for 6-8 weeks.
Complications are bronchitis, bronchopneumonia, and bronchiectasis.
Control
Early diagnosis is possible by only bacteriological examination of nasopharyngeal swabs.
Patient should be isolated until considered to be non-infectious.
Erythromycin, ampicillin, septran or tetracycline.
3 doses, each of 0.5 mL of DPT vaccine given IM, at 1 month interval, starting at 6 weeks
of age. Booster dose given at 18-24 months.
Morphology
gram-negative coccobacilli. Nonmotile, nonsporing.
Culture
aerobic, temperature is 35 to 6°C. Bordet-Gengou (Glycerol-potato-blood agar) medium.
Incubation for 48 to 72 hours, colonies are small, smooth, opaque, greyish white, refractile.
Hazy zone of hemolysis surrounds the colonies.
2. Biochemical reactions
Biochemically inactive. Does not ferment sugars, form indole, reduce nitrate, split urea or
utilise citrate. Oxidase positive, produces catalase.
Resistance
Killed by heating at 55°C for 30 minutes, drying, disinfectants.
Antigenic structure
1. Agglutinogen – All strains carry factor I and one or more of the other factors. Factor I to
6 present only in B. pertussis, 7 is found in all strains of the three species. Factor 12 is
specific for B. Bronchoseptica. Factor 14 for B. parapertussis.
2. Lipopolysaccharide – heat stable, endotoxin of the cell wall. Not protective.
3. Heat labile toxin (HLT)
4. Tracheal cytotoxin (TCT) – causes damage to the respiratory epithelium, makes more
prone to secondary infection.
5. Pertussis toxin (PT) – heat labile exotoxin, causes profound lymphocytosis.
7. Filamentous haemagglutinin (FHA) – mediates attachment of the bacteria to ciliated
epithelial cells of the respiratory tract. Also adheres to erythrocytes.
Pathogenesis
Incubation period 1 to 2 weeks. Transmitted by droplets. Last for 6 to 8 weeks. Three
stages, catarrhal, paroxysmal and convalescent. Each for two weeks.
Cases are maximally infective during catarrhal stage. During convalescent stage violent
spasm, continuous coughing, followed by ‘whoop’. During Convalescent stage, frequency
and severity of coughing gradually decreases.
Complications
Disease is self-limiting –
a) sub conjunctival haemorrhage due to the pressure effects of violent coughing.
2) bronco pneumonia and lung collapse.
3) convulsions and coma
Lab diagnosis
1. Microscopy – demonstration of bacilli in the respiratory secretions by fluorescent
antibody technique.
2. Culture –
a) prenasal swab – A swab is passed along the floor of the nasal cavity.
b) Cough plate method – Culture is held 10 to 15 cm in front of mouth during coughing.
Treatment
tetracycline, chloramphenicol, erythromycin, and ampicillin.
Prophylaxis
3 IM injections at intervals of 4 to 6 weeks. Given before the age of six months, booster at
the end of the first year. Vaccination is started at the age of six weeks.